• Frontline Plus for Dogs 0-22 lbs - ORANGE, 12 MONTH

    Frontline Plus for Dogs 0-22 lbs - ORANGE, 12 MONTH

    Regular Price: $202.99Sale Price: $155.99
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    Temporary Price Reduction! FRONTLINE Plus Orange for Dogs 0-22 lbs

    Recommended by veterinarians, FRONTLINE Plus Orange for Dogs 0-22 pounds is a powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. FRONTLINE Plus is specially formulated for dogs and puppies aged eight weeks and older weighing less than 22 pounds. Available without a prescription, FRONTLINE Plus only needs to be applied once a month for thorough pest control.

    life cycle of the commom flea
    Flea life cycle.
    View larger.
    life cycle of ticks
    Tick life cycle.
    View larger.

    Quickly Kills Fleas, Ticks, and Chewing Lice

    This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. FRONTLINE Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. FRONTLINE kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

    Waterproof Formula

    Thanks to its waterproof formula, FRONTLINE Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in FRONTLINE, fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

    EPA Registered Logo

    This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

    Package Contents

    Box includes three 0.67-milliliter tubes of FRONTLINE Plus for Dogs.

    FRONTLINE Plus Orange
    for Dogs 0-22 lbs
    • Kills fleas, flea eggs, ticks, and
      chewing lice
    • Fast-acting formula
    • Includes 12 one-month
    • Waterproof formula
    • Easy-to-use applicator
    • For dogs eight weeks and older
      weighing less than 22 pounds
    • Per Dose: $11.17
    More Info
    Got Fleas?

    A product guide to flea
    and tick products.

    Flea Facts You Should Know

    Interesting flea facts to help your
    pets be pest free.

    Fleas: Understanding the Enemy

    All about fleas and prevention.


    Helpful information on ticks and your

    FAQs about Fleas and Ticks
    Frontline Plus for Dogs Lifestyle shot
    FRONTLINE Plus for Dogs is Available In:
    (0 - 22 pounds)
    (23 - 44 pounds)
    (45 - 88 pounds)
    (89 - 132 pounds)
    3 month
    6 month
    12 month
    3 month
    6 month
    12 month
    3 month
    6 month
    12 month
    3 month
    6 month
    12 month

    Usage Info

    How FRONTLINE Plus Works

    Use FRONTLINE Plus for fast-acting, long-lasting flea and tick control. When you apply FRONTLINE, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, FRONTLINE provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

    Simple Three-Step Application

    Applying FRONTLINE Plus to your pet is an easy three-step process. First, remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down. Next, hold the applicator upright and away from your face and body and snap off the tip. Finally, place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.

    To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully.


    To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

    Weight Dosage
    Up to 22 pounds Apply contents of one applicator (0.67 milliliter) once per month
    23 - 44 pounds Apply contents of one applicator (1.34 milliliters) once per month
    45 - 88 pounds Apply contents of one applicator (2.68 milliliters) once per month
    89 - 132 pounds Apply contents of one applicator (4.02 milliliters) once per month
    All weights Apply contents of one applicator (0.5 milliliter) once per month




    Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

    Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


    Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

    Main Purpose

    To kill adult fleas and ticks.


    Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


    Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

    Main Purpose

    To break the flea life cycle and stop further infestation.

    Active Ingredients % by Weight
    Fipronil 9.8%
    (S)-Methoprene 8.8%
    Inert Ingredients 81.4%
    Total 100%

    Some animals are sensitive or allergic to the ingredients in FRONTLINE, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

    Net Contents

    Twelve tubes, each 0.023 fluid ounces (0.67 milliliters)

    Frontline Plus for Dogs 0-22 lbs- ORANGE, 3 MONTHFrontline Plus for Dogs 0-22 lbs- ORANGE, 3 MONTHReg price: $53.99
    Sale price: $40.99
    Frontline Plus for Dogs 0-22 lbs - ORANGE, 6 MONTH6 Mo Frontline Plus SmReg price: $101.99
    Sale price: $77.99
    Frontline Plus for Dogs 23-44 lbs - BLUE, 3 MONTHFrontline Plus for Dogs 23-44 lbs - BLUE, 3 MONTHReg price: $53.99
    Sale price: $40.99
    Frontline Plus for Dogs 23-44 lbs - BLUE, 6 MONTHFrontline Plus BlueReg price: $102.99
    Sale price: $78.99
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    Customer Reviews

    DISCLAIMER: The results described on the testimonials on this site, are the individual experiences and personal opinions of those who have purchased and used the products. These testimonials are not intended to make any claims that the products can be used to diagnose, treat, mitigate, cure or prevent any disease or medical condition.
    Click here to see all reviews
    Keeps fleas off my dog by sandyowl from Elkton MD10/03/2013

    Frontline is very effective at keeping my dog flea free.

    by from 05/16/2014

    Great Product by Marty from New York11/06/2012

    Frontline Plus works very well on my shih tzu. He is free of fleas/ticks/mites since we've been using this product on him. Good work Frontline!!

    by max from broward county florida02/21/2013

    frontline plus is a good product. been using it for 5 years.

    Been using it for years by Mike from Delaware10/28/2011

    Dogs still get fleas but big flea infestations don't develop.

    Used this product for years by VA-Cacher from Northern Virginia11/28/2012

    We live next to 35 acres of woods which is home to over 20 deer. Our dog is five years old and we have used this product since she was old enough to use it and she has never had a problem with ticks or fleas. So that tells me it works for her.

    Outstanding by Jen06/11/2008

    This works great!

    Never a problem and our dog is 6 years old. by Peggy from Philadelphia, PA10/23/2012

    Have used this product from the time our dog came to us at 8 weeks old. We have never experienced any problems with the product and the product has done the job it is supposed to.

    Doctor recommended by Happy Gal from Aiea, HI05/10/2013

    We live in Hawaii so it's summer all year long and my dog has never had a flea or tick. It's also easy to apply.

    Frontline by Pela from Nebraska10/17/2011

    Have ordered before and this time the order went just as planned as well. Much appreciated!

    Great product by SA10/23/2012

    Great product and excellent service - Thanks!

    good product by dlb from Portland, OR10/26/2012

    I have been buying Frontline for 8 years for both of my dogs. I find that it works well. I forgot to apply it one month and one of my dog's got fleas. I applied Frontline and washed her with flea shampoo and after a couple of weeks they were gone. I know other people say it doesn't work, but that is not the case with me.

    Cheaper by the dozen by Jill07/02/2013

    Great product at a cheaper price than i can purchase from my vet or pet store.

    GREAT VALUE by Storm's mom from Maryland10/23/2012

    Having done a lot of internet price checking, the sale price that ENTIRELY PETS offered was unbeatable! This is very helpful, especially in these economic times. THANKS FOR THE PRICE BREAK, E.P.!

    Frontline Plus for dogs by Cindy from NE Ohio01/17/2015

    I have used this product for many years with no problem AND no flea or tick in sight. But about 2 years ago I tried a flea med that claimed to be as good as Frontline Plus and almost immediately we had fleas. I will stick with Frontline Plus even though it is a little more expensive because it works!

    Kills them dead by kraleigh07/04/2012

    Just gave our 4 dogs baths. 3 of the 4 had dead ticks or fleas. No live ones. We are in a semi-rural area.

    Frontline by Tina05/03/2013

    I would recommend this product to anyone who has a pet. I have been using Frontline for the past 10 years and very satisfied with no complaints whatsoever.

    Works great by Jan01/23/2013

    I have used Front Plus for many years and it does the trick for my 2 dogs. I live in a warm climate and I am happy to say that my dogs have never gotten fleas.

    Good price on Frontline by crazy coton mom from Chicago, Illinois10/16/2011

    With two dogs, medicine for them gets quite expensive. I was happy to find a good price for the frontline plus.

    Frontline Plus by doxie from NC11/07/2012

    I used to buy this for my 2 doxies then switched to advantix b/c it repels mosquitos. One of my dogs acted crazy (very hyper) after applying advantix so I switched back. No problems, cheapest price I could find, fast shipping.

    Frontline Plus by ncn305 from Pittsburgh, PA08/24/2013

    Great product, does what it says it will do. My dogs are flea and tick free all season long. Plus it doesn't irritate their skin.

    product great/shipping bad by vireya from Plm Bch Gdns FL12/31/2013

    This, the third time, USPS has crushed the boxes every time

    Frontlibe Plus Orange 0-22 pounds by Debster from Lakeland, Fla05/30/2012

    I have a new TT puppy, she weighs about 6 pounds. I had no reservations about using Frontline Plus on her as well as my larger dog. She showed no adverse reaction after I applied and she is only 9 weeks old.

    Frontline Plus Orange for Dogs 0-22 pounds by MM03/01/2013

    Switched from Advantage to Frontline Plus because the fleas in my area became immune to Advantage. The dogs are much more comfortable. The groomer is not seeing fleas and having to use a dip and my family is not getting flea bites. Vet recommended this switch in meds. and I'm extremely happy to be using it on my 3 dogs!

    by from 04/15/2013

    I've been using this product for years for ticks, not fleas. It kills them after they attach. While I have found some live and feeding ticks over the years, for the most part I find dead attached ones. The idea is that the ticks die before they can spread Lyme disease.

    an by area from ofIf


    it's by expensive from :The


    Awesome by The Pittlucks' Zoo from Lake In The Hills, Illinois03/15/2012

    Best Prices for a Name brand product that works! Always had success with Entirely Pets and Frontline.

    Frontline Plus is Tried and True by Melissa from NJ04/10/2014

    I have been using Frontline Plus on my dogs for many years. Safe to say, we have never had a flea outbreak! The medicine is easy to administer, my dogs don't mind it, except I wish it would absorb more quickly. I have to remember not to pet them for a few hours or else I end up with Frontline on my hands! Entirely Pets has had the lowest prices hands down.

    Frontline Plus Orange by LovesShih-tzu04/25/2012

    Best price with reputable company; compare with others and you'll agree.

    Best price ever! by skcs03/11/2012

    Great product and with a 15% coupon plus free shipping, it's a fantastic deal. I've used Frontline Plus for many years on my Shih Tzuís and it works great. I highly recommend this product.

    Frontline Plus by Mystery Reader05/30/2012

    What can I say. It does what it says it does. But the good thing is Entirely Pets ships it quickly.

    Frontline Plus by Sharon from PA05/30/2012

    Always get what I need quickly and at the best prices around..

    Great Product by BA10/20/2011

    An excellent product that does what it's advertised to do and the price here is as good as it gets.

    by from 01/14/2014

    by ethan04/24/2012

    Have used this product for years with successful results.

    Usual product for less by sbusi2410/11/2011

    The products tend to be the same everywhere, I just look for the best deal and I found that here. :)

    frontline plus orange for dogs by DotC05/30/2012

    Excellent.....the ticks are terrible this year, this product really works even if a tick jumps on my dogs they fall off dead.

    No problem with this product by Linda from Delaware09/05/2013

    This productive is effective without any known problems using it

    Great Deal by Kitkat05291959 from Palatine, IL03/15/2014

    Frontline is a great product and the purchase price was awesome!

    Wish I would have found EntirelyPets sooner! by Westie Mom from Louisiana02/16/2012

    Can't believe I've been paying 20% more at my Vet's office for the exact same product.

    We love EntirelyPets by Deedle from Battle Creek, MI01/23/2013

    Always prompt service and the best prices - very dependable.

    Frontline by Yorkie mom from Pa07/07/2014

    Been using this product on my dogs for many years. Entirely Pets has the best prices, hands down... Service is great and they arrive in record time!

    by annba8604/02/2012

    The items I ordered arrived quickly. Will buy again.

    Best deal going! by Weezie from Pennsylvania08/16/2013

    The prices and fast delivery can't be beat! Been using this product on my Yorkies for years. You won't be sorry purchasing this product, or the service provided by Entirely Pets!

    very quick delivery by Is from maryland04/24/2012

    No problems it was delivered fast = this is a heck of a year for ticks --- it was just so warm -- be careful!!!!

    Quality flea and mite control by SJP from Port Charlotte, FL03/11/2012

    Have used for over 10 years....recently switched to one of the more reasonable priced products - not as good - so I'm back to FrontLine.

    by laura from Memphis, TN10/25/2012

    Great product at a great price! I would definitely recommend

    Tick Control by randy from Costa Rica03/08/2013

    We now live in Costa Rica and purchased a product locally. It did not control the ticks on our dog. We had a friend bring this product from the US and it is doing a pretty good job.

    Great product by kg11/15/2013

    I have used frontline plus for years and find it works as advertised .

    great price for this product by pat from honolulu, HI10/18/2011

    we use frontline every 3 mos and our pugs never have fleas.

    by from 01/31/2014

    Frontline Plus works by PJ03/09/2012

    I have always used this product for my dogs. Recently I switched to a lower priced alternative - big mistake! My pup was covered with fleas after each walk, driving my dog and me crazy. This never happened with Frontline Plus so I'm back and won't switch again. Safety is a big concern but my dogs have never had any adverse reactions.

    FrontLine Plus the best by Kenzie1mom from New Jersey07/25/2013

    Entirely Pets ia a wonderful online service. I order Frontline Plus and the price was the cheapest anywhere. Even my Vet could not match their price. I have two dogs and I always get a year's worth of Frontline Plus and split it so each dog is good for six months... The product was shipped fast and the price could not be beat on any other web site....

    Really works! by Ducklady from Annapolis, MD04/01/2014

    I've been using Frontline for several years. Since I have birds, I cannot have fleas in the house because we can't spray inside to exterminate. We've been using Frontline on the dogs and cats, and we've been lucky to have a flea-free home. We've tried other products, but some are not safe for cats. Since my pets sleep together, we have found Frontline to be safe for all of them, and works well for fleas and ticks.

    Frontline by judy from KY07/24/2013

    3 small dogs/good price at EntirelyPets. This product recommended by vet, (who would like to sell it to me).

    Good product by fireflyy from Okeechobee, Fl06/29/2013

    This is not the first time I used frontline on my dogs. I had used a product my vet had suggested until it got too expensive. Frontline seems to be doing ok. The only thing I have noticed id that when we take the dogs outside, they come back in with one or two fleas on them and it takes a while fro the frontline to kill them.

    Good Service, Very Good Price by Penelope28805/30/2012

    We haven't used the new EntirelyPets supply of Frontline Plus on our dog yet (still have some of last year's product, bought on another site). Assuming the product is of good quality, would have to say that we're completely satisfied with the company's service. The product was accurate and arrived quickly. The only glitch was that we didn't receive an e-mailed order confirmation. We called and were able to get the confirmation through EntirelyPet's customer service...not a big deal. We'd order from this website again.

    Great Product, Excellent Price by Marsh301 from Milwaukee, WI12/25/2013

    Forget about PedMeds. They charge more for their products to pay for their commercials. Some people thought these mail order companies for pet products were expired products or soon to expire. NOT SO. The items I ordered, Frontline, expire at the end of 2015!

    Wonderful Product by Angela11/29/2011

    Your prices I have yet to beat anywhere else.

    Frontline; a no-brainer by Robi from Pomona, CA03/16/2012

    No pills No stinky sprays No bothersome collars Frontline is the easiest product I have ever used for flea control. I have 4 dogs; ALL different breeds. And this is one product I can use on all four to provide great protection from the "critters".

    Six dogs by Marty from Orlando, Fl05/29/2012

    Having six small dogs make you vigilant of quality, price, variety, convenience, and customer service. Entirely Pets puts all this together in their website. Frontline took care of a flea infestation we got while using Advantage.

    Essential Protection by metrogirl from Gold Coast, Australia01/19/2012

    I think it is vital to ensure the health and safety of your dog and that includes protecting it with Frontline Plus. This is a very good protection that keeps your dog free from fleas, ticks and lice. It must be used every four weeks though otherwise it's effectiveness lessens. Why would you allow your best friend to suffer. There is no "natural" way of protecting them. EntirelyPets also offers the best price for one year's supply, which is the most cost effective.

    best product & best delivery service by mickey03/17/2012

    frontline is the best flea and tick control ever I have a white dog and fleas seem to attach to white since using frontline not one flea.

    Good stuff been using for years by KIB from NC10/31/2012

    Only had one incident of a flea in many years that i have been using this. No infestation though. Have 4 dogs and need to use all year due to warmer climate.

    Great Price by Spike03/02/2013

    Very competitive price for a quality product. Will defiantly shop here again.

    by Lauren05/01/2013

    Great product. I've done a ton of research, looking for the best price for Frontline, and Entirely Pets is the best around. Quick delivery, too. Very satisfied. Thanks so much.

    effective product by lu from Milwaukee, WI06/22/2013

    Frontline Plus has worked well for the dogs in my family. We've had no fleas and no ticks since using this. I typically apply it just once every couple of months but ticks are bad this year so I've applied it every 6 weeks thus far.

    The best product for the lowest price by Happy Owner from Fairfield, CT11/02/2011

    We've been using Frontline Plus on our cats and dogs for years, and it works. And this is definitely the lowest price in stores or online that I've been able to find.

    Returned it, they kept my money by Boston Holly10/23/2012

    My vet advised that my dog and 2 cats have fleas. I've used this product for years successfully , until I started purchasing it on-line.


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