Denosyl is a nutritional supplement that helps minimize a variety of liver problems in dogs and cats. It has also been shown to improve liver health and function by protecting and repairing liver cells. It is recommended to improve hepatic glutathione levels in dogs and cats. For optimal absorption, give your dog or cat Denosyl on an empty stomach, at least an hour before feeding.
FELINE AND CANINE DENOSYL ADMINISTRATION GUIDE
Total daily administration
and tablet size
Up to 12 pounds (5.5 kg)
One tablet of 90 mg
13 to 34 pounds (6-15.5 kg)
One tablet of 225mg
35 to 65 pounds (16 to 29.5 kg)
One tablet of 425 mg
66 to 120 pounds (30 to 54.5 kg)
Two tablets of 425 mg
Over 120 pounds (54.5 kg +)
Three tablets of 425 mg
The number of tablets can be gradually reduced or may be increased at any time depending on the pet's needs.
Denosyl, a nutritional supplement, is the pure and stabilized salt of S-Adenosylmethionine for veterinary use only. It is the only brand researched in medical trials for veterinary use in dogs and cats.
S-Adenosylmethionine is an endogenous molecule synthesized by cells throughout the body and is formed from the amino acid methionine and ATP. It is an essential part of three major chemical pathways in the body.
Denosyl has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidants that protects hepatic (liver) cells from toxins. A study found that low liver glutathione concentrations are common in dog and cats with decreased liver function.
For optimal absorption, tablets should be given on an empty stomach, at least 1 hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulties administering tablets to their pets, this medication maybe disguised in a small bite of food. Studies have shown that, in many cases, tablets or capsules given as a "dry swallow" do not pass into the stomach in cats, but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the table into the stomach. Denosyl 9- mg tablets are ideal for cats because of their small size.
Storage: Store in a cool, dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.
What does the liver do?
The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.
Because it does so much, the liver may be subject to many things: injury, both direct and indirect, infection, and toxicity. Some of the signs and symptoms of compromised liver function in pets may include: weakness, vomiting, poor appetite, and/or seizures. But if there is mild or early stage liver compromise, the pet can appear normal. If you notice any of these symptoms or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.
Excellent Supplement for my Dog's Liver by Angie from Albuquerque, NM11/30/2011
I'v been using this supplement for while. A year ago, my beloved Benji was diagnosed with idiopathic epilepsy and the vet put him on phenobarbital and other drugs. Unfortunately, long term treatment with phenobarb WILL cause liver damage, it is the reason why I'm using this supplement, to strenghten his liver. Every time he gets blood work done, our vet his liver is in very good shape. This is mostly due to the Denosyl. I'm very happy it's helping Benji's liver!
Working Well by westcaldwellmom from North Jersey03/07/2012
My vet recommended Denosyl for my 12 year old Shitzu whose liver is not functioning as well as it once was. I use Denosyl with this diet: white rice, oatmeal and I/D Low Residue dog food. It's working well. My dog is peppier and has no diarrhea.
back order by cary12/24/2012
Can't review. On back order for 6 weeks from Entirely Pets
So glad I can save a bit of money on my senior buddy's meds by getting these online.
Denosyl by tsmith3 from Murfreesboro,TN11/14/2011
This product is very good for helping keep liver levels in check with your older pet. I have been using this for years and my pet is doing fine. Would recommend it -
My only issue is with Entirely pets and how they send your order. They put it in a soft package and the boxes of meds gets smashed in shipment. I have complained a couple of times but nothing has changed. They offer good prices but their shipping lacks standards.
great product, good value by Biosquint from Tucson, Arizona04/18/2013
One of my cats has severe liver/galladder problems so he is on a special diet. Part of his treatment includes taking one 90mg Denosyl pill every day for the rest of his life. His liver enzymes went from extreme to normal in one month on this treatment and a low fat diet. Unfortunately, my vet's cost for the Denosyl was almost $30/month. I tried some other brands of SAM-e to get a better price but they did not work as well and his liver enzymes went up again. The Denosyl is the only one that seems to help. Thanks to Entirely Pets, I can afford to keep him on the brand that keeps him as healthy as possible.
Good product by Pauline02/12/2008
Again, my vet prescribes this, in combination with Marin, for my two pomeranians who have had elevated liver enzyme issues - One was elevated over 3000, over 10 times the normal high, and after a week, the reading was 900 - pretty good drop for a week. We are continuing on this medication (with Marin) for the meantime. In a couple weeks we will have more bloodwork to see how much more the level has dropped. Again, do check with your vet IF your dog has liver problems before giving this just to make sure it might not aggravate an existing condition. Otherwise if there are no existing health problems, it would be a good support herbal "medication" for the continue well being of your dog's liver.
denosyl by k.fuori01/12/2009
Ive been so pleased with the price and service at Entirelypets Ive acually have spread the word so we can all save and get excellent service.
thank you so much and my little Punkin thanks you too!
by from 12/12/2012
This product is AMAZING
a by liver from problemOur
vet by though from firstMUST
Great product by Marty02/28/2012
Much more convenient to purchase here. Delivered to my door quickly and easily.
Great Service. Gret price. by Randy from Phoenix, AZ07/17/2012
Ordering is easy. Delivery is always prompt and better than expected.
Great to strenghten my dog's liver by Angie from Albuquerque, New Mexico11/07/2012
I have been using this product for over a year now, after my beloved Benji was diagnosed with epilepsy. He is being treated with a couple of different drugs, phenobarbital being one of them. This drug will cause liver damage on a long term treatment. Thanks to Denosyl, Benji's liver is in excellent shape and has not been affected by the levels of phenobarbiotal in his system. I'm glad my vet suggested this product, I'm very happy with the results and I'm even happier I found Denosyl at a great price. Thanks, Entirely Pets!
by from 06/04/2012
I think "Entirely Pets" is a wonderful source for all your pet needs. I purchased the Denosyl for my 15 yr old rat terrier, and so far so good! The FortiFlora is a must for all pets, from birth to the twilight years. And they evidently love the taste when i mix with their food. It keeps them "regular & normal" with their bathroom issues (especially my older terrier). I use the Flora for my 1 yr old rat terrier also. Thanks for also making ordering easy and safe!
Springs, by CO" from Denosyl & FortiFloraJ.C.
Best product by angela02/25/2013
Denosyl saved the life of my mom's dog, who is 12 and has an outbreak of hepatitis.
Awesome Product by Katie from Valdosta, Ga01/23/2012
The Denosyl is an excellent product and the pricing is much better than at my local vets office. My dog, Zack, has been on this product for over a year and has done very well on it.
Denosyl by RC11/25/2012
I've ordered from Entirely Pets a few times before, with no problem. However, with this shipment of supplements, the boxes of Denosyl were very poorly packaged (a barely padded shipping envelope) for shipping and 4 of the 6 boxes were completely smashed. Therefore some of the pills were also smashed which could possibly compromise their effectiveness, as they are not to be subjected to any moisture of any kind. The pills aren't inexpensive, so I was obviously displeased and disappointed. I hope Entirely Pets will begin to package merchandise more carefully.
6 Pack Denosyl for small dogs by cactus0912/18/2012
Great product, poor service!! I usually spend about $500 per year on this from Entirely Pets. Last order was on backorder for weeks with no projected date of delivery. Claimed MFR backorder and had me contacts MRF for more info. MRF had no supply problems to any supplier. Went to another Vet Supplier online and had the product delivered immediately. EntirelyPets.com probably lost me as a customer.
by from 06/07/2013
Our Cat has liver issues. the vet recommended Denosyl. We've been using it for a couple of years now, and the liver issues are nicely controlled.
Mary by New Jersey from Fabulous
Denosyl is outstanding
Denosyl is amazing by Pj from Miami, Fl04/21/2012
I have been giving Denosyl to one of our cats since it was diagnosed with hyperthyroid issues.
So when another of the cats became sick ,stopped eating and vet couldn't help, we thought we'd try denosyl. Within a week a cat that seemed to be at the end of life was back to its old self! We now supplement with Denosyl 3x weekly and our old boy is looking great.
It's 3 x cheaper than the vets by dio from california10/29/2012
My dog has be on denosyl for the last 2 years.due to liver and kiddney promblems and
he is still alive because of this medicine.
Denosyl a miracle drug for my cats by Sue from Milwaukee, WI10/24/2011
When my first cat developed kidney problems I thought she didn't have long to live. Our vet put her on Denosyl. Within 4 months she had gained back all her weight and was acting like herself again. Then our second cat started with liver problems a year later and was put on Denosyl. Again she gained some of her weight back and her liver is once again functioning normally. Denosyl has greatly improved our cats lives and I would recommend it to anyone whose cats are having kidney or liver problems.
Best Prices on the web by JerzeyJoe from West Deptford,New Jersey06/19/2012
We have been buying Denosyl online from entirely pets for at least 7 years,Saving us hundreds of dollars,The same product from the vets office was 3 times the price at our vets,If your dog or cat needs Denosyl this is the place to buy it,We will be a customer as long as our dog needs these meds.They are used to help the Liver due to damage from our dogs Seizure Meds.
Used this product before. by Candace11/06/2012
I haven't received the shipment yet. Today's date is Nov 6, 2012.
Good Product....Bad Packaging by tsmith3 from Tennessee06/05/2012
I am a regular customer of Entirely Pets and I love the prices, you can't beat them. The only issue I have is with the packaging. Products are sent in envelopes that are easily crushed in shipment. My orders come flattened out most of the time. I have complained but receive no response on this.
In this case, a lifesaver. by tinheart from Joliet, Illinois04/03/2013
My wife's chihuaua has insufficient liver capacity. Denosyl 90 mg helps it do the job of cleaning Brewster's blood. When first diagnosed, the doctor estimated Brewster's life span at five to eight years. He is going strong and looking good and will be nine years old come April 15, 2013. Of course Denosyl is not the only measure we are taking. It is an important part of his treatment.
Life Saver! by CinderellaMoments from Texas03/16/2012
This product is incredible. Denosyl along with a special dry food diet saved my Yorkies life. She was at deaths door due to her malfunctioning liver. Now she's back to being a healthy, happy, playful dog. And the price on this site is the best I've found anywhere.