• 3 Pack Denosyl for dogs over 35 lbs (90 tablets) 425 mg

    3 Pack Denosyl for dogs over 35 lbs (90 tablets) 425 mg

    SKU: DENO3PK425
    Regular Price: $172.99Sale Price: $132.39
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    #1 Veterinarian Recommended LiverDenosyl is a nutritional supplement that helps minimize a variety of liver problems in dogs and cats. It has also been shown to improve liver health and function by protecting and repairing liver cells. It is recommended to improve hepatic glutathione levels in dogs and cats. For optimal absorption, give your dog or cat Denosyl on an empty stomach, at least an hour before feeding.


    Body weight Total daily administration and tablet size
    35 to 65 pounds (16 - 29.5 kg) One tablet of 425 mg
    66 to 120 pounds (30 - 54.5 kg) Two tablets of 425 mg
    Over 120 pounds (30 - 54.5 kg) Three tablets of 425 mg
    The number of tablets can be gradually reduced or may be increased at any time depending on the pet's needs.

    Usage Information

    Ingredients: S-Adenosylmethionine

    Denosyl, a nutritional supplement, is the pure and stabilized salt of S-Adenosylmethionine for veterinary use only. It is the only brand researched in medical trials for veterinary use in dogs and cats.

    S-Adenosylmethionine is an endogenous molecule synthesized by cells throughout the body and is formed from the amino acid methionine and ATP. It is an essential part of three major chemical pathways in the body.

    Denosyl has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidants that protects hepatic (liver) cells from toxins. A study found that low liver glutathione concentrations are common in dog and cats with decreased liver function.

    For optimal absorption, tablets should be given on an empty stomach, at least 1 hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulties administering tablets to their pets, this medication maybe disguised in a small bite of food. Studies have shown that, in many cases, tablets or capsules given as a "dry swallow" do not pass into the stomach in cats, but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the table into the stomach. Denosyl 9- mg tablets are ideal for cats because of their small size.

    Storage: Store in a cool, dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.

    What does the liver do? The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.

    Because it does so much, the liver may be subject to many things: injury, both direct and indirect, infection, and toxicity. Some of the signs and symptoms of compromised liver function in pets may include: weakness, vomiting, poor appetite, and/or seizures. But if there is mild or early stage liver compromise, the pet can appear normal. If you notice any of these symptoms or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.

    Customer Reviews

    DISCLAIMER: The results described on the testimonials on this site, are the individual experiences and personal opinions of those who have purchased and used the products. These testimonials are not intended to make any claims that the products can be used to diagnose, treat, mitigate, cure or prevent any disease or medical condition.
    Click here to see all reviews
    Great Purchase by Kat12/30/2011

    This was less then half the price as the vets and it was delivered in a timely manner BUT I ordered 3 boxes and they were all in one package and the package was totally open at the top so I wasn't pleased about that but everything was ok with the boxes. Hopefully next time they will make sure it is well sealed.

    good product by doris from Quebec, Canada11/01/2012

    I used to buy Zentonil but Denosyl do the same job. My dog's last blood test was very good.

    Cheaper here by Poodle11/04/2013

    Recommended by vet so who am I to talk about its efficacy. Will say, though, that it's less expensive here than anywhere else I've found online.

    great price by fuzz from rhinelander WISCONSIN01/25/2012

    this product was a third the cost of purchasing through my vet. Thanks

    Denosyl for Cataracts in dogs by Tom from TN05/22/2014

    I use glutathione to control/reverse my cataracts, and I searched for a veterinary product to do the same for my dog Spike. Denosyl is sold for treating the liver, but if you read the "fine print" it greatly increases the dog's own production of glutathione in the liver. If you research glutathione you will learn that it 1.) must be made in the body from other precursors, and 2.) it performs many vital tasks in improving overall health. Denosyl is an excellent source of a precursor for glutathione (but not for human consumption - you can use Sam-E or N-Acetylcystiene to do that). It has significantly improved Spike's health.

    Life Saver for my best friend! by NancyinTX from Texas05/10/2013

    My then 13 year old Border Collie, Josie, was diagnosed with severe liver disease more than a year ago and declining rapidly. With a little research on of my own I made the decision to put her on a daily regime of a recommended LD product called Marin. When Marin was not readily available I substituted another LD product called Denosyl. To this daily dose I added a supplemental nutrient and antioxidant capsule of Proanthozone along with the vet recommended dose of Prednisone and a strict LD Diet kibble. It's amazing to see the quality of life Josie has enjoyed since I began the routine! She moves a little slower these days when she plays her favorite game of fetch but she is eating well, has a healthy coat and has regained her happy joyful personality! I don't know if it can be attributed to just one thing but, I'm not willing to risk changing any of it. Worth a try for sure. Please, NO MEAT SCRAPES no matter how much you'd like to give your pet a little treat, as just a small piece reverses Josie's condition drastically-learn from my mistake. Best to you and your beloved dog!

    Denosyl by Ernie from Carlsbad, NM03/26/2012

    This product works and the price at Engtirely Pets is better than others.

    Never Received Purchase by mcfa18 from Columbus, OH05/29/2013

    The product works well but was backordered and I still have not received it. The backorder is for quite a long time so I had to obtain the product elsewhere in the interim. Thankfully, I was able to do so because the health of my dog depends upon it. I do not know whether the issue was with the manufacturer or the purchasing folks at Entirely Pets.

    Dog with tumor on liver by Snoopsmom02/25/2011

    My 13 year old mixed breed was diagnosed with an inoperable liver tumor two years ago. She had elevated levels of liver enzymes, which led to an ultrasound revealing the tumor. Our vet recommende denosyl, which supports liver function. Knock wood, two years later she is still going strong!! And buying online makes this supplement affordable. Worth the cost to keep my best friend with me for as long as possible!!!

    Required med by Lablover11/23/2012

    My dog take phenobarbitol and potassium bromide to prevent seizures. He takes Denosyl to keep his liver functioning well. He needs this and I am pleased that Entirely Pets can provide it.

    Whatever it takes by David from Christiansburg, VA11/30/2011

    Denosyl is fairly expensive, but I will do whatever it takes to keep my dogs healthy. My 13 year old was diagnosed with liver disease 5 years ago and prescribed Denosyl. She is still doing well. Entirely Pets makes it much more affordable.

    worst purchase ever by Kiwi from Canada09/17/2013

    order apparently doomed from the get go! First off, was advised it was back-ordered. Got tired of waiting, so cancelled (TWICE) by email. No response. Order duly arrived (regardless of cancellation emails) some 8 weeks later. By then had decided to accept, as Visa payment had already been processed. However on opening order, found only ONE packet of Denosyl, instead of the three I had paid for. Phoned Entirely Pets (since email obviously useless) only to be told that orders could only be cancelled by PHONE. (where on site does it say that???), but when informed of the 2 missing packets, rep. grudgingly and abruptly stated I would be "credited for whole order". Emailed some 2 weeks later to see why my Visa had not been credited - only to find that it was a "store credit" - can only be used when/IF I buy more products. A BAD experience all round, and you can be sure that once I have used up my "store credit" I'll be taking my business elsewhere. (a far simpler solution would have been to apologize and send the missing 2 packets at Entirely Pets' expense!)

    Great price for product & no prescription needed!! by JandL11/22/2011

    Great product! My dog has acute liver disease and needs Denosyl for the remainder of her life, so I try to find the cheapest price out there. Normally I would need a prescription for this product, but EntirelyPets did not require one. You can't beat the price!

    Customer service needs to improve by Dave McG07/25/2013

    I ordered this product on June 12 and the order confirmation advised that it was backordered. No information since. It would be nice to get an update regarding availability.

    Saves Money by Jan09/03/2013

    This product was prescribed for my dog by her vet. To purchase it from the vet costs twice as much as when you buy it from Entirely Pets. Good service too.

    Denosyl 425mg by Sylvia from Burlington, ON09/06/2012

    At the advice of our vet, our dog has just finished a 3-week course of Denosyl 425 and his liver is back to normal. Obviously the product worked and we are truly happy with his quick recovery.

    Denosyl is a miracle worker! by Clyde Redbone from North Carolina06/05/2012

    I have a 15 year mixed breed dog who years ago was very ill and near death. The doctor said he had the same thing as Serosis of the liver. He told me to try Denosyl. This made a huge difference. He bounced back and has never been better. It may not work for all dogs but it is worth a try. Entirely Pets also sells it the cheapest.

    Great Pricing by poohdlekb12/08/2011

    This is a great price for this product! Denosyl keeps my dog healthy.

    by from 01/07/2014

    saved my dogs life by Gene04/15/2013

    This product saved my dogs life , I lost her mother to liver failure . I wished I had found it sooner . When I found Sadie was having the same problem as her mom the Vet said to try this , after 6 mo. her liver numbers were cut in half , I gave her 2 pills per day then after about 9 mo. her numbers were good enough that I now give her just one pill per day and her numbers are in the good range , and have been for about 9 mo. Best stuff ever

    They never delivered the product by Me from Baltimore, MD05/31/2013

    They want a review on a product that was never received. WTF???

    Comment by Hank from Apple Valley,CA.04/29/2013

    If it were not for Entirely Pets I would be paying much more to medicate my dog by my vet. Thank you so much Entirely Pets.

    Excellent Product by Susan02/28/2013

    My dog was having serious liver problems a little more than a year ago and now he is doing great. He has been taking Denosyl for a year now and I wouldn't take him off it!!!

    WORST COMPANY by Sarah from Farmington Hills, MI08/07/2013

    The product is a necessity due to my dogs illness. I have been looking for a cheaper place to purchase since my dogs meds run about 400 per month. I love this product but this company is awful. I placed an order for this on 6/11/13 and received a back order notification immediatly after. I called 3 weeks later and they informed me they have a shipment coming in 2 weeks and they will expedite it. It is now 2 months later and "I" contacted them again only to find out they do not know when the next shipment will come in. I am glad they notify their customers who rely on these medications. I rather pay more than be treated like my order is not important. I will never purchase here again!!!

    EntirelyPets Entirely Out of this World by Vicky from Roanoke, VA10/08/2011

    My dog has liver issues and has to take Denosyl. This medicine is expensive through a vet. However, I found it at a much lower price at EntirelyPets.com. I soon found out that was only a small part of what EntirelyPets offered. I get free shipping and often get percentages off of my order. But the best part is that I can order it and within 2 days I have the order. I highly recommend using them. Thank you EntirelyPets!

    by from 01/12/2013

    Product rocks...company rots!! by Pebbles from Long Island, NY08/13/2013

    Ordered this product...MEDICINE FOR A SICK DOG.. on 05/22/2013 and it was FINALLY delivered on 08/12/2013. Called the company 3 times over 3 months and was told it would be shipped the next week. I will NEVER do business with this company again!!

    Denoysl Effectiveness by Frank from Johnson City, TN03/04/2010

    My dog is going on 13 and was taken to the vet with anemic like symptoms. It turned out to be a problem with the spleen and lukemia like symptoms on the body. He has been in treatment now since early Oct of 09. This product has helped him wonderfully. He is recovering and this product seems to be protecting his liver. He is still under treatment but he's holding his own and now the doses are been reduced 3 times. I think this product just might be what has pulled through all the toxic medications he's be on for over 6 months.

    by jeff10/30/2011

    This medicine is exactly the same as was given at the vet but a lot more inexpensive. Delivery is completed in a timely fashion as well.

    Life saver by Celje from Arizona09/05/2014

    This product saved my senior dogs life. I would recommend it for liver problems for senior dogs.

    Used Denosyl for years by Ellie's Mom from Phoenix, Arizona04/01/2014

    Great product that has helped my dog who struggles with liver issues. She has been on Denosyl for many years and it has helped to keep her liver values stable.

    Best Online Price by Judi from New Cumberland, PA11/30/2011

    We have had our GSD on Denosyl and Marin for almost 5 years now due to liver disease. I searched the internet and found Entirely Pets to be the best price anywhere. Just recently they have offered the 3 month auto-ship which I really love. We have her dog food on auto-ship and now her meds. I don't have to worry about running out ever again. Thank you EntirelyPets. We also like your choices of toys for dogs. Great prices and quality.

    Good product by DogMom22bcs11/06/2011

    My dog has been on Denosyl for several years; I do think it has helped. I would suggest slightly more/better packing, as the boxes come slightly crushed - but the contents are fine.

    Brought down liver enzymes by Red Dog07/30/2012

    This product, along with Marin, and over the course of a few months, helped to significantly bring down our senior's high liver enzyme level.


    Questions and Answers

    6 Pack Denosyl for dogs over 25 lbs (180 tablets) 225 mg6 Pack Denosyl for dogs over 25 lbs (180 tablets) 225 mg
    Reg price: $197.99
    Sale price: $151.79
    Denosyl for dogs over 35 lbs (30 tablets) 425 mgDenosyl for dogs over 35 lbs (30 tablets) 425 mg
    Reg price: $63.99
    Sale price: $48.99
    6 Pack Denosyl for dogs over 35 lbs (180 tablets) 425 mg6 Pack Denosyl for dogs over 35 lbs (180 tablets) 425 mg
    Reg price: $343.99
    Sale price: $264.59
    Denosyl  for Dogs Professional Line (30 Chewable Tabs)Denosyl SAMe Tabs Professional Line
    Reg price: $38.99
    Sale price: $29.99

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