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    Denosyl for dogs over 35 lbs (30 tablets) 425 mg

    Item Number: DENO425MG
    Regular Price: $59.50Sale Price: $44.52
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    #1 Veterinarian Recommended LiverDenosyl is a nutritional supplement that helps minimize a variety of liver problems in dogs and cats. It has also been shown to improve liver health and function by protecting and repairing liver cells. It is recommended to improve hepatic glutathione levels in dogs and cats. For optimal absorption, give your dog or cat Denosyl on an empty stomach, at least an hour before feeding.


    Body weight Total daily administration and tablet size
    35 to 65 pounds (16 - 29.5 kg) One tablet of 425 mg
    66 to 120 pounds (30 - 54.5 kg) Two tablets of 425 mg
    Over 120 pounds (54.5 kg +) Three tablets of 425 mg

    The number of tablets can be gradually reduced or may be increased at any time depending on the pet's needs.

    Usage Information

    Ingredients: S-Adenosylmethionine

    Denosyl, a nutritional supplement, is the pure and stabilized salt of S-Adenosylmethionine for veterinary use only. It is the only brand researched in medical trials for veterinary use in dogs and cats.

    S-Adenosylmethionine is an endogenous molecule synthesized by cells throughout the body and is formed from the amino acid methionine and ATP. It is an essential part of three major chemical pathways in the body.

    Denosyl has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidants that protects hepatic (liver) cells from toxins. A study found that low liver glutathione concentrations are common in dog and cats with decreased liver function.

    For optimal absorption, tablets should be given on an empty stomach, at least 1 hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulties administering tablets to their pets, this medication maybe disguised in a small bite of food. Studies have shown that, in many cases, tablets or capsules given as a "dry swallow" do not pass into the stomach in cats, but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the table into the stomach. Denosyl 9- mg tablets are ideal for cats because of their small size.

    Storage: Store in a cool, dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.

    What does the liver do? The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.

    Because it does so much, the liver may be subject to many things: injury, both direct and indirect, infection, and toxicity. Some of the signs and symptoms of compromised liver function in pets may include: weakness, vomiting, poor appetite, and/or seizures. But if there is mild or early stage liver compromise, the pet can appear normal. If you notice any of these symptoms or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.

    Customer Reviews

    DISCLAIMER: The results described on the testimonials on this site, are the individual experiences and personal opinions of those who have purchased and used the products. These testimonials are not intended to make any claims that the products can be used to diagnose, treat, mitigate, cure or prevent any disease or medical condition.
    Click here to see all reviews
    4.84 rating based on 55 reviews
    Wish they were smaller! by Allie10/27/2011

    My dog needs 2 of these every day to help treat his hepatitis and I wish these were smaller and easier to give him since he has to eat them on an empty stomach. On the other hand, this is the only place I've found them at this strength and the price is fair!

    Seen a difference by Lori from lexington, ky01/27/2013

    Since my dog was put on this product, I saw him get his appetite and weight back so I think it is helping his condition.

    Denosyl 425mg by thegreatcommish from Bakersfield,California01/24/2013

    Thank you for offering this life sustaining product at a reasonable price. Our "KING' of the house, Rudy had to have two rather large cancerous tumors removed...resulting in the removal of over half of his liver. We thought that we had lost him for sure, but he has made a fantastic recovery. It has been six months now since he became ill, and everyday is a blessing. He loves to go swimming in the pool, go on his daily walks, and play "keep away" with his big rawhide bone!!!

    Great Value by bubbs from Mesa, Arizona06/12/2012

    I am certainly glad to have found Entirely Pets. The prices are more in line, and the quality of service I received was exceptional. I ordered on line, and got through the process without aggravation. My dog is now on Denosyl, and hopefully this will restore her liver function. Thank you for such good service.

    by Hank from Apple Valley,CA.10/24/2012

    I have searched the internet as well as stores that sell dog medications and have found that EntirelyPets beats them all! Some of these places that I checked on charge much more for a specific medication than EntirelyPets does and I am very grateful for that. Thank you. Many of us out here are trying very hard to take care of our pets properly, but those that charge higher prices to make more profit does not help anyone out here in their stuggle to purchase affordable medication for their pets.

    Denosy by Michael from Montreal08/06/2012

    Perfect service and fast delivery fo Canada. 10/10

    Great price! Fast Service!! by Jennifer M from Riverview, Fl10/27/2012

    Very happy with Entirely Pets. Best price around. Signed up for Auto reship. Received my product fast, and in time before we ran out of the medication! Would recommend Entirely Pets!!

    by Sayhi from Mechanicsville, VA01/23/2013

    Back in May my 14 year old Siberian began to have liver issues and incontinence. She wouldn't get up and the vet believed she was close to death. I refused to give up so we put her on Denosyl (and several other supplements) and today she acts like a puppy again.

    denosyl by debbie from Kane, PA07/09/2014

    Have to give to my dog for a year for elevated liver enzymes

    She's Still Kickin' by Blondie07/24/2014

    My vet suggested giving Denosyl to help my aging dog with liver issues. One and a half years after he thought she might be on her last leg, She's still Kickin;!!

    Great product by poohdle06/27/2012

    This keeps my girl healthy. She has liver disease and has been on it for quite awhile.

    For my Barney by Mountain Girl from Bayfield, CO01/28/2013

    Unfortunately, my Barney has liver issues. He's been on denosyl for about 3 years. He is now over 14 and still hanging in there. Only the best for him. My only dislike of denosyl is the price, but because companies and vets know how much we love our pets, they can set the price at anything and we'll pay it...

    Denosyl by Jan06/02/2013

    This product was prescribed by our vet and will probably be something our dog will take for the rest of her life. The vet charged almost three times what Entirely Pets charged and it was exactly the same product. We are very happy with our experience with Entirely Pets.

    it works by cindi03/14/2013

    My dog has had her liver values reduced by half while on denosyl. Although values still high it has helped. Will keep her on it.

    Denosyl product by jmar63 from Kernersville, North Carolina08/26/2014

    I don't know if this product is working or not. It would be nice if these came in a chewable form. Not all animals will take the pill. Even when hidden.

    Best price anywhere on Denosyl by Bonnie03/29/2012

    My 15 year old Shetland Sheepdog has been on this for more than three years. I've researched multiple websites for the best supplier, but had missed EntirelyPets and was using another company. Found EntirelyPets to be the best price ever. Delivery was as promised. I have set up a monthly reorder.

    by Jason11/06/2012

    Great product for the health of a dog's liver.

    Fast service by Jillian from Beach Park IL12/27/2013

    Very fast service and good pricing on this vet recommend product for my dog.

    Definite Buy by wiffylee from Waterford, MI02/05/2012

    I have searched for this medication that is not a prescription, and found it very expensive elsewhere. Not only is it cheaper but Entirely Pets allow you to set up if you need this monthly, every couple of months or however you may need the product. That takes the worry out of having to order it.

    GREAT PRODUCT and GREAT PRICE by Marnie04/27/2012

    A very good product and it was recommend by my dogs vet. Her blood tests have improved since on the Denosyl.

    It really helps by Patsy H from Florence, KY08/13/2014

    Our veterinarian recommended we try Denosyl for our almost 15-year-old Brittany, Roxy. Within a very few days we saw a difference in her cognitive function. She is alert, "connected," in great spirits and doing beautifully. The only issue is that you have to give the med on an empty stomach with no food for an hour after. However, we've worked it out and she is truly doing well.

    by from 11/17/2009

    Just less than a year ago our large, 130 lb shepherd mix, had a liver enzyme count that was off the charts. The vet couldn't even measure it. We began giving him Denosyl 425 mg and in 3 months his enzyme count was high but measurable at 710.

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    A huge difference by KD03/31/2008

    Daily pain meds were raising our 14 y.o. Golden Ret mix liver enzymes dangerously, but Denosyl (2/day for 65-70# dog) brought her down from "off the charts" to "almost normal" again. Her overall health is greatly improved. And she takes them easily in a pill pocket, no bitter taste like some meds.


    Questions and Answers

    3 PACK Denosyl for dogs over 25 lbs (90 tablets) 225 mg3 PACK Denosyl for dogs over 25 lbs (90 tablets) 225 mg
    Reg price: $97.99
    Sale price: $74.99
    6 Pack Denosyl for dogs over 25 lbs (180 tablets) 225 mg6 Pack Denosyl for dogs over 25 lbs (180 tablets) 225 mg
    Reg price: $193.99
    Sale price: $148.99
    3 Pack Denosyl for dogs over 35 lbs (90 tablets) 425 mg3 Pack Denosyl for dogs over 35 lbs (90 tablets) 425 mg
    Reg price: $140.99
    Sale price: $129.99
    6 Pack Denosyl for dogs over 35 lbs (180 tablets) 425 mg6 Pack Denosyl for dogs over 35 lbs (180 tablets) 425 mg
    Reg price: $357.00
    Sale price: $258.99

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