Marin for dogs is a combination of silybin and vitamin E. It is available as a single strength.
Silybin is the most biologically active component of an extract known as silymarin. Silymarin/silypin has been shown to have beneficial effects on liver function. Vitamin E, a membrane-associated antioxidant, helps protect the liver against oxidant injury.
The combination of silybin, vitamin E, and zinc in Marin for Dogs provides a multi-faceted approach to liver support.
Silybin/silymarin has many different mechanisms of action. In-vitro and in-vivo studies have shown that it protects agains oxidative stress; promotes protein synthesis within hepatocytes, a mechanism for liver cell regeneration; inhibits leukotriene production, which can be beneficial as production of leukotrienes is a component of the inflammatory response; stimulates biliary flow and production of hepatoprotecive bile salts (e.g. beta-muricholate and ursodexycholate) and increases levels of glutathione.
In a study, silybin was shown to be protective in acute Amanita phalloides mushroom poisoning in dogs, where one-third of the control dogs died, while all dogs in the silybin-group lived. Silybin-group dogs also had lower bilirubin, AST, ALT, and ALP levels and improved prothrombin times compared to control dogs. In another report, the liver enzymes improved in five out of six dogs with 30 days of silymarin administration.
Vitamin E, a memberate-associated antioxidant, benefits liver function because oxidant damanage to hepatocytes can affect liver health. Vitamin E has been shown to reduce the oxidative damage to the hepatocyte mitochondrial membranes caused by hydrophobic bile salts (these bile salts build up in the liver when bile flow is impaired) Vitamin E use has been reported in dogs for its antioxidant role that also help to support hepatic health.
Administration
Marin for Dogs is formulated in a tasty chewable tablet that may be given as a treat or crumbled over the food. Tablets are scored for ease of administration. Recommended administration amounts are provided below.
Marin, coupled with Denosyl, saved my dog's life. This is an excellent product. We have seen an excellent turnaround in our dog's health and well being.
Marin by fourgirls10/30/2011
My vet recommended Marin for my yorki poo 3 years ago . She is now 14 going on 15 years, and doing well.
With the Marin and Nutro Sr. dog food we helped her liver problem. The Marin helped with the bloating .
Great Product Except... by Underthemattress04/15/2012
This has helped our dog significantly, however, she does not like the taste and I have to break them up and hide each half in a treat for her to take them. It has helped her liver.
Milk Thistle by Csig10701/21/2012
My vet told me this was a wonderful product, and Entirely Pets delivered in an efficient manner. Will definately use them again for my pets' needs.
Best purchase by Shelley10/11/2011
Excellent customer service and prompt delivery. Pricing very competitive on brand name products. Explanantions on usage and dosage of product very clear to understand.
Good product by Pauline02/12/2008
I have used this product for some time in dogs with impaired liver function. I find it to be very helpful in managing my dog liver issues - high enzymes, etc. I originally purchased it from my vet who suggested it but I find better prices here - especially with the combination of Denosyl - which is another great product for dogs with liver issues. Do check with your vet if your dog does have liver problems to make sure this is okay for your dog. For both of my pomeranians who have had liver issues and nigh ALK values - my vet perscribes it. It may turn out to be a lifetime maintenance drug for my dogs. I ilke the fact that it is kind of "herbal" and not just a 'drug'.
by jp from alexander city, al03/22/2012
my dog has been taking this med since 2008 . fast delivery!
