Marin for dogs is a combination of silybin and vitamin E. It is available as a single strength.
Silybin is the most biologically active component of an extract known as silymarin. Silymarin/silypin has been shown to have beneficial effects on liver function. Vitamin E, a membrane-associated antioxidant, helps protect the liver against oxidant injury.
The combination of silybin, vitamin E, and zinc in Marin for Dogs provides a multi-faceted approach to liver support.
Silybin/silymarin has many different mechanisms of action. In-vitro and in-vivo studies have shown that it protects agains oxidative stress; promotes protein synthesis within hepatocytes, a mechanism for liver cell regeneration; inhibits leukotriene production, which can be beneficial as production of leukotrienes is a component of the inflammatory response; stimulates biliary flow and production of hepatoprotecive bile salts (e.g. beta-muricholate and ursodexycholate) and increases levels of glutathione.
In a study, silybin was shown to be protective in acute Amanita phalloides mushroom poisoning in dogs, where one-third of the control dogs died, while all dogs in the silybin-group lived. Silybin-group dogs also had lower bilirubin, AST, ALT, and ALP levels and improved prothrombin times compared to control dogs. In another report, the liver enzymes improved in five out of six dogs with 30 days of silymarin administration.
Vitamin E, a memberate-associated antioxidant, benefits liver function because oxidant damanage to hepatocytes can affect liver health. Vitamin E has been shown to reduce the oxidative damage to the hepatocyte mitochondrial membranes caused by hydrophobic bile salts (these bile salts build up in the liver when bile flow is impaired) Vitamin E use has been reported in dogs for its antioxidant role that also help to support hepatic health.
Administration
Marin for Dogs is formulated in a tasty chewable tablet that may be given as a treat or crumbled over the food. Tablets are scored for ease of administration. Recommended administration amounts are provided below.
Marin for Large Dogs - Liver tabs by rosie01/05/2012
My dog has been on these liver pills for several years, on my vet's recommendation. I have been buying from Entirely Pets for most of that time. Deliveries are always timely, package is in good condition, and product has decent time til expiration.
Great Liver Cleanser! by Kim10/23/2011
This is an excellent liver cleansing product. My dog has epilepsy. Her liver count was high. We saw a significant decrease in her liver count after 3 months! I highly reccommend this. Just crumble it onto the food.
Good price by Mary the nurse02/08/2012
you have the best price for this product (at least for past 2 years)-
Great Product by Jansack11/08/2011
This product was recommended by our vet for one of our weimer that has liver problems and it has been good for our big boy.
Marin by Bev from Upstate, NY01/18/2012
My dog has been on Metacam for a few years so my vet recommended that I add the Marin treatment to help offset the effects that the Metacam can have on the liver. So far...so good!
great product by plumeria from Santa Monica, CA03/15/2012
My older dog needs liver support. The meds my vet recommended had to be taken 1 hour prior to a meal. That's pretty inconvenient and easy to forget. The Marin has exactly the same ingredients but are taken with food so can be given at meal time. Plus these are tasty treats, not a pill.
Liver Disease in Dogs by Barbara11/02/2008
Excellent product used in conjunction with Denosyl for dogs with liver disease.
Outstanding Product by Julie's Mom from Los Angeles, CA11/30/2011
My 29 lb. Keeshond was diagnosed with Copper Storage disease 6 years ago. Her liver enzymes were off the charts; there was no cure and the best I could hope for was that they might keep her comfortable for a year with various meds. One of those was Marin. I also changed her food to LD dry mixed with Spots Stew. Two years later, her liver enzymes were normal and they are still normal 6 years later. She is still taking 1/2 tablet Marin once a day (her only medication now). She's almost 14 and you wouldn't know there was ever anything wrong with her.
Marin helped my dog as she fought cancer by al.fred701/23/2012
My dog is currently taking chlorambucil and rimadyl to hopefully help combat the metastasis of any errant cancer cells post-op. Due to the medications, some of her liver levels were too high. Using Marin helped bring the levels down considerably after using it for only two weeks.
Marin For Large Dogs by Zondra's Mom03/04/2012
About two years ago when Zondra had senior blood work done the vet noticed that her liver enzymes were elevated. Zondra has been on Marin ever since. This last November the vet discovered an inoperal mass on Zondra's bladder and another one on her spleen. Zondrnow has to take pain medicine which has been linked to liver problems. However, as part of her nightly medication administration Zondra still takes the Marin to help keep her liver as healthy as possible. I have no complaints against Marin, if anything it has helped regulate my terminally ill dog's liver enzymes level.
Love these! by Allie10/27/2011
These chewables are great - my dog gets one per day to help treat his hepatitis and I just crumble on his kibble - he doesn't even know it's there!
by Belle from Max Meadows VA10/17/2011
Seems to be helping, although my dog," Darlin"
is on other meds, and takes milk thistle and Denamarin as well, (for when she doesn't eat). It certainly doesn't hurt to try it.
