1. Home > 
  2. Dog Supplies > 
  3. Kidney & Liver & Renal Health > 
  4. Liver Support Supplements > 
  5. Denamarin for Dogs & Cats > 
  6. Denamarin for Large Dogs Over 35 lbs (30 Tabs)

  • Stack of three ten count blister packsStack of three ten count blister packs
  • Directions of useDirections of use
  • List of ingredientsList of ingredients
  • Denamarin list of ingredients and directions for storage and useDenamarin list of ingredients and directions for storage and use

Denamarin for Large Dogs Over 35 lbs (30 Tabs)

1. Select pet:
2. Select count:
3. Select type:
This item is currently out of stock!


NOTE: Limited supply item - only three (3) per customer per order.


Denamarin help protect liver cells from cell death and may help cell repair and regeneration. Denamarin also helps support your petís liver through the administration of silybin. Silybin is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance.

When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly. Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione, an important compound for liver health formed when SAMe is metabolized.

While best known for supporting the liver in dogs and cats, Denamarin also has a place in supporting brain health. Denamarin provides SAMe in a stabilized form to help with brain health and act as a neuroprotector. Denamarin also provides a bioavailable form of silybin which supports oxidative balance.

  • Increases levels of glutathione, an important compound for liver health
  • Has also been shown to help protect liver cells from cell death and may help cell reparation and regeneration
  • Supports petís liver with silybin, which maintains a healthy oxidative balance
  • Provides SAMe in a stabilized form to help with brain health and act as a neuroprotector
  • Easy to administer, chewable tablets for large dogs
  • Ingredients

    S-Adenosylmethionine (425 mg) and Silybin A+B (35 mg)

    Useful Information

    Weight Daily Feeding
    35-65 lbs 1 tablet
    66-120 lbs 2 tablets
    Over 120 lbs 3 tablets

    Customer Reviews

    Review Summary
    216 Reviews
    84% (181)
    11% (24)
    3% (6)
    0% (0)
    2% (5)
    95% Recommend this product (206 of 216 responses)
    By BobRob
    Gilbert Arizona
    Keeping My Ginny Alive
    May 4, 2022
    My 14 1/2-year-old miniature schnauzer has been on this medication for the last 10 years. I attribute her long life to this medication. It's been tough to find lately, but EntirelyPets has had it and at a competitive price. Thanks!
    • Sometimes can be difficult to find. Prices are increasing!
    By Pam
    Has helped ours dogs
    March 2, 2022
    We have used it with a Pomeranian and now a Brussels griffon. It has helped with mobility and even hair growth. Both dogs were elderly and had cushings disease. Definitely a great product
    By Huili Q.
    new york
    perfect product perfect price
    February 25, 2022
    good products
    By Diana A.
    Keeps my pup in the pink with a blue pill
    October 11, 2021
    This medical regime keeps my pup's liver enzymes in the normal range. IT WORKS.
    • Works
    • Too large for pup to swallow so cut it in half ... which she does not like the taste of.
    By Huili
    new york
    perfect product perfect price
    June 16, 2021
    perfect product perfect price
    By Mary
    Phenomenal product
    June 8, 2021
    My 15 YO pekingese had become lethargic and did not have much interest in eating. Blood work showed liver enzyme were elevated. I began giving her this product and within 3 days she was dramatically improved. Her energy was amazing!!!!! She tootled around the house like she was a puppy. Her appetite returned to voracious levels. Her liver enzymes returned to normal. We continued to give this to her long term.
    • Rapidly effective. Easy to give in small dab of cheese.
    • Must wait 1 hour after giving product before dog can eat.......poor baby!
    By Eric
    Las Vegas, NV
    Great Product, Great Price
    April 29, 2021
    Great liver supplement. It was recommended by my vet for my pug. Found a much better price through entirelypets. Would definitely purchase again
    • Great price, quick shipping, solid liver supplement
    • Nothing I can think of
    By Cindy M.
    Very good medication.
    April 25, 2021
    This has brought my dogs liver counts back in line and using them everyday keeps them there.
    • Easy to give.
    • Animal can't eat for over a hour after giving.
    By Jan
    Crawford, tx
    Cat saved by Denamarin!!
    December 24, 2020
    My 12 year old kitty had high enzymes. 1000 in oct. started Denamarin thru vet and had him checked in nov. enzymes down to 400 and in December Down to 200. On meds and will go back in January. Do daily meds plus vitamins with iron and prednisone. Improvement! Cat looks good! Has bright eyes and all is functioning better. He is eating and more active! Thank you!
    By chuck v.
    good product
    November 17, 2020
    good product
    • good product
    • none
    By Devoted P.
    Dallas, TX
    Supports healthy liver!
    September 26, 2020
    I have been using this product for years on various pets with liver disease. My most recent is a 14 year old minature toy fox terrier that was diagnosed with hepatic carcinoma in 2018. She underwent chemo and radiation and has been in remission since mid 2019. I started her on Denamarin on the advise of her oncologist and her liver values have been very stable since her remission date. I now give this to some of my other senior fur babies to help boost their aging liver issues.
    By GBG
    Yucaipa, Ca
    Denamarin Meds
    September 22, 2020
    It appears that it is helping my Gordon Setter Liver function. Good product.
    Merchant Response:We feel the same way about your pros and cons. Wish it wasn't so expensive, but it's a difficult substance to produce. It oxidizes rapidly once exposed to oxygen. Great care is taken during manufacturing including doubling the active amount as well as entracoting and blister packing. Take care GBG!
    • Reasonably priced for this med/
    • Still a bit pricy
    By Linda
    Great for dogs with liver issues
    September 15, 2020
    My vet swears by this product and it has kept my dogís liver issues in check for six years.
    • It works
    • None
    By Neal T.
    Purchase of Denamarin
    April 27, 2020
    Great price and quick delivery. What more can you ask for.
    • see above
    • no cons
    By Summerbuff
    Wilmington, NC
    Works great!
    April 24, 2020
    My vet recommended this product to reduce my dogís ALT and it has definitely helped.
    • Effective
    • Easy to administer
    • No side effects
    • Expensive but worth it and Entirely Pets has the best price
    By Ilse
    Wstern, Maine
    Vet recommended
    April 23, 2020
    My vet recommended Denamarin for our dog as her liver enzymes were elevated. After just one month, her levels had dropped to almost normal levels. I will keep her on this for sure!
    By Kenton B.
    Dog Liver Function Decline
    April 10, 2020
    My Hannah's liver (she is 12) started declining in function last year (Please do a complete blood panel on your pups every year!). My Vet recommended Denamarin as the first course of treatment. It really helped improve her enzyme numbers. Now she is also on an additional med and we have stabilized or really slowed the decline of her liver function. She is active, happy and eating well.
    An expensive product but liver blood screens showed it to be very effective in my case.
    Merchant Response:Beautiful Denamarin testimonial Kenton. Be well
    • Effective in my dog's case.
    • Expensive.
    By Regina M.
    Helps my dogs liver
    February 11, 2020
    Blood work came back better after being on this.
    • Dog likes it.
    By Paul B.
    Quick Delivery, Good Price
    December 31, 2019
    Exactly what the vet wanted for our dog. Delivered quickly at a good price.
    By Cynthia
    Omaha, NE
    Great Product at a Great Price
    December 29, 2019
    Recommended by our Vet for our dachshund. She has been on this for several years and helps her liver condition. Great price!
    By Brenda W.
    Denamarin for Cats and Small Dogs up to 12 lbs (30 Tabs) Was: $36.99 Sale Price: $27.99
    December 28, 2019
    Helped my Stella's liver numbers go down,
    By MB
    Great Product!
    August 17, 2019
    My dog has been taking these for a few years now. Great product!
    By Chase
    Excellent service
    June 30, 2019
    Quick very easy transactions will keep purchasing from entirely pets.thank you
    • All good
    • None
    By Chris
    Quick an easy
    June 27, 2019
    Easy to order and at a great price. Product arrived quickly. Very satisfied.
    By Sharon
    Cool, CA
    Is improving my dogs liver enzyme levels
    June 24, 2019
    Have been giving this product for a few months now, and seems to be helping improve many of his liver enzyme levels.
    • Easy to give - he is a 60lb border collie, and he gobbles them up like treats.
    • none
    By Jeannette
    Anahuac, Texas
    Denamarin chewable
    June 23, 2019
    I really like how my dog will readily take this medication.
    • Easy to give to my dog
    • None
    By Hope
    Brooklyn NY
    June 21, 2019
    I give this product everyday to my dog Brooklyn. Vet recomended this for her liver. It keeps her healthy.
    • Helps with your dogs liver function.
    By Darryl G.
    Great product for High liver Enzymes ☆
    June 14, 2019
    Been using this product for my 12 year old Schnoodle with liver issues and it has done an Excellent job; Price is Very reasonable on Entirely Pets!
    • Good Price & Product
    • None as of yet!
    By Melissa
    Helpful tip with Cat
    June 10, 2019
    Just wanted to give a tip I found when giving this to cats since it should not be crushed: get it wet. At first my cat took it fine, then she caught on and it became a case if cheeked meds. She'd run off and drop it elsewhere. I thought to run in under the faucet for a second just prior to giving it. Seems to work! She doesn't love it but it goes down with ease!
    By Donna
    Scranton, Pa.
    liver problems
    June 4, 2019
    This product helps my dog live a better life.

    Questions and Answers

    1 Question & 0 Answers
    from Cranberry Twp, PA asked:
    August 26, 2015
    What is the size of the 425 mg tablet?

    Denamarin for Cats and Small Dogs up to 12 lbs (30 Tabs)Denamarin for Cats and Small Dogs up to 12 lbs (30 Tabs)Reg price: $44.99
    Sale price: $34.49
    Denamarin for Medium Dogs 13 to 34 lbs. (30 Tabs)Denamarin for Medium Dogs 13 to 34 lbs. (30 Tabs)Reg price: $59.99
    Sale price: $45.99
    Denamarin for Dogs of All Sizes (30 Tabs)Denamarin for Dogs of All Sizes (30 Tabs)Reg price: $59.99
    Sale price: $45.99
    Denamarin for Dogs of All Sizes (75 Tabs)Denamarin for Dogs of All Sizes (75 Tabs)Reg price: $136.99
    Sale price: $104.69