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  6. Nutramax Denosyl Liver and Brain Health Supplement for Large Dogs, With S-Adenosylmethionine (SAMe), 30 Tablets


Nutramax Denosyl Liver and Brain Health Supplement for Large Dogs, With S-Adenosylmethionine (SAMe), 30 Tablets

Item: DENO425MG
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NOTE: Limited supply item - only three (3) per customer per order.


Denosyl contains SAMe (s-adenosylmethionine) to help support the liver health of dogs and may support brain health.† It is available in enteric-coated tablets. Denosyl Liver Health Supplements are brought to you by Nutramax Laboratories Veterinary Sciences, the #1 veterinarian recommended supplement company.†*Source: Survey conducted among small animal veterinarians who recommended animal supplements.

Key Benefits:

  • Liver Support: Denosyl features s-adenosylmethionine (SAMe) to support the liver by increasing levels of glutathione, an important antioxidant for liver health and the liver's main detoxifier
  • Bioavailability: The SAMe in Denosyl has been proven to be bioavailable, meaning it enters your pet's bloodstream to help support the liver
  • Cognitive Support: Research has shown that SAMe may also support cognitive function in dogs and act as a neuroprotector
  • From the #1 Veterinarian Recommended Supplement Company*: Nutramax Laboratories Veterinary Sciences has been a leader in pet health for over 30 years, and provides supplements to support joint health, digestive health, and overall wellness
  • Backed by Science: Nutramax Laboratories Veterinary Sciences supplements are veterinarian formulated with high-quality ingredients to ensure your pet is receiving a safe supplement


Active Ingredients:

S-Adenosylmethionine 425 mg.

Useful Information

For dogs 35 - 65 lbs, 1 tablet per day.

For dogs 66 - 120 lbs, 2 tablets per day.

For dogs over 120 lbs, 3 tablets per day.

Tablets should be given on an empty stomach for optimal absorption. They may be given at least two hours after a meal or one hour before a meal.


Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.


Denosyl is available enteric-coated tablets for cats and dogs.

The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.

Because it does so much, the liver may be subject to many things: injury, both direct and indirect, infection, and toxicity. Some of the signs and symptoms of compromised liver function in pets may include: weakness, vomiting, poor appetite, and/or seizures. But if there is mild or early stage liver compromise, the pet can appear normal. If you notice any of these symptoms or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.

Your veterinarian will advise you as to the amount to initially administer. Depending on your pet's response and status, your veterinarian may eventually adjust this amount to meet your pet's individual needs. Remember, Denosyl enteric-coated tablets should not be broken. When increasing or decreasing their administration, adjustments should be done in full tablet increments. Some pets are given Denosyl only for a short period of time, although Denosyl may be used longer in other animals.
While response varies, owners may note a change in their petís appetite, activity, and attitude.
Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Denosyl and how it may be helping to support your petís liver function.
Denosyl has been shown to be well-tolerated by both dogs and cats with a wide margin of safety.
Yes, your veterinarian may recommend combining Denosyl with other products and/or dietary modifications. There are no known adverse interactions of Denosyl with drugs or other supplements. Denosyl may even protect against negative effects on the liver caused by some medications.
While other S-Adenosylmethionine (SAMe) products are available, there can be a significant variance in product quality and activity levels of SAMe. Denosyl is produced using high-quality, researched ingredients and under strict manufacturing standards.
Administration of methionine is not recommended. Providing high levels of methionine to pets with liver compromise may not increase the production of natural S-Adenosylmethionine and has been shown in some cases to increase liver damage.

Customer Reviews

Review Summary
28 Reviews
82% (23)
11% (3)
7% (2)
0% (0)
0% (0)
89% Recommend this product (25 of 28 responses)
By Huili
Flushing, NY
March 26, 2022
By MariaB
Chino Hills, CA
Helps liver function
September 17, 2017
It's hard to tell exactly what this product does, but my dogs has always had very elevated liver numbers and our vet suggested this supplement to prevent them from being even higher. It seems to help, as his numbers were slightly higher than usual during the time we weren't using this product.
By kathy
Good product
December 29, 2016
Have dog needing liver supplement and very happy with this product
By Patty
Menasha, WI
Great product!
February 24, 2016
My 12 year old golden has been on Denosyl since last August when I contacted a holistic vet for Thunder's hip pain and Laryngeal Paralysis. His tongue was a dark pink/purple color indicating inflammation and blockages. Since we started on the Denosyl his tongue has turned a very healthy pink and has stayed that way. I would recommend this product!
By Barbie
La Jolla Calif.
Good price!
October 22, 2015
Entirely Pets price was less than 1/2 for this liver supplement than at the vets!
By Barbara
Cave Creek Arizona
Polo Polo Standard Poodle
July 18, 2015
3 months ago, Polo was diagnosed with high liver value of 800. Only after 3 months it is now down to 400. Incredible results.

Barbara & Polo
By jmar63
Kernersville, North Carolina
Denosyl product
August 26, 2014
I don't know if this product is working or not. It would be nice if these came in a chewable form. Not all animals will take the pill. Even when hidden.
By Patsy H.
Florence, KY
It really helps
August 13, 2014
Our veterinarian recommended we try Denosyl for our almost 15-year-old Brittany, Roxy. Within a very few days we saw a difference in her cognitive function. She is alert, "connected," in great spirits and doing beautifully. The only issue is that you have to give the med on an empty stomach with no food for an hour after. However, we've worked it out and she is truly doing well.
By Blondie
She's Still Kickin'
July 24, 2014
My vet suggested giving Denosyl to help my aging dog with liver issues. One and a half years after he thought she might be on her last leg, She's still Kickin;!!
By debbie
Kane, PA
July 9, 2014
Have to give to my dog for a year for elevated liver enzymes
By Jillian
Beach Park IL
Fast service
December 27, 2013
Very fast service and good pricing on this vet recommend product for my dog.
By Jan
June 2, 2013
This product was prescribed by our vet and will probably be something our dog will take for the rest of her life. The vet charged almost three times what Entirely Pets charged and it was exactly the same product. We are very happy with our experience with Entirely Pets.
By cindi
it works
March 14, 2013
My dog has had her liver values reduced by half while on denosyl. Although values still high it has helped. Will keep her on it.
By Mountain G.
Bayfield, CO
For my Barney
January 28, 2013
Unfortunately, my Barney has liver issues. He's been on denosyl for about 3 years. He is now over 14 and still hanging in there. Only the best for him. My only dislike of denosyl is the price, but because companies and vets know how much we love our pets, they can set the price at anything and we'll pay it...
By Lori
lexington, ky
Seen a difference
January 27, 2013
Since my dog was put on this product, I saw him get his appetite and weight back so I think it is helping his condition.
By thegreatcommish
Bakersfield, California
Denosyl 425mg
January 24, 2013
Thank you for offering this life sustaining product at a reasonable price. Our "KING' of the house, Rudy had to have two rather large cancerous tumors removed...resulting in the removal of over half of his liver. We thought that we had lost him for sure, but he has made a fantastic recovery. It has been six months now since he became ill, and everyday is a blessing. He loves to go swimming in the pool, go on his daily walks, and play "keep away" with his big rawhide bone!!!
By Sayhi
Mechanicsville, VA
Review for Denosyl for dogs over 35 lbs (30 tablets) 425 mg
January 23, 2013
Back in May my 14 year old Siberian began to have liver issues and incontinence. She wouldn't get up and the vet believed she was close to death. I refused to give up so we put her on Denosyl (and several other supplements) and today she acts like a puppy again.
By Jason
Review for Denosyl for dogs over 35 lbs (30 tablets) 425 mg
November 6, 2012
Great product for the health of a dog's liver.
By Jennifer M.
Riverview, Fl
Great price! Fast Service!!
October 27, 2012
Very happy with Entirely Pets. Best price around. Signed up for Auto reship. Received my product fast, and in time before we ran out of the medication! Would recommend Entirely Pets!!
By Hank
Apple Valley, CA.
Review for Denosyl for dogs over 35 lbs (30 tablets) 425 mg
October 24, 2012
I have searched the internet as well as stores that sell dog medications and have found that EntirelyPets beats them all! Some of these places that I checked on charge much more for a specific medication than EntirelyPets does and I am very grateful for that. Thank you. Many of us out here are trying very hard to take care of our pets properly, but those that charge higher prices to make more profit does not help anyone out here in their stuggle to purchase affordable medication for their pets.
By Michael
August 6, 2012
Perfect service and fast delivery fo Canada. 10/10
By poohdle
Great product
June 27, 2012
This keeps my girl healthy. She has liver disease and has been on it for quite awhile.
By bubbs
Mesa, Arizona
Great Value
June 12, 2012
I am certainly glad to have found Entirely Pets. The prices are more in line, and the quality of service I received was exceptional. I ordered on line, and got through the process without aggravation. My dog is now on Denosyl, and hopefully this will restore her liver function. Thank you for such good service.
By Marnie
April 27, 2012
A very good product and it was recommend by my dogs vet. Her blood tests have improved since on the Denosyl.
By Bonnie
Best price anywhere on Denosyl
March 29, 2012
My 15 year old Shetland Sheepdog has been on this for more than three years. I've researched multiple websites for the best supplier, but had missed EntirelyPets and was using another company.
Found EntirelyPets to be the best price ever. Delivery was as promised. I have set up a monthly reorder.
By wiffylee
Waterford, MI
Definite Buy
February 5, 2012
I have searched for this medication that is not a prescription, and found it very expensive elsewhere. Not only is it cheaper but Entirely Pets allow you to set up if you need this monthly, every couple of months or however you may need the product. That takes the worry out of having to order it.
By Bob
Fantastic medication
November 17, 2009
Just less than a year ago our large, 130 lb shepherd mix, had a liver enzyme count that was off the charts. The vet couldn't even measure it. We began giving him Denosyl 425 mg and in 3 months his enzyme count was high but measurable at 710.

A few months later it was down to 615, and today , 3 months after that, it has dropped to 508.

Still a high reading but really excellent results from using Denosyl. We will continue the use indefiiitely.
A huge difference
March 31, 2008
Daily pain meds were raising our 14 y.o. Golden Ret mix liver enzymes dangerously, but Denosyl (2/day for 65-70# dog) brought her down from "off the charts" to "almost normal" again. Her overall health is greatly improved. And she takes them easily in a pill pocket, no bitter taste like some meds.

Questions and Answers