1. Home > 
  2. Dog Supplies > 
  3. Kidney & Liver & Renal Health > 
  4. Liver Support Supplements > 
  5. Denosyl for Dogs & Cats > 
  6. Nutramax Denosyl Liver and Brain Health Supplement for Small Dogs and Cats, With S-Adenosylmethionine (SAMe), 30 Tablets


Nutramax Denosyl Liver and Brain Health Supplement for Small Dogs and Cats, With S-Adenosylmethionine (SAMe), 30 Tablets

Item: DENO90MG
1. Select pet size:
2. Select count:


NOTE: Limited supply item - only three (3) per customer per order.


Denosyl contains SAMe (s-adenosylmethionine) to help support the liver health of cats and dogs and may support brain health in dogs.  It is available in enteric-coated tablets for both dogs and cats. Denosyl Liver Health Supplements are brought to you by Nutramax Laboratories Veterinary Sciences, the #1 veterinarian recommended supplement company. *Source: Survey conducted among small animal veterinarians who recommended animal supplements.

Key Benefits:

  • Liver Support: Denosyl features s-adenosylmethionine (SAMe) to support the liver by increasing levels of glutathione, an important antioxidant for liver health and the liver's main detoxifier
  • Bioavailability: The SAMe in Denosyl has been proven to be bioavailable, meaning it enters your pet's bloodstream to help support the liver
  • Cognitive Support: Research has shown that SAMe may also support cognitive function in dogs and act as a neuroprotector
  • From the #1 Veterinarian Recommended Supplement Company*: Nutramax Laboratories Veterinary Sciences has been a leader in pet health for over 30 years, and provides supplements to support joint health, digestive health, and overall wellness
  • Backed by Science: Nutramax Laboratories Veterinary Sciences supplements are veterinarian formulated with high-quality ingredients to ensure your pet is receiving a safe supplement


Active Ingredients:

S-Adenosylmethionine 90 mg.

Useful Information

For dogs up to 12 lbs, 1 tablet per day.

For cats up to 12 lbs, 1 tablet per day.

For cats over 12 lbs one tablet twice daily.

Tablets should be given on an empty stomach for optimal absorption. They may be given at least two hours after a meal or one hour before a meal.


Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.


Denosyl is available enteric-coated tablets for cats and dogs.

The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.

Because it does so much, the liver may be subject to many things: injury, both direct and indirect, infection, and toxicity. Some of the signs and symptoms of compromised liver function in pets may include: weakness, vomiting, poor appetite, and/or seizures. But if there is mild or early stage liver compromise, the pet can appear normal. If you notice any of these symptoms or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.

Your veterinarian will advise you as to the amount to initially administer. Depending on your pet's response and status, your veterinarian may eventually adjust this amount to meet your pet's individual needs. Remember, Denosyl enteric-coated tablets should not be broken. When increasing or decreasing their administration, adjustments should be done in full tablet increments. Some pets are given Denosyl only for a short period of time, although Denosyl may be used longer in other animals.
While response varies, owners may note a change in their pet’s appetite, activity, and attitude.
Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Denosyl and how it may be helping to support your pet’s liver function.
Denosyl has been shown to be well-tolerated by both dogs and cats with a wide margin of safety.
Yes, your veterinarian may recommend combining Denosyl with other products and/or dietary modifications. There are no known adverse interactions of Denosyl with drugs or other supplements. Denosyl may even protect against negative effects on the liver caused by some medications.
While other S-Adenosylmethionine (SAMe) products are available, there can be a significant variance in product quality and activity levels of SAMe. Denosyl is produced using high-quality, researched ingredients and under strict manufacturing standards.
Administration of methionine is not recommended. Providing high levels of methionine to pets with liver compromise may not increase the production of natural S-Adenosylmethionine and has been shown in some cases to increase liver damage.

Customer Reviews

Review Summary
35 Reviews
83% (29)
11% (4)
0% (0)
6% (2)
0% (0)
83% Recommend this product (29 of 35 responses)
By Huili Q.
new york
perfect product perfect price
January 31, 2022
great products
By N A.
Kiryat Tivon, State
My cat lost his appetite and became lethargic after swallowing this pill
November 3, 2021
I tried to give it to my cat that was recently been diagnosed with diabetes and is also showing signs of pancreatitis but this certainly didn’t do him any good. I gave him one pill on two different occasions (since I wasn’t sure at first that his bad physical reaction was caused by the Denosyl) and both times he got sicker…might be good for other pets though…
By Peggy
My Pomeranians much needed prescription was satisfied.
December 22, 2020
Denosyl was prescribed for my 2 small Pomeranians and it has helped them. As for ordering from EntirelyPets, it was a highly recommended site. And everything went very smoothly and my irder arrived in a good time. Great packaging.
By Danielle
Qu?bec, Canada
Denosyl is a very good product!
November 8, 2020
Very good product to maintain liver function’s well! We have a good experience with Entirely pets. Very easy to order and pay. Shipping and Time to receive my order were better than I expect. And no problem with customs, in delivery in (Qu?bec), Canada.
By Bob
BayLee Loves it.
April 9, 2020
Our 14 year old Papillion has liver problems. This produce is made to help him with the problem and it seems to work
  • No problem in getting him to take the small pill.
  • None
By Reesey's M.
Great Purchase
September 5, 2017
We've been using Denosyl for about a month now, and although our baby has not had her liver enzymes rechecked as of yet, I can already tell that this pill has helped. She seems to be getting back to her old self. Also, there are no side effects! Every thing has been a positive...
By Lala
Hong Kong
recommed to buy if needed
October 21, 2016
My dog got kidney problem, the vet has recommended to take Fortekor and this supplement. After few months later, my dog kidney' problem is under control. Although the vet said we can stop to give Denosyl. But I felt no harm to give it to my dog if she is fine.
By Tom
Not Satisfied
January 28, 2016
I purchased the Denosyl because you were out of stock on the Zentonil. There is nothing particularly wrong with the product, but I crush the tablets up to mix with my cat's food. The Denosyl has a coating that does not crush well and sticks to the crusher when pouring into the cat food.
By Buddy's M.
Henderson NV
Great Price!!
January 18, 2016
It is so awesome that you offer this product, which is identical to the Rx my vet gave Buddy, at less than half the price of getting it from the vet. Your ordering process is simple and it was received in just a few days. Thanks!
By Catsanddogmom
Albuquerque, NM
Very good product
December 10, 2015
I've been using this products for approx, 5 years, since Benji, my beloved Coton de Tulear, was diagnosed with epilepsy and had to be put on phenobarbital, among other drugs. Long-term use of phenobarb. will cause liver damage. Therefore, I have been using Denosyl to strengthen his liver. So far, he is doing very well and blood work indicates that his liver function is totally fine, in spite of the 32 grams of phenobarb. per day he takes. There is no doubt that a big part of his liver function being good is due to taking one tablet of Denosyl every night, on an empty stomach.
I definitely recommend this product to strengthen and maintain good liver function.
By flysunshine
Easy to give
November 8, 2015
My cat has to take this the rest of her life from what it looks like as she has been on liver meds since 2010 and goes every 6 months for blood work. This keeps it under control and she is able to keep the pill down even if she has eaten before hand. Other meds want you to give it to them on an empty stomach which is not possible for my cat as she likes to graze at her food from time to time, when ever she feels hungry.
By David
Livingston, Texas
Good Product for dog's health
September 15, 2015
We have used Denosyl for our Chihuahua, who has had liver problems from birth. Denosyl was recommended by our vet and has helped her health to improve for the last 8 years. Great product for your dog's liver problems.
By Salad
July 21, 2015
I recently had to put our 17 year-old Jack Russell on daily pain medication. He still gets around OK, but needed something to lessen his stiff back legs and improve the quality of his life.
Pain meds can cause harm to a dog's liver. Liver disease is not usually reversible or curable.
I always do extensive research before I give anything to any of our FOUR dogs. I'm also a nurse so I'm very particular and the product information needs to be of sound medical reasoning.
To help protect Ditto's liver, I put him on Denosyl once a day. It promotes better liver function and will help prevent liver damage that occurs often with prescribed pain medications, especially in very senior pets.
We also put him on Marin daily for liver function as well.
Entirely Pets so far has had the best prices on many products we use. That is a huge plus for us since we have FOUR beloved dogs!
By April
New York
Review for Denosyl for small dogs and cats (30 tablets) 90 mg
September 29, 2014
It has maintained Spooky's liver and has kept him healthy. Its had to put the pill down his throat without food so sometimes spits it out or throws up the pill. I wish there was an easier way to administer the pill.
By Steph
Good supplement for dog with liver issues
March 2, 2014
Our 11-year old female Pomeranian began having liver issues a year ago (Feb. 2013) where her liver does not produce enough albumin. The vet suggested that Denosyl might assist her liver health and she was started on the supplement at that time. After starting Baby on the supplement, her appetite improved, as did her energy level. The liver issue is a life-long issue and the Denosyl is helping with her quality of life. She was sluggish and low energy prior to starting her on Denosyl, so I can only conclude that her liver and overall health are improved, and that her quality of life is better for having given her the supplement. I would recommend it highly.
By gale
covington, ga
quick service
February 3, 2014
i have a small dog that has liver issues. she has been on denosyl for quite some time. it really helps her. entirely pets has a very competitive price with other sites. the thing i have noticed the most is that entirely pets delivers much quicker than some of the other sites. when she is about out, it always comes in time. i would recommend this site over any other i have used.
By junglegirl
Battle Creek, MI
Great Product
October 3, 2013
So far Denosyl has worked as good as the product we purchased directly from our vet. We really like the savings we get with the 3 pack offer!
By puppiesmom
Amherstburg, Ont., Canada
This supplement works!
September 24, 2013
Years ago, our Teddy, a yorkie, at 7.5 years of age, developed leptospirosis, after exposure to the bacteria. He went into kidney & liver failure. His liver enzymes were elevated. Following the initial critical phase of his care, because of his elevated liver enzymes, our vet put Teddy onto Denosyl. Within 1 month, his liver enzymes were normal. Apparently, many dogs don't live too long after contracting leptospirosis, Teddy, lived to be 16.5 years old. I really feel that because Teddy received excellent veterinary care from the doctors &pet nurses, & the Denosyl we had him for another 9 joyful years!
By RickM
Edmonton, Alberta, Canada
Great Experience
August 8, 2013
Placed my first order with Entirely Pets for 5 packages of the Denosyl 90 for my little baby girl, Krowka. The price is very fair and the product arrived in a timely manner, even though I am in Edmonton, Alberta, Canada and this had to go through our Customs.
Just a heads-up though to anyone ordering this or similar products from Canada ... I spoke with Health Canada and Canada Customs regarding importing such products as I began having problems with another supplier. Apparently there is no problem as long as you do not order more than a 3 month personal supply. Any more than that and you enter into commercial importing territory and different rules apply. But don't ask me how they determine what a 3 month supply is - it of course depends on how many pills you give your pet daily. Some get 1 pill, like my baby, some may get 2 per day. But those are the hoops you have to jump through.
Perhaps no matter how much of this you need to order, simply have Entirely Pets write "3 month's supply" somewhere on the shipping documents. Hope this helps someone avoid delays and keep their pets healthy.
By Pettrained
Dallas-Ft. Worth, Texas
Life Saving
May 28, 2013
We have a chihuahua-yorky mix. We found out he has a liver problem when he fell lifeless in our backyard while running after our other dogs. My husband gave him artifical respiration and rushed him to our vet. He will have to be on Denosyl for the rest of his life. He has had no other episodes since then. We are grateful to Entirely Pets because it makes Denosyl more affordable. They always send it in a timely manner. Since we are dependent on this product, it is great to have a reasonable resource.
By trailwaif
Elizabeth Lake, CA
Small pill easy to give
April 10, 2013
This pill is smaller than the last brand I got in the same dosage, and much easier for the cat to swallow.
By LovesSissy
Awesome Meds!
November 14, 2012
I would like to Thank You for your Product
By clearasglas
Birmingham, AL
Great prices on this product
October 23, 2012
My Chi-chi has a liver disease and requires Denosyl. The cost is much less than at my Vet. Glad I found Also, they are very quick with shipping.
By Annie
Denosyl for Cats
July 13, 2012
This medicine has kept my 15 year old cat alive for the past two years. When you look at her you would never know she has Thyroid and Liver problems. I would recommend this product to anyone to help keep their best friends healthy and happy!!!!
By Randa
Has helped my dog
May 7, 2012
My dog was diagnosed over 5 years ago with a type of kidney & liver disease. Doctors told me that this disease would most likely shorten his life and require special food & medicine. They prescribed him denosyl and 5 years later I had a full lab check done to evaluate the status of his disease. Well good news the denosyl is proving to be very beneficial as his disease has showed little to no progression. Looks like my best friend has made it past the 5 years they estimated and hopefully he will be around for many many more years. I have definitely had a good experience with this supplement.
By Max O.
Oregon Coast
Great product
May 2, 2012
I have now had two elderly canines on the Denosyl liver support. It really seems to help as their liver values have actually improved with usage. Please remember to NOT give with Tramadol and/or other contraindicated drugs.
By hflash
Alabaster, AL
Great price!
January 17, 2012
My dog has to take denosyl for a health condition (prescribed by Vet.). I found the product on at less than half the price I pay for it at the Vet. With the economy in the shape it's in, I am forced to find the cheapest products I can. The product was received in a timely manner, without damage. Will definitely recommend and continue using them myself.
By almitra
Review for Denosyl for small dogs and cats (30 tablets) 90 mg
January 16, 2012
Denosyl at this site is the best price I've found online....I recommend it highly.
By nld916
East Freetown, MA
good product
November 25, 2011
I paid $30 for this from my veterinarian. Here it was $19. Good deal!!
By CestMoi
Chicago, IL
Keeps my pet healthy
October 21, 2011
Phantom was diagnosed with liver disease back in 2008. The combination of denosyl and another prescription drug has kept him in good health all this time! He's still with us today.

Questions and Answers

1 Question & 1 Answer
from Texas asked:
September 30, 2019
I have a dog that weighs 22 lbs. How many pills do I give and what size?
1 Answer
Hi Carolyn, you would get the medium size and you would give one tablet. 
Submitted by: Customer Service on October 2, 2019