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Frontline Spray (250 mL)

Item: FSPRAY10012
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Frontline Spray for Dogs & Cats can be applied directly for both immediate and long-lasting control of fleas and ticks for up to 30 days. This effective spray contains fipronil to kill existing flea and tick infestations. It also kills fleas before they lay eggs, effectively preventing reinfestation. Safe for puppies and kittens 2 days of age or older, Frontline Spray helps reduce flea and tick infestations in multi-pet households, and is great for the initial treatment of flea allergy dermatitis. The spray bottle is easy to use, provides fast and even application and can be reapplied regularly.

  • Kills Fleas
  • Kills newly emerged adult fleas before they lay eggs
  • Stops existing infestations and prevents establishment of new infestations
  • Kills fleas which may cause flea allergy dermatitis
  • Rapidly eliminates chewing lice infestations
  • Aids in control of sarcaptic mange infestations in dogs
  • Kills all life stages of ticks (larva, nymph and adult), including brown dog ticks (Rhipicepalus sanguineus), American dog ticks (Dermacentor variabilis), lone star ticks (Amblyomma americanum) and deer ticks (Ixodes scapularis).
  • Kills ticks that may transmit Lyme disease, Rocky montain spotted fever, ehrlichiosis, babesiosis, anaplasmosis, haemobartonellosis and other tick-borne diseases

Frontline Spray is great for controlling emergency flea infestations as well as for regular use and along with with other monthly flea and tick medications like Frontline Top Spot, Frontline Plus, or Advantage.

Frontline Sprays do not contain the potentially toxic insecticides found in most pet store sprays.


fipronil 0.29%
TOTAL 100.00%

Useful Information

It is a violation of Federal law to use this product in a manner inconsistent with its labeling. TO PREVENT HARM TO YOU AND YOUR PET, READ ENTIRE LABEL AND ATTACHED DIRECTIONS BEFORE EACH USE. Follow all directions and precautionary statements carefully. Use only on dogs and cats. Do not use on rabbits. Do not use on any other animals.

To kill fleas and all stages of brown dog ticks, American dog ticks, lone star ticks, deer ticks (which may transmit Lyme disease) and chewing lice, apply FRONTLINE® Spray to dogs, cats, puppies or kittens as follows:

To Open: Push the button on top of the trigger and turn the nozzle to the spray position.

To Close: Push the button on top of the spray and turn the nozzle to the X position.

  • Wear household latex gloves.
  • Hold the bottle in upright position. Ruffle the animal's coat with one hand while applying spray mist to the animal's back, sides, abdomen, legs, shoulders, and neck.
  • For head and eye area, spray FRONTLINE on a gloved hand and rub gently into animal's hair.

Do not get this product in your pet's eyes or mouth. Apply spray mist until animal's hair is damp to thoroughly wet. Approximately 1 to 2 pumps per pound of the animal's body weight will be required. Pets with long or dense coats will require the higher rate.

As with any flea control product, wash hands and exposed skin thoroughly with soap and water after use.

To prevent flea build-up pr reinfestation, use FRONTLINE Spray prior to the onset of flea season and monthly thereafter. Ticks do not need to receive spray directly upon their body for complete control. Multiple monthly treatments are recommended for the elimination of mites. Do not reapply to spray for 30 days.

FRONTLINE Spray remains effective even after bathing, water immersion, or exposure to sunlight.


HAZARDS TO HUMANS. CAUTION. Harmful if swallowed or absorbed through the skin. May cause severe eye irritation. Avoid breathing spray. Avoid contact with skin, eyes or clothing. Wash hands thoroughly with soap and water after handling and before eating, drinking, chewing gum, or using tobacco. Persons applying this product must wear household latex gloves.


For external use only. May cause severe eye irritation. Take care not to spray in the animal’s eyes or facial area. Do not use on kittens and puppies under eight weeks. Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist or become more severe, consult a veterinarian immediately. Certain medications can interact with pesticides. Consult a veterinarian before using this product on medicated, debilitated, aged, pregnant or nursing animals.

WARRANTY: To the extent consistent with applicable law, the Seller makes no warranty, expressed or implied, concerning the use of this product other than indicated on the label. Buyer assumes all risk of use and handling of this material when such use and handling are contrary to label instructions.

FIRST AID Have the product container or label with you when calling a poison control center or doctor, or going for treatment.

IF IN EYES: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice.

IF ON SKIN OR CLOTHING: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control center or doctor for treatment advice.

IF SWALLOWED: Call a poison center or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by a poison control center or doctor. Do not give anything by mouth to an unconscious person.

Customer Reviews

Review Summary
31 Reviews
74% (23)
6% (2)
3% (1)
10% (3)
6% (2)
87% Recommend this product (27 of 31 responses)
By Mike C.
Roseland, Virginia
Review for Frontline Spray (250 mL)
September 22, 2015
Excellent product especially for us because we live in the woods!
By T G.
Prompt Perfection
June 9, 2015
Our vet told us this product was not available. I came home, went to your site, and ordered it! The spray arrived promptly, was well packaged, and functioned beautifully. Thank you so much for your service and care.
March 11, 2015
By Gayla
Hephizibah, GA
Great Value
September 4, 2014
I like to use this form of Frontline because I find it far more economical than the tubes. Great purchase.
By mes
November 27, 2013
This killed ticks on cats for 2 days. Tick heads were embedded in cats skin, but were dead. The next day it repelled ticks, because they would crawl off the cats unto me. The fourth day the ticks were alive and embedded in the cat's skin again. Directions say "Do not reapply for 30 days". We had already applied the Frontline in tubes the week previously.

We do not have a flea problem, Frontline is good for that.
By brileyville
Frontline Spray
October 3, 2013
I have used this product for over 15 years and it is the best flea and tick product out there for dogs that have long hair!!
By janie
frontline spray
September 29, 2013
Use this on my chihuahuas, works very very well.
Gave some to a friend, that had bad flea problem, she loved it.
By poodlesr4us
September 26, 2013
My dogs are happy and us humans are happy, NO FLEAS !!!
By Geli
A Spray for (small) Dogs & Cats!!!
May 16, 2013
We live in the deep country...lots of Ticks! Having a Dachshund, picking up 5+ ticks daily, from sniffing the ground. These ticks are "piggy-back-riding" easily on these long dragging-the-ground ears. A lot worse, than both my two cats combined! Then, years ago, after complaining to the Vet, he suggested the Frontline Spray BECAUSE it can be used on small dogs AND Cats! Used it for 4 yrs. now, and NEVER look back, even considering using another products on my 3 pets! It SOOO works!
By pibblemom
Great spray
February 20, 2013
This is a great flea/tick spray. It does smell strong when first applied but the smell fades quickly. I prefer this spray over monthly flea/tick applications.
By Susan
Very Pleased!
December 17, 2012
Frontline Spray is convenient and easy to use. I use it once a month on my show poultry and it really works for keeping poultry pests (lice, mites, etc.) off of the birds. They are happy and so am I!
By Susan
great for small dogs
November 15, 2012
I like to use this on small dogs, Doesn't leave greasy spot on dogs coat. Drys like hair spray, but combs out soft.
By Mama C.
New Jersey
It did what?
November 6, 2012
Not get rid of fleas that's what. Not too happy about applying pesticides to my animals over and over again with no results. Cats not thrilled with the cool mentholated alcohol feeling either.
By Candy
What a mess!
October 26, 2012
When this order came in, it was all over the place. The container hadn't been closed tightly, and I lost over half the bottle in the packaging. So I put it on my dogs as the vet had shown me before, and it has done nothing. When I used it in the past, it worked great! So I don't know. This time around it doesn't seem to be working. Very disappointed :(
By Grayhaven
Crossville, TN
Frontline Spray
October 19, 2012
We use it to get the mites on our alpacas. These are pesky little bugs and it works as long as we are diligent to spray 21 days after the first spaying. Great price from Entirely Pets. They are usually the cheapest.
By debbie
Eureka, NC
great product
August 10, 2012
great price for a great product. i use this for my chihuahuas and kittens. the frontline spray works great and if much more affordable than the other products. delivery was fast. will definetly order more .
By Cathy
Great product
June 26, 2012
This product was recommended by my vet to treat rabbit fur mites at a lower dosage. It is working on the mites and the rabbit seems to be more comfortable, just after the one application.
By Roo's M.
Good product but
June 21, 2012
I have used this product for years, but this year itdoesn't seem to be working at controlling fleas as well as other years. When I opened the package the bottle "spray" was in the on position and about 1/3 of the bottle was empty. Very disappointing for a product that is fairly expensive. I have to wonder how long the "spray" was in the on position and if this had an effect on the quality of the product.
By judegrunes
Ft. Lauderdale, Florida
Flea Spray
May 3, 2012
I was disappointed that my dogs were still scratching away when I got the Frontline Plus spray to augment the pills.
By Ginger
Independence, KY
Great product
May 2, 2012
It works just as well as the individual treatments but it saves us money. I have three dogs & two cats and it can be used on all of them.
By Joaney
New York
my comment
April 6, 2012
The frontline spray is ok for a small short haired dog but I have a sheltie of course it has a long coat which it says to wet the whole coat .
When we got done we didnt have any left oh maybe enough to spray a throw rug she sleeps on.,I would not recommend this product to anyone that has a large or long haired dog..I think this product should mention for short hair dogs only as it was very expensive for 1 month treatment..

By Cat
Columbus, Oh
Excellent Product
December 28, 2011
This is the only flea spray that I can use on my dogs to treat for fleas that doesn't give them a reaction. My two schnauzers reacted to other treatments, but seems to do fine with Frontline.
By Judy
Chino Valley, AZ
Frontline Flea Spray
November 23, 2011
I've used this product for about 30 yeqrs and it works wonderful. I've never had a dog or cat have a reaction from it. It does a wonderful job of removing and keeping at bay the fleas and tick.
By Selyn
Canaan, NH
Customer Service
October 29, 2011
I am impressed with this product, however, I would not order with this company again. Very disappointed in the lack of communication on their behalf. I placed the order b4 3pm on sat and requested 2 day delivery. Was expecting order to be here by the following Wed the latest. Called Thursday, was told that the item can ship ground only (which wasn't conveyed at the time of order, nor had anyone contacted me to let me know of the shipping delay). I waited until the following Tuesday for the item to be delivered. Very disappointed.
By Jay
Frontline Spray 250mL
October 25, 2011
Excellent product; easy to use, especially handy in spray bottle when you have multiple cats as is more economical.
Great service ordering and product arrived very quickly. Thank you for such a great on line service.
By yorkiemom
Wisconsin / Oklahoma
LOVE Frontline!!
October 18, 2011
We LOVE Frontline spray! It is so much more economical than the flea/tick preventive "drops" (my 2 Yorkies are under 6 lbs. each, and the directions are 1 spray per pound). It dries really fast, plus I love that it doesn't have the extra chemical in it that makes it move through the oils/sebaceous glands....unlike the "drops," the spray stays where you put it. Another thing I love about Frontline (besides that it works so well of course!) is that they have done extensive bathing testing, so they know that it lasts even after a bath. Oh! And because the spray doesn't move through the oils/sebaceous glands, I can bathe them as soon as it's completely dry, which is pretty fast. Frontline spray has worked well for us for years (and I've used the Frontline drops on my cats for even longer).
By marcella
Miner, MO
Good Product
October 13, 2011
We have 3 dogs and 4 cats and we use this spray on all of them monthly, we've tried almost every product on the market and nothing seemed to work till we tried Front Line spray. Thanks for such a good product Front Line.
By sarap
wonderful stuff
July 28, 2011
i keep 7 cats and two german shepherds flea free with a spray every other week. very effective and economical.
By charo
Hamilton, GA
Great Stuff!!
June 14, 2011
I got this for a puppy I bought who was loaded with fleas. The spray worked since he was only 6 weeks old. Now, 12 years later I am still using this product. In fact, I have taken it to a new level. I worked in DCFS with families that had pets with fleas and ticks. I took this product, put about 1/8 c in 16-32 oz of water in a spray bottle and used it to spray the inside of my vehicle before going into any of these homes. I also used it on my clients pets and sometimes on their furniture. I still today, use this potion at my current job which is on a farm. I spray the cloth chairs in the office and once a month the funiture in the cottage. I have kept the fleas and other bugs down tremendously. It does not affect the human body in any way. In fact, I have sprayed myself (clothing) prior to going to work if I had to work outside near the animals or barn area. I no longer bring home fleas and other bugs from my jobs.
By giggles
Jacksonville, FL
Review for Frontline Spray (250 mL)
January 20, 2010
works great as long as you follow instructions on label, at one time i used less than directed thinking this might be too dangerous for the pet, but ended up with fleas that my dog picked up from outside; so i have been using as directed and have not had any problems since!

Questions and Answers

1 Question & 1 Answer
from DALLAS, GA asked:
March 17, 2015
Does this NEED to be use with other flee products or can this be used by itself and be effective?
1 Answer
Hello, I would contact your vet and ask them if your should use others things with this.
Submitted by: Customer on June 6, 2019 from Union City, CA

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