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ProNeurozone Small Dogs (60 Tabs)

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ProNeurozone Chewable Tablets provide cognitive support and may delay the development of age-related brain damage and memory loss. Antioxidant supplementation benefits brain health and complements the management of established cases of cognitive dysfunction. Ingredients such as acetyl-L-carnitine, lecithin, bioflavanol (grape seed extract) and bilberry extract efficiently cross the blood-brain barrier, which may increase the overall effectiveness of the formula. Research suggests that the simultaneous activities of such compounds are more beneficial than that of each on its own.

Key Benefits

  • cognitive health supplement for senior pets
  • specifically formulated to protect the brain from oxidative damage and to prevent age-related behavioral changes that lower a pet's quality of life.
  • Antioxidant formula contains ingredients that have been shown to enhance brain health.
  • Flavored chewable tablets.
  • for use in Dogs

Dogs exhibiting age-related behavioral impairment

Changes could occur in 4 categories: orientation, social interaction, house training, and sleep-wake cycle. Each will show increases of occurrences as the dog ages.

  • Regressions in house training, orientation, and social interaction
  • Changes in sleeping and eating patterns
  • fear or anxiety not previously exhibited
  • increased or repetitive activity or vocalization
  • decreased responsiveness to known commands and activities


Guaranteed Analysis - Each Tablet Contains
(All values are minimum quantities unless otherwise stated)
Small Dog
Vitamin E 5 IU
Thiamine (B1) 2 mg
Riboflavin (B2) 2 mg
Niacin (B3) 5 mg
Vitamin B6 1 mg
Vitamin B12 0.003 mg
Folic Acid 0.07 mg
Acetyl-L Carnitine* 100 mg
Alpha Lipoic Acid* 50 mg
Bioflavanol* 20 mg
Cysteine* 5 mg

(* Not recognized as an essential nutrient by the AAFCO Dog Food Nutrient Profiles)


Microcrystalline Cellulose, Dextrate, Pork Liver Meal, Acetyl-L-Carnitine, Alpha Lipoic Acid, Dried Seaweed Meal, Soy Lecithin, Stearic Acid, Salmon Oil, Grape Seed Extract (source of Bioflavanol), Silicone Dioxide, Corn Starch, d-Alpha-Tocopheryl Acetate, Cranberry Powder Extract, Sorbitol, Safflower Oil, Niacinamide, Cysteine, Brewer's Yeast, Bilberry Powder Extract, Thiamine Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Rosemary Powder Extract, Sage Powder, Folic Acid, Vitamin B12 Supplement.

Guaranteed Analysis - Each Tablet Contains
(All values are minimum quantities unless otherwise stated)
Medium and Large Dog
Vitamin E 10 IU
Thiamine (B1) 5 mg
Riboflavin (B2) 5 mg
Niacin (B3) 10 mg
Vitamin B6 1 mg
Vitamin B12 0.003 mg
Folic Acid 0.14 mg
Acetyl-L Carnitine* 200 mg
Alpha Lipoic Acid* 100 mg
Bioflavanol* 50 mg
Cysteine* 10 mg

(* Not recognized as an essential nutrient by the AAFCO Dog Food Nutrient Profiles)


Microcrystalline Cellulose, Dextrate, Pork Liver Meal, Acetyl-L-Carnitine, Alpha Lipoic Acid, Dried Seaweed Meal, Soy Lecithin, Salmon Oil, Silicone Dioxide, Grape Seed Extract (source of Bioflavanol), Stearic Acid, d-Alpha-Tocopheryl Acetate, Corn Starch, Cranberry Powder Extract, Niacinamide, Cysteine, Bilberry Powder Extract, Safflower Oil, Sorbitol, Brewer's Yeast, Thiamine Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Rosemary Powder Extract, Sage Powder, Folic Acid, Vitamin B12 Supplement.

Behavioral changes associated with aging effects on the brain can begin to interfere with a pet's normal functions.

ProNeurozone contains ingredients that have been shown to promote brain health.

Ingredient Rationale: ProNeurozone®

Vitamin E - Vitamin E is an effective antioxidant for protecting cells from oxidation. It may slow the process oflipid peroxidation in cell membranes and slow brain aging.

Thiamine B1 - Thiamine B1 enhances brain activity and cognitive function and acts as an antioxidant.

Riboflavin B2 - Riboflavin B2 helps activate vitamin B6 and folic acid.

Niacin B3 - Niacin B3 is important for production of chemical signal molecules and for proper function of the nervous system. It is often used to supportmemory.

Vitamin B6 - Vitamin B6 plays a major role in the production of neurotransmitters. It is necessary for normal brainfunction and the absorption of vitamin B12, and it inhibits increases in homocysteine, which can cause DNA damage, oxidative stress, and neuronal cell death.

Vitamin B12 - Deficiencies of vitamin B12 are associated with poor cognition, specifically the speed at which information is processed. Vitamin B12 works together with vitamin B6 and folic acid to normalize homocysteine levels. It is also involved in the production of acetylcholine (a chemical messenger).

Folic acid - Folic acid regulates neurogenesis, programmed cell death, and may normalize homocysteine levels.

N-acetyl-cysteine(NAC) - NAC is a free radical scavenger and reduces lipid peroxidation. It also helps the body make glutathione, which is an important antioxidant for protecting against neuronal toxicity and improving cell-mediated immunity.

Alpha-Lipoic Acid - Shown to supportmemory in animals, alpha-lipoic acid lowers age-associated increase of oxidative damage and the loss of brain mitochondrial function. Alpha-lipoic acid is unique in its effectiveness against both fat-and water-soluble free radicals, and it prevents depletion of vitamins E and C. It can reduce neuronal damage and may enhance detoxifying agents such as glutathione.

Acetyl-L-Carnitine (ALCAR) - A mitochondrial metabolite, acetyl-L-carnitine protects the brain from mitochondrial dysfunction and neurotoxicity and enhances brain energy metabolism. ALCAR efficiently crosses the blood-brain barrier and supports cognitive function and short-term memory.

Bioflavanol/Polyphenols - Protects brain tissue by reducing neuronal damage from oxidative stress. This is one of the few antioxidants, which cross the blood-brain barrier to protect brain cells. It reduces lipid peroxidation andsupports healthy DNA in the brain. Together the bioflavanol and soy lecithin form a complex, which reduces capillary permeability and fragility providing vascular protecting activity. US Patent Numbers 4,963,527 and 4,698,360.

Rosemary extract - Rosemary promotes acetylcholine, supportsmemory, and contains as many as 10 choline-sparing compounds.

Sage powder - Sage supportsacetylcholine. People have been taking sage for memory loss for centuries. In 1597, well-known herbalist John Gerard said that sage "is singularly good for the head and brain and quickeneth the nerves and memory." Cranberry extract-Cranberry, a powerful antioxidant, protects cell membrane lipids from oxidation and has been shown to protect brain cells.

Bilberry extract - Bilberry is another potentfree radical scavenger. It increases production of memory cells and protects the brain fromage-related neurological deficits. Bilberry supports capillary health, and the health of the blood-brain barrier. It protects healthy cell membranes from lipid peroxidation and supports healthy retinal function. US Patent Numbers 4,258,055 and 5,196,449.

Spirulina - Spirulina is a highly bioavailable free radical scavenger that supports brain health. Spirulina enhances formation of neurotransmitters, and it is an additional source of essential minerals, B and E vitamins, choline, amino acids, and essential fatty acids. It is also the richest source of beta-carotene.

Soy lecithin - Soy lecithin promotes cognitive health by protecting the cell membrane structure,and it helps preserve mitochondrial function.

Omega-3 fatty acids - Fatty acids are one of the primary structural components of the brain. They promote the bioavailability of fat-soluble antioxidants such as vitamin E, and support brain health as we age.

Useful Information

Recommended Usage:
Small Dogs
1-39 lbs. 1 tablet per day
Medium and Large Dogs
40-90 lbs. 1 tablet per day
90+ lbs. 2 tablets per day

Indications: For animals displaying behavioral signs of cognitive decline or for other conditions related to oxidative stress and aging.


Even with nutritional supplements, over-ingestion could cause adverse clinical signs. Please see our recommendations below. The Animal Poison Control Center telephone number is (888) 426-4435.
  • Not necessary to induce vomiting.
  • Watch for side-effects, diarrhea and vomiting are possible. If these effects do occur, they should not last more than 24 hours.
  • Stop usage for about a week.
  • Induce vomiting if overdose has occurred within 12 hours.
  • After 12 hours, not necessary to induce vomiting.
  • Watch closely for next 24 hours for side effects; excessive drowsiness, tachycardia and hypertension are possible.
  • Stop usage for about a week.
  • Induce vomiting, ideally within an hour of ingestion
  • Watch for side effects, including continued vomiting, ataxia, hypersalivation, tremors, seizures, and weakness. If these side effects are present, please call your veterinarian or local veterinary emergency clinic.
  • Stop usage for one week

Induce vomiting by orally administering equal parts water and hydrogen peroxide. Use 1 teaspoon peroxide plus 1 tsp water for every 5 lbs of the pet's body weight, not exceeding 9 teaspoons (or 3 Tablespoons).

In about 2% of dogs, gastrointestinal distress has been associated with glucosamine supplementation. Prosamine and ProMotion contain glucosamine. In these dogs, Proanthozone is a good alternative.

There have been reports of hyperactivity associated with ProNeurozone use, which is a rare but documented effect of choline supplementation in some pets.

There are positive reports of use in a Lion-tailed Macaque and other birds, a dolphin, a giraffe, calves, rabbits, and pot-bellied pigs.
The liver flavoring is from pork and the beef, bacon and beef and cheese flavors are vegetable based. The tuna flavoring is from fish.
There are no known contraindications for using Proanthozone or ProMotion and Rimadyl (or another NSAID) together.
Reports of renal failure in animals related to grape or raisin ingestion are not in any way connected to grape seed extract. In fact, negative reactions in dogs have occurred from ingestion of seedless grapes. Numerous studies have proven grape seed extract to be safe for animals and it is a GRAS (generally recognized as safe) ingredient for animal feed/supplements.
We employ a national independent laboratory to perform post-production analyses on our products. With this extra quality control measure, we can ensure label claims and guarantee safety.

Customer Reviews

Review Summary
7 Reviews
86% (6)
14% (1)
0% (0)
0% (0)
0% (0)
100% Recommend this product (7 of 7 responses)
By JavaDog
Omaha, NE
Sleeping again!
February 6, 2019
Our senior toy poodle struggled with nighttime restlessness and other signs of dementia. As a result, we hadn't sleep well in months. After taking ProNeurozone for a week, he has slept well for two consecutive nights and is showing more playfulness. We are so grateful for this product!
ProsSleeping again!
By KB M.
Tucson, Arizona
Review for ProNeurozone Small Dogs (60 Tabs)
July 29, 2015
Seems to be helping with cognitive function. Maggie is more aware and alert when taking Proneurozone. Thanks for a great product!
Clermont FL
May 8, 2015
I think that it is really helping my small dog, a Tibetan Spaniel. He is on some other medicine too, but I would like to think this is helping him, as well. He takes it one of two ways, I crush it up and put it in his food or break it in half and put it in a piece of bread.
By Dog L.
January 15, 2014
This product gave me back my dog. My very healthy, very normal 16 year old Jack Russell literally overnight became overcome with panic and anxiety. The vet said this was "Old Dog Syndrome" and prescribed different anti-anxiety drugs, tranquilizers and a variety of other medications over a three month period. None of them worked. My dog was up all night, every night, panting and completely terrified. As a last resort, my vet suggested ProNeurozone. Within a week of my dog taking ProNeurozone, she was noticeably calmer, happier and her sleep pattern was becoming normal again. Now after one month, my 16 year old Jack Russell is back to normal again. She is happy, active, eats heartily, chases squirrels and sleeps all night again. Only downside is she hates the way ProNeurozone tastes. The bottle says they are chewable tablets but she spits them out, so I have to pill her rather than her eating them on her own, but a small price to pay for her complete recovery!
Great Product
September 5, 2013
We tried Senilife prescribed by the Vet. It is liquid in a capsule. Our little dog (15 yrs) hated it - After our vet reviewed the ingredients in ProNeurozone and approved it, we purchased one bottle. Our elderly dog of 6 lbs ate in on her food and after 1 month, her senility issues dissipated. She rarely has an accident in the house and is aware of her surroundings. We are on our 5th bottle. Truly grateful that we found this product!
By kitsap-kits-n-K9s
Allyn, WA
Super supplement for "over-the-hill" pups
October 26, 2011
My 3rd bottle. This keeps my puppy-mill rescue 17-yr old chihuahua thinking he is a puppy.
By Amanda
Seems to Help
November 25, 2010
My vet recommended this for my 14 year old Lhasa Apso who had been starting to wander aimlessly around the house, stare off into space, seeming difficulty in hearing and seeing, and having "accidents" frequently indoors. She said it would take at least a month to notice any change. A week or two ago (well over a month since we started the product), it did occur to me that my dog had stopped having accidents in the house. She is more responsive and alert. I feel these changes can be attributed to this product.

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