- Betulinic acid, the active ingredient in Zentrol®, is derived from two natural sources: Souroubea species, a vine that grown in central and South American rainforests, and the naturally shed bark of Platanus species trees growing in North Carolina.
- When given as needed, the ingredients in Zentrol elicit a calming effect on those dogs that exhibit fearful behavior triggered by loud noises.
- Sourobea spp. 1.10 g
- Platanus spp. 0.90 g
Administer 1/2 tablet for every 11 lb. of body weight directly or with food at least 60 minutes before loud events that may cause stress-induced behavior changes in your dog, such as thunderstorms, fireworks, holiday activities or other similar events.
|Up to 11 lbs.||1/2 tablet|
|12-23 lbs.||1 tablet|
|24-3 lbs.||1.5 tablets|
|36-47 lbs.||2 tablets|
|48-59 lbs.||2.5 tablets|
|60-71 lbs.||3 tablets|
|72-83 lbs.||3.5 tablets|
|84-95 lbs.||4 tablets|
|96-107 lbs.||4.5 tablets|
|108-119 lbs.||5 tablets|
|120-131 lbs.||5.5 tablets|
|132-143 lbs.||6 tablets|
|144-155 lbs||6.5 tablets|
Storage and Safety:
- Store at controlled room temperature (68-77*F)
- Keep our of reach of other animals and children
- For dogs only
- Should not be used to modify behavior in aggressive dogs
- Intended for supplemental or intermittent use only
- The most commonly reported reaction following administration was vomiting
- Long-term use has not been studied
Other Information to Know:
- The natural components of Zentrol® have been reported to act together in as little as 60 minutes during a dog's exposure to loud noises, such as thunder.
- Inactivity time (withdrawal, hiding, cowering, pacing) increases in dogs that experience noise aversion. Inactivity time for dogs exposed to noise and given betulinic acid at both 1x and 2x the suggested dose was found to be significantly less than that of the placebo group.
- The blood level of the hormone cortisol is often used as a measure of stress. In dogs that are moderately to highly upset during exposure to noise, those given betulinic acid at 4x the suggested dose showed lowered cortisol levels that were nearly identical to the cortisol levels in dogs given diazepam, a drug used to treat anxiety and nervousness.
- When given to dogs for up to 28 consecutive days at up to 10x the recommended dose, no negative health effects occurred.