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Zentrol Chews (60 count)
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Zentrol Chews (60 count)

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Zentrol® Chewable Tablets For canine patients suffering from stress-related behavior as a result of short-term events, such as thunderstorms, a vacuum cleaner, large crowds, construction equipment, babies/children, fireworks and more. Zentrol® chewable tablets were designed to reduce stress-related behaviors in as little as 60 minutes. To bring awareness to clients that may not know that help exists for these concerns, feel free to use these memes on this site in a positive, educational way. These memes are designed for both social media and sharing as well as for printing posters and clinic handouts.

  • See positive effects in as few as 60 minutes.
  • Can be used as needed
  • Easy to administer
  • All natural active ingredients
  • Beef Flavored
  • No negative health effects even at up to 10x the recommended dose



  • Betulinic acid, the active ingredient in Zentrol®, is derived from two natural sources: Souroubea species, a vine that grown in central and South American rainforests, and the naturally shed bark of Platanus species trees growing in North Carolina.
  • When given as needed, the ingredients in Zentrol elicit a calming effect on those dogs that exhibit fearful behavior triggered by loud noises.
    Guaranteed Ingredients:
  • Sourobea spp. 1.10 g
  • Platanus spp. 0.90 g

Useful Information

Administer 1/2 tablet for every 11 lb. of body weight directly or with food at least 60 minutes before loud events that may cause stress-induced behavior changes in your dog, such as thunderstorms, fireworks, holiday activities or other similar events.

Dosing Schedule
Up to 11 lbs. 1/2 tablet
12-23 lbs. 1 tablet
24-3 lbs. 1.5 tablets
36-47 lbs. 2 tablets
48-59 lbs. 2.5 tablets
60-71 lbs. 3 tablets
72-83 lbs. 3.5 tablets
84-95 lbs. 4 tablets
96-107 lbs. 4.5 tablets
108-119 lbs. 5 tablets
120-131 lbs. 5.5 tablets
132-143 lbs. 6 tablets
144-155 lbs 6.5 tablets
    Storage and Safety:
  • Store at controlled room temperature (68-77*F)
  • Keep our of reach of other animals and children
  • For dogs only
  • Should not be used to modify behavior in aggressive dogs
  • Intended for supplemental or intermittent use only
  • The most commonly reported reaction following administration was vomiting
  • Long-term use has not been studied
    Other Information to Know:
  • The natural components of Zentrol® have been reported to act together in as little as 60 minutes during a dog's exposure to loud noises, such as thunder.
  • Inactivity time (withdrawal, hiding, cowering, pacing) increases in dogs that experience noise aversion. Inactivity time for dogs exposed to noise and given betulinic acid at both 1x and 2x the suggested dose was found to be significantly less than that of the placebo group.
  • The blood level of the hormone cortisol is often used as a measure of stress. In dogs that are moderately to highly upset during exposure to noise, those given betulinic acid at 4x the suggested dose showed lowered cortisol levels that were nearly identical to the cortisol levels in dogs given diazepam, a drug used to treat anxiety and nervousness.
  • When given to dogs for up to 28 consecutive days at up to 10x the recommended dose, no negative health effects occurred.

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