• 12 MONTH Advantage II Flea Control Extra Large Dog (for Dogs Over 55 lbs.)

    12 MONTH Advantage II Flea Control Extra Large Dog (for Dogs Over 55 lbs.)

    Regular Price: $180.99Sale Price: $138.99
    One Time Order

    Autoship & Save!    [MORE DETAILS]


    The new and improved Advantage II now offers flea and lice protection for your dog. Flea and lice treatment with Advantage II gives your dog a safe solution that only needs to be applied once a month. Dogs and puppies older than 7 weeks and weighing over 55 lbs are fit for this flea and lice killing formula.

    This formula will kill fleas completely by eliminating their eggs and larvae by using a variety of ingredients and compounds. It contains a fast-acting formula that kills fleas quickly and prevents them from returning.

    Advantage II uses the compound pyriproxyfen to kill fleas and other insects by interfering with their maturity cycle. Targeting insects, pyriproxyfen does not affect mammals. Other flea killing properties like adulticidal, larvicidal, and ovicidal kill fleas and prevent them from emerging again. Imidacloprid paralyzes fleas so they are killed before biting your dog and also reduce the incidence of flea-related allergies.

  • Kills adult fleas within 12 hours and re-infesting fleas within 2 hours
  • Integrated flea control (IFC) disrupts flea life cycle with pyriproxyfen
  • Waterproof
  • Guaranteed US EPA approved
  • Application quick and easy with easy-squeeze tube
  • Each package of this long lasting topical lasts for 4 or 6 months
  • Per Dose: $10.00

  • Top

    Usage Information

    Application Instructions: Apply entire contents of tube on the neck at the base of the skull. monthly application.

    Length of Effectiveness:
    Under normal conditions, the product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven (7) days. After flea control is attained, return to a monthly retreatment schedule.

    Keep out of reach of children

    See back panel for First Aid. For Directions for Use, and Storage and Disposal, see supplemental labeling inside.


    Effective Flea Control . . . No Prescription Required!
    Active Ingredients % By Weight
    Imidacloprid 9.10 %
    Pyriproxyfen 0.46 %
    Other Ingredients 90.44 %
    Total 100.0 %
    Net Contents: 6 Tubes, each 0.135 fl oz (4.0 ml)

    How Advantage® II Works
    Use Advantage® monthly to kill fleas on you cat. The active ingredient, imidacloprid, acts on the nervous system of the flea to cause paralysis and susequent death. CLICK HERE for additional information on Advantage II.

    Customer Reviews

    DISCLAIMER: The results described on the testimonials on this site, are the individual experiences and personal opinions of those who have purchased and used the products. These testimonials are not intended to make any claims that the products can be used to diagnose, treat, mitigate, cure or prevent any disease or medical condition.
    Click here to see all reviews
    Great product; great price by mytwocents from Texas07/05/2012

    I always buy my Advantage from Entirely Pets. They have the best price and this stuff really works. I bought some for my daughter, who was having a huge flea problem and within hours of applying on her five dogs and treating the carpet, there was a noticeable difference and the fleas have not returned.

    Why even sell this product? by Burton's Mom from Knoxville, TN04/18/2012

    You need to seperate these products on your website. I was in search of advantix and thought that's what I was ordering. To my surprise, I received Advantage II. Who would even use this when there is Advantix? I've call ed for an RMA # and since returned the product. I suggest making a clear seperation of the products on your webpage.

    To your door. by Dan11/29/2013

    We have always used Advantage II since the vet introduced us to it. But ordering it online was easy, and no expensive trip to the vet to end up bringing home the same product. Not to mention that it is a fraction of the price that the vet charges for the exact same flea control.

    thank you by sampson labs from Florida04/16/2013

    great prices, great shipping time Thank you!

    great value by lynnelab07/11/2014

    Great flea control and easy to apply. Much cheaper buying from EntirelyPets rather than from vet's office.

    Advantage has stopped working by Sarah from Los Angeles, CA05/29/2012

    We bought the 12 month supply of advantage II and it seems to no longer be effective. We put it on our puppy, who is allergic to fleas, and less than two weeks later she had fleas again. I don't know if the formula has changed or the fleas are now resistant but it's not doing anything for my poor itchy girl.

    by nonick03/19/2012

    Convinient, helpful, works as expected, reasonable price.

    Best on the market!! by Jungle Jane from Ohio10/08/2013

    I am soooo tired of throwing away my hard earned money on flea products that DON'T WORK! Advantage 2 works for me and I actually get a whole month's worth of protection. My dogs walk around with a smile on their face instead of a frown now. They can actually walk on 4 feet instead of trying to itch at the little pest every few steps. Thanks !! Advantage 2 !!!

    Advantage II is a great product. by Hilary03/24/2013

    I never have any flea trouble when using Advantage II, and Entirely Pets always has the best price. The package always arrives quickly, too.

    Best product by Eli Mae from Arkansas09/22/2013

    If you only have a problem with fleas this is the best product to use on your four legged family members. It is easy to use and you don't have to try to trick your pet into taking a pill to get rid of them. I will always continue to use Advantage.

    Advantage II by EliMae from Ohio08/30/2013

    This is a great product for cats & dogs for flea control! The only downside is it doesn't help with ticks. I use it for 10 shop cats, 9 home cats & 2 dogs...NO Fleas!!

    Best flea protection by Deb from Pensacola, FL06/09/2013

    I have three dogs and a cat in Florida! Fleas can be a problem but NOT when I use Advantage II on all of them regularly. We are "Flea Free" thank you!

    Advantage II large dog by Sue from PA08/13/2013

    The flea product arrived within a couple of days. Wow -that was fast!

    No more fleas! by MPOWPOW from Texas07/28/2014

    We have FOUR 55+ pound dogs. The Advantage II Flea Control has been the best product to kill & control flea infestation. Coupled with the yard spray, we have totally eliminated all the fleas!! We have tried other products, but to no avail. This product is 5 stars! Don't waste your money on other products.

    Never a sign of a flea or a tick by Texas Jazz from West Texas10/25/2012

    Max was 2 when we adopted him. It has been 6 years and we have used nothing but Advantage and then Andvantage II when it came out. Never have seen a sign of a flea or a tick. Can't do better than that!

    advantage by catlady from townsend, delaware07/05/2012

    safiest product on the market. Its all I ever use. I do alot of rescue for animals and I can trust it to work.

    advantage ll by catlady from townsend, de11/05/2013

    Best product and cheap. Entirely Pets delivery is fast and safe.

    Works Great by phil09/30/2013

    Advantage is one of the best products on the market. I noticed a difference within a few hours. It didn't bother my dog at all and we've not had any flea issues since using it. I'm really impressed with the quality and price.

    Fleas war, I win by Mes Amis Poilus from Canada10/06/2014

    Best product I have bought for fleas and ticks. really satisfied

    by from 10/23/2012

    I put this on my dogs a week ago and they are scratching fleas again. I bought the same product several months ago from petsmart (I did not realize that I was out so had to purchase it at petsmart -- much more expensive) and it seemed to kill the fleas for quite some time -- it seemed to work correctly.

    if by the from productI


    by RTPLady05/29/2012

    This is a Good product. I've used it before and will use it again

    Prompt service by entirely pets by Bobbie06/20/2014

    The product doesn't inform you of the amount of the liquid in each tube. I wish they did.

    dont order from here by george11/01/2011

    ordered on 100911 it is now nov. 1st still no product

    by from 07/18/2012

    Love the service of entirely pets. Sadly, this product, Advantage, just doesn't seem effective against the fleas in Central Florida any longer.

    isn't by working from forAt


    best value by milos02/19/2013

    I have priced Advantage on many sites and with many vets, this is by far the best priced and fast fuss free shipping. I have 4 large dogs and it's great to get the best working products for this price and delivered to the door.

    Great Deal!! by needlewings from Union Furnace, OH05/30/2012

    Fast shipping, great price, even a better price with a coupon and a very good product! Thanks! Couldn't have been happier!

    great for treating both cats and dogs by catlady from Enid, OK02/19/2013

    My vet told me how to save money by buying this large size to use both on my cats and dogs. This has saved me a lot of money and the advantage II is great product.

    12 month advantage II Flea Control by kate from Fort Worth ,Texas07/05/2013

    Great product and Great price. My boys remain flea free

    Always a Great Choice !!! by Roxxy from Graham, WA.05/14/2014

    Works very well on both my Large dogs...one is 85# and the other is 130#......No Fleas......

    Advantage by 5badkatz from Orlando Florida02/06/2012

    Product really works without making pets sick or smell funny. I hate fleas. Can't imagine life without this any more.

    disappointed by jake's mom10/28/2012

    i ordered program flea control, it wasn't available so entirely pets substituted another brand. without asking! i returned it unopened. after weeks of emails and phone calls no refund....they did not refund my money until i disputed the $100+ charge with my credit card company. NOT acceptable!


    Questions and Answers

    See more from
    4 MONTH Advantage II Flea Control Extra Large Dog (for Dogs Over 55 lbs.)4 Mo Advantage II (55+ lbs)
    Reg price: $63.99
    Sale price: $48.99
    6 MONTH Advantage II Flea Control Extra Large Dog (for Dogs Over 55 lbs.)6 Mo Advantage II (55+ lbs)
    Reg price: $93.99
    Sale price: $71.99
    4 MONTH Advantage II Flea Control Small Dog (for Dogs under 10 lbs.)4 Mo Advantage II (3-10 lbs)
    Reg price: $60.99
    Sale price: $46.89
    6 MONTH Advantage II Flea Control Small Dog (for Dogs under 10 lbs.)6 Mo Advantage II (3-10 lbs)
    Reg price: $83.99
    Sale price: $63.99

    Security Seals
    EntirelyPets.com, Pet Supplies & Foods  Retail, Union City, CA


    ~ My Account Login ~

    Sign into your EntirelyPets Account for the best experience!