• 4 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)

4 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)

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Regular Price: $72.99Sale Price: $49.95
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K9 Advantix II BLUE for Extra Large Dogs over 55 lbs

Keep your dog safe from irritating and dangerous pests with k9 Advantix for dogs over 55 Lbs. Formulated for dogs seven weeks of age and older and weighing over 55 pounds and under, K9 Advantix II outperforms its competitors not only by killing more varieties of pests, but also by repelling them to prevent future attacks.

Repels and Kills Ticks, Fleas, and Mosquitos

The active ingredients in K9 Advantix II help keep your dog safe from ticks, fleas, and mosquitoes. These effective compounds attack the pests' nerve cells, paralyzing and effectively killing them, as well as repelling them from future attacks. Most ticks are repelled and killed before they can attach, which may reduce the risk of transmitting disease-causing organisms to your pet. K9 Advantix II effectively kills and repels Deer ticks, American dog ticks, Brown dog ticks, and Lone Star ticks.

K9 Advantix II for Extra Large Dogs over 55 lbs
  • Kills and repels ticks, fleas, and mosquitoes
  • Repels biting flies and kills lice
  • Waterproof formula won't wash off from swimming or bathing
  • Includes four convenient one-month doses
  • Easy to apply
  • For dogs seven weeks of age and older and weighing over 55 pounds and under
  • Per Dose: $12.25
Dog flea life cycle
K9 Advantix II and Frontline Plus Comparison Chart
Fights Against Fleas at All Stages of Development

K9 Advantix II protects your pet against fleas at all stages of the parasite's development. K9 Advantix II breaks the flea life cycle by killing the living fleas on your dog before they can lay eggs. It also prevents the development of existing flea eggs, larvae, and pupae, helping to prevent future infestations.

K9 Advantix II also kills reinfesting fleas (newly hatched fleas jumping back on your dog) within two hours, and it prevents fleas on a treated dog from infesting your home.

Effective Against Biting Flies and Lice

In addition to complete tick, flea, and mosquito protection, K9 Advantix II also repels painful biting flies from feeding on your dog, and it effectively kills up to 100 percent of lice within one week of treatment.

Waterproof Formula

K9 Advantix II is waterproof, so there's no need to reapply after your dog has a bath or goes for a swim. Studies show that dogs are still protected against parasites after exposure to water, though for best results, dogs treated with K9 Advantix II should be bathed with a non-detergent shampoo.

Package Contents

Box includes four 4.0-milliliter tubes of K9 Advantix II for Extra Large Dogs over 55 pounds.

Flea Cycle

Usage Info

How to Apply

Applying K9 Advantix II to your pet is a fast and easy process. First, remove the K9 Advantix II applicator tube from its packaging and use scissors to peel down the foil. Next, hold the applicator tube in an upright position and pull the cap off the tube. Use the upturned cap to break the protective seal, and you're ready for application.

For easiest application, your dog should be standing upright. Evenly apply the entire contents of the K9 Advantix II tube to two or three spots from the back of the shoulder to the base of the tail. Part the hair at each spot until the skin is visible, then place the tip of the tube on the skin and gently squeeze out a portion of the solution. Be careful not to apply an excessive amount of the solution in any one spot, otherwise some of the solution might run off the side of your dog. Dispose of the container and do not reuse or refill. Do not empty unused product in any indoor or outdoor drain.

For optimal control and prevention of parasites, use K9 Advantix II every month. K9 Advantix II is available in four- and six-month supplies. Do not use K9 Advantix II on cats or any animals other than dogs.

Application Instructions

Evenly apply the entire contents of the tube to four to six spots on the top of the back--from the shoulder to the base of the tail. Apply monthly.

Length of Effectiveness

Under normal conditions, the product is effective for one month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven days. After flea control is attained, return to a monthly retreatment schedule.

Hazards to Humans

Causes eye irritation. Harmful if swallowed. Do not get in eyes or on clothing. Avoid contact with skin. Wash hands thoroughly with soap and warm water after handling.

Hazards to Domestic Animals

*For external use on dogs only.
*Do NOT use on animals other than dogs.
*Do NOT use on puppies under seven weeks of age.

Do not get this product on dog's eyes or mouth. Consult your veterinarian before using this product on debilitated, aged, pregnant, or nursing animals. Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately. If your animal is on medication, consult your veterinarian before using this product.

Do Not Use on Cats

Due to their unique physiology and inability to metabolize certain compounds, cats must not use this product. If applied to a cat, or ingested by a cat that actively grooms a recently treated dog, this product may have serious harmful effects. If this occurs, contact your veterinarian immediately.

Environmental Hazards

This product is extremely toxic to fish. Do not add directly to water. Do not contaminate water when disposing of product or package.

First Aid

Have the product container or label with you when calling a poison control center or doctor, or when going for treatment.

If in eyes: Hold eye open and rinse slowly and gently with water for 15 to 20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice.

If swallowed: Call poison control center or doctor immediately for treatment advice. Have person sip a class of water if able to swallow. Do not induce vomiting unless told to do so by the poison control center or doctor. Do not give anything by mouth to an unconscious person.

If on skin or clothing: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15 to 20 minutes. Call a poison control center or doctor for treatment advice.

To physician: Treat patient symptomatically.

Keep out of reach of children.



How long does K9 Advantix last?

A single application of K9 Advantix keeps working for one month.

How often should I use K9 Advantix?

Experts recommend monthly application to keep your dog protected year-round.

My dog is strictly indoors. Should I still use K9 Advantix?

Yes, ticks and fleas can be brought into the home by people or other pets--without owners even realizing it. Immature flea stages remain dormant until conditions are appropriate for development. This is why it is also important to protect indoor pets.

Can I bathe my dog during the month after application?

Yes, you can give your dog a bath. A non-detergent shampoo is recommended for best results.

How young can the dog be for application?

K9 Advantix is gentle enough for puppies as young as seven weeks.




Imidacloprid is an ectoparasiticide, an antiparasitic agent that targets parasites living primarily on the surface of a host. Chemically classified as a chloronicotinyl nitroguanidine, imidacloprid inhibits neurotransmitter transmission in insects, resulting in paralysis and death.


Imidacloprid exhibits both adulticide and larvicidal flea efficacy; it not only kills adult fleas and larvae on your pet, but it also kills larval stages in your pet's immediate surroundings.

Main Purpose

To kill fleas at all stages of their life cycles and stop them from being able to move or feed.


Permethrin is the additional ingredient in Advantix. It belongs to the Type I class of pyrethroid acaricides and insecticides, and it also acts as a repellent. Pyrethroids affect muscle and nerve cells' sodium ion channels by increasing their mean open time, which leads to hyperexcitability and death of the parasite.


Thanks to its repelling activity, permethrin reduces parasite bites and thus the risk of diseases and stress for your dog.

Main Purpose

To repel ticks, sand flies, and mosquitoes; to kill ticks and fleas.

Two Proven Ingredients with Enhanced Activity

Imidacloprid and permethrin work together to overwhelm the nervous system of the parasite, providing neurotoxic activity beyond that of each compound alone. This leads to more profound and quicker insect paralysis and death.

Specifically, imidacloprid increases the efficacy of permethrin by activating insect nerve cells and increasing the frequency of neurotransmissions. As a result, more sodium channels are opened and the pyrethroid can interact much better with its target site.


Pyriproxyfen is a pyridine-based pesticide. A juvenile hormone analog, it interferes with the hormone signaling of growing insects, so that insects in immature stages are unable to mature. Additionally, a female insect that touches the toxin will produce eggs that will not hatch.


Pyriproxyfen provides an added layer of protection for pets and their surroundings. It interrupts the flea life cycle at multiple stages, halting the growth and development of insect eggs and larvae and preventing reinfestation.

Main Purpose

To prevent flea eggs from hatching and larvae from growing.

Active Ingredients % by Weight
Imidacloprid 8.80%
Permethrin* 44.00%
Pyriproxyfen 0.44%
Other Ingredients 46.76%
Total 100%
*cis/trans ratio: max 55% () csi and min 45% () trans
Net Contents

Four tubes, each 0.135 fluid ounces (4.0 milliliters)

6 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)6mo Lrg Dog (21-55lb) K9 Advantix 2Reg price: $101.99
Sale price: $74.95
12 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)12 Mo K9 Advantix II (21-55lb)Reg price: $200.99
Sale price: $148.95
6 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)6mo XLrg Dog (55lb+) K9 Advantix 2Reg price: $102.99
Sale price: $74.95
12 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)12 Mo K9 Advantix II (55+lb)Reg price: $205.99
Sale price: $148.95
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Customer Reviews

DISCLAIMER: The results described on the testimonials on this site, are the individual experiences and personal opinions of those who have purchased and used the products. These testimonials are not intended to make any claims that the products can be used to diagnose, treat, mitigate, cure or prevent any disease or medical condition.
Click here to see all reviews
Highly effective by CZ12/12/2012

Does what it says it's going to do. I've neve had a problem even in hot humid Florida

great product by kitkat from southwest florida07/27/2012

we have used advantage since our dog was a puppy. She is now 9 years old and we are still using the product...that says something doesn't it

Great Product by Freckles Mom from Pinnacle, NC04/25/2012

This will be the second year for us using this product. Last year we had no fleas or ticks on Freckles. Will be starting her new supply on the 1st of May. Recommended this product to my sister for her dog.

Worked great by Angie11/15/2013

After trying numerous products, including Frontline, flea dips,knockout spray, and diatimacious earth, I was ready to tear my hair out. I switched to Advantic and the flea problem was under control within 2 days.

Good product by tswinth from Oklahoma10/12/2011

Advantix keeps fleas, ticks, and other bugs from sticking to my dogs' hair and that says a lot during the summer time. I have two long haired dogs and it really helps to have a product that provides protection and also keeps bugs from being in my home.

QUESTIONABLE by DEBMO from san antonio, tx02/17/2012

Product states it would repel ticks, it does not. Good on fleas.

Super easy and fast by PyrResqr from Rowlett Tx08/23/2012

I love K9 Advantix anyway so it's always nice to catch it on sale. Entirely Pets is super easy to order from and the shipping is fast!

Good product by Susan from MA10/29/2013

Seems to work well, still gets the occasional tick but better than other products.

Great product & price by Carol50 from St. Louis, MO07/11/2013

We live in St. Louis with lots of fleas, ticks, biting flies, mosquitos, etc. and our poor dog was scratching and itching to the point of sores. I applied the K9 advantix II and within 36 hrs the itching and scratching had stopped. The sores have healed and he's doing great. The product has performed as advertised and is MUCH less expensive than Frontline

Best flea control for Golden Retrievers by PC from Bradenton, FL03/06/2013

This product has always worked better for me than any other flea control. I tried Frontline when my dog was a pup and it did NOTHING. The Bayer products are the only ones that work. I especially like the fact that they are absorbed and don't leave an oily residue.

Very Good ! ! by J-Cin from Wilmington, DE07/10/2013

We know fleas have been bad in our area, but We Have Been Flea Free !

Great product by Angel from Providence, RI05/09/2014

I am happy with this product. I previously purchased Front Line, I was satisfied with this product also. However, my veterinarian dermatologist recently advised me to switch to Advantix II.

Fast shipping! by Jennifer12/29/2012

Works great at keeping the fleas off, and I got it within a couple days, super fast shipping!

This is The Best protection product! by Lin from Hollis, Prince of Wales Island, Alaska07/05/2014

I have been using K9Advantix since it first came out, for my Newfoundland dogs. Here where we live in Alaska, we do not have a flea or tick problem but we have a huge issue with mosquitoes, no-see-ums and aweful biting flies of all sizes which will drive human and animal alike, crazy with their painful bites. K9Advantix are the only drops I have found to work effectively against these biting critters and most drops only guard against fleas and ticks. Great product!! When I moved to Alaska, I discovered that no companies would ship it here. Then I discovered EntirelyPets and after one conversation I learned that they would indeed ship to Alaska. I was skeptical but they did it...and quicker than we usually get things. I am a fan of EntirelyPets and a lifetime user of K9 Advantix!

by elemutt06/13/2013

This product has worked well on my shepherds.

What A Relief! by BB's friend from Houston, Tx.11/27/2012

I had given my sweetheart an ingestible flea deterrent I had gotten from the vet. It did absolutely nothing and my poor dog was itching and miserable. I really didn't have time to run all over town looking for something else, when I found K9 advantix II at Entirely Pets. They made ordering easy, were very courteous, and the order arrived in a timely manner. Both the dog and I are very happy.

4 month k9 advantix 11 by marty from Arizona08/15/2014

I am not sure that there was anything in the tube. The dog felt dry after the application.

Great by Kay from Wheeling, WV11/14/2013

Super Fast Shipping, Order was Correct, Great Product for my puppy.

Go Away Fleas! by BJ from Bostic, NC07/27/2012

I purchased a 4 pack of K9 Advantix II for my dog. I discovered that my son's two dogs were suffering from fleas because he had not been financially able to afford a flea treatment. We put K9 Advantix II on the dogs and in just a couple of days all their fleas were gone! My dog has not had a tick all summer and she is an outside dog. K9 Aadvantix II is the best!

by evelatte from Richmond, VA06/20/2012

frontline does not work on my dogs, K9 works well, I have 3 outside dogs and so far no fleas! It was the only thing that worked for us last year and fleas where really bad.

by carebear322 from Indiana07/29/2013

Great product. We had previously purchased the leading brand flea & tick medicine and it did not work at all. This started working in the 1st day!

Disappointing results by ErinE from Tucson, Az11/27/2013

We have four large dogs who suddenly had ticks. We have used the Advantix II for three months and are still finding live ticks on the dogs...First we washed the dogs with a tick/flea shampoo, sprayed the yard every 3 weeks, washed all bedding, and vacuumed. I would not recommend this product to anyone.

Protection at a decent price by Pam from Mooresville, North Carolina05/20/2013

Sam's vet prescribed Advantix II and it works great!. The only problem is that the vet is so expensive on the products they sell. Thankfully, I found Entirely Pets and can keep Sam on Advantix for a more reasonable price.

Great flea & tick medicine by Bailey's mom from Asheville, NC12/29/2012

Bailey (my pooch) had stopped responding to her usual flea/tick medication. I switched to Advantix and have had no continued problems. I have recommended this to her groomer, who has since recommended it to many other of her clients.

Big thanks!!! by karenedillon from Grand Prairie, TX06/05/2012

This is the best product for flea control. Entirely Pets has the best price, even including shipping that I have found so far.I will continue to order all my pet needs from entirely Pets...Thanks guys!

ADVANTIX II X Lg. Dog by KShep from Turnersville, NJ05/01/2014

Best price for best product of this kind. Used on 84 lb. German Shepherd.

did not work by 1lab1shepard2dach from alabama09/22/2012

I have used k9 advantix 1 for years and loved it. i could use it on the dogs every 6weeks and not 4. then this II came along and has failed everytime ive used it (6 different dogs, 4 different breeds). I have even tried it on 2 other dogs that didnt live here. the fleas didnt even die... i wasted a lot of money ordering the 12 month supply. will not attempt to try again! now its off to looking for something that works...

Switched to K9 Advantix by Goldie's mom from New Jersey11/14/2012

this has been the worst year for fleas. I had to switch from the other product I was using to Advantix. Seems to be working.

Flea and tick prevention by Lucy10/23/2012

We live in a wooded area in Texas. This product has kept both fleas and ticks off of my dog. I can bathe her in between applications and it seems to continue to do the job.

no more,no more,no more by Cindy from MILFORD, DELAWARE06/02/2011

my two dogs, ruby & buddy have been using this product for over 2 yrs. unbelievable, no more ticks, no more fleas, and yes, no more horseflies,etc. as soon as you put this on, it seems like our dogs are smiling all the time. if your dogs are having problems with all of the above, i suggest you try this particular product. oh, and make sure you go by body weight, very important.

Good stuff by Lu Rae from Martinsburg, WV07/29/2012

I switched from Frontline Plus to this because they repel alot more and there is not a greasy mess on my dogs coat for a couple of days after application.

best you can buy by cece11/15/2012

I have used all flea products and this is the best.Used Frontline on my dog and she had a reaction to it.This product is great and I tell my friends and family to use it.Been very happy and will not change.

by Lisa Marie07/02/2013

great and works very well every month!!!

by from 07/05/2012

We had major flea issues. They were all over the house, biting our kids, and making our dog crazy. She would not stay in our yard because of the fleas. Other flea treatments had not helped. Less than one day after treatment with Advantix our dog was back to normal.

the by house from quicklyThe


Incredible product! by Robbi from Canyon, Texas07/13/2012

I live on a small ranch in Texas. I have always used a flea/tick product on my dogs, however my Rott was continually bothered with flies. My neighbor told me about Advantix so I ordered it and tried it on both dogs. Since using K-9 Advantix I noticed a HUGE difference in the amount of flies bothering my Rott. I've seen maybe one or two on her, but they land and then take off again. Thank you, thank you, thank you!

Great purchase by bo from South Carolina08/07/2013

The flies would bother my lab and this is a great product that keeps them away. It work great for flees and ticks also.

Smart change by jean10/12/2011

After using Frontline plus for 5 years, K9 Advantix II wins hands down. Ticks dead before they dig in. Not a flea to be found. Easy to use applicator.

K9 Advantix ll by Debra K from Lewiston, Maine08/13/2013

This stuff works great, my dogs have had no fleas or ticks or lice this year, works much better than the Frontline Plus I used to use, I will be using this from now on

Advantix II seems to be working thus far by CandCfam from Tacoma, WA05/14/2013

The price was right, the shipping very fast, the application easy and seems to be working so far. No complaints!

by dawn01/03/2013

Have used this before with good luck but this time I found a tick on my dog (house pet) 2 days after applying the K9 advantix. Not very please about that.

It works! by Su02/29/2012

I'm always leery of trying new 'topical flea' products. So many of them don't work anymore, but I was forced to since the product I was using was discontinued. Hadn't tried this one yet, the reviews looked good for the most part, and I'm happy to report that the product works. Haven't had a problem with fleas at all.

K 9 Advantix II by tigerlickin from USA10/30/2011

I love the product. It works great and is cheaper than 1-800-pet-meds.

great purchase by cher from southeast florida11/06/2012

Been using for years for our dogs...........always has worked and we have been very happy with the product

by from 05/30/2012

Thank you for the recent order of K-9 Advantix II. The price is better than most and I do not have a problem with fleas if I use it monthly!

Very Happy with my purchase by Rosie from Jackson, MSThanks,


A product we trust everytime (but cheaper) by kellyjenne05/28/2012

We have never had fleas or tics on our pets since using advantix, but wanted to find something else since buying from the vet was costly. Using EnitrelyPets let us continue to use Advantix but at a way lower cost

Worked Well by Mello from Florida11/22/2012

We've been battling ticks. Advantix II didn't work 100% as advertised but is helping us control them so far.

Excellent product by hunter from Quebec Canada11/26/2012

After 6 weeks now,my 2 dogs have no ticks at all.It was the worst season for ticks.Before i used Anvantix, they got 2 ticks each... Very satiafied.Thanks.

by warlorde from Louisiana10/30/2011

Fantastic product. Works very well to prevent flea infestation. Thanks


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