• 6 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)

6 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)

SKU: 5461650
Regular Price: $102.99Sale Price: $74.95
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K9 Advantix II BLUE for Extra Large Dogs over 55 lbs

Keep your dog safe from irritating and dangerous pests with k9 Advantix for dogs over 55 Lbs. Formulated for dogs seven weeks of age and older and weighing over 55 pounds and under, K9 Advantix II outperforms its competitors not only by killing more varieties of pests, but also by repelling them to prevent future attacks.

Repels and Kills Ticks, Fleas, and Mosquitos

The active ingredients in K9 Advantix II help keep your dog safe from ticks, fleas, and mosquitoes. These effective compounds attack the pests' nerve cells, paralyzing and effectively killing them, as well as repelling them from future attacks. Most ticks are repelled and killed before they can attach, which may reduce the risk of transmitting disease-causing organisms to your pet. K9 Advantix II effectively kills and repels Deer ticks, American dog ticks, Brown dog ticks, and Lone Star ticks.

K9 Advantix II for Extra Large Dogs over 55 lbs
  • Kills and repels ticks, fleas, and mosquitoes
  • Repels biting flies and kills lice
  • Waterproof formula won't wash off from swimming or bathing
  • Includes six convenient one-month doses
  • Easy to apply
  • For dogs seven weeks of age and older and weighing over 55 pounds and under
  • Per Dose: $11.50
Dog flea life cycle
K9 Advantix II and Frontline Plus Comparison Chart
Fights Against Fleas at All Stages of Development

K9 Advantix II protects your pet against fleas at all stages of the parasite's development. K9 Advantix II breaks the flea life cycle by killing the living fleas on your dog before they can lay eggs. It also prevents the development of existing flea eggs, larvae, and pupae, helping to prevent future infestations.

K9 Advantix II also kills reinfesting fleas (newly hatched fleas jumping back on your dog) within two hours, and it prevents fleas on a treated dog from infesting your home.

Effective Against Biting Flies and Lice

In addition to complete tick, flea, and mosquito protection, K9 Advantix II also repels painful biting flies from feeding on your dog, and it effectively kills up to 100 percent of lice within one week of treatment.

Waterproof Formula

K9 Advantix II is waterproof, so there's no need to reapply after your dog has a bath or goes for a swim. Studies show that dogs are still protected against parasites after exposure to water, though for best results, dogs treated with K9 Advantix II should be bathed with a non-detergent shampoo.

Package Contents

Box includes six 4.0-milliliter tubes of K9 Advantix II for Extra Large Dogs over 55 pounds.

Flea Cycle

Usage Info

How to Apply

Applying K9 Advantix II to your pet is a fast and easy process. First, remove the K9 Advantix II applicator tube from its packaging and use scissors to peel down the foil. Next, hold the applicator tube in an upright position and pull the cap off the tube. Use the upturned cap to break the protective seal, and you're ready for application.

For easiest application, your dog should be standing upright. Evenly apply the entire contents of the K9 Advantix II tube to two or three spots from the back of the shoulder to the base of the tail. Part the hair at each spot until the skin is visible, then place the tip of the tube on the skin and gently squeeze out a portion of the solution. Be careful not to apply an excessive amount of the solution in any one spot, otherwise some of the solution might run off the side of your dog. Dispose of the container and do not reuse or refill. Do not empty unused product in any indoor or outdoor drain.

For optimal control and prevention of parasites, use K9 Advantix II every month. K9 Advantix II is available in four- and six-month supplies. Do not use K9 Advantix II on cats or any animals other than dogs.

Application Instructions

Evenly apply the entire contents of the tube to four to six spots on the top of the back--from the shoulder to the base of the tail. Apply monthly.

Length of Effectiveness

Under normal conditions, the product is effective for one month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven days. After flea control is attained, return to a monthly retreatment schedule.

Hazards to Humans

Causes eye irritation. Harmful if swallowed. Do not get in eyes or on clothing. Avoid contact with skin. Wash hands thoroughly with soap and warm water after handling.

Hazards to Domestic Animals

*For external use on dogs only.
*Do NOT use on animals other than dogs.
*Do NOT use on puppies under seven weeks of age.

Do not get this product on dog's eyes or mouth. Consult your veterinarian before using this product on debilitated, aged, pregnant, or nursing animals. Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately. If your animal is on medication, consult your veterinarian before using this product.

Do Not Use on Cats

Due to their unique physiology and inability to metabolize certain compounds, cats must not use this product. If applied to a cat, or ingested by a cat that actively grooms a recently treated dog, this product may have serious harmful effects. If this occurs, contact your veterinarian immediately.

Environmental Hazards

This product is extremely toxic to fish. Do not add directly to water. Do not contaminate water when disposing of product or package.

First Aid

Have the product container or label with you when calling a poison control center or doctor, or when going for treatment.

If in eyes: Hold eye open and rinse slowly and gently with water for 15 to 20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice.

If swallowed: Call poison control center or doctor immediately for treatment advice. Have person sip a class of water if able to swallow. Do not induce vomiting unless told to do so by the poison control center or doctor. Do not give anything by mouth to an unconscious person.

If on skin or clothing: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15 to 20 minutes. Call a poison control center or doctor for treatment advice.

To physician: Treat patient symptomatically.

Keep out of reach of children.



How long does K9 Advantix last?

A single application of K9 Advantix keeps working for one month.

How often should I use K9 Advantix?

Experts recommend monthly application to keep your dog protected year-round.

My dog is strictly indoors. Should I still use K9 Advantix?

Yes, ticks and fleas can be brought into the home by people or other pets--without owners even realizing it. Immature flea stages remain dormant until conditions are appropriate for development. This is why it is also important to protect indoor pets.

Can I bathe my dog during the month after application?

Yes, you can give your dog a bath. A non-detergent shampoo is recommended for best results.

How young can the dog be for application?

K9 Advantix is gentle enough for puppies as young as seven weeks.




Imidacloprid is an ectoparasiticide, an antiparasitic agent that targets parasites living primarily on the surface of a host. Chemically classified as a chloronicotinyl nitroguanidine, imidacloprid inhibits neurotransmitter transmission in insects, resulting in paralysis and death.


Imidacloprid exhibits both adulticide and larvicidal flea efficacy; it not only kills adult fleas and larvae on your pet, but it also kills larval stages in your pet's immediate surroundings.

Main Purpose

To kill fleas at all stages of their life cycles and stop them from being able to move or feed.


Permethrin is the additional ingredient in Advantix. It belongs to the Type I class of pyrethroid acaricides and insecticides, and it also acts as a repellent. Pyrethroids affect muscle and nerve cells' sodium ion channels by increasing their mean open time, which leads to hyperexcitability and death of the parasite.


Thanks to its repelling activity, permethrin reduces parasite bites and thus the risk of diseases and stress for your dog.

Main Purpose

To repel ticks, sand flies, and mosquitoes; to kill ticks and fleas.

Two Proven Ingredients with Enhanced Activity

Imidacloprid and permethrin work together to overwhelm the nervous system of the parasite, providing neurotoxic activity beyond that of each compound alone. This leads to more profound and quicker insect paralysis and death.

Specifically, imidacloprid increases the efficacy of permethrin by activating insect nerve cells and increasing the frequency of neurotransmissions. As a result, more sodium channels are opened and the pyrethroid can interact much better with its target site.


Pyriproxyfen is a pyridine-based pesticide. A juvenile hormone analog, it interferes with the hormone signaling of growing insects, so that insects in immature stages are unable to mature. Additionally, a female insect that touches the toxin will produce eggs that will not hatch.


Pyriproxyfen provides an added layer of protection for pets and their surroundings. It interrupts the flea life cycle at multiple stages, halting the growth and development of insect eggs and larvae and preventing reinfestation.

Main Purpose

To prevent flea eggs from hatching and larvae from growing.

Active Ingredients % by Weight
Imidacloprid 8.80%
Permethrin* 44.00%
Pyriproxyfen 0.44%
Other Ingredients 46.76%
Total 100%
*cis/trans ratio: max 55% () csi and min 45% () trans
Net Contents

Six tubes, each 0.135 fluid ounces (4.0 milliliters)

12 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)12 Mo K9 Advantix II (21-55lb)Reg price: $200.99
Sale price: $148.95
4 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)4 Mo K9 Advantix II (55+ lbs)Reg price: $72.99
Sale price: $49.95
12 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)12 Mo K9 Advantix II (55+lb)Reg price: $205.99
Sale price: $148.95
2 MONTH K9 Advantix II GREEN for Small Dogs (upto 10 lbs)2 Mo K9 Advantix II (4-10 lbs)Reg price: $38.99
Sale price: $29.99
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Customer Reviews

DISCLAIMER: The results described on the testimonials on this site, are the individual experiences and personal opinions of those who have purchased and used the products. These testimonials are not intended to make any claims that the products can be used to diagnose, treat, mitigate, cure or prevent any disease or medical condition.
Click here to see all reviews
Advantix works great! by Pam from Statesville, North Carolina08/17/2014

Sam stays outside and he is older, so he needs the protection from fleas, ticks, flies, etc that Advantix provides. Entirely Pets has the best price on Advantix and fast service. I won't order from anywhere else.

GLAD I SWITCHED by berrylady from Powder Springs, GA12/15/2012

Had been using Frontline Plus but this seems to work better/more effective. Best prices at Entirely Pets!

by from 08/07/2013

Good product by lilachaze from Upstate NY02/19/2014

But not as easy to use as other flea/tick drops.

Best purchase ever by Carol from Alpine, NJ07/09/2013

This is the second time I have used K9 Advantix II and I prefer it over Frontline. My dog kept getting ticks when I used Frontline and so far he has been tick free with Advantix

Best way ever to purchase a product by Connie from Irvine, CA11/29/2011

I purchased advantix II and found that this was the best price and the fastest delivery that I have ever found. I don't want my dog to have fleas and with this product and your company I will never have to worry. Thanks so much. Connie

Tick protection too! by Cody & Carson's mom from Western New York12/14/2012

No one wants fleas, but ticks are a real danger too! Not only is your pet at risk if you live out in the country. Do you know that birds can drop them in your yard? Be safe and take the extra protection!

by from 09/27/2013

This didn't remotely work on my dog. When I contacted customer service they told me she probably was still itching because of the previous bites and to wash my bedding. When that didn't help they told me to contact the manufacturer. I've purchased frontline from them before and it failed to work also. (Reason I switched to Advantix).

be by spending from anyI


We Love This Stuff by Kimberly from Washington State01/21/2015

Many other people I know struggle with fleas on their pets, but we NEVER have fleas on our dogs.

Works great! by Betheski7703/15/2012

I have been using advantix on my dog for years now and have never seen a flea or tick on her. I know there are ticks in our yard too, so I make sure to apply every month. I highly recommend this product.

Worth It! by Rottie Mommy from San Diego, CA11/29/2012

We treat both of our Rottweilers with Advantix II, and have seen it in action. Both dogs sadly got ticks on a camping trip, and the Advantix II stopped the ticks from embedding in their skin. I would highly recommend this product.

I suppose all things come to those who wait... by Stillwaitingfordelivery from Kaneohe, Hawaii (windward side of Oahu)03/29/2012

I love this product but I am really put off by this dealer. You see, I placed the order a couple weeks ago and my credit card was charged but then I got a message that the order was back ordered and that's the last I've heard. No update, no apology, no attempt to keep my business, no nothing. Nice going, Entirely Pets! And then you want me to review the product and your service? Talk about a self infliected shot to the foot (or worse.)! The "image" I would select in order for add personality to the review would be the thousands of ticks that are about infest my dogs - springtime in Hawaii is the time that I need these the most. So, how about an update before you ask for praise?

Advantix works great by Murdoc11/14/2013

We live in a swampy area with lots of flying insects and have found that Advantix really helps keep mosquitoes and yellow flies away from our dogs.

by Agi from New Jersey07/05/2012

This product was recomended to me by my vet, works great and is cheaper then frontline

by Barb dog lover from Berlin md03/18/2013

My vet recommends this over frontline now.

by from 11/25/2012

by Leslie12/24/2012

This is a good product for fleas, etc., and it doesn't cost as much as if you purchased it at the vet's.

Depends on your needs by Laura from Vidalia, Ga.11/06/2012

I have always had pretty good results with this product. They are all good but I feel you need to switch off every now and then. I haven't used it in a while and it seemed to kill the fleas this time.

Good Product by Nana from Fort Worth, TX05/31/2012

We always order this for our dog. We love the way that it repels flies and mosquitoes also.

by Cassie9105/16/2014

K-9 Advantix works great on fleas and ticks, it is also a very reasonable price!

best price from entirely pets by wjohnb from Hendersonville,TN11/06/2012

Would'nt use anything else. Best on the market.

works great by Mary from Atlanta02/14/2014

I have used this product for all of my dogs and it works like advertised and I am very satisfied.

by Nat07/19/2012

I am overall pleased with K9 advantix; although, the tubes of solution in this particular box DO NOT have as much solution as usual.

Great Product by SC Lab11/10/2011

I have been using advantix for years with no flea or tick problem. I love entirelypets.com. I always get what I order when I order. I have even talked to them on the phone and they are always super helpful.

Entirely Pets by Bo Georges06/12/2013

Products are as stated and delivered in a tinmely fashion.

Great Product by Elaine from San Diego, CA04/24/2012

I've used K9 advantix and K9 advantix II now on my dogs for about 5-6 years. I've never seen a tick or flea on them and they're outdoor dogs.

Bug free by Bounder's Provider from San Antonio10/25/2011

This is an excellent product at an excellent price that was delivered exactly as expected. Thanks!

Not all I had hoped for. by DJ06/02/2012

This product works great on ticks, but not on fleas. I have applied it twice,2 weeks apart, and the fleas will be lessened for a few days and then they're back in full force. This is the first time I have purchased this product and was hoping to use just one product for both ticks and fleas, but it's not working out.

Chance/Oakley by Chance/Oakley03/21/2013

K9 Advantix II works great for flea & tick protection. Entirely Pets makes ordering easy & affordable.

Complete protection! by pguest from NW Indiana01/01/2013

I have tried several products for my 2 German Shepherds over the years and for the last year I only purchase K9 ADVANTIX II for my Girls. Coco and Nelli are outside 16 hours a day with our horses so they need to be protected from all the nasty bugs in the woods and fields they live and play in.

K9 Advantix II for Dogs by Debbie from West Bend, WI06/11/2013

I have used this product for about 2 years now & it works great. I have tried others products & this has been the best one. It also stops flys & other bugs from landing on the dogs.

VERY pleased with this product! by Just Laura from Auburn, Michigan05/04/2014

We have a German Shepherd who tends to get irritated skin rather easily, so it's really important to me that he is comfortable and itch-free. Between the change in diet and the use of this product, he is a much happier dog! No more scratching and nibbling at himself. K9 Advantix works fast and I love that it kills multiple pests at multiple stages - it pretty much covers all the bases!

Kills fleas and ticks and protects my dog. by Jeannie from Galway, NY05/08/2013

Great product. Kills fleas and ticks and protects my dog.

Works Wonders! by ME10/31/2011

I live in southern marsh land and the bugs are really nasty here. I use this on my dog and I never have to worry about her coming inside my home. If i see a tick on her they die before I can get to them. I also have an inside only cat. She has never gotten fleas either. Very Happy!

Great product Great Company by groomer from Woodridge, Il04/08/2014

I love K9 Advantix, I am a groomer and I have my dog at the shop with me all the time. As you can imagine many dogs come in with fleas and we do flea baths and recommend K9 Advantix but for as long as I have been using the product, even being around all the other dogs with fleas my dog has never gotten fleas.

Terrific Product! by BSW from Florida04/13/2011

This is the best dog medicine against all outdoor pests! I've tried them all and even when I was using the Frontline Advantage, mosquitos still had my dog scratching all day. Love that K9 Advantix II takes care of him all the way!

Gets the Job Done by Sue07/15/2012

I love this product! I have alot of dogs and used to use another flea/tick product that did not stop the ticks from biting. K9 Advantix II not only repels fleas and ticks, but keeps ticks from biting and attaching to my dogs. Love it! I consider myself to be a great pet owner, but my 72 pound shepherd mix still got anaplasmosis from a tick bite. Once I switched to K9-NO PROBLEMS. I would highly recommend this to everyone!

K9 Advantix II by sam881812/06/2012

Very happy with this product, used it with my last dog and never had any problems with fleas or ticks. Our dog did so well with it, no side effects. Our new dog has done very well on it as well.

Love it by Mary from South Carolina11/28/2012

Works MUCH better on my 2 labs than Frontline did (which we had used for years)! Very, very happy with K9 Advantix II

by from 03/26/2014

Effective Flea Management by Shiloh06/03/2013

The dogs were scratching before this product but once we started, no more itching for them and no ticks on them. It is working just as it should and we will be purchasing more.

Good Purchase by KOBS from San Diego, CA10/11/2013

I like this product. It takes care of more little pests that the dogs go through. With the West Nile Virus and others pests, the dogs won't have to suffer with the diseases that these pests cause.

K9 Advantix II 6 month Extra Large Dog by LC from Monroe, WA06/18/2012

We have a Golden Retriever, and have had him on a regular program with Advantix as he likes the water A LOT, and we have never had a problem with it washing off. Also, with the broad spectrum of critters it kills, I feel it is the best treatment on the market, and with Entirely Pets reasonable prices, it amounts to about $10.00 a month. Well worth not having to worry about fleas, etc.!

by from 05/09/2012

Been using Advantix and now Advantix II for 3 years. It's done exactly what it is supposed to without any negative side effects.

shopping by and from EntirelyPetsDid


This product is the best by Dkelley from Pa02/05/2013

The best overall product I have used yet.

by from 05/30/2014

This is a great product keeping the fleas and ticks away from my dogs. No pills to take, just open the foil and put the liquid from the neck to tail, couldn't be simpler.

friends by to from yourI


offering by affordable from productsThank


good change by burt01/16/2015

I've been using Frontline for several years and decided it was time for a change.I am glad i did, as we live in a tick infested area. When my wife brushed my Golden after several days she combed out 3 ticks.

No bugs by baby fast from Oklahoma City, OK08/17/2013

This product works great. Has a funny order that lasts until you bathe the dogs but it works great. I think the most important thing is it gives you peace of mind that there are no critters attacking your animals that you don't have to worry.

EXCELLENT by JOHN10/30/2011

I like buying from your website , great prices ever , safe and trust .

Advantage II for Dogs by puglover from Florida03/06/2012

Execellent Product for my Pugs... Only Product will use on my Pugs

K9 Advantix II Flea & Tick Control by kittenonkeys from Central Louisiana08/06/2014

I've been using this product for my pets for several years now, and it is very effective. Entirely Pets ships quickly, and this is a convenient way to shop.

Best flee protection for dogs by Kat from Puyallup, WA04/17/2012

I purchase K9 Advantix for my golden retriever and shiloh shephard every year. It has provided excellent protection for both dogs when we're living on either side of the mountains in Washington State.

Quite Satisfied by NYNJdogowner from Upstate NY05/18/2013

K9 Advantix is a great product and EntirelyPets has it for a very reasonable price. Max says woofTHANKSwoof!

the best by gotti from ny04/02/2014

have been using this product for years now and it is the best used on my three dogs-no problems

K9 ADVANTIX II Extra Large Dog by roy from Syracuse,NY10/18/2011

Works great! Highly recommended by my Vet.

Every other month by larry from Florida04/23/2013

I rotate, one month K9 advantix, the other front line +.

Works great, but.... by Buddy and Rikki's Mom from Huntington Beach, CA10/30/2011

I have to reapply it after 25 days or so or my dogs get itchy.

Works the best! by mr. greenjeans from Batchewana Bay, ON05/30/2012

After trying other products, I have concluded that this product delivers the best protection for our best friends. I live in Northern Ontario, along Lake Superior, where May is black fly season then followed by mosquitoes for the rest of the summer. My large lab is protected and can enjoy the outdoors. What is especially good is that it does not wash off once absorbed into the skin. Just keep your dog out of water the first day that you apply K9 Advantix II and it will last a full month. I only wish I had used this on earlier beloved pets so that they could have gotten through nasty bug infestations.

by from 01/01/2013

I have a 4 year old Labrador that lives outside.

only by product from thatThis


Outstanding Service by Judy from North West Georgia12/10/2012

I have been ordering my Flea/Tick medication from EntirelyPets for years. Their shipping service is beyond EXCELLENT!! Highly recommend this company!

Best product of its kind! by Annemarie from Greensboro, NC10/27/2011

I have used K9 Advantix II since adopting my dog, Austin, in April. I live adjacent to an extensive and heavily wooded park where we walk twice a day, every day. On weekends, we spend 2-3 hours a day in the park/at the dog park. During the summer Austin did a fair amount of swimming, as well. Austin has not had a flea or tick issue since using K9 Advantix II!

Works good. Good value. by Ralphie from Troy, Ohio04/04/2013

Have used this brand for several years. Entirely Pets has the best price.

Flea Free by Deb from Pensacola, FL09/18/2013

We have three dogs and a large yard. We are flea free thanks to Advantix II. We use the cat formula for our cat as well. Easy to administer and Entirely pets makes it very affordable. Makes for happy dogs & cats and happy owners!!

by autumn07 from Ontario, Canada10/23/2012

K9 Advantix is great for keeping ticks off your dogs. We live on a farm in an area that is known to be a high populatioin of ticks and I have no worries of ticks biting my dogs.

Flea and tick control at great prices by Harrison's Person10/29/2011

I've used and recomended Entirely Pets to all my pet pals, because the prices are good, the delivery is timely, the sales are great, and the products are top notch.

by abbydogmom01/09/2013

Only problem I have is that my dog get a slight irritation and itches a lot after I apply it.


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