Denestra® with SAMe supports liver metabolic activity and proper liver function for cats and dogs. SAMe, or S-Adenosyl-Methionine, is a naturally occurring substance found in all living beings. SAMe in its biological form contributes to better pet health through a number of chemical processes. With just one pill you can give your pet support for healthy normal liver and joint function at the same time.
Denestra™ with SAMe supports liver metabolic activity and proper liver function for cats and dogs. SAMe, or S-Adenosyl-Methionine, is a naturally occurring substance found in all living beings. SAMe in its biological form contributes to better pet health through a number of chemical processes: transmethylation, trassulfuration, and aminopropylation. These processes can affect liver and joint health in animals. Through the process of transsulfuration, natural SAMe is converted into a compound called glutathione, a potent antioxidant and liver detoxification tool. This detoxification tool assists normal cleansing of the liver from impurities, which in turn may help the body from exposure to heavy metal or environmental toxins. Denestra with naturally occurring SAMe has added benefits for pet joint health as well. During the aminopropylation process, methylthioadenosine (MTA) is produced. MTA helps support cartilage matrix production in the joints, and may help maintain the effectiveness of proteoglycans, molecules that are critical for the lubrication of joints.
Denesta with SAMe is a pill that you can administer to your cat or dog in a pill pocket or hide in a piece of food to guarantee it is swallowed. With just one pill you can give your pet support for healthy normal liver and joint function at the same time.
For Use In: Dogs and Cats
Denestra should be swallowed and administrated on an empty stomach, one hour before or two hours after a meal (overnight fast is preferred). Do not cut or crush tablets. May be disguised in treats for easier administration.
Maintenance Administration: Dosage may be increased or decreased at any time at the recommendation of your Veterinarian.
Liver Support by Rosiebearmom from Fort Worth, TX02/06/2013
My dog needed help with her liver. I am hoping Denestra will give her that support.
by from 11/15/2014
This is a 5-star product with a manufacturer problem. It appears the most recent shipment of 100mg SAM-e arrived in the Entirely Pets warehouse in open unsealed boxes in new blister packs that are too big for the package. All with a 2 month expiration date on the product.
Entirely by Pets from for3
buying by multiple from boxesKinda
Great for Senile Dog! by teddysmom from albuquerque, nm07/24/2013
This is a great product for my aging dog that's getting a little drifty. The price was more than excellent and shipping was quick!
hope it works as well as denosyl by Okie48 from Oklahoma02/18/2013
Our 12 year old dog has been taking denosyl for 4 years and it has effectively reduced her liver enzyme level to a reasonable number. Denosyl has not been available a couple of times when we've needed to place an order over the past year. We tried the milk thistle pill and were not happy with the size of it. This product is an acceptable size for our little Havanese to get down. This is important to us as all directions say not to cut or crush the pills. This is a less expensive alternative to denosyl, but I guess that the jury will be out on it until bloodwork is done to see if it's as effective.
Great Product-Great Price by Poppi from Issaquah WA11/25/2013
Sometimes it is difficult to find SAMe in 100mg tablets, with no additional ingredients. Denestra puts out a great product, Entirely Pet's pricing makes it very affordable.
I STARTED USING THIS FOR MY LARGE DOG ABOUT A YEAR AGO OR MORE ITS WORKS FOR HIM HE IS 13 YO MY VET RECO
MENDED SAM-E THAT WAS QUITE EXPENSIVE I AM ON SS,SO I CHOSE THIS.
This Is Helping by tuffyb from Hartselle, AL07/07/2013
My little Chihuahua mix who is 14+ years old has been having a lot of problems over the past several months. She is deaf, can't see very well, and has weakness in both her back legs. Due to her hearing and vision losses she had been just kind of standing around much of the time, acting like she didn't know where to go or what to do. She has been on SAM-E now for about a month and I think it has helped her. She is more alert and interacts with me and our other pets more than she was before. She can also navigate her way through the house better, which is a big plus for her and for me.
Our little dog had meningitis as a result of heartworm. He has to be on prednisone for probably the rest of his life. I worried about his liver and doctors couldn't tell me what I should give Jake for liver support. I went on-line to Entirelypets.com and looked under "liver support". With the advice of a customer service rep., I purchased Denestra and Marin. Within a few days after dosing Jake, he began feeling and acting like his young self again. He hasn't had any of the recurring symptoms since he has been taking the 2 supplements. I totally recommend them. It is absolutely a miracle.
This is working. I'll find out today for sure when my Penny gets her levels checked again, but it seems to be doing a great job! She feels a lot better & is playing around more.
by from 11/14/2011
I AM SO HAPPY THAT ONE OF YOUR REPS SUGGESTED I TRY DENESTRA FOR MY SHIH TZU'S LIVER PROBLEM. IT IS A LOT CHEAPER THEN THE ZENTONIL 200 THAT I WAS ORDERING FOR HIM.THANKS TO THE REP WHO SUGGEST THAT I TRY DENESTRA ALSO CALLED SAME. MY SONNY HAD A TUMOR ON THE GLAND NEXT TO THE KIDNEY THE SIZE OF A GOLF BALL AND IT WAS PRESSING ON A MAIN BLOOD VESSEL, HIS SURGERY WAS 6/9/2011 AND HE IS DOING GREAT. WE SWITCHED T0 DENESTRA ON THE ORDER FOR MAY 16,2011. WE KNEW HE HAD A LIVER PROBLEM AND ONE VET THOUGHT HE MIGHT HAVE CUSHING DISEASE BUT DURING ALL THE TESTS FOR SURGERY WE FOUND OUT HE DOES NOT HAVE CUSHING DISEASE BUT WE ARE STILL GIVING HIM THE DENESTRA AND IT IS BETTER FOR MY POCKET BOOK!
HILTON HEAD ISLAND, SC by from MAGGIE"
Great product by nicky from new zealand06/19/2014
Have used it on 2 of my elderly dogs with liver disease now and for both of them it dramatically reduced their liver enzyme counts and maintained them at the lower levels. I use it in conjunction with human milk thistle (100mg) tablets as Denestra doesn't contain silymarin which is also a must have in my book. I import this produce into New Zealand for my dogs and it still works out at a fraction of the cost!!
Don't have a lot to say by Angie from Albuquerque, New Mexico02/01/2013
I can't really say a lot about this product because, like Denosyl, I use it as a supplement to strengthen my dog's liver, since he is being treated with phenobarbital due to epilepsy. The only issue I've had so far is that because of the size of tablet and the fact that it cannot be cut, Benji has thrown it up on a couple of ocassions. Denestra is much larger so I prefer Denosyl for Benji.
Great Product! by Mandy Lynn from Mesa, AZ04/21/2014
Started giving these to our 15 year old Chow approximately 1 month ago and she has shown major improvement in her mobility. She seems like she is much happier and enjoys short walks which she hadn't done in years. I recommend NOT using Greenies pill pockets with this product as my experience was that they prevented the Denestra pill from dissolving and eventually caused vomiting of days worth of pills. I'm not sure if it's the combination of the two products or the fact that from what I've read on-line Greenies are all around bad. I've had success with a spoonful of peanut butter.
Works Great! by Mandy Lynn from Mesa, AZ03/26/2014
We have a 14 year old Chow Chow who was acting very sluggish, depressed, and stiff in the joints. After only 2 days we see improvement in all areas. Hopefully it's long term!
Denestra by froglady05/31/2013
This product is great for our dog. And the bubble packaging keeps it fresh and ready to go.