• S Adenosyl 225 (SAMe) for MEDIUM / LARGE DOGS - 225 mg (30 tabs)

    S Adenosyl 225 (SAMe) for MEDIUM / LARGE DOGS - 225 mg (30 tabs)

    SKU: S-ADEN22530
    Regular Price: $38.99Sale Price: $28.79
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    S Adenosyl 225 (SAMe) for medium to large dogs is used to improve liver metabolic activity and restore proper liver function. Contains antioxidants to help neutralize oxygen free radicals, amino acids to stimulate glutathione synthesis and reduce oxidative damage, B-vitamins to provide nutritional support ensuring proper protein and energy metabolism, and vitamin B-6 for synthesis of cysteine in the liver detoxification pathway.

    Unique, enteric-coated delivery system allows it to stand up formidably to stomach acid and effectively deliver the S-Adenosylmethionine 1,4 butanedisulfonate (SAMe) to the small intestine for proper absorption. Both strengths contain SAMe and other important ingredients for proper liver support such as milk thistle to help protect liver cells from toxins and reduce damage to those cells caused by some prescription drug use.

    Usage Information

    Dogs 20 to 40 lbs...............1 tablet daily
    Dogs 41 to 90 lbs...............2 tablets daily
    Dogs over 90 lbs ...............3 tablets daily

    If feeding more than 1 tablet, divide daily dose between AM and PM. Tablets should be given on an empty stomach, at least one hour before feeding. Tablets are sensitve to moisture and extreme heat ans should not be split or crumbled.



    Active Ingredients: (per 1 tablet)
    SAMe (S-Adenosyl-L-Methionine) 225 mg
    N-Acetyl L-Cysteine 40 mg
    L-Taurine 33 mg
    D-Alpha Tocopheryl Acetate 20 IU
    Zinc Ascorbate 20 mg
    Milk Thistle 40 mg
    Pyridoxin HCI 16 mg
    B-Complex Proprietary Blend 14 mg
    Vitmain E 20 IU

    Inactive Ingredients: Coating Agents, Croscarmellose Sodium, Dicalcium Phosphate, Magnesium Stearate, Stearic Acid.

    Customer Reviews

    DISCLAIMER: The results described on the testimonials on this site, are the individual experiences and personal opinions of those who have purchased and used the products. These testimonials are not intended to make any claims that the products can be used to diagnose, treat, mitigate, cure or prevent any disease or medical condition.
    Click here to see all reviews
    Liver Assist recommended by Vet by Dubini from Boca Raton, FL03/26/2014

    We started our 37 lb Border Collie/Chow Mix on these after our girl was diagnosed multiple times with an enlarged liver that was worsening from exam to exam along with some of the blood test results. These basically stabilized her conditions for what had to be at least the last 5 years of her life which stretched to a very happy and energetic 15 years. They are a little pricey but much lower at Entirely Pets than anywhere else that we found and we always received "fresh" sealed packages on time when ordered.

    Substitute by Bluorbit from Wisconsin06/19/2012

    My dog had gotten in to one of my other dog's medication. After a 2 night hospital stay she was prescribed a liver health supplement where the main ingredient was SAMe. The supplement the vet provided was a bit hard to locate so I saw this, that has most of the same ingredients, and also for a better price, so I thought I would try it. I will know for sure if it's working as well at her next liver function test. I can just drop it in her food and she eats it easily enough. If for some reason I find it isn't working as well as the other supplement I will switch back but for now, it seems to do the trick.

    S-Adenosyl 225 by Gray12/15/2012

    S-Adenosyl was reccommended to us for our dog that has been on phenobarbital for 6 years for seizures, when his liver enzymes got high. The product has not only help his enzymes, but he is a calmer and happier dog! I will keep him on this forever, it has made a nervous and anxious dog a much happier dog.

    Great Price for Same Product by SH11/17/2012

    I have two dogs who have currently been prescribed this product. Initially one was given Denamarin which is more expensive and had stocking problems at vet. When second dog required it and vet was out of Denamarin, I was told that this was generic. Decided to see what could get online. This site had it at a substantial savings and I could get as much as I needed and it was delivered quickly. Best of all worlds.

    Fantastic prodduct by shark06/21/2012

    Our pet loves this product, it is keeping her alive. Thank you...

    Good Product- Good Price by cje04/17/2014

    This product is great for my13 year old beagle who had her gall- bladder removed about a year ago.and needs liver support. She has bounced back from near death to happy, healthy and full of life. I have used Denosyl chewables along with milk thistle and switched to this product about a month ago because of the added ingredients it has. I would like to see it offered in a chewable form.

    Dog Meds arrived Fast by naturegirl10/22/2012

    I appreciated the fast delivery of meds. Unfortunately my old girl has left us and will no longer be needing this medication. Im sure it helped her as long as I was giving it to her. Thank you, Nan

    life saver!! by tinker from missouri02/03/2013

    If your vet cannot figure out why your dog is thin, no worms etc. He may give you a special dog food to help. It did not help mine. The stool was light colored and still was with this mew feed. I found a vet that had some S Adenosyl. It was like a miracle! She started to gain weight and was feeling great, jumping around like a pup. Definately worth a try.

    Dog Meds arrived Fast by naturegirl06/06/2012

    I really needed my S Adenosyl 225 pills and they were here in 2 days after ordering. They also have been a life saver for my old dog who tore her acl ligaments and couldnt have surgey. Being told she wont walk again. I proved them wrong as this med helped her and now she can really get where she wants. Not fast but she walks everywhere. she feels good too .: Thanks!

    Why pay more by Satisfied repeat customer from Tampa Bay, Florida04/03/2013

    The same product for a lot less money. Fast delivery.

    by from 10/23/2012

    This product is VERY expensive, and although my 12 year old dog's liver function is still ok, SAMe has done nothing to reduce her liver enzymes, even after 2 years or so of using this.

    how by the from priceIt


    Great price by quiltmama from Clermont FL03/01/2012

    I've looked all over the internet for a cost-effective choice for this supplement. Great price! Exactly what my vet wanted at a good price.

    sam-e 225mg medium dogs by beagle lady from Odessa, Florida12/05/2012

    on the advice of my Vet, I put my 10 year old female beagle on sam-e 225mg. I give it to her at least one hour before her dinner as directed on the label. She thinks it's a treat and I have no problem with her accepting it. So far, she is doing very well and tolerates it without problems. She will continue taking it long term, she has already been on it for 6 months. Excellent product and very reasonably priced from EntirelyPets.com

    very good product by linda01/27/2012

    My dog has been on the s-adenosyl-225 for several years now and with good results.

    by from 06/21/2014

    My dog Maggie got sick on March 26th 2014. After vets visit and specialty Vet Clinic in another town they told me she was terminal with liver cancer. They had put her on S-Adenosyl-225 on March 29th. I brought her home on April 4th to say goodbye and have a couple of days with her before I had to put her down. By monday april 7 she seemed to be getting better.

    April by 4th from wasHer


    International postage VERY slow by clyde from Australia01/03/2013

    Very happy with product and price and information from entirely pets. Unfortunately, once the product left USA, it took a few weeks to arrive in AUSTRALIA.....we were unable to track any further details after it left USA. I realise this is not the fault of entirely pets, but in future, I will allow ONE month when I need to re-order. Great product, well packaged. Thanks

    Thanks for saving me money by lizbeth05/17/2013

    I have been using this product for a couple months. My dog had a failing liver and this has helped so much. I feel like it has bought me more time with her. I was getting this from her vet but this site saves me money every month and the auto ship keeps me from forgetting.

    Quality Poduct by John Kinnel from Yuma, Az.06/10/2013

    Great product, my dog's liver health is improving with the use of this product.

    S Adenosyl 225 (SAMe) by Kris05/15/2014

    Tablets are HUGE! Way too big. Also found out from my vet that it's a concern that they're not in those individual foil packets. They can lose their potency. Overall not satisfied with the product, but the service and shipping from Entirely Pets was great. I'd order from them again, but I would not order this product unless it was for a giant dog or a horse. Did I mention, the pills are HUGE!

    by from 01/28/2012

    Entirely Pets always has the Sam-E product that I need for my dog, Emmit, at a reasonable price. The turn around time from when I order, to when the product is received is unbelieveable.

    have by recommended from EntirelyI


    Great purchase by Leslie12/26/2012

    My dog has a liver issue and by taking adenosyl, she keeps her enzyme level in check. Thanks,

    WORKS GREAT! by SHARK from DISNEYLAND10/23/2012


    Seems to be working by Remus2 from Michigan10/22/2012

    I have been using the SAMe for close to a year, along with Cushex homeopathic drops and our 12 year old girl is doing very well. We caught it early on and her symptoms have remained mild. Am very happy with the product. But we also give an extra 100 mg milk thistle daily on the advice of our Vet.

    This product works! by Desert Dweller from Las Vegas, NV03/09/2013

    My vet prescribed Denosyl after one of my dogs had elevated liver enzymes. WIthin a week the second test showed that the elevated enzyme levels had plunged dramatically! I now have him on Denosyl maintenance and home-cooked meals (chicken, sweet potato, and rice). He just turned 13, so I am hoping for some excellent additional future senior years.

    S Adenosyl 25 by Lillian07/19/2013

    Seems to work just as well as Denamarin for my dog and is less expensive.

    by from 04/29/2013

    Product was prescribed by vet, found it here for 1/2 price! It truly has saved my little fellow's life. HIGHLY RECOMMEND IT.

    exactly by as from vetFAST


    goes with gluta dmg by great dane keeper from MICHIGAN02/16/2012

    good product and price use the reorder option. It works great !!

    Sam-e for dogs by Emmits mom from Greenfield, WI11/26/2012

    Emmit has been on this for several years and is doing great. Entirely Pets has the best prices for this great product.

    by from 04/24/2013

    Switched to this because I have a dog with Microvascular Displaysia (acquired liver shunts). She weighs about 80 lbs and Denamarin has gone THROUGH the ROOF in price! This has about the same ingredients and my vet said it was a great substitute. I have noticed she's doing as well as she did on the Denamarin for LESS than 1/2 the cost of Denamarin.

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    Great Value! by JaimeD827 from Sacramento, CA01/15/2013

    My dog was prescribed this for Cushing's Disease and my vet was charging a LOT more for the exact same product. I found it here at Entirely Pets for a fraction of the cost. I have just placed my second order thru you...you have a lifelong customer. Thanks!

    S-Adenosyl-225 by Leslie01/29/2012

    This product keeps the liver issue under control with my dog. Very happy with it.

    I appreciate by Desert Dweller from Nevada12/23/2012

    both the quality of the product, and the speed at which it was shipped. This producte helped decrease my Lab's elevated liver enzymes.

    by from 06/11/2014

    I have been giving this Antioxidant to both my dogs. Leela had Osteosarcoma and Maya has had some reoccuring bladder issues. Leela survived 5 months longer, I attribute it to good food and antioxidants.

    had by any from bladderMaya


    S Adenosyl 225 (SAMe) by kevin02/02/2013

    I have been using this product for several years. I feel it has helped my pet as a liver spplement. I recommend it to other pets

    Best Liver Support product by taz from Kingman Arizona10/11/2013

    Been giving Fluffy this brand of liver support medication . She is 12 years old now and doing well. I highly recommend this product.


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    This product has met all of the stringent quality and safety standards set by the NASC.

    The NASC (National Animal Supplement Council) is a non-profit self regulatory group that set specific guidelines to which manufactures must strictly adhere.

    This seal is meant to minimize risk by providing an easy way of communicating to consumers that a product and its manufacturer meet particular standards of quality, customer safety and service.

    Those products that have the seal for NASC Quality and Safety standards have been strictly audited and were determined as meeting the following criteria:

    • Consistent manufacturing quality control
    • A system for evaluating complaints and adverse events
    • Clear and accurate labels compliant with codes and restrictions for all forms of labeling

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