• Frontline Plus for Dogs 12 months
    • Spot on applicator
    • Frontline Plus for dogs rear

    Frontline Plus for Dogs 45-88 lbs - PURPLE, 12 MONTH

    Regular Price: $211.99Sale Price: $155.99
    One Time Order

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    Temporary Price Reduction! Frontline PLUS Purple for Dogs 45-88 lbs

    Recommended by veterinarians, Frontline PLUS Purple for Dogs 45-88 pounds is a powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. FRONTLINE Plus is specially formulated for dogs weighing 45-88 pounds. Available without a prescription, FRONTLINE Plus only needs to be applied once a month for thorough pest control.

    life cycle of the commom flea
    Flea life cycle.
    View larger.
    life cycle of ticks
    Tick life cycle.
    View larger.

    Quickly Kills Fleas, Ticks, and Chewing Lice

    This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. FRONTLINE Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. FRONTLINE kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

    Waterproof Formula

    Thanks to its waterproof formula, FRONTLINE Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in FRONTLINE, fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

    EPA Registered Logo

    This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

    Package Contents

    Box includes three 2.68-milliliter tubes of FRONTLINE Plus for Dogs.

    Frontline PLUS Purple
    for Dogs 45-88 lbs
    • Kills fleas, flea eggs, ticks, and
      chewing lice
    • Fast-acting formula
    • Includes 12 one-month
    • Waterproof formula
    • Easy-to-use applicator
    • For dogs weighing 45-88 pounds
    • Per Dose: $11.92
    More Info
    Got Fleas?

    A product guide to flea
    and tick products.

    Flea Facts You Should Know

    Interesting flea facts to help your
    pets be pest free.

    Fleas: Understanding the Enemy

    All about fleas and prevention.


    Helpful information on ticks and your

    FAQs about Fleas and Ticks
    Frontline Plus for Dogs Lifestyle shot
    FRONTLINE Plus for Dogs is Available In:
    (0 - 22 pounds)
    (23 - 44 pounds)
    (45 - 88 pounds)
    (89 - 132 pounds)
    3 month
    6 month
    12 month
    3 month
    6 month
    12 month
    3 month
    6 month
    12 month
    3 month
    6 month
    12 month

    Usage Info

    How FRONTLINE Plus Works

    Use FRONTLINE Plus for fast-acting, long-lasting flea and tick control. When you apply FRONTLINE, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, FRONTLINE provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

    Simple Three-Step Application

    Applying FRONTLINE Plus to your pet is an easy three-step process. First, remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down. Next, hold the applicator upright and away from your face and body and snap off the tip. Finally, place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.

    To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully.


    To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

    Weight Dosage
    Up to 22 pounds Apply contents of one applicator (0.67 milliliter) once per month
    23 - 44 pounds Apply contents of one applicator (1.34 milliliters) once per month
    45 - 88 pounds Apply contents of one applicator (2.68 milliliters) once per month
    89 - 132 pounds Apply contents of one applicator (4.02 milliliters) once per month
    All weights Apply contents of one applicator (0.5 milliliter) once per month




    Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

    Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


    Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

    Main Purpose

    To kill adult fleas and ticks.


    Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


    Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

    Main Purpose

    To break the flea life cycle and stop further infestation.

    Active Ingredients % by Weight
    Fipronil 9.8%
    (S)-Methoprene 8.8%
    Inert Ingredients 81.4%
    Total 100%

    Some animals are sensitive or allergic to the ingredients in FRONTLINE, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

    Net Contents

    Twelve tubes, each 0.091 fluid ounces (2.68 milliliters)

    Frontline Plus for Dogs 45-88 lbs - PURPLE, 3 MONTHFrontline Plus for Dogs 45-88 lbs - PURPLE, 3 MONTHReg price: $54.99
    Sale price: $41.99
    Frontline Plus for Dogs 45-88 lbs - PURPLE, 6 MONTH6 Mo Frontline Plus LgReg price: $106.99
    Sale price: $81.99
    Frontline Plus for Dogs 89-132 lbs - RED, 3 MONTHFrontline Plus for Dogs 89-132 lbs - RED, 3 MONTHReg price: $57.99
    Sale price: $43.99
    Frontline Plus for Dogs 89-132 lbs - RED, 6 MONTH6 Mo Frontline Plus XLReg price: $109.99
    Sale price: $83.99
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    Customer Reviews

    DISCLAIMER: The results described on the testimonials on this site, are the individual experiences and personal opinions of those who have purchased and used the products. These testimonials are not intended to make any claims that the products can be used to diagnose, treat, mitigate, cure or prevent any disease or medical condition.
    Click here to see all reviews
    Flea and Tic control by JM from San Antonio, TX10/25/2012

    We have used this product for 9 years with great results, we travel with our pets a lot and they are out in the woods so need more protection than the normal house pet and they get it with Frontline Plus. Great product

    frontline plus by junior from honolulu12/24/2013

    have been using frontline plus forever it seems and before that regular frontline, maybe 25 plus years. I apply it every 5 weeks just to be safe from fleas because I walk 3 of our 4 dogs daily . It complements the heart guard I am now using now. I was on sentinel for a long time but after the production problem with sentinel (shortage) my vet switched me to heart guard and told me to just stay on it because I am using frontline anyway.

    by taz01/08/2013

    we live in the woods and hike alot and like the way it works

    Great product by Star71 from Oklahoma03/16/2012

    I have used this product for years and it works great for my dogs.

    Great by oconnorsusan8802/21/2012

    I was very happy with the prices at EntirelyPets.com and the shipping time was as expected. Very pleased with the product and service. Will shop here again.

    Flea and Ticks BE GONE! by Kris from Ohio01/06/2013

    Frontline Plus is by far the best product I have ever used to keep fleas and ticks off both my cats and dogs. I have tried other products and had horrible results, I'll stick to Frontline Plus...

    Great Product by DoggyMommy07/12/2012

    I've been using this product for 10 years on both of my indoor/outdoor dogs and have never had a flea problem. I choose Entirely Pets for competitive prices and the fast delivery. I've been totally satisfied with Entirely Pets service.

    by from 01/01/2013

    Ticks are terrible in western PA and Frontline plus helps keep them to a manageable level.

    great by with from pricesEntirely


    Price is right by kg02/10/2012

    Good price and shipping was fast will buy from Entirely Pets again.

    cheaper then the vet office by mollylover from Indiana03/26/2012

    I live in a small town so shopping around for pet supplies really isn't an option. I ordered the flea meds from EntireleyPets because they are a cheap alternative to getting the Frontline from our vet who charges $250 for a 12 month supply. I put this on my dogs from April until September and they never have had fleas or any adverse reactions.

    Frontline Plus by Shasta from West Bend, WI11/01/2013

    Just put the Frontline Plus on the dogs, as we do the 1st of every month, year round. Now we can go to training, the field, or the pool facility without fear of bringing home unwanted company.

    by jz07/23/2012

    Product was just as advertised and arrived in a timely manner.

    smooth transaction by sk from midwest12/12/2012

    Good prices, fast shipping and processing.

    Love this product by lovethemK9s from Colonial Beach VA05/30/2012

    Since using this product I have never seen a flea or tick on any of my dogs. Of course we live in the city and sometimes go hiking in the woods...as long as it's not too hot. They do go to doggie daycare and I still haven't had any issues with fleas/ticks. The only thing I don't like is how crusty the hair around the application area gets, especially on the short haired dogs. Eventually I'd like to go chemical free with flea/tick medicine but until I do, I'll keep using this product.

    Used it for years - have never seen a flea by Recycler29 from SC11/26/2012

    Excellent speed of delivery. Have been happy with all my purchases from Entirely Pets!

    Great product, great price. by Gary in NC from Lenoir, NC06/19/2014

    Frontline Plus is the only topical flea/tick product I use on my two yellow labs. In my region of NC ticks are a big problem. Using Frontline Plus we see those little monsters either dead, dying, or doing their best to abandon ship. I've used K9 Advantix II, which caused a bad reaction in my dogs and PetArmor, which didn't seem to do anything. Frontline Plus is what I always come back to. EntirelyPets.com has timely specials which allow me to stock up while saving some green.

    great product / best price by KWEENHALLOWEEN from WAUCONDA, IL11/06/2012

    I do a lot of comparison shopping and with 7 cats & dogs, I have to pinch every penny

    by Tess12/13/2013

    I have been using this product for several years and have no fleas or ticks.

    by warren05/12/2013

    Have three labs and have used Front Line Plus regularly for 12 years and have never had a flea problem . Must be great stuff.

    does the job by Travelbyrd from Upstate NY03/26/2012

    We live near a wooded area and our dog plays in the park regularly. We've used Frontline for his weight bracket since he was a puppy and it has done well.

    good experience by beepipes from linden tn03/18/2012

    frontline works extremely well for our four dogs. We live in tick country and even if a tick gets on the dog, it dies really quickly. The price was excellent and with the free shipping it was even better!

    Frontline Plus by Labrador Landing from Maine05/22/2013

    Works like a charm, my girls are flea and tic free.

    Great Price by FurIsFlyin' from New York01/23/2013

    Great product and at entirelypets you get fast service and a great price. I've been using entirelypets for at least 10 years. It's the best online store.

    Great product, easy to use by jenk813 from high point nc10/12/2013

    This is a product I have used for years. Easy to use, it works and not toxic to cats.

    Extremely fast delivery on Frontline by bb from NH10/02/2013

    this order was sent to me by Entirely Pet, received in perfect condition and with incredibly fast delivery. Entirely Pet has become my "go to" site for health products for my goldens. Just can't beat the prices.

    Love the Price! by Jeneene from Ohio02/04/2012

    This product is very pricey in the stores and especially at the vet's. I have two large dogs and need to keep my expenses as low as possible. Have cats too.

    Effective all year round by J T from VA04/09/2013

    I have used this for more than 3 years on our two rescue dogs. They stay outside except for extreme temps or when there's inclement weather. I have never seen a single tick or flea on them with the amount of time they are outside on 3 acres of land. On their annual visit to the vet, they're praised for being parasite-free.

    resistant fleas by tadmore254 from Blue Ridge Mnts. Virginia06/20/2014

    I don't know what is going on but the fleas and ticks are building up immunity or the company has lowered the effectiveness... but the fleas and ticks act like this product is all free all inclusive vaycay! The bugs are bad this year!

    frontline by MIKEY from sunrise, fl02/21/2013

    been using frontline for a number of years-the product is great and your prices make it that much better

    Worked great for 2 weeks by Shaun02/06/2013

    Fleas gone for about 2 weeks then they were back. Have had better luck with other products lasting longer.

    Best deal on the market by Magoo,Milo,Muddy from Cedar Crest,NM04/02/2014

    Outstanding product, have used it for years

    by from 05/09/2013

    We live in central Florida on acreage containing wetland, woodland and scrub environments, and our curious, energetic, young dog has run of the entire place. We require maximum protection for our dog who plays outside but lives indoors with us.

    tried by other from topicalThough


    by Sharon06/19/2012

    We've been using this product for several years on our two dogs and are really pleased with the result.

    Frontline Plus by Judy from CT01/09/2013

    I tried the cheap stuff, Pet Armour and Pet Sentry and neither worked. Back to the good stuff!

    Great product & price by Rhonda from Visalia, CA05/30/2012

    Frontline Plus is my choice for flea protection for my 3 dogs. I was extremely happy with price and fast processing/ship of my order!

    Works well. by DW06/05/2013

    Entirely Pets has the best Price I've found for Front Line Plus for Dogs. They always ship quickly and I have used this company for years. Never have had a problem. Front Line Plus works great. Keeps fleas and ticks off the dogs. The only draw back is a greasy spot for a couple of days on their backs.

    by GS from PA01/23/2015

    Frontline Plus is easy to apply. Have had no problems with fleas and ticks. Use it on 5 dogs.

    GEAT PRODUCT by kay from Npales, Florida03/16/2012

    I not only love Frontline Plus for Dogs (although I do worry about long range effects to my furry lovies!!)....but I really love ENTIRELY PETS....my orders arrive in great shape and the customer service is A+++.

    frontline Plus by jeani from NY01/07/2014

    Used product for years and it does work on my pets. Ticks were awful this past year. Use as directed and one will be happy they used frontline plus

    Prompt service by Mary from Phoenix, AZ11/13/2011

    I have used Frontline Plus for several years and have found the price at Entirely Pets to be the lowest. The free shipping and prompt service make this an exceptional buy!

    Great product by Roxie from Orlando, FL03/13/2012

    I've used Frontline Plus for years now on both of my dogs and I have NEVER had fleas in my house or on my dogs. I have had ticks attach themselves to my dogs & occasionally they stay but 99% of the time they fall off dead the next day! I highly recommend this product.

    Worst Customer Service Ever!!! by Maureen from Centereach, NY05/29/2014

    Sent emails, had live chats, left phone messages with no feedback what so ever. Never received the product & could not resolve the issue.

    Best Price by rjeatonw from Arvada, CO.10/25/2011

    The price for this priduct was the lowest I found.

    Excellent product by Thisby02/26/2014

    Our dogs have been on Frontline Plus for years and have never had fleas. This is an excellent product. Shipping was fast, and the price was very competitive.

    by WINSTON05/08/2013

    Product was as expected and at a reasonable price.

    Good for our greyhounds by warnertv204/26/2014

    We have used this product for many years for all our greyhounds, past and present.

    Frontline Plus by berrylady from Powder Springs, GA03/27/2012


    Great Price by PajamaMama from Washington, DC01/15/2014

    This is the same thing the vet sells for much more. Buy it from Entirely Pets!

    Good Stuff by Retriever Believer from West Bend, WI07/19/2014

    Fleas and Ticks and bugs! Oh, my! Now the dogs are safe with Frontline Plus.

    great product by Babe12/16/2011

    Best prices and the shipping is fast. Absolutely no complaints. Try the company you will love it.

    by 5greyt12/04/2011

    I have used this product on my five greyhounds and have been happy with the results.

    by from 03/14/2012

    Frontline Plus definitely does the job right, and isn't greasy like some other products I've tried before I discovered Frontline Plus.

    this by product from forHave


    by from Regards

    by from Sandy"


    Great Product by Our Three Dogs10/18/2011

    This is an amazing price. If you get a coupon and free shipping, this is almost half of what you would pay elsewhere!

    Great price & service by Kim from NY01/22/2012

    Great price & fast delivery. Only place i buy frontline from.

    Frontline works by golden from Northern New Jersey12/01/2011

    We are very happy with this product. After one of our hikes, my golden had a lot of ticks on her and within 24 hrs. they were dead and she was fine. The vet said if she didn't have Frontline on, she could have been very sick. We use this products 12 months.

    NO FLEAS by gailym from ROCHESTER, NY09/20/2014


    Works Great! by Nashmozzi from Brookings, SD04/30/2012

    We have always used Frontline and it works fantastic. It's easy to apply and dries quickly.

    good product by kspetlover07/02/2012

    Easy to apply. We live out in the country, so lots of tick problems. Seems to be keeping them under control.

    Frontline Plus for Dogs by Jeanne from utica, ny04/01/2014

    This product works great for my 2 labs and is the cheapest here on entirelypets.com.

    Great Price by whitedog07/08/2013

    I have purchased Frontline for years from Entirely Pets. I have checked around on other web-sites and have found that Entirely Pets has the best price. The product arrives very quickly in the mail and I've never had any problems. I highly recommend Entirely Pets.

    Very good product by GG from Texas01/24/2014

    Been using it since 1997 on three dogs. never had a flea or tick issue. Never had negative effects on the dogs. For us, it has done no harm.

    Good product for dogs by Cristy from Wisconsin04/05/2014

    Ive gotten this every year since I first got my dog and it's worked great. I only wish there was a better way to apply besides the oil on the back.

    Only Flea Med to Use by Vickster from West Virginia11/29/2013

    Frontline Plus has always been the flea/tick medicine I use. Have 5 dogs and live in the country so have to have a product that works.

    as good as it gets by Ben04/10/2012

    I'm not a fan of putting pesticide-like products on my dogs, but the ticks are so abundant this year that it's barely working. The product is fine...... I wouldn't use anything stronger, and certainly nothing weaker this year.

    Works by HouseMom02/07/2013

    This product is great, we use it every month for great results.

    by House O' Dogs06/17/2012

    Great product for parasite prevention in buggy Oklahoma! Keeps my dogs flea/tick free during our exceptionally long bug season!

    Awesome product - Excellent Price by Kim T from Ohio01/16/2013

    I have been using Frontline Plus for years. It's a great product and I use it faithfully year round to protect against fleas and ticks. I have priced Frontline plus at the vet, pet stores and online and this is the best price I have found that is a US approved product.

    Works for us! by Big Bad Woofer from Southeast Georgia03/05/2012

    What can I say about Frontline Plus, well---it works!!!. We have used this product on our retrievers for years. It is safe and lasts all month and there are never any sign of fleas. It kills ticks too, just not as quickly. I do wish it repelled instead of having to wait until they bite. However, until a safe and proven product appears that does that we will use the Frontline Plus. Good price too.

    does what it is advertised to do by kg03/24/2014

    I have used this product for several years. This is a very good price on this product.

    Great savings!! by tina04/11/2013

    I have been using this product for years and love it!!!

    It Works!! by dog-friend from delaware04/21/2013

    Great product. We are surrounded with herds of deer.... no living ticks & never a flea.

    by from 04/16/2012

    I shop everywhere and found this to be the best price. I wasn't going to buy the cats Frontline now but couldn't pass up the discount offered :) so I did.

    to by a from forestWe


    The only flea product I'll use by Emily from Tennessee04/28/2010

    This is the only product I'll use for any of my pets. I have a boxer, a mastiff, and a cat and I use Frontline Plus for all of them. Some of the other brands peter out after a few weeks and you'll see fleas pop up here and there - not with Frontline! Here in the South, I use this all year round on my pets and we never have any problems. Works great even through weekly baths. Also, my mastiff has very sensitive skin and gets sick easily with certain meds; I've never had this problem once I started using Frontline Plus.

    Frontline Plus for 4 Golden Retrievers by Jan Sofranko10/31/2011

    I have found over the years that Entirely Pets has the fastest, easiest and most economical ordering for my monthly application of Frontline Plus for my 50+ pound Golden Retrievers. I have recommended this company to my Golden friends. I've never been disappointed with the service I've received and my product order ships immediately. Thank you for being available to those of us who live way out in the country.

    Good product by RescuedDogsandCatsRule from Rural Eastern CT11/13/2011

    Living in a deeply wooded area, our three dogs are constantly picking up ticks. Since switching to Frontline the frequency of their being diagnosed with tick-borne illnesses has decreased dramatically. We wish there was something 100% effective, but this is the best we've found.

    Substitute Frontline not what I ordered by Gerri from Colorado04/10/2013

    I ordered Frontline and was told it would be sent to me in a few days. After waiting nearly 2 1/2 weeks I received a substitute frontline from Europe not the Frontline made in the USA. According to your company Frontline was hard to come by So they sent me a substitute from Europe without even informing me of the situation. There is no Frontline shortage in this country so I don't know why they told me that to begin with. Second I would never give my pet anything from Europe that is not approved in this country. I should have been told of this shipment before they even sent it out to me but instead they just took it upon themselves to send me something I did not want . They did credit me the shipping but I had to pay for the shipping back to them which was no fault of my own. I doubt I will ever use this company again.

    Great flea fighter by Judy10/18/2011

    All of my dogs are on this product & it helps keep them flea free. They have never had an adverse side effect to it & they have to another well known brand. Also you can give it to pregnant & lactating females with no ill effects.

    Best Price by TwoRetrievers02/21/2013

    I came across this website while googling prices for this product. Your price was hands down the best price and not even much more than the "Generic" prices. Thanks! I recommended this to someone else I know.

    Great Product! by Jen07/28/2014

    I have been buying this product for years and it is great. I have a lot of woods in my back yard and my dogs are always well protected with Frontline plus.


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