EntirelyPets Online Pet Supply Retailer
Home > Health and Nutrition > Flea and Tick Medicine & Supplies > Flea Medicine for Dogs > Frontline Flea And Tick Control > Frontline Plus for Dogs > 
Home > Pet Supplies > All Pet Supplies > Traveling with your Pet > Frontline Plus for Dogs > 

  • Watch Video

Frontline Plus for Dogs 0-22 lbs - ORANGE, 6 MONTH

Item Number: FPLUS6OR22
Regular Price: $88.99Sale Price: $67.89
One Time Order

Autoship & Save!    [MORE DETAILS]

Send Page to Friend


Temporary Price Reduction! FRONTLINE Plus Orange for Dogs 0-22 lbs

Recommended by veterinarians, FRONTLINE Plus Orange for Dogs 0-22 pounds is a powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. FRONTLINE Plus is specially formulated for dogs and puppies aged eight weeks and older weighing less than 22 pounds. Available without a prescription, FRONTLINE Plus only needs to be applied once a month for thorough pest control.

life cycle of the commom flea
Flea life cycle.
View larger.
life cycle of ticks
Tick life cycle.
View larger.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. FRONTLINE Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. FRONTLINE kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, FRONTLINE Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in FRONTLINE, fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes three 0.67-milliliter tubes of FRONTLINE Plus for Dogs.

for Dogs 0-22 lbs
  • Kills fleas, flea eggs, ticks, and
    chewing lice
  • Fast-acting formula
  • Includes six one-month
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older
    weighing less than 22 pounds
  • Per Dose: $11.50
More Info
Got Fleas?

A product guide to flea
and tick products.

Flea Facts You Should Know

Interesting flea facts to help your
pets be pest free.

Fleas: Understanding the Enemy

All about fleas and prevention.


Helpful information on ticks and your

FAQs about Fleas and Ticks
Frontline Plus for Dogs Lifestyle shot
FRONTLINE Plus for Dogs is Available In:
(0 - 22 pounds)
(23 - 44 pounds)
(45 - 88 pounds)
(89 - 132 pounds)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month

Usage Info

How FRONTLINE Plus Works

Use FRONTLINE Plus for fast-acting, long-lasting flea and tick control. When you apply FRONTLINE, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, FRONTLINE provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying FRONTLINE Plus to your pet is an easy three-step process. First, remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down. Next, hold the applicator upright and away from your face and body and snap off the tip. Finally, place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.

To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Weight Dosage
Up to 22 pounds Apply contents of one applicator (0.67 milliliter) once per month
23 - 44 pounds Apply contents of one applicator (1.34 milliliters) once per month
45 - 88 pounds Apply contents of one applicator (2.68 milliliters) once per month
89 - 132 pounds Apply contents of one applicator (4.02 milliliters) once per month
All weights Apply contents of one applicator (0.5 milliliter) once per month




Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients % by Weight
Fipronil 9.8%
(S)-Methoprene 8.8%
Inert Ingredients 81.4%
Total 100%

Some animals are sensitive or allergic to the ingredients in FRONTLINE, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Six tubes, each 0.023 fluid ounces (0.67 milliliters)

Frontline Plus for Dogs 89-132 lbs - RED, 12 MONTHFrontline Plus for Dogs 89-132 lbs - RED, 12 MONTHReg price: $182.99
Sale price: $140.39
Frontline Plus for Dogs 0-22 lbs- ORANGE, 3 MONTHFrontline Plus for Dogs 0-22 lbs- ORANGE, 3 MONTHReg price: $46.99
Sale price: $35.89
Frontline Plus for Dogs 0-22 lbs - ORANGE, 12 MONTHFrontline Plus for Dogs 0-22 lbs - ORANGE, 12 MONTHReg price: $167.99
Sale price: $132.99
Frontline Plus for Dogs 23-44 lbs - BLUE, 3 MONTHFrontline Plus for Dogs 23-44 lbs - BLUE, 3 MONTHReg price: $47.99
Sale price: $36.89
Related Items
Allergroom Shampoo by VIRBAC (8oz)
Allergroom Shampoo (8oz)
Siphotrol Yard Spray (32oz)
Siphotrol Yard Spray (32oz)
White Rope - Booda Bone
White Rope - Booda Bone


Customer Reviews

Click here to see all reviews
4.59 rating based on 56 reviews
used to work good by Sandy from Virginia03/31/2013

i have used this stuff for years for my dogs but over the last few years it has stopped working very well. i have since moved on to other products. dont think its a bad product just think the fleas have gotten used to it.

It works by sparky08/02/2012

we live in south east Florida, ticks can be a summertime problem. Following a pest contol routine for the yard, home and our 2 dogs, Trixie and Chewy very few to no flees or ticks.

Frontline Plus by Anne01/12/2013

Frontline Plus Great price. Product arrived on time.

Just not sure...?? by Lucy from Austin, Tx05/06/2012

Did not work for my Yorkies...they still have fleas!?!

Good product for good price by JR04/03/2012

This product has consistently helped with the unwanted fleas and ticks and your pricing makes it worthwhile to shop here. Delivery was amazingly fast and I didn't pay for faster shipment.

Best Price by SLA30 from St. Paul, MN01/31/2013

Better price than through my vet. It works when I use it. My dog contracted Anaplasmosis two times when not on Frontline from a deer tick. Devastating. It's a must in warmer weather.

tick control by ms. hawaii from Oahu, Hawaii03/01/2013

the continual warm weather we have here in Hawaii is a problem for us dog owners..we must be vigilant to control ticks on our dogs..I have been using this product for years and it has done a very good job at controlling the ticks on my dogs. Buying it online here from EP is the best buy..haven't found it more convenient and cheaper with prompt shipment,anywhere else. Have been buying from EP for years now and have always enjoyed their prompt service.

My Dog Couldn't Live Without It by Dottie08/18/2012

I have been using Frontline Plus for many years. My Shih-Tzu is 13 years old. Since day one I have never seen a flea or tick on him.

Good Protection by Tammy from Lakewood, CA01/20/2013

I have used Frontline plus for my dogs for the last several years and it provides good protection from fleas for about a month. They seem happier and more content after I put Frontline on them. I will continue to use this medication to protect my dogs.

This Product works! by Carol from Martinez, CA01/24/2012

We have fleas and ticks in our area and this product is the only one we found that really does what it says it will. Have tried other products over the years for our 14 year old cockapoo and they did not work.

safe and affordable by Cheryl10/10/2011

I feel safe buying Frontline Plus from Entirely Pets. I know it is the genuine product and not an imitation. I always receive my orders in a timely fashion and often will get a sample with my order which is a very nice little touch. Though any product can cause a reaction I haave not had any with Frontline Plus. My dogs, including my 16 year old are happy and flea free!

No, thanks by Gigi from Hartwick, New York11/13/2012

This product made my dog itch and itch. I don't know if it works, because I had to bathe her to get it off.

by from 12/06/2011

This product is amazing! It really keeps the fleas at bay for my pekingese. All his stratching stops and the fleas and their eggs disappear.

to by comment from onAlso


Works Great by Clair Bear's Mom from Louisiana03/06/2012

Frontline is so easy to apply and works so well. In just two days, there was no more scratching or evidence of fleas.

frontline plus by rick from san antonio,texas11/07/2011

recieved within few days and recied what was ordered

still the best I've ever used by pittiekisses08/29/2012

I have tried other flea and tick protection products and I still believe nothing works as well as Frontline.

Always reliable! by Lynda W. from Va.08/16/2012

I have always been able to depend on Frontline to kill fleas! Although sometimes I may need to reapply sooner than 30 days when fleas are very active. But with frequent vacuuming, that seems to help.

it works by hef321 from Houston, TX03/20/2013

recommended by my veterinarian. I think it works...

by from 04/17/2012

whats not to like

by from product


used by for from 4producr


Frontline Plus for Dogs by Donna from North Carollina01/14/2012

Always prompt service, and prices are good.

great purchase by Mikey12/04/2012

The Frontline was a great buy. That is why I only buy at Entirely Pets

Bug proof your pet by bw3 from Ashtabula, Ohio05/21/2013

The Frontline Plus seems to work very well. I use it on 5 dogs and no fleas again this year.

Great Product by angel from Deville, La10/19/2011

I've always used Frontline on all my animals. It works Great on Flea's and Ticks. I also love the fact that it doesn't irratate my dogs or cats skin like other products.

by from 03/21/2013

We had been purchasing our dog's meds from another company when we happened to hear about Entirely Pets. Much to our surprise their prices were even lower than what we had been used to paying. We decided to give Entirely Pets a try. Our first experience ordering from them was handled with polite, quick, and efficient service. We are very satisfied, and we recommended Entirely Pets to two of our sons, who are also dog owners.

Martin" by Very Pleasant Surprise from SusieTobey


Great Purchase by Dan from Lewistown, PA06/25/2013

The Frontline works - my dog is flea free!

NO more fleas by Diezel from Mass10/23/2012

have been using frontline + for years,have never had a flea problem

Works!!! by Sandra12/04/2012

We switched to another product that included heartworm medicine in addition to flea control because our finiky Yorkie will not take the heartworm meds. She got fleas and kept them. We used flea shampoos. The best thing was to comb them out. We reordered Frontline+ like we had used before and now the fleas are gone and staying gone. Don't know what to do about the heartworm medicine though. Maybe we could alternate months...Frontline+ & the other one???

Great Product by QOEWRC10/22/2012

I have never had any issues using this product. Works well and eliminates flea families!

Excellent product by Kat04/16/2013

This product works very well for my two small breed dogs. Shipping was very fast!

delivery timely by uni from Balto., MD06/26/2012

I purchased several items, and one of them was unavailable immediately. I needed the Frontline because the time for use was near. Instead of making me wait to receive the entire delivery, Entirely Pets' customer service rep (very curteous), sent the items separately at no extra cost to me. It makes me a faithful customer. No fleas or ticks because Frontline has been working for Dani Girl for 7 years. Thanks!

No bugs by BJ from Chandler, AZ06/18/2013

We put this on our little dog once a month. She knows the drill and sits still so I can put it between her shoulder blades on her hair. She likes to play with other dogs at the doggie day care now and then...so she is protected...and so are they.



good product by Nia from California10/27/2012

i kept forgetting to reorder frontline and my dog ended up with a few fleas so i reordered it and now my dog has no fleas anymore.. it worked pretty fast ;)

Frontline Plus by womaninthemist from Oahu, Hawaii01/19/2012

Excellent, and so much cheaper than the vet's office.

Slow Delivery by Mike from Fla10/27/2011

Products are great, but it should not take ten days for delivery. Find another way. Other products ordered the same day from Center Pet Pharmarcy arrived a week earlier...................

Outstanding by Jen02/14/2008

This works great!

Best Prices by J. Burns01/10/2009

Of all the sites I've ordered from, Entirely Pets has the best prices and delivery is quick and products are safely sealed.

Wonderful by M. Dent10/27/2009

Entirely Pets has great prices. Best that I've found. I have used Frontline Plus on my dog since he was a pup and I have never had any problems with it. It's a great product!!!!

Why We Use Frontline Plus by Rita06/09/2013

This product, unlike another product that we previously used, is gentle for our dog and causes no skin problems whatsoever. We have had a good experience with it protecting our pet in a safe way!

More Doggie Love by Susan from Salem OR11/20/2012

Yep, I have two little female dogs as well as my bigger guy. So here's what I said before: Frontline Plus is an awesome product and protects my dogs year round. No fleas on my dogs, no fleas in the carpet, no fleas on the furniture. And fleas LOVE to bite me, so I know if there's a flea anywhere around. Oh yeah, my dogs aren't spoiled or anything, but they do sleep on my bed. : ) So I'm very happy with zero fleas and no scratching! And none of my dogs has ever had a bad reaction with Frontline Plus--no side effects is good!

pest-free all year!! by Carole from Clifton, NJ07/03/2012

Frontline Plus for small dogs (under 22 lbs) keeps away all fleas and ticks, especially when you have dogs that LOVE the outdoors. whether running through the grass or on the beach, this product works GREAT even on long haired dogs with dense undercoats like my Pomeranians! use once a month and keep your dogs happy and yourself worry-free!

Love this product by calidogs01/11/2012

Frontline plus is wonderful. My little dogs sleep in our bed and it's always nice to know that there will never be any live critters traveling around. Frontline has always been great, it does its job.

Works GREAT by LZ01/20/2013

We have a field behind our house and this stuff is AWESOME! I have three dogs and they NEVER have any flea or tick issues. This is the only stuff we use!

Dependable Product by Maggie Pistol from Kensington, MD11/24/2011

One thing is they have it wrapped up so much for child proof, that you have to wonder whether all of that is necessary. However, I am pleased with Frontline, the combo for fleas and tics.

Frontline by oink from Cape Coral, FL11/30/2011

Don't believe the package says it can protect your pets up to 30 days. You'd better re-apply every 2 to 3 weeks. Remember, it won't get rid of flea eggs.

excellent by JavaPrincess06/23/2013

Easy to use and works well. The only negative for me is the residue left on her hair. It's obvious something has been applied.

Works well by Vicki from Texas10/27/2012

Works well but it seems to wear off a few days before the next application is due.

by from 06/11/2013

Great price, great product! by JH04/27/2012

Entirely Pets never fails with their prices on this product!

Great Purchase! by Gail from Pilot Mountain, NC03/27/2012

I have used this product for years and living in an area which is abundant with fleas, I can say that this product is effective.

best price around by daisysmom05/30/2012

After comparing several online sites I settled on Entirely Pets as having the lowest cost for Frontline of all of them. This left me totally satisfied with the product and Entirely Pets too.

Frontline Plus by Muffin's Daddy07/16/2012

Always a good product. Even better at Entirely Pets' price!

Great price and fast shipping. by Jeaux from Louisiana11/29/2011

Very good product. I have been using this product for at least 12 years.

Beware of this product by Dissatisfied12/07/2011

Two days after use, my dog came down with lethargy, trembling, hiding out of fear and an eye infection. At first we didn't associate it with Frontline, but the same thing happened a month later on the next flea treatment. I went online and found that many dogs have had very serious problems from this product. Even though most vets say it is safe, it is NOT safe for all dogs.

by pooch02/28/2012

I have used Frontline Plus for years, and think it works great---for fleas. My dog gets a lot of ticks now (we hike), however, and it does not seem to help at all for those bugs. He still gets them, they still bite him, and seem to stay attached until we use the Trix Ticklasso we purchased from EntirelyPets (which works great!) to remove them. I recommend Frontline Plus for fleas, but not for a tick problem.

Extremely pleased!! by Judi from Rome, NY06/24/2012

Was very happy with the product being the same as purchased straight from the vet. There are so many counterfeit out there. Also the product arrived within a few days and customer service was very helpful with all questions. I will most definitely order again!

Great purchase, great price by 704grow08/06/2012

My first order from entirelypets.com and I was extremely satisfied with how quickly my order was processed & shipped.

another quality product by Africa from Eaton, IN10/23/2012

A must for all dog owners. I buy often for my doggies.

Repeat Customer by SiraP10/20/2011

Frontline Plus is the best product for fleas and ticks!

Annoying Bugs by DogsRule from Northern California01/27/2012

Been using Frontline Plus for years. 2nd time to order it from EntirelyPets. Tried Advantage, but it does not control ticks & made my doggie throw up every time it was used. Then tried Advantix - also my doggie throws up with that. Sometimes still find a few ticks - yeck!!!! Again the box arrived a little smashed!! from this place... and they charged me for the shipping to get a smashed box - again. Told them to put extra padding before shipping, but they did not follow instructions for shipping. They could definitely reduce the price a little more!! You can order it here, or get it from the warehouse store, similiar price.


Questions and Answers

Stay Connected

Copyright 1999 - 2014 EntirelyPets.com - All Rights Reserved
Sitemap - Privacy Policy - Mobile Site - Contact Us

CALL US TOLL FREE: 1-800-889-8967


~ My Account Login ~

Sign into your EntirelyPets Account for the best experience!