liver Denosyl is a nutritional supplement that helps minimize a variety of liver problems in dogs and cats. It has also been shown to improve liver health and function by protecting and repairing liver cells. It is recommended to improve hepatic glutathione levels in dogs and cats. For optimal absorption, give your dog or cat Denosyl on an empty stomach, at least an hour before feeding.
FELINE AND CANINE DENOSYL ADMINISTRATION GUIDE
Total daily administration
and tablet size
Up to 12 pounds (5.5 kg)
One tablet of 90 mg
13 to 34 pounds (6-15.5 kg)
One tablet of 225mg
35 to 65 pounds (16 to 29.5 kg)
One tablet of 425 mg
66 to 120 pounds (30 to 54.5 kg)
Two tablets of 425 mg
Over 120 pounds (54.5 kg +)
Three tablets of 425 mg
The number of tablets can be gradually reduced or may be increased at any time depending on the pet's needs.
Denosyl, a nutritional supplement, is the pure and stabilized salt of S-Adenosylmethionine for veterinary use only. It is the only brand researched in medical trials for veterinary use in dogs and cats.
S-Adenosylmethionine is an endogenous molecule synthesized by cells throughout the body and is formed from the amino acid methionine and ATP. It is an essential part of three major chemical pathways in the body.
Denosyl has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidants that protects hepatic (liver) cells from toxins. A study found that low liver glutathione concentrations are common in dog and cats with decreased liver function.
For optimal absorption, tablets should be given on an empty stomach, at least 1 hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulties administering tablets to their pets, this medication maybe disguised in a small bite of food. Studies have shown that, in many cases, tablets or capsules given as a "dry swallow" do not pass into the stomach in cats, but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the table into the stomach. Denosyl 9- mg tablets are ideal for cats because of their small size.
Storage: Store in a cool, dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.
What does the liver do?
The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.
Because it does so much, the liver may be subject to many things: injury, both direct and indirect, infection, and toxicity. Some of the signs and symptoms of compromised liver function in pets may include: weakness, vomiting, poor appetite, and/or seizures. But if there is mild or early stage liver compromise, the pet can appear normal. If you notice any of these symptoms or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.
DISCLAIMER: The results described on the testimonials on this site, are the individual experiences and personal opinions of those who have purchased and used the products. These testimonials are not intended to make any claims that the products can be used to diagnose, treat, mitigate, cure or prevent any disease or medical condition.Click here to see all reviews
4.88 rating based on 78 reviews
Denosyl at this site is the best price I've found online....I recommend it highly.
Great price! by hflash from Alabaster, AL01/17/2012
My dog has to take denosyl for a health condition (prescribed by Vet.). I found the product on entirelypets.com at less than half the price I pay for it at the Vet. With the economy in the shape it's in, I am forced to find the cheapest products I can. The product was received in a timely manner, without damage. Will definitely recommend entirelypets.com and continue using them myself.
Awesome Meds! by LovesSissy11/14/2012
I would like to Thank You for your Product
Small pill easy to give by trailwaif from Elizabeth Lake, CA04/10/2013
This pill is smaller than the last brand I got in the same dosage, and much easier for the cat to swallow.
by from 02/16/2012
Denosyl for Cats by Annie07/13/2012
This medicine has kept my 15 year old cat alive for the past two years. When you look at her you would never know she has Thyroid and Liver problems. I would recommend this product to anyone to help keep their best friends healthy and happy!!!!
Life Saving by Pettrained from Dallas-Ft. Worth, Texas05/28/2013
We have a chihuahua-yorky mix. We found out he has a liver problem when he fell lifeless in our backyard while running after our other dogs. My husband gave him artifical respiration and rushed him to our vet. He will have to be on Denosyl for the rest of his life. He has had no other episodes since then. We are grateful to Entirely Pets because it makes Denosyl more affordable. They always send it in a timely manner. Since we are dependent on this product, it is great to have a reasonable resource.
Truly a lifesaver! by RCH from Overland Park, KS01/25/2011
Without a doubt, Denosyl has contributed to keeping my dog alive!! Due to a liver shunt, my dog experienced some liver damage. After surgery, my vet recommended that I give her Denosyl on a daily basis from now on. In follow-up tests of her liver, there are no health issues found. I believe this product has added to her playfulness and zest for life. The 90 mg pill is small enough to easily insert in her mouth and easily swallowed. I am a true believer of Denosyl!
good product by nld916 from East Freetown,MA11/25/2011
I paid $30 for this from my veterinarian. Here it was $19. Good deal!!
quick service by gale from covington,ga02/03/2014
i have a small dog that has liver issues. she has been on denosyl for quite some time. it really helps her. entirely pets has a very competitive price with other sites. the thing i have noticed the most is that entirely pets delivers much quicker than some of the other sites. when she is about out, it always comes in time. i would recommend this site over any other i have used.
Good supplement for dog with liver issues by Steph03/02/2014
Our 11-year old female Pomeranian began having liver issues a year ago (Feb. 2013) where her liver does not produce enough albumin. The vet suggested that Denosyl might assist her liver health and she was started on the supplement at that time. After starting Baby on the supplement, her appetite improved, as did her energy level. The liver issue is a life-long issue and the Denosyl is helping with her quality of life. She was sluggish and low energy prior to starting her on Denosyl, so I can only conclude that her liver and overall health are improved, and that her quality of life is better for having given her the supplement. I would recommend it highly.
Great Experience by RickM from Edmonton, Alberta, Canada08/08/2013
Placed my first order with Entirely Pets for 5 packages of the Denosyl 90 for my little baby girl, Krowka. The price is very fair and the product arrived in a timely manner, even though I am in Edmonton, Alberta, Canada and this had to go through our Customs.
Just a heads-up though to anyone ordering this or similar products from Canada ... I spoke with Health Canada and Canada Customs regarding importing such products as I began having problems with another supplier. Apparently there is no problem as long as you do not order more than a 3 month personal supply. Any more than that and you enter into commercial importing territory and different rules apply. But don't ask me how they determine what a 3 month supply is - it of course depends on how many pills you give your pet daily. Some get 1 pill, like my baby, some may get 2 per day. But those are the hoops you have to jump through.
Perhaps no matter how much of this you need to order, simply have Entirely Pets write "3 month's supply" somewhere on the shipping documents. Hope this helps someone avoid delays and keep their pets healthy.
Keeps my pet healthy by CestMoi from Chicago, IL10/21/2011
Phantom was diagnosed with liver disease back in 2008. The combination of denosyl and another prescription drug has kept him in good health all this time! He's still with us today.
Great Product by junglegirl from Battle Creek, MI10/03/2013
So far Denosyl has worked as good as the product we purchased directly from our vet. We really like the savings we get with the 3 pack offer!
Great product by Max in Oregon from Oregon Coast05/02/2012
I have now had two elderly canines on the Denosyl liver support. It really seems to help as their liver values have actually improved with usage. Please remember to NOT give with Tramadol and/or other contraindicated drugs.
Awesome Product! by Sissy from Sherwood, MI11/01/2012
This product is saving her life. Thank you for being there. :-)
by from 02/25/2013
Great prices on this product by clearasglas from Birmingham, AL10/23/2012
My Chi-chi has a liver disease and requires Denosyl. The cost is much less than at my Vet. Glad I found entirelypets.com. Also, they are very quick with shipping.
by April from New York09/29/2014
It has maintained Spooky's liver and has kept him healthy. Its had to put the pill down his throat without food so sometimes spits it out or throws up the pill. I wish there was an easier way to administer the pill.
by from 01/25/2011
Tolly is 12 years old and has liver damage from a lifetime on phenobarbital for seizures. A year ago his ALT number shot up to over 500, 100 is high normal. After a few months on the Denosyl the numbers started to drop. He is now maintaining almost within normal range. He's playing like a kitten.
is by an from excellentDenosyl
Has helped my dog by Randa05/07/2012
My dog was diagnosed over 5 years ago with a type of kidney & liver disease. Doctors told me that this disease would most likely shorten his life and require special food & medicine. They prescribed him denosyl and 5 years later I had a full lab check done to evaluate the status of his disease. Well good news the denosyl is proving to be very beneficial as his disease has showed little to no progression. Looks like my best friend has made it past the 5 years they estimated and hopefully he will be around for many many more years. I have definitely had a good experience with this supplement.
Seems to work good by Rhonda06/20/2008
My geriatric cat (15 years old) had lost a lot of weight and looked very sickly. She wouldn't groom herself either. The vet found she was great on her kidneys and thyroid, but had abnormal liver enzymes in some recent blood work. We did not want to go through the expense and pain to the cat of additional tests, so my vet recommended Denosyl. He said that it would help the liver to regenerate. We haven't had additional blood work done yet, but it's been a month and she looks and feels 100% better. She even grooms herself now, so I think it's really worked well.
A Life-Saver by Richard01/23/2009
This stuff really works!!! After spending a small fortune at our money-grubbing vet, denosyl was recommended to stabalize our 17 yr old cat's liver problems. He was at death's door, lost a lot of weight, vomiting, quit grooming etc. After a year, he has put on weight and almost back to his old self, albeit he is an "old man", but now great for his age. This stuff works and we have saved lots of money by not going back to vet over and over again for expensive tests etc. The bottom-line, our cat is old and Denosyl helps him lead a normal life for his age related liver problems. We will keep on giving him a daily dose as he has steadily improved so much over the past years daily Denosyl!!!
love it by Dianne03/01/2009
works great and is a great deal thank you.
Denosyl by Jennifer from Chehalis, WA10/03/2013
I really like using your site. It is easy to use and the delivery is always very speedy!!!
This supplement works! by puppiesmom from Amherstburg, Ont., Canada09/24/2013
Years ago, our Teddy, a yorkie, at 7.5 years of age, developed leptospirosis, after exposure to the bacteria. He went into kidney & liver failure. His liver enzymes were elevated. Following the initial critical phase of his care, because of his elevated liver enzymes, our vet put Teddy onto Denosyl. Within 1 month, his liver enzymes were normal. Apparently, many dogs don't live too long after contracting leptospirosis, Teddy, lived to be 16.5 years old. I really feel that because Teddy received excellent veterinary care from the doctors &pet nurses, & the Denosyl we had him for another 9 joyful years!