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Cholodin Canine (50 tablets)

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CHOLODIN contains sources of choline and posphatidylcholine, two of the most common phospholipids.

 When present in sufficient dietary quantities, these components act as neurotransmitter precursors, which are chemicals manufactured and released by nerve cells that initiate the sending of "messages" from those cells.

Occasionally, geriatric dogs and cats display clinical signs unexplainable by a specific pathological diagnosis. Examples include:

  • Lethargy and reduced awareness of surroundings.
  • Poor coat; excessive shedding or thin, dry coat.
  • Chronic constipation or fecal incontinence.
  • Inappropriate urination.
  • Poor appetite; animal eats too little to maintain an adequate body weight.
  • Poor mental acuity.
  • For animals displaying one or more of these conditions, choline supplementation with CHOLODIN® may be a very effective aid in treatment.

    CHOLODIN has four major functions:

    1. It is a significant dietary factor in preventing fatty-liver syndrome in diabetic dogs.
    2. It can donate methyl groups needed to synthesize other compounds.
    3. It is necessary for acetyl-choline formation.
    4. It is a component of phospolipid and lecithin, and a constituent of plasmalogens, which are abundant in mitochondria and in sphingomyelin, found particularly in the brain.

    Formulated with a flavor base (Pork Liver Meal).


    Active Ingredient(s):
    CHOLODIN® contains: Phosphatidylcholine (from soy lecithin), choline (as chloride), dl-methionine, inositol, zinc (as oxide), niacinamide, vitamin E, thiamine (mononitrate), riboflavin, pyridoxine (HCl), selenium (sodium selenite), vitamin B12 (cobalamin concentrate), and dexpanthenol. Formulated with a Liver Meal (Pork) flavor base.

    Useful Information

    Dosage and Administration:
    Usual Daily Dose: Cats and Small Dogs ½-1 tablet ¼-½ teaspoonful Large Dogs 1-2 tablets ½-1 teaspoonful The tablets may be fed by hand or crumbled and mixed with food.

    Customer Reviews

    Review Summary
    45 Reviews
    73% (33)
    20% (9)
    4% (2)
    0% (0)
    2% (1)
    96% Recommend this product (43 of 45 responses)
    By Beth
    Palm Springs, CA
    Best Ever -- Cost & Efficacy
    June 17, 2020
    I started my 16 year-old dog, Dixie on CHOLODIN on the recommendation of the Dachshund Rescue Org where I adopted her from 3 years ago. After taking CHOLODIN for about a month, I've noticed that she's much more alert, she seems happier and she's once again interested in life and what's going on around her. But most importantly for us, her appetite has come back! So many times we'd worry, thinking we were going to lose her after she'd sometimes go 2-3 days with no interest in food at all!

    The sale price at Entirely Pets was such that I couldn't AFFORD NOT to have my other dachshund, 12-yr old Piper, start taking CHOLODIN too! Although she hasn't shown any symptoms of dementia as yet, why take the chance? I wish I'd known about CHOLODIN 2 years ago when Dixie first started showing symptoms of Canine Cognitive Disorder.
    • Cost
    • Efficacy
    • None
    By nanny g.
    Vancouver, WA
    Review for Cholodin Canine (50 tablets) CHEWABLES
    November 7, 2018
    I have been using this for over 11 years with my Summer Lynn. It is great for older dogs but I used it daily when Summer Lynn was young.
    • Dogs love it!
    • None
    By Jan
    Great product
    August 2, 2017
    My Jack Russell mix has had 2 small seizures in the last 10 months. My vet recommended the Cholodin for him since it helps with neuro transmitters. He wasn't ready for more serious medication yet. He hasn't had any more seizures since taking the Cholodin. It does not require a prescription. Not every vet knows about this. My vet in CA has been working with all kinds of animals for many years and knows her stuff. Glad entirely pets carries it!
    By Vicki
    Syracuse, NE
    Best product ever
    July 24, 2017
    My vet recommended this product for my 14 yr old lab who has CDS (canine dysfunctional syndrome) after the first week I saw no change by the end of the 2nd week was a big change, his anxiety was greatly lessened - he let me sleep all night! He was also much calmer & happier, he is again wagging his tail and acting like he used to! He is much happier now, he has been on it about 1.5 months now, he is eating, feeling , & moving better, he has put on weight and looks great! He is still improving! Awesome product! Just give it time, glad I did!
    By Terry
    Allyn, Washington
    Trying it to see how it does.
    July 21, 2017
    I have an almost 18 year old miniature Dachshund who is showing signs of dementia. He has been peeing in the house. A friend, who rescues Dachshunds, recommended this product to see if it slows down the dementia. So far, it seems to be helping him.
    By Josie
    San Diego, CA
    My dog likes it
    April 5, 2017
    However, it wasn't as successful as I had hoped in restoring her hearing as a vet friend told me it might be. Apparently, it works for a good percentage of dogs after only a month and if it does work, it should be continued. Otherwise, it's an expensive snack. But we love Entirely Pets!
    By Mona
    Didnt work for my dog
    July 10, 2016
    My dog has CCD-this product was highly recommended for brain function-unfortunately after 6 days-I stopped-they say you see results in 30 days. I guess I was impatient since he was more agitated. This product did not work for my dog-but alot of other customers have had good results. I WOULD recommend it though.Thats why I gave it a 3 star rating-
    By Foxsea
    Port Orange, Florida
    I'm Hopeful
    May 17, 2016
    May be too soon to make a decision. The directions say results might not be seen until after 4 weeks. My Chihuahua (14 years old) has been on this for about 3 weeks, so I'm really not sure. If I don't see any improvement on this medication, I'll look for other meds/options.
    Review for Cholodin Canine (50 tablets) CHEWABLES
    March 25, 2016
    Dog just loves his "candy". Love your prices!!!
    By Scout's M.
    Cholodin Chewables
    March 18, 2016
    Scout is a 12 yr. old yellow. Our vet suggested we use this product 3 yrs ago and it has really keep him healthy and perky. Some people have remarked during walks, that he does not look his age!
    I always order through Entirely Pets because of their quick delivery and reasonable pricing.
    By Lorry
    Can't believe results.
    February 10, 2016
    My dog is 2 months shy of 14. she definitely was showing many signs of canine dementia-barking constantly, bewildered, unfriendliness to family members, pacing, sleeplessness. In a word she was nothing like she always was. the first week on the pills there was a definite improvement. Now 19 days after taking 1 pill daily, I have my sweet, loving dog mostly back. she still barks a little too much, but I feel that will improve also. Anyway I am ordering more Cholodin for her, and will keep giving her the pill daily.
    By Doxy
    Dallas, TX
    Definitely worth trying
    January 18, 2016
    (Original review on Amazon 2009. Additional information added 2016)

    I purchased this product in early January in the hopes of helping my very senior dachshund with her canine equivalent to Alzheimer's. In all fairness, this supplement does work and I saw definite response within about 48 hours. However, I ended up euthanizing her after she had only been on it for two weeks (unrelated problem) so my experience with it is somewhat limited.

    Where I did see almost immediate improvement was in her alertness. At nearly 17, nothing was going to reverse her problems completely, but that symptom did show quite dramatic improvement almost overnight. Within the two weeks that she was on the supplement, I saw improvements in panic attacks and awareness of her surroundings. Her physical symptoms improved, too, though in all fairness, the supplement might have done more good there if she had not been suffering from the results of a spinal stroke she had had two and a half years ago. I didn't see a lot of incontinence improvements, but again, her physical issues may have been the culprit there. What I didn't see a response was in the sleep/wake patterns and the vocalization that generally accompanies those problems. Again, though, she was only on the supplement for two weeks, so that might take more time.

    All in all, I'd say I saw a moderate positive response to most of the symptoms this supplement is meant to address. Again, nothing was going to reverse 17 years of aging, but if you have a dog who is beginning to show (or as in my dog's case, is well on the way) the "Old Dog Syndrome", this is definitely something to try. Also, one thing to keep in mind is that a 20 lb dog is going to generally get 1/2 a pill a day. You might want to keep that in mind if you're ordering a bottle to "try."

    Fast forward 7 years from the 2009 review.

    Since my review, my husband and I began fostering nothing but senior dogs, and this product has become a staple on my "dog shelf." I have now used it on at least a half dozen seniors, and I've seen marked improvement in each dog. Keep in mind that each dog will show improvement to a different degree on different things. The two areas I've seen the most consistent improvement on is in eating and the neurological areas...circling, confusion, lost in corners.

    I've also experienced a couple of the negative side effects the manufacturer talks about, but after taking them off the supplement for a few days and then returning them to it, the side effect disappears (usually some form of vocalization or mild anxiety).

    Cholodin is my default go to when I start seeing difficulty in my seniors. In a couple of cases, I've used it as a dog has begun to go blind, and this has helped them through the initial trauma of losing their sight; something that can be very helpful for a lot of dogs. it's also my first go to when I see some of the beginnings of senior dog dementia.

    As I said in my 2009 review, this isn't a miracle drug. Some animals benefit from it more than others (I've had one that benefited, but still needed more help from a prescription drug), and all of them to varying degrees. If you have a dog under 25 lbs, you have 1/2 a tablet per day, and that 50 tablet bottle is well worth the price to see if your dog will improve. And generally I begin to see improvement by the third day; and by the third week, I know I've gotten about as much as I'm going to get from it, which is hugely helpful.

    I'm changing this from 4 to 5 stars, and I highly recommend giving Cholodin a try if you have an older dog who is beginning to have difficulties.
    By kodybalody
    Frederic, WI
    Cholodin Canine
    August 2, 2015
    We have a 14 year old Scottish Terrier. She started sleeping most of the day, started messing in the house and acted confused when spoken to. After 5 days the change was remarkable. Now her energy level is back to where she was 2 or 3 years ago. No messing in the house and her confusion has subsided a bunch. I don't know if this product works this well on every senior dog, but I certainly advise anyone that loves their old friend to give it a try. Thank you for a great product.
    By Abitabb
    Cholodin - Super Geritol for Pets
    July 9, 2015
    This is a fantastic supplement with solid research behind it. I've used it with four elderly dogs - puts a spring into their step, improves mental sharpness and interest, helped control epilepsy with one dog as well as protecting her liver while one large continuous doses of NSaids.

    It is a really amazing product - have never had a side effect or pet that couldn't or wouldn't tolerate it. Entirely Pets consistently has the best pricing once shipping is figured in.
    By Elvie64
    Must have Supplement
    April 3, 2015
    I am using this with my third senior dog. I did notice a remarkable improvement in "old dog shakes" when I first started using it. Now I have the old fellas on the supplement before they show signs of age related weakness, so there's not such a dramatic improvement.
    By Ron
    Washington State
    Cholodin Canine Chewables
    February 11, 2015
    Our vet sold us a small supply to try as our dog is over 12 years old. Seems to work and this price was hard to beat.
    By The H.
    Oakland, NJ
    One of our best decisions
    September 1, 2014
    Our Sunshine is about 15 years old and has begun to show his age. He has been on thyroid meds for about 2 years and has never grown back all the hair he lost before the start of treatment. Early this year he started treatment for Cushings. He had also started showing signs of cognitive dysfunction. We have always needed to watch him closely in the yard because he was compulsive about eating dirt.

    I heard about Colodin and checked it out. When I read the reviews for it I was quite skeptical because it sounded too good to be true. I am no longer a skeptic.

    We started to see some improvement after about three weeks. Since then the changes have been significant. He has been getting Cholodin for seven weeks now and for the past three weeks -
    Zero episodes of lying on the floor barking at nothing, getting lost on the way from one room to another, and appearing to forget why he got up.
    His hair is filling in the bare spots quickly.
    Eating dirt has become a thing of the past.
    By IzzyB
    Cholodin works!
    May 19, 2014
    I have been giving these to my senior Bichon for a few years, and they seem to help his senility issues. He loves the taste and eats them quickly.
    By jim
    castaic, ca.
    easy for dog to take
    May 4, 2014
    my dog likes the taste of the product and takes it willingly. seems to cut down on his seizers
    By EvaAupperlee
    Northern New Jersey
    Cholodin Canine Chewable
    April 29, 2014
    My Libby is an old lady. My black lab is the sweetest thing. She has an issue with incontinence. She is NOT aware that she leaks. I feel that this would mortify her as she aims to please. I actually stumbled upon this site and have to say just how grateful I am. This is my 3rd order of Cholodin Canine Chewables have helped with this messy issue.
    By Sandy
    New York
    March 29, 2014
    My 10 year old dog is blind and developed doggy dementia. I had read that this product might help him with his problem. We are still on the first bottle, but he seems to be doing a bit better. He's not getting lost in the yard like he did and he's able to find his bed at night now as well. Has it helped? I don't know for sure, but I think it may have and I would recommend it.
    By Max
    Ft. Mohave, Az
    Something necessary for my dog's health
    February 3, 2014
    I have an almost 8 year old Doberman who has a liver enzyme problem. My Veterinarian recommended that I give him the Cholodin. In the beginning the liver count bounced up and down but the last two checks have been very good. I take him back this month for another check and am expecting good results again. I buy the product from Entirely Pets instead of from the Vet because the price is a lot lower.
    By Zia
    Portland OR
    January 31, 2014
    Seems to help my dog a bit - not the raves I found in other reviews, but certainly not hurting.
    By JG
    Good for older dogs
    November 6, 2013
    I've given this to my two older dogs (a 13-year-old golden and a 10-year-old pug) and I believed it has helped both of them. Both seem to be more alert and playful.
    By Crystal
    Urbana, Illinois
    Awesome vitamin supplement great value
    October 13, 2013
    Stubby our rat terrier has been on these for a
    long time. A great supplement to help keep him healthy . It is very affordable and I highly recommend it. Stubby is almost 15 and 1/2.
    By Texter
    Houston, TX
    Cholodin is the Bomb!
    June 19, 2013
    These supplements have truly helped our 'golden retriever' with alertness & agility. She's 12 & was suffering with periodic seizures/anxiety. She was 1st put on Pheno (1/2 tablet) for a few months but since starting on Cholodin - she has been seizure free for months & even brings us her frisbee once in a while! Amazing improvement. She's more alert as well! Recommended! :-)
    By Dog O.
    Definitely Helps with Dementia
    May 21, 2013
    My dog has suffered from dementia as he has gotten older. We've had 16 great years and counting! Initially my vet recommended Anopryl and this worked great but was very expensive. My vet recommended supplement alternatives like Novafit, but most of these have been ineffective alternatives. Cholodin has been the best supplement to help with his disorientation. It is more long-term (I give it twice daily) but after a month I was gradually seeing improvement. And although I still use Novafit together with the Cholodin when the dementia gets really bad, this second supplement is only used on a rare occasion. I walk him twice a day and even the neighbors have noticed his improvement!
    By Osmany
    Miami. Florida
    Awesome purchase, I'll go for the refill...
    May 18, 2013
    Wonderful product with a visible impact on my 11years old buddy....
    By peggy
    Boulder. CO
    Seems to help my pet's mental status.
    May 13, 2013
    Before I started using this he seemed to be developing dementia,but now he seems much less confused. A friend reccomended it.
    By KLKS
    Baltimore, MD
    Works well
    April 3, 2013
    I have a. 15 year old dog and since taking it for about a month she is more alert and awake during the day. She doesn't run into things the way she used to and she doesn't get surprised as easily. She still wets in the house but not as frequently. Overall I have noticed a marked improvement, so if u have an old dog it's worth a try and reasonably priced.

    Questions and Answers

    Cholodin Canine (500 tablets)Cholodin Canine (500 tablets)Reg price: $173.99
    Sale price: $133.59