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  6. 3 Pack Denosyl for small dogs and cats (90 tablets) 90 mg


3 Pack Denosyl for small dogs and cats (90 tablets) 90 mg

Item: DENO90MG-3PK
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NOTE: Limited supply item - only three (3) per customer per order.


Denosyl is a daily supplement that helps support proper liver function. Support of a compromised liver, regardless of the cause, is essential if function is to be improved. Denosyl has not only been shown to markedly increase glutathione levels in the livers of dogs and cats, but to go far beyond that. Denosyl has been shown to protect liver cells from cell death and may be useful in cell repair and healing. It's main ingredient is S-Adenosylmethionine (SAMe).

Key Benefits:

  • Denosyl is formulated for liver and brain health
  • Increases levels of glutathione, an important compound for liver health
  • Has also been shown to help protect liver cells from cell death and may help cell reparation and regeneration
  • Increases cerebrospinal fluid in the brain that pets lose as they age
  • Easy to administer tablets for medium dogs

How It Works

Denosyl has been shown to markedly increase liver levels of glutathione,1,2 an important compound for liver health formed when SAMe (S-Adenosylmethionine) is metabolized. Denosyl has also been shown to help protect liver cells from cell death3,4 and may help cell repair and regeneration.5

While best known for supporting the liver in dogs and cats, research has shown that the SAMe in Denosyl may help support cognitive function in dogs.6 Denosyl provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.7-9


  1. Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66:330-341.
  2. Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
  3. Webster CRL, Boria P, Usechak P, et al. Vet Therapeutics 2002;3:474-484.
  4. McCool J, Johnston A, Webster CRL. In Proceedings. 21st Annual ACVIM Forum 2003;abstract #134.
  5. Center SA. In Proceedings. 18th Annual ACVIM Forum 2000;550-552.
  6. Rème CA, Dramard V, Kern L, et al. Vet Therap 2008;9(2):69-82.
  7. Tchantchou F, Graves M, Ortiz D, et al. J Nutr Health Aging 2006;10(6):541–544.
  8. Tchantchou F, Graves M, Falcone D, Shea TB. J Alzheimers Dis 2008;14:323–328.
  9. Shea TB, Chan A. J Alzheimers Dis 2008;13:67–70.
  10. Westfall DS, Twedt DC, Steyn PF, et al. J Vet Intern Med 2001;15(5):467-470.
  11. Graham JP, Lipman AH, Newell SM, Roberts GD. Am J Vet Res 2000;61(6):655-657.



Useful Information

Because the tablet must be kept intact to prevent destruction by moisture, administration range is based on the nearest whole-tablet. The chart below is provided as a guide for administration. Daily administration may also be calculated based on 20 mg/kg of body weight and rounded to the closest tablet size or combination of sizes.

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. Studies have shown that, in many cases, tablets or capsules given as a "dry swallow" do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.10,11 Denosyl 90 mg tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.

Denosyl Canine and Feline Daily* Administration Guide

For Cats (90 mg)
Body Weight Body Weight Number of Tablets Per Day
Up to 12 lbs Up to 5.5 kg 1 tablet
Over 12 lbs Over 5.5 kg 2 tablets
For Small Dogs (90 mg)
Body Weight Body Weight Number of Tablets Per Day
Up to 12 lbs Up to 5.5 kg 1 tablet
For Medium Dogs (225 mg)
Body Weight Body Weight Number of Tablets Per Day
13 - 34 lbs 6 - 15.5 kg 1 tablet
For Large Dogs (425 mg)
Body Weight Body Weight Number of Tablets Per Day
35 - 65 lbs 16 - 29.5 kg 1 tablet
66 - 120 lbs 30 - 54.5 kg 2 tablets
Over 120 lbs Over 54.5 kg 3 tablets

The number of tablets can be gradually reduced or increased at any time depending on the pet's needs.

Many pets are maintained long-term on every-other-day or every-third-day administration.


Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat.


Denosyl is available enteric-coated tablets for cats and dogs.

The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.

Because it does so much, the liver may be subject to many things: injury, both direct and indirect, infection, and toxicity. Some of the signs and symptoms of compromised liver function in pets may include: weakness, vomiting, poor appetite, and/or seizures. But if there is mild or early stage liver compromise, the pet can appear normal. If you notice any of these symptoms or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.

Your veterinarian will advise you as to the amount to initially administer. Depending on your pet's response and status, your veterinarian may eventually adjust this amount to meet your pet's individual needs. Remember, Denosyl enteric-coated tablets should not be broken. When increasing or decreasing their administration, adjustments should be done in full tablet increments. Some pets are given Denosyl only for a short period of time, although Denosyl may be used longer in other animals.
While response varies, owners may note a change in their pet’s appetite, activity, and attitude.
Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Denosyl and how it may be helping to support your pet’s liver function.
Denosyl has been shown to be well-tolerated by both dogs and cats with a wide margin of safety.
Yes, your veterinarian may recommend combining Denosyl with other products and/or dietary modifications. There are no known adverse interactions of Denosyl with drugs or other supplements. Denosyl may even protect against negative effects on the liver caused by some medications.
While other S-Adenosylmethionine (SAMe) products are available, there can be a significant variance in product quality and activity levels of SAMe. Denosyl is produced using high-quality, researched ingredients and under strict manufacturing standards.
Administration of methionine is not recommended. Providing high levels of methionine to pets with liver compromise may not increase the production of natural S-Adenosylmethionine and has been shown in some cases to increase liver damage.

Like all medicines, Revolt has some side effects. The most common is hair loss at the site of application with or without inflammation (redness, flaking) in cats. Other side effects reported in cats and dogs include vomiting, diarrhea with or without blood, anorexia (decreased appetite), lethargy (sluggishness), salivation, rapid breathing, pruritus (itching), urticaria (welts, hives), erythema (skin redness), ataxia (incoordination), fever and rare instances of death. There have also been rare reports of seizures in dogs.

If you have additional questions about possible side effects, talk to your veterinarian.

In well-controlled clinical studies, selamectin was used safely in dogs and cats receiving other veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.

Tell your veterinarian about all medicines you have given your dog or cat in the past, and any medicines that you are planning to use with Revolt. This should include other medicines that you can get without a prescription. Your veterinarian may want to check that all of your dog's or cat's medicines can be given together.

Revolt is flammable - Keep away from heat, sparks, open flames or other sources of ignition. Store below 30°C (86°F). After application, empty tubes can be placed in your normal household refuse for disposal.

Customer Reviews

Review Summary
43 Reviews
88% (38)
12% (5)
0% (0)
0% (0)
0% (0)
95% Recommend this product (41 of 43 responses)
By Huili
new york
perfect product perfect price
June 16, 2021
perfect product perfect price
By dcabin01
Beaumont, Tx
Great supplement. Used over 10 years.
April 9, 2018
Denosyl was recommended by my vet over 10 years ago to treat liver problems for our little Chihuahua, Brandy. She had liver surgery when she was only about 5-6 months old and we have been using Denosyl ever since. Great Supplement! Helped to save Brandy's life and she is still going strong now at 11 years old.
Great Product!
David C.
By Dave
Beaumont Tx
Denosyl works
February 8, 2017
I have been using Denosyl for my Chihuahua ever since she was a puppy. As a puppy, she had a malfunctioning liver ailment and the vet recommended Denosyl for her. She is now 10 years old and doing very well with this product use. Thanks for this wonderful product.
By B W.
Liver Count Normal
February 1, 2017
My fourteen year old Shih Tzu Champ's liver count was back to normal on his last blood work. I feel strongly that it was due the the SAMe in the Denosyl product. I will continue to keep him on this product.
By Pam
Fast Shipping!
October 21, 2016
Our cat has liver issues and this product was recommended by her Vet. While this product will not cure her problem it has helped as her bloodwork has remained stable. I cannot say how happy I am with the lightening fast shipping! Thank you!
By David
Livingston, Texas
best product for liver
June 29, 2016
Have used this product for over 9 years. It helps the little dog's liver and kidney health and is a very good product for this
By Doxiemom
Protects the liver-vet. recommended
May 16, 2016
Denosyl was recommended by the internal medicine vet. that my dogs sees for various health issues. His liver values have decreased by half since he has been on this product. He takes it twice a day as recommended. It doesn't have a bad taste so my dog chews it with no problem. I highly recommend this product.
By flysunshine
Liver meds
April 7, 2016
My cat gets this each day and gets tested every 6 months. This helps to keep her liver test lower down to where it functions better. It's easier to give to her as anything added to her food, she won't eat. This will stay down unlike some of the other pills for liver.
By Anne's c.
Philadelphia, pa
February 16, 2016
This product is a big help to my cat, specially as I can buy it at a reasonable price. My cat will need this product for the rest of her life, so glad to find it on your website
By Angel2b50
Works well
February 10, 2016
It seems to help my dog's liver with all the prescription drugs he takes for his seizures.
By Jackie
January 19, 2016
At the advice of my vet, my diabetic 15 year old Schipperke has been taking this for 4 years. It seems to help and he has a little more pep and eats better when on it.

I started to buy it from Entirely pets because it was cheaper. I didn't know I could buy without prescription until I saw it on their website.

Entirely Pets is my first go to website for pet stuff I am looking for.
By Anne's c.
September 7, 2015
My cat had to start taint these tablets recently, and I was glad to find them on your website with a good price and very good shipping.
By CathiT
More affordable
May 21, 2015
I have been giving Denosyl to my dog for over 12 years. I have found it much more affordable to purchase it through than through my vet. My only complaint is that the boxes always arrive completely crumpled. The meds are fine, they come in a blister pack, but the box itself is always smashed up. I would still recommend the purchase.
By Snoopy
PItman, NJ
September 4, 2014
My Dog Schultz(Dachshund) has liver, gall bladder, Cushings, etc. This medicine was prescribed for him by his Dr. One box at the Vets office cost what 3 boxes your company charges. Schultz has been on this for 2 years and when blood work is done, 3x a yr, this supplement keeps his levels perfect.
By cheriberry
Grass Valley, CA
Angel feels great!
February 8, 2014
Purchased this product on the advice of my vet. My dog is peppy and very happy.
By betsyjo
Dayton, ohio
liver disease in miniature dachshund
January 4, 2014
Betsy is a miniature dachshund, she has been on phenobarbital for seizures most of her life. She is almost 15 years old. We discovered she had liver disease shortly after she turned 14, Vet attempted to remove her from Phenobarbital with out success. However denosyl did lower her liver enzymes a significant amount. We had to put her back on phenobarbital after a major seizure. and her enzyme level once again rose but denosyl is keeping numbers from getting higher. She is perky and eats foods for her liver health.We did not want to lose her yet. but mostly do not want her to suffer. denosyl has worked wonders for her.
By BichonLover
Dog Meds
September 23, 2013
I always get my Denosyl, which has been helping her liver for years, from Entirely Pets. They send fast and are usually correct. Once, when they sent the wrong dosage for one box, they promptly sent another one to me and told me I could donate the other box to my vet.
By pet l.
July 17, 2013
helps my dog able to live a normal life.
Easy to administer.
By drjk
new jersey
June 28, 2013
so far very satisfied with both product and pricing...
By Poppi
Issaquah WA
Excellant Value
June 25, 2013
Denosyl which is Sam-E only is a great product, especially as 100 mg size is not possible to buy in human form.

The fact that Entirely Pets sells a 3 pack makes it a great buy.
By cat o.
Denosyl for cats
March 15, 2013
My vet prescribed Denosyl for my 13 year old cat with chronic pancreatitis. As far as I can tell, it is helping maintain her pancreatitic enzyme level at a normal level. She is no longer experiencing pain from elevated numbers.
By Cocoa
Good value
March 13, 2013
This product provides additional protection to my pet because she takes phenobarbital for seizures.
By Jim K.
Commitment Kept
March 8, 2013
The order was correct and timely ... that's what counts!
By Hatlover
upstate, NY
Easy effortless purchase
February 26, 2013
So happy to find Denosyl at Entirely Pets. Saves me time and money instead of a trip to the vet. Love having it delivered right to my door.
By Flshirl
Port St. Lucie, FL
Great Purchase
February 22, 2013
Entirely Pets not only had the Denosyl for small dogs that I needed for my little Yorkie available, but the shipping was very fast as well. I am very pleased with this transaction and will order from this store again.
By Jennifer
Chehalis, WA
November 28, 2012
This product has been a life saver for my little dog. The customer service has been very helpful as well. I was having trouble with a Groupon and your staff was very good at making it work!!!

By syl
November 6, 2012
price wise you can't beat this. my dog is doing so good on this and he is looking great.

the best part is i can afford it to keep rascal well.
By Terri
So Grateful for Entirely Pets!
October 25, 2012
I have been a customer of Entirely Pets for many years. In comparing prices, they always come out the winner. I receive orders promptly. Their customer service is excellent and they are always available to answer questions. I highly recommend Entirely Pets!
By danhart
Just like the one at the vet
October 25, 2012
I bought Denosyl from Entirely Pets and I paid less than half what I pay at the vet for the exact same thing!
By Gotadimple
Backordered Product
August 7, 2012
This is a good product at an excellant price. Unfortunately the manufacturer is behind on delivery of this as well as Denamarin.

Entirelypets pricing is the best you can find. Too bad they don't have more influence with Nutramax.

Questions and Answers

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