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  6. 3-PACK Denestra SAMe 100 mg (180 Tablets)


3-PACK Denestra SAMe 100 mg (180 Tablets)

Item: SAME100MG60-3PK
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Denestra SAMe is a dietary supplement that contains S-Adenosylmethionine (SAMe), a naturally occurring compound found in the body. SAMe plays a vital role in various biochemical processes, including the production of neurotransmitters and the maintenance of cell membranes.

Key Benefits:

  1. Liver Health: SAMe is known for its positive effects on liver health. It supports the production of glutathione, a powerful antioxidant that helps protect liver cells from damage caused by toxins, medications, and oxidative stress.
  2. Mood and Emotional Well-being: SAMe is involved in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine, which are crucial for regulating mood and emotions. Supplementing with SAMe may help improve mood, reduce anxiety, and alleviate symptoms of depression.
  3. Joint Health: SAMe has anti-inflammatory properties that can help reduce joint pain and inflammation. It is often used as a complementary therapy for conditions like osteoarthritis, where it can support joint mobility and promote overall joint health.
  4. Cognitive Function: SAMe is believed to have neuroprotective properties and may help support cognitive function and memory. It is being investigated for its potential benefits in conditions such as Alzheimer's disease and age-related cognitive decline.
  5. Energy and Vitality: SAMe is involved in the production of adenosine triphosphate (ATP), which is the body's primary energy source. By supporting ATP production, SAMe may help improve energy levels, promote vitality, and reduce fatigue.

It's important to note that individual results may vary, and it's always recommended to consult with a healthcare professional before starting any new dietary supplement.


  • Pet Life Stage: Adult, Senior
  • Food Form: Supplement
  • Breed Size: Small Breeds, Medium Breeds, Large Breeds, All Breeds, Giant Breeds, Extra Small Breeds
  • Product Form: Tablet
  • UPC: 814087005526

Denestra with SAMe supports liver metabolic activity and proper liver function for dogs and cats. SAMe, or S-Adenosyl-Methionine, is a naturally occurring substance found in all living beings. SAMe in its biological form contributes to better pet health through a number of chemical processes: transmethylation, transsulfuration, and aminopropylation.


These processes can affect liver and joint health in animals. Through the process of transsulfuration, natural SAMe is converted into a compound called glutathione, a potent antioxidant and liver detoxification tool. It supports normal detoxification and cleansing of the liver from impurities, which in turn may help the body from exposure to heavy metal or environmental toxins.

Additional Benefits

Denestra with naturally occurring SAMe has added benefits for pet joint health as well. During the aminopropyl ation process, methylthioadenosine (MTA) is produced. MTA helps support cartilage matrix production in the joints, and may help maintain the effectiveness of proteoglycans, molecules that are critical for the lubrication of joints.



S-Adenosyl-L-methionine disulfate p-toluensulfonate, Microcrystalline cellulose, Mannitol, Carboxymethylstarch sodium salt, Colloidal silica anhydrous, Glycerol behenate, Magnesium stearate.

Coating Ingredients:

Methacrylic acid copolymer, Glycerol palmitostearate, Medium chain triglycerides, Titanium dioxide, Colloidal silica anhydrous, Talc, Triethyl citrate, Yellow iron oxide (III).

Useful Information

Animal Weight Daily
Less than 15 lbs. 1 Tablet
16-35 lbs. 2 Tablets

Denestra® should be administrated on an empty stomach, one hour before or two hours after a meal (overnight fast is preferred). Do not cut or crush tablets. May be disguised in treats for easier administration. Dosage may be increased or decreased at any time at the recommendation of your Veterinarian.


If animal's condition worsens or does not improve, stop product administration and consult your Veterinarian. In case of accidental overdose, contact a health professional immediately.


For use in animals only.


Store in a cool dry place. Keep out of reach of children and pets. Keep tablets in their original blister pack until used. Tablets are sensitive to moisture and extreme heat.

Customer Reviews

Review Summary
15 Reviews
67% (10)
27% (4)
7% (1)
0% (0)
0% (0)
100% Recommend this product (15 of 15 responses)
By British
British Columbia
Good product
October 10, 2020
I purchased these because my dog was diagnosed with a liver condition. It was hard to find the correct dosage for a dog, so Denestra is perfect for that. I also like the box tells you the medicinal as well as non medicinal ingredients, which another brand l previously did not. Also the cost was lower than the other brand. Although l haven't started using them yet, l know that SAM-e does lower my dog's liver enzymes.
  • Great value for money and they work.
  • I have to buy from the US but they were very cost effective and shipping costs were reasonable also. It's just that the sometimes get hung up at customs and you aren't sure if they will get here.
By Kat C.
Olive Branch, MS
Denestra SAMe
July 4, 2018
Great product for a great price! I'll definitely purchase again.
By Puck
St louis
It saved my dog's life
August 9, 2017
My dog's liver counts were way too high.. I consulted with my vet and put her on a different product, the exact same thing as this product. The good news is that for 3 additional years we've had Missy She is in the seventeenth year of her life. Her liver counts have about return to normal. The reason I went with this product is that it was cheaper
By Lovetheson
Revised review
July 20, 2017
I previously posted a review saying to be careful about expiration dates. Since then EntirelyPets replaced the boxes that were soon to be expired with boxes that will not expire for s long time. I very much appreciated that. As far as using Sam-e I have given this to my senior dog for several years. I think it helps her keep going. I will continue to give it to her.
By Lovetheson
Be careful of expiration date
June 16, 2017
I would recommend Sam-e, but I would ask about the expiration before making a purchase. I just received this pkg of 180 today, 6/16/17. My dog gets one a day so this should last 6 months. Unfortunately all of the packages that were sent to me expire 9/17. I would not have ordered them had I realized that Entirely Pets was going to ship me products that were so close to expiring. They may still be potent past their expiration date but it is disappointing just the same. I will not be placing another order.
By Wyatt T.
Gold Hill Oregon
Denestra ( SAME )100
May 1, 2017
Great supplement @ a great price
SAME was Veterinarian prescribed for my dog with elevated liver enzymes determined by pre-dental lab work. I have seen a overall improvement in his appetite since adding this product. I have been using SAME for years and can say it has helped my joints and mood. I was excited to find this product @ this great price. I will keep my little buddy on this product for his overall well being
By Winnie
Seems to help
August 23, 2016
Liver values have been better since using this product.
By Velvet
Vancouver, BC
Has helped her liver
March 28, 2016
This product has helped Jessie's liver ALT get back to normal. I was going to discontinue giving it to her but I found when I didn't give it to her, she was more likely to throw up bile.
By SylviaK
Kingsville ON
This is a staple for my senior dog
February 10, 2016
I have a 15 year old dog who has been on this for a couple of years. This helps with her night time anxiety. I do know it works as when I was out for a few weeks it became apparent how the denestra helped her. She became very restless in the evening and would oil her dog bed. This with Senilife has kept her going to enjoy her older years.
By cande77
July 12, 2014
By Poppi
Issaquah WA
Great Product-Great Price
November 25, 2013
Sometimes it is difficult to find SAMe in 100mg tablets, with no additional ingredients. Denestra puts out a great product, Entirely Pet's pricing makes it very affordable.
By teddysmom
albuquerque, nm
Great for Senile Dog!
July 24, 2013
This is a great product for my aging dog that's getting a little drifty. The price was more than excellent and shipping was quick!
By tuffyb
Hartselle, AL
This Is Helping
July 7, 2013
My little Chihuahua mix who is 14+ years old has been having a lot of problems over the past several months. She is deaf, can't see very well, and has weakness in both her back legs. Due to her hearing and vision losses she had been just kind of standing around much of the time, acting like she didn't know where to go or what to do. She has been on SAM-E now for about a month and I think it has helped her. She is more alert and interacts with me and our other pets more than she was before. She can also navigate her way through the house better, which is a big plus for her and for me.
By Okie48
hope it works as well as denosyl
February 18, 2013
Our 12 year old dog has been taking denosyl for 4 years and it has effectively reduced her liver enzyme level to a reasonable number. Denosyl has not been available a couple of times when we've needed to place an order over the past year. We tried the milk thistle pill and were not happy with the size of it. This product is an acceptable size for our little Havanese to get down. This is important to us as all directions say not to cut or crush the pills. This is a less expensive alternative to denosyl, but I guess that the jury will be out on it until bloodwork is done to see if it's as effective.
By Rosiebearmom
Fort Worth, TX
Liver Support
February 6, 2013
My dog needed help with her liver. I am hoping Denestra will give her that support.

Questions and Answers

1 Question & 1 Answer
from Woodstock, GA asked:
September 21, 2017
what are the ingredients?
1 Answer


Ingredients: S-Adenosyl-L-methionine disulfate p-toluensulfonate, Microcrystalline cellulose, Mannitol, Carboxymethylstarch sodium salt, Colloidal silica anhydrous, Glycerol behenate, Magnesium stearate.

Coating Ingredients: Methacrylic acid copolymer, Glycerol palmitostearate, Medium chain triglycerides, Titanium dioxide, Colloidal silica anhydrous, Talc, Triethyl citrate, Yellow iron oxide (III).

Submitted by: Customer Service on August 13, 2019

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