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  6. Denestra SAMe 400 mg (60 Tablets)


Denestra SAMe 400 mg (60 Tablets)

Item: SAME400MG60
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Denestra SAMe is a dietary supplement that contains S-Adenosylmethionine (SAMe), a naturally occurring compound found in the body. SAMe plays a vital role in various biochemical processes, including the production of neurotransmitters and the maintenance of cell membranes.

Key Benefits:

  1. Liver Health: SAMe is known for its positive effects on liver health. It supports the production of glutathione, a powerful antioxidant that helps protect liver cells from damage caused by toxins, medications, and oxidative stress.
  2. Mood and Emotional Well-being: SAMe is involved in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine, which are crucial for regulating mood and emotions. Supplementing with SAMe may help improve mood, reduce anxiety, and alleviate symptoms of depression.
  3. Joint Health: SAMe has anti-inflammatory properties that can help reduce joint pain and inflammation. It is often used as a complementary therapy for conditions like osteoarthritis, where it can support joint mobility and promote overall joint health.
  4. Cognitive Function: SAMe is believed to have neuroprotective properties and may help support cognitive function and memory. It is being investigated for its potential benefits in conditions such as Alzheimer's disease and age-related cognitive decline.
  5. Energy and Vitality: SAMe is involved in the production of adenosine triphosphate (ATP), which is the body's primary energy source. By supporting ATP production, SAMe may help improve energy levels, promote vitality, and reduce fatigue.

It's important to note that individual results may vary, and it's always recommended to consult with a healthcare professional before starting any new dietary supplement.


  • Pet Life Stage: Adult, Senior
  • Food Form: Supplement
  • Breed Size: Small Breeds, Medium Breeds, Large Breeds, All Breeds, Giant Breeds, Extra Small Breeds
  • Product Form: Tablet
  • UPC: 814087006073

Denestra with SAMe supports liver metabolic activity and proper liver function for dogs and cats. SAMe, or S-Adenosyl-Methionine, is a naturally occurring substance found in all living beings. SAMe in its biological form contributes to better pet health through a number of chemical processes: transmethylation, transsulfuration, and aminopropylation.


These processes can affect liver and joint health in animals. Through the process of transsulfuration, natural SAMe is converted into a compound called glutathione, a potent antioxidant and liver detoxification tool. It supports normal detoxification and cleansing of the liver from impurities, which in turn may help the body from exposure to heavy metal or environmental toxins.

Additional Benefits

Denestra with naturally occurring SAMe has added benefits for pet joint health as well. During the aminopropyl ation process, methylthioadenosine (MTA) is produced. MTA helps support cartilage matrix production in the joints, and may help maintain the effectiveness of proteoglycans, molecules that are critical for the lubrication of joints.



S-Adenosyl-L-methionine disulfate p-toluensulfonate, Microcrystalline cellulose, Mannitol, Carboxymethylstarch sodium salt, Colloidal silica anhydrous, Glycerol behenate, Magnesium stearate.

Coating Ingredients:

Methacrylic acid copolymer, Glycerol palmitostearate, Medium chain triglycerides, Titanium dioxide, Colloidal silica anhydrous, Talc, Triethyl citrate, Yellow iron oxide (III).

Useful Information

Animal Weight Daily
Less than 15 lbs. 1 Tablet
16-35 lbs. 2 Tablets

Denestra® should be administrated on an empty stomach, one hour before or two hours after a meal (overnight fast is preferred). Do not cut or crush tablets. May be disguised in treats for easier administration. Dosage may be increased or decreased at any time at the recommendation of your Veterinarian.


If animal's condition worsens or does not improve, stop product administration and consult your Veterinarian. In case of accidental overdose, contact a health professional immediately.


For use in animals only.


Store in a cool dry place. Keep out of reach of children and pets. Keep tablets in their original blister pack until used. Tablets are sensitive to moisture and extreme heat.

Customer Reviews

Review Summary
9 Reviews
89% (8)
0% (0)
0% (0)
11% (1)
0% (0)
89% Recommend this product (8 of 9 responses)
By oscar f.
September 23, 2023
Great product and service and shipping.
By Lisa
Really works
May 26, 2023
Our four legged baby is closing in on thirteen years old. About a year and a half ago she went on Meloxicam for her arthritis. It was not long before she started to have her liver test results increase from the NSAID. After doing some research and discussing with her vet, we put her on 400mg of SAM-e twice a day (dosage associated with her weight). There was a positive impact to her liver test results and it has continued to help her with that issue ever since.
Wished I’d known it was out there sooner, we would have started her on it even before she needed the Meloxicam.
  • It does work
  • It is a bit pricey, but I always get it when it’s on sale so that helps.
  • The 400mg pills are of course larger, but I only have to give her one, twice a day that way.
By Micki
Lake Tahoe
Difficult to administer
May 9, 2016
I cannot speak for the medical effectiveness of this product. I hope that it is worth the trouble of getting my Standard Poodle to take it. He is usually very compliant with meds or anything we ask him to do. But he seems to hate the taste and smell of this drug. Hiding it in peanut butter or other treats does not work. He can smell it and knows what is coming. Hopefully "Entirely Pets" can ask the drug company to improve the recipe. I am not sure how many more pills I can get into him before we all give up.
By Sally
Okotoks, Alberta, Canada
Amazing Results
May 7, 2016
My 11 Siberian Husky Toby had extremely high ALT Liver values. After conducting research, I decided to try SAMe (Denestra) for this serious medical issue. 1.5 years later I am happy to report that Toby's liver values are in the normal range and he is happy and healthy. Very grateful for this wonderful product
By Susan
Cave Creek, AZ
Great price
January 29, 2016
Two of my dogs had high liver enzymes and were prescribed Adenosyl which was very expensive through my Vet's office. I researched prices online and discovered Entirely Pets and even confirmed that Denestra was the same product. I've been very happy with getting a much more affordable price and how easy it is to reorder and get delivery.
By Mandy L.
Mesa, AZ
Great Product!
April 21, 2014
Started giving these to our 15 year old Chow approximately 1 month ago and she has shown major improvement in her mobility. She seems like she is much happier and enjoys short walks which she hadn't done in years. I recommend NOT using Greenies pill pockets with this product as my experience was that they prevented the Denestra pill from dissolving and eventually caused vomiting of days worth of pills. I'm not sure if it's the combination of the two products or the fact that from what I've read on-line Greenies are all around bad. I've had success with a spoonful of peanut butter.
By Mandy L.
Mesa, AZ
Works Great!
March 26, 2014
We have a 14 year old Chow Chow who was acting very sluggish, depressed, and stiff in the joints. After only 2 days we see improvement in all areas. Hopefully it's long term!
By nicky
new zealand
Great product
July 24, 2013
This has helped reduce my old dogs elevated liver enzyme levels by over 1/2. Very happy with it & will continue to use it.
By froglady
May 31, 2013
This product is great for our dog. And the bubble packaging keeps it fresh and ready to go.

Questions and Answers

2 Questions & 2 Answers
January 25, 2019
My dog is 125 pounds. Heâ‚"s a large breed. I am confused on the dosing. Do I give him 3 pills at once, or do I give him 1 pill, 3 times per day?‚ 
1 Answer
Administration Animal Weight Daily 35-65 lbs. 1 Tablet 66-99 lbs. 3 Tablets Over 100 lbs. 3 Tablets
Submitted by: EntirelyPets on April 29, 2019

from Burlington NC asked:
July 25, 2017
What is the difference between Dnestra SAME and Denamarin Do they both serve the same purpose?
1 Answer

Denestra (SAMe) is pure SAMe great for liver function.

Denamarin includes SAMe + a small amount of Silybin A+B.
Silybin is a milk thistle extract, also known to be good for liver function.

They are both good, and both have had great customer feedback for dogs with liver issues.

Submitted by: Customer Service on July 1, 2019

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