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  6. Denestra SAMe 400 mg (60 Tablets)


Denestra SAMe 400 mg (60 Tablets)

Item: SAME400MG60
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Denestra™ with SAMe supports liver metabolic activity and proper liver function for dogs and cats. SAMe, or S-Adenosyl-Methionine, is a naturally occurring substance found in all living beings. SAMe in its biological form contributes to better pet health through a number of chemical processes: transmethylation, trassulfuration, and aminopropylation. These processes can affect liver and joint health in animals. Through the process of transsulfuration, natural SAMe is converted into a compound called glutathione, a potent antioxidant and liver detoxification tool.

It supports normal detoxification and cleansing of the liver from impurities, which in turn may help the body from exposure to heavy metal or environmental toxins. Denestra with naturally occurring SAMe has added benefits for pet joint health as well. During the aminopropylation process, methylthioadenosine (MTA) is produced. MTA helps support cartilage matrix production in the joints, and may help maintain the effectiveness of proteoglycans, molecules that are critical for the lubrication of joints.

Denesta with SAMe is a pill that you administer orally to your dog or cat or may administer in a pill pocket to guarantee it is swallowed. With just one pill you can give your pet support for healthy normal liver and joint function at the same time. It can be used with prescription drugs.

For Use In: Dogs & Cats

    Key Features:
  • 100mg active SAMe
  • Supports Liver
  • Supports Joints
  • Cognitive Function
  • Stabilized Enteric Coated Tablets


Ingredients: S-Adenosyl-L-methionine disulfate p-toluensulfonate, Microcrystalline cellulose, Mannitol, Carboxymethylstarch sodium salt, Colloidal silica anhydrous, Glycerol behenate, Magnesium stearate.

Coating Ingredients: Methacrylic acid copolymer, Glycerol palmitostearate, Medium chain triglycerides, Titanium dioxide, Colloidal silica anhydrous, Talc, Triethyl citrate, Yellow iron oxide (III).

Useful Information

Animal Weight Daily
35-65 lbs. 1 Tablet
66-99 lbs. 3 Tablets
Over 100 lbs. 3 Tablets

Denestra® should be administrated on an empty stomach, one hour before or two hours after a meal (overnight fast is preferred). Do not cut or crush tablets. May be disguised in treats for easier administration. Dosage may be increased or decreased at any time at the recommendation of your Veterinarian.

CAUTIONS: If animal's condition worsens or does not improve, stop product administration and consult your Veterinarian. In case of accidental overdose, contact a health professional immediately.

WARNINGS: For use in animals only.

STORAGE: Store in a cool dry place. Keep out of reach of children and pets. Keep tablets in their original blister pack until used. Tablets are sensitive to moisture and extreme heat.

Customer Reviews

Review Summary
7 Reviews
86% (6)
0% (0)
0% (0)
14% (1)
0% (0)
86% Recommend this product (6 of 7 responses)
By Micki
Lake Tahoe
Difficult to administer
May 9, 2016
I cannot speak for the medical effectiveness of this product. I hope that it is worth the trouble of getting my Standard Poodle to take it. He is usually very compliant with meds or anything we ask him to do. But he seems to hate the taste and smell of this drug. Hiding it in peanut butter or other treats does not work. He can smell it and knows what is coming. Hopefully "Entirely Pets" can ask the drug company to improve the recipe. I am not sure how many more pills I can get into him before we all give up.
By Sally
Okotoks, Alberta, Canada
Amazing Results
May 7, 2016
My 11 Siberian Husky Toby had extremely high ALT Liver values. After conducting research, I decided to try SAMe (Denestra) for this serious medical issue. 1.5 years later I am happy to report that Toby's liver values are in the normal range and he is happy and healthy. Very grateful for this wonderful product
By Susan
Cave Creek, AZ
Great price
January 29, 2016
Two of my dogs had high liver enzymes and were prescribed Adenosyl which was very expensive through my Vet's office. I researched prices online and discovered Entirely Pets and even confirmed that Denestra was the same product. I've been very happy with getting a much more affordable price and how easy it is to reorder and get delivery.
By Mandy L.
Mesa, AZ
Great Product!
April 21, 2014
Started giving these to our 15 year old Chow approximately 1 month ago and she has shown major improvement in her mobility. She seems like she is much happier and enjoys short walks which she hadn't done in years. I recommend NOT using Greenies pill pockets with this product as my experience was that they prevented the Denestra pill from dissolving and eventually caused vomiting of days worth of pills. I'm not sure if it's the combination of the two products or the fact that from what I've read on-line Greenies are all around bad. I've had success with a spoonful of peanut butter.
By Mandy L.
Mesa, AZ
Works Great!
March 26, 2014
We have a 14 year old Chow Chow who was acting very sluggish, depressed, and stiff in the joints. After only 2 days we see improvement in all areas. Hopefully it's long term!
By nicky
new zealand
Great product
July 24, 2013
This has helped reduce my old dogs elevated liver enzyme levels by over 1/2. Very happy with it & will continue to use it.
By froglady
May 31, 2013
This product is great for our dog. And the bubble packaging keeps it fresh and ready to go.

Questions and Answers

2 Questions & 2 Answers
January 25, 2019
My dog is 125 pounds. He√Ę‚‚¨‚"Ęs a large breed. I am confused on the dosing. Do I give him 3 pills at once, or do I give him 1 pill, 3 times per day?√‚¬†
1 Answer
Administration Animal Weight Daily 35-65 lbs. 1 Tablet 66-99 lbs. 3 Tablets Over 100 lbs. 3 Tablets
Submitted by: EntirelyPets on April 29, 2019

from Burlington NC asked:
July 25, 2017
What is the difference between Dnestra SAME and Denamarin Do they both serve the same purpose?
1 Answer

Denestra (SAMe) is pure SAMe great for liver function.

Denamarin includes SAMe + a small amount of Silybin A+B.
Silybin is a milk thistle extract, also known to be good for liver function.

They are both good, and both have had great customer feedback for dogs with liver issues.

Submitted by: Customer Service on July 1, 2019

Denestra SAMe 200 mg (60 Tablets)Denestra SAMe 200 mg (60 Tablets)Reg price: $51.99
Sale price: $39.59
3-PACK Denestra SAMe 200 mg (180 Tablets)3-PACK Denestra SAMe 200 mg (180 Tablets)Reg price: $103.99
Sale price: $79.99
3-PACK Denestra SAMe 400 mg (180 Tablets)3-PACK Denestra SAMe 400 mg (180 Tablets)Reg price: $181.99
Sale price: $139.99
Denestra SAMe 100 mg (60 Tablets)Denestra SAMe 100 mg (60 Tablets)Reg price: $26.99
Sale price: $20.49
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