1. Home > 
  2. Dog Supplies > 
  3. Kidney & Liver & Renal Health > 
  4. Liver Support Supplements > 
  5. SAMeLQ Chewable Tablets > 
  6. SAMeLQ 225 Chewable Tablets 60 ct


SAMeLQ 225 Chewable Tablets 60 ct

Item: S-ADEN22560
1. Select type:
2. Select strength:
3. Select count(tablets):
This item is currently out of stock!


SAMeLQ® Chewable Tablets are formulated to help support normal liver function in dogs and cats. S-adenosyl methionine (SAMe) and n-acetyl L cysteine help support normal detoxification and cleansing of the liver from impurities. Glycyrrhizinate Ammonium (licorice root extract), quercetin and L-taurine are antioxidants which help enhance the immune response.

The SAMeLQ® Chewable Tablets are readily accepted. Dogs and cats love the great taste.


per 1 tablet SAMEeLQ® 100 SAMEeLQ® 225 SAMEeLQ® 425
S-Adenosyl Methionine 100 mg 225 mg 425 mg
Quercetin 20 mg 45 mg 85 mg
N-Acetyl Cysteine 18 mg 40 mg 75.5 mg
L-Taurine 13.5 mg 30 mg 57 mg
Zinc Ascorbate 9 mg 20 mg 38 mg
Glycyrrhizinate Ammonium
(Licorice Root Extract)
7 mg 15 mg 28 mg
Vitamin B3 1 mg 2.5 mg 4.5 mg
Vitamin B5 1 mg 2 mg 4 mg
Vitamin B6 0.5 mg 1 mg 2 mg
Vitamin B1 0.35 mg 0.75 mg 1.5 mg
Vitamin B2 0.35 mg 0.75 mg 1.5 mg

Inactive Ingredients: Anhydrous Dicalcium Phosphate, Pig Liver Powder, Maltodextrin, Stearic Acid, Hydrogenated Castor Oil, Sodium Croscarmellose, Anhydrous Colloidal Silica.

Useful Information

Tablets should be given on an empty stomach.

SAMeLQ® 100
Up to 10 lbs ½ tablet daily
10.1-15 lbs 1 tablet daily
15.1-20 lbs 1½ tablets daily
20.1-25 lbs 2 tablets daily
25.1-30 lbs 2½ tablets daily
30.1-35 lbs 3 tablets daily
SAMeLQ® 225
10.1-15 lbs ½ tablet daily
15.1-30 lbs 1 tablets daily
30.1-45 lbs 1½ tablets daily
45.1-60 lbs 2 tablets daily
60.1-85 lbs 2½ tablets daily
85.1-100 lbs 3 tablets daily
SAMeLQ® 425
15.1-30 lbs ½ tablets daily
30.1-55 lbs 1 tablets daily
55.1-85 lbs 1½ tablets daily
85.1-115 lbs 2 tablets daily
115.1-160 lbs 2½ tablets daily
Over 160 lbs 3 tablets daily

CAUTIONS: Safe use in pregnant animals or animals intended for breeding has not been proven. If animal's condition worsend or does not improve, stop product administration and consult your veterinarian. Caution in use with antidepressants. Caution in use with blood thinners.

WARNINGS: For animals use only. Keep out of the reach od children and animals. In case of accidental overdose, contact a health professional immediately.

STORAGE: Store at room temperature

Customer Reviews

Review Summary
30 Reviews
80% (24)
17% (5)
3% (1)
0% (0)
0% (0)
97% Recommend this product (29 of 30 responses)
By Norma
Torrance, CA
May 13, 2020
excellent product my dog has been taken for so many years, and it help her a lot with her liver.
By Suzie
Great stuff!
May 4, 2017
She can't wait to get them in her mouth . She runs across the room.
By Josie's D.
Just As Ordered
February 28, 2017
Product arrived on time as listed by the seller.
By Archieismine
Columbus, Ohio
Price is right
May 3, 2016
Archie tore his ACL. When testing for his surgery the DR. found elevated levels in his liver. After 1 week on SAdenosyl 225 (SAMe) his levels were down enough to have his surgery. Per the DR. she suggested I go through EntirelyPets because of their prices.
By van
melbourne, fl
Review for SAMeLQ 225 Chewable Tablets 60 ct
December 24, 2015
van's liver function tests were high. once we started giving him this product suggested by our vet his liver function tests are all normal thank you
By shary
North Dakota
September 17, 2015
S Adenosyl 225 (SAMe) for MEDIUM / LARGE DOGS - 225 mg (60 tabs) ole girl of 13 has been on this a year and a half has helped her so much..
By silfrox2003
Redmond, Wa
Review for SAMeLQ 225 Chewable Tablets 60 ct
July 25, 2015
The milk thistle supplement seems to be effective for my dogs health.
By dutch
Review for SAMeLQ 225 Chewable Tablets 60 ct
July 3, 2015
seems to be working fine the dog is still alive!
By shary
north dakota
It helps
June 22, 2015
My black lab has liver problems very high enzymes...been giving her these and thank God the enzymes are lower...Im so glad I found Entirely pets...My vet wanted double the price...with entirely pets ..I can double my order and still be cheaper then the vets..
By JordieLynn
Penfield, NY
Doesn't seem to do anything
April 24, 2015
This is not really helping our dog. Sad to say. Not sure if it really does what is is supposed to do.
By PatandGang
S-Adenosyl, SaMe
April 23, 2015
I have purchased this exact same product from my veterinarian and paid considerably more. It is difficult to determine if the product helps as stated, I just know that our vet recommends the product and if I can purchase it at a lesser price, I will!
Houston, TX
On Time Service
April 13, 2015
Our Labradoodle has a high liver enzyme count. She has been taking S-Adenosyl for seven years and it works very well keeping her count where it belongs. Our vet prescribed it and it works. Entirely Pets delivered our order fast and correct.

Tasha is a very healthy nine year old!
By Bill
St. Pete, FL
S Adenosyl 225 (SAMe)
April 9, 2015
Appears to be good product. We are using for Anna for help with liver functions at older age .......
By colquitt
texarkana, tx
great price
February 10, 2015
getting same product/same brand/much better price than my vet.
By johnnymac
Walkerton, Indiana
Review for SAMeLQ 225 Chewable Tablets 60 ct
January 29, 2015
The product was excellent, the best of all is how fast the order is filled and shipped. The price is not bad but the amount you have to order in order to receive free shipping is a little high which brings the price of the product back to about the same as what the Vet charges. All in all very satisfied.
By C S.
Fast Shipping
January 25, 2015
Each time I've ordered products from Entirely Pets, I've been surprised at their prompt arrival. That means a lot to an owner whose dog needs daily medication.
New Orleans, La
January 18, 2015
My vet recommended this product for elevated liver values for my 17 year old dog. She still runs around like she is a puppy most of the time. This is due to wellness checkups which found this problem. Early intervention of potential problems is the key to a pet's longer life.
By EmTeeKay
New Jersey
So Far So Good
September 19, 2014
I purchased this because my 11 year old Golden was experiencing unexplained seizures. It was added to Levetiracetam 500 mg (generic for Keppra), which he had been on since January 2014.

He's been taking this for 2 months, which was when he had his last seizure and none have occurred since he's been on this. So far, so good.

He tolerates it well. No nausea. Just can't give it with food nor break it up. So you have to stick it whole deep down his throat by hand. Yuck! Thank goodness it's a Golden and they are good when you stick your hand in their mouths.

Otherwise, I'd give it a higher rating, but it's still too early.
By madmama
great deal!
July 9, 2014
Same medication that the vet sells, only MUCH cheaper!
By DoggyMom
Mesquite, NV
Great Product
February 1, 2014
Our dog will be 16 in a couple of months and is doing incredibly well with this product! We are so amazed at how much it has improved his quality of life at this stage. I would recommend this to anyone that has a dog with any type of liver enzyme issues.
By puginmud
Great service as always from Entirely Pets!
July 22, 2013
I swear by this product. I firmly believe that it has helped keep my pug with a severe liver shunt alive for 8 years!
By Butch
Good product
April 10, 2013
Seems to be doing some good. Plus the price is fair.
By Weimdogs
Good Purchase
March 19, 2013
I purchased this product after finding out that my 7yr old adopted weim had elevated liver enzymes. He's been on this product for over a month along with a Hills Science Liver diet and some of his enzymes have decreased. I will continue to give this product in hopes of restored liver function!
By Fester
Noticeable improvement for arthritis pain
February 12, 2013
I give these to my 15 year old corgi. We ran out, and after a few days I could definitely tell he did not feel as good and moved more stiffly. After re-ordering, he is back to feeling great, so I know this product definitely works.
By Angie
S Adenosyl 225/ liver disease
March 2, 2012
I am very pleased with this product and I received it in just a few days. This is the same meds that my vet tried to sell me at at about 1/2 the cost. My dog Murphy (14yrs) has to take one pill everyday to help the function of her liver.
By T H.
San Diego, CA
Really Works
January 28, 2012
I have 2 elderly dogs whose ALT counts had risen above normal. This brought both their counts back to normal. They will both be on it for the rest of their lives. There is no side effects. If there was, my one dog would have experienced them. My only suggestion would be to make a bottle with more than 60 tablets. I need to purchase at least one bottle month. It would help with multi-pet families if there was a bottle with 120 tablets in it.
By Vic
Centennial, CO
Maggie's Protector
November 2, 2011
We must give our Aussie Shepherd mix many medications for her heart (Mitral Regurgitation). The SAMe helps keep her healthy and happy. Thank you Entirely Pets for making this product so readily available.
Review for SAMeLQ 225 Chewable Tablets 60 ct
October 31, 2011
My vet recommended that my dog "Shadow" needed to take this for a liver enzyme problem. I had not found it any where they advised and the vet was currently out. So yes, very happy with this product. Shadow is a little friskier even though she is 13. I will be ordering this product again.
By Ted
price increase
October 29, 2011
I was a loyal customer until May of 2011. Thats when you increased the price of s-adenosyl 225 (60 tabs) for med. to large dogs, from $33.24 on 3-29-11 to 49.95 in May. That's such a jump in price that I figure that you must be overcharging on everything else you sell which is OK with me but I won't be buying it.
By Apryl
Cheaper than Human Sam-e
August 4, 2008
I like this product because it is cheaper than sam-e you get in pharmacies and it works just as well. My pet has chronic high liver values due to chronic use of N-SAIDS (anti-inflammatories) for arthritis and she has cushings disease which also increases liver values and using s-adenosyl have brought her liver values down and has really helped protect her liver!

Questions and Answers

1 Question & 1 Answer
from Buena,NJ asked:
December 5, 2015
My vet prescribed this for my 22 lb. dog who just had dental surgery. They are too big . If I buy the smaller one I can give him two pills, but only if they are smaller in size. How big are the smaller dosage?
1 Answer
The smaller pills, intended for smaller dogs: would be an option, you would administer 2-3 tablets daily as per the label on the back of the item.
Submitted by: Customer Service on December 8, 2015

SAMeLQ 100 Chewable Tablets 60 ctSAMeLQ 100 Chewable Tablets 60 ctReg price: $87.09
Sale price: $66.99
SAMeLQ 225 Chewable Tablets 30 ctSAMeLQ 225 Chewable Tablets 30 ctReg price: $60.99
Sale price: $46.79
SAMeLQ 425 Chewable Tablets 30 ctSAMeLQ 425 Chewable Tablets 30 ctReg price: $10,599.00
Sale price: $81.49
SAMeLQ Chewable TabletsSAMeLQ Chewable Tablets