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  6. Advantage II Flea Control for Large Cats Over 9 lbs, 4 Month

Advantage II Flea Control for Large Cats Over 9 lbs, 4 Month Video

Advantage II Flea Control for Large Cats Over 9 lbs, 4 Month

Item: 5461685
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This item is excluded from shipping to Maine (ME)


Advantage II Flea Control for Large Cats Over 9 lbs, (4 Month) helps protect your furry friend from parasitic pests and the potentially harmful diseases they can transmit with Advantage II Flea Treatment for Small Cats & Ferrets. This highly-effective, veterinarian-recommended treatment is specifically formulated to kill all life stages of fleas on contact with no painful biting required. With three-way protection that kills the eggs, larvae, and adults, it breaks the flea life-cycle to help prevent re-infestation of your pet and your home. The waterproof formula continues working for up to four weeks, even after bathing; for use on large cats 8 weeks or older and weighing over 9 pounds, as well as ferrets 10 weeks or older and weighing 1 pound or more.

Key Features and Benefits

  • Veterinarian-recommended
  • Safe to use for cats 8 weeks or older and weighing over 9 pounds
  • Safe to use for ferrets 10 weeks or older and weighing 1 pound or more.
  • Fast-acting formula kill fleas on contact in as quickly as 12 hours after application.
  • Completely kills eggs, larvae and adult fleas to break the life-cycle and prevent re-infestation.
  • Waterproof formula continues working for up to four weeks, even after bathing.
  • Convenient, monthly topical application contains imidacloprid and pyriproxyfen; available in packs of 2, 4, 6, or 12 treatments.


Active Ingredients by Weight
Imidacloprid 9.10%
Pyriproxyfen 0.46%
Other Ingredients 90.44%
Total 100.00%

Useful Information

View Advantage II for Cats product label.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

How To Open

  1. Be sure tube is at bottom of pouch.
  2. Using scissors, cut the pouch across the top and remove tube.

How to Apply

  1. Remove one applicator tube from the package. See "How to Open" section
  2. Hold application tibe in an upright position facing away from you and your pet's face and eyes. Pull cap of tube.

  3. Turn the cap around and place other end of cap back on tube.
  4. Twist cap to break seal, then remove cap from tube.
  5. Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your catís eyes, or allow your cat to ingest this product. The product is bitter tasting and salivation may occur for a short time if the cat licks the product immediately after treatment. Treatment at the base of the skull will minimize the opportunity for the cat to lick the product. Do not allow the product to run off.

  6. Discard empty tube as described in Storage and Disposal.
  7. Under normal conditions this product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four (4) weeks. Do not retreat more often than once every fourteen (14) days for kittens or once every seven (7) days for small and large cats. After flea control is attained, return to a monthly retreatment schedule.


  • Use only on cats or kittens 8 weeks and older. Do not apply to cats or kittens weighing less than 9 lbs. Do not use on other animals.
  • Do not apply more than one (1) tube per treatment, even for larger cats.
  • Do not have contact or allow children to have contact with treated area until completely dry.
  • Storage and Disposal

    Do not contaminate water, food, or feed by storage or disposal.

    Pesticide Storage:

    Store in a cool, dry place inaccessible to children and pets.

    Pesticide Disposal and Container Handling:

    Nonrefillable container.

    If empty:

    Do not reuse this container. place in trash or offer for recycling if available.

    If partly filled:

    Call your local solid waste agency or 18004229874 for disposal instructions. Never place unused product down and indoor or outdoor drain.


    Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes or clothing. Wash hands thoroughly with soap and warm water handling. Keep out of reach of children. Do not contaminate feed or food.

    Hazards to Domestic Animals

    For external use only.Do not apply to cats or kittens 8 weeks of age or weighing less than 9 lbs. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing cats. Individual sensitivities, while rare, may occur after using ANY pesticide product for cats. If signs persist, or become more severe, consult a veterinarian immediately. If your cat is on medication, consult your veterinarian before using this or any other product.

    Possible Side Effects

    Monitor your cat after application. Side effects, although very rare, may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as hypersalivation, vomiting or diarrhea have also been reported. If these or other side effects (such as lethargy) occur, consult your veterinarian or call 1-800-422-9874.

    Customer Reviews

    Review Summary
    398 Reviews
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    94% Recommend this product (376 of 398 responses)
    By Judson
    Cats are pest free...
    December 25, 2022
    Very effective flea control for my cats, & easy to apply. Works for one month or little longer.
    Effective & easy to apply. None
    By Jacqueline
    Keeps my Baby Safe!!!
    August 7, 2022
    Easy to apply, just make sure it is high enough on the neck that they cannot reach it to lick it
    easy to apply if you do not pply properly, they can each it t make sure you apply high enough that cats cannot lick off
    By Katherine
    Millville, Nj
    Keeps the fleas away
    August 8, 2021
    My cats don't go outside, but the dogs do. Even though the dogs get top spot, the bugs sometimes hitch a ride. This top spot kills the fleas when they bite. Good product.
    Works within 20 minutes. Afraid to get the cat wet and even though it is put on the back of the neck one of my cats always reaches it.
    By LBumgarner
    Hickory, NC
    Works, keep fleas and ticks off my pets.
    May 23, 2021
    Thus far haven't found any fleas or ticks on my pets.
    Easy to use. Makes the hair fall out on one of my kitties.
    By Dave
    it works
    April 12, 2021
    Otis had bumps and scabs from the fleas, this helped stop new problems while the chlorhexidine wipes helped the old problems and now he has great skin
    Merchant Response:Otis is glad for the help even if he doesn't like the liquid.
    easy to apply, long lasting, effective he hates the application of liquid, but I suspect its the easiest way :)
    By LINDA
    Advantage II Flea Control for Large Cats Over 9 lbs. 4 Month
    October 16, 2020
    By Joe S.
    Rochester, NY
    September 25, 2020
    Very satisfied.
    By Lisa
    Mt. Airy, NC
    Advantage II Flea Control
    September 18, 2020
    I order these for my cats and it works great. They do not put up a fight when I put it on them. I even put one on the stray cat that comes around since he is around my cats some. By fighting off fleas, their fur stays soft and silky and they are not scratching. DEFINITELY RECOMMEND!!
    By Mike
    San Leandro , California
    Excellent !
    September 14, 2020
    Thee best flea control product out there , because it works - tried many others that DO NOT work
    By patricia
    oshawa, ON
    works will
    April 28, 2020
    keeps them off
    By Rita
    Birmingham, AL
    Good so far!
    April 7, 2020
    I have seen where my Cats are scratching a lot less since putting these on them. Will buy again.
    By mike f.
    San Leandro , California
    April 2, 2020
    The BEST flea control product out there = Always works perfectly / monthly - I have tried other brands to save $$ ,but they Did Not work / stop the fleas - For me its Advantage hands down , the only brand that's worth IT !!
    Merchant Response:You got it Mike! Take care in the 'Dro! %uD83D%uDC36
    By Tammy w.
    Gaston, sc
    Great product
    July 21, 2019
    Advantage ll is a great product for fleas on my cats.
    By Harvey
    September 24, 2018
    Will definitely purchase from again works great....
    By Connie
    Excellent Value
    July 5, 2018
    I've checked prices and Entirely Pets always beats the others for same products. Fast, fast delivery. I've been ordering for years and have always been happy. Highly recommended.
    No need to walk the pet always insi Litter box, of course!
    By BigFATcat
    San Francisco
    Effective for cats and other animals
    May 24, 2018
    I started using Advantage for my cats and rabbit (vet recommended). The vet will need to tell you the correct dosage for rabbits. It kills the fleas without making the host sick.
    Safe for cats and small pets May not last for a month
    By Tiger
    Completely satisfied
    September 2, 2017
    Works great, even on the barn cats! I will get it again.
    By Dale P.
    Works Great!
    August 15, 2017
    I have 5 indoor cats and I put this on all of them. Normally I wouldn't use a flea product because they don't go outside, but of course, my dog brought in fleas. After a day I noticed the cats stopped itching. So it worked right away. It's best to put it on before you go to bed at night. (So you don't pet the area and it has ~8 hours to absorb). Try to get it right onto their skin behind the neck/shoulder blades. It remains oily on their skin for a day or so, so really try to rub it in well. I did notice some of them scratching again after literally 4 weeks, so I reapplied.
    By Sallie J.
    Auburn WA
    July 24, 2017
    works very good product. I would buy again
    By mamabear
    advantage flea control
    July 22, 2017
    I have 3 adult cats, and never have a flea problem with them, they are inside/outside cats.
    By Mikie
    Southern California
    flea control for kitty
    July 13, 2017
    Sassy is 10 years old and with this product has never had fleas or any parasite.
    By Coley
    port hope, Ontario, canada
    guaranteed prevention
    May 23, 2017
    This product will keep your fur baby flea free!
    By Coley
    port hope, Ontario, canada
    guaranteed prevention
    May 16, 2017
    Excellent. Wouldn't buy any other brand. Keeps my household flea free all year long. I have 4 cats. 16 year old female, 9yr old male, 5yr old female, one yr old male. They all go outside and are flea free guaranteed.
    By Cat L.
    South Carolina
    1 of the best products of its kind.
    April 30, 2017
    We have been using this product for a least ten (10) years and have it currently on auto ship as we have rescue cats (50+) that are contained on premises. We highly recommend this.
    By Kitty L.
    Works great
    April 6, 2017
    I've been using this product for years. I love how my kitties don't scratch from fleas bites!
    By 7cats&me
    Baton Rouge, Louisiana
    100% all around purchase
    January 18, 2017
    I have seven cats that use Advantage, I buy a years worth of flea drops for all seven cats at one time. I find every order made at Entirely Pets to be good due to it being the lowest cost I can find, the products are always fresh so not to expire before the following 12 months that I need them (before usable expiration date), the delivery is fast & well boxed.
    By TONK
    January 2, 2017
    By micky
    rochester, ny
    great product
    December 31, 2016
    I had purchased another flea topical product and used it for 3 months, but did not see any improvement. I then decided to try this Advantage II and was amazed and how quickly it worked. I now believe the first product was somehow defective. I will continue to purchase this product, from Entirely Pets, because of how well it worked and this company's customer service. I consistently receive my orders in less than 4 days. This is critical, especially when dealing with a flea problem. Entirely Pets is Great!!
    By grannypal
    Plant City, Florida
    Great protection
    December 29, 2016
    The cats have used this product for many years because it works.
    By Mary
    Southern Vermont
    So Easy!
    November 6, 2016
    Cats over 9lbs. are BIG cats and trying to do anything with them can be tricky. So the quick, easy application of the Advantage ll flea medicine is...well, an advantage.

    Questions and Answers

    1 Question & 1 Answer
    from pittsburgh, PA asked:
    April 7, 2015
    what is the use by date on the advantage II on sale?
    1 Answer
    Advantage Flea Control products have no expiration date.
    Submitted by: Customer Service on April 8, 2015