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  6. Advantage II Large Cats Over 9 lbs.|Vet-Recommended Flea Treatment & Prevention|4-Month Supply

Advantage II Large Cats Over 9 lbs.|Vet-Recommended Flea Treatment & Prevention|4-Month Supply Video

Advantage II Large Cats Over 9 lbs.|Vet-Recommended Flea Treatment & Prevention|4-Month Supply

Item: 5461685
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Deliver total flea protection to your cat or kitten with Advantage II Large Cat. This vet-recommended, topical treatment and prevention formula kills adult fleas, flea larvae, and flea eggs on contact within 12 hours of application - meaning fleas can be eliminated before they bite or lay new eggs. Effectively break the flea life cycle, control existing flea and lice infestations, and prevent further infestations with one simple application. Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.

Advantage II Large Cat is a trademark of Elanco or its affiliates.

Key Benefits:

  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application


Active Ingredients by Weight
Imidacloprid 9.10%
Pyriproxyfen 0.46%
Other Ingredients 90.44%
Total 100.00%

Useful Information

View Advantage II for Cats product label.

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

How To Open

  1. Be sure tube is at bottom of pouch.
  2. Using scissors, cut the pouch across the top and remove tube.

How to Apply

  1. Remove one applicator tube from the package. See "How to Open" section
  2. Hold application tibe in an upright position facing away from you and your pet's face and eyes. Pull cap of tube.
  3. Turn the cap around and place other end of cap back on tube.
  4. Twist cap to break seal, then remove cap from tube.
  5. Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your cat’s eyes, or allow your cat to ingest this product. The product is bitter tasting and salivation may occur for a short time if the cat licks the product immediately after treatment. Treatment at the base of the skull will minimize the opportunity for the cat to lick the product. Do not allow the product to run off.
  6. Discard empty tube as described in Storage and Disposal.
  7. Under normal conditions this product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four (4) weeks. Do not retreat more often than once every fourteen (14) days for kittens or once every seven (7) days for small and large cats. After flea control is attained, return to a monthly retreatment schedule.


  • Use only on cats or kittens 8 weeks and older. Do not apply to cats or kittens weighing less than 9 lbs. Do not use on other animals.
  • Do not apply more than one (1) tube per treatment, even for larger cats.
  • Do not have contact or allow children to have contact with treated area until completely dry.

Storage and Disposal

Do not contaminate water, food, or feed by storage or disposal.

Pesticide Storage:

Store in a cool, dry place inaccessible to children and pets.

Pesticide Disposal and Container Handling:

Nonrefillable container.

If empty:

Do not reuse this container. place in trash or offer for recycling if available.

If partly filled:

Call your local solid waste agency or 18004229874 for disposal instructions. Never place unused product down and indoor or outdoor drain.


Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes or clothing. Wash hands thoroughly with soap and warm water handling. Keep out of reach of children. Do not contaminate feed or food.

Hazards to Domestic Animals

For external use only.Do not apply to cats or kittens 8 weeks of age or weighing less than 9 lbs. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing cats. Individual sensitivities, while rare, may occur after using ANY pesticide product for cats. If signs persist, or become more severe, consult a veterinarian immediately. If your cat is on medication, consult your veterinarian before using this or any other product.

Possible Side Effects

Monitor your cat after application. Side effects, although very rare, may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as hypersalivation, vomiting or diarrhea have also been reported. If these or other side effects (such as lethargy) occur, consult your veterinarian or call 1-800-422-9874.

Customer Reviews

Review Summary
400 Reviews
79% (317)
14% (55)
3% (13)
1% (5)
3% (10)
95% Recommend this product (379 of 400 responses)
By Bella
Just what I needed.
May 9, 2024
Just what I was looking for and at a great price.
By Kllh260
Federal Way, Wa
Been using for years - works!
July 3, 2023
We’ve been using this product for years on our cat and it seems to work. She’s mostly inside, but the dog goes in and out, as do we (of course) and she’s never had a problem with fleas with this being put on monthly year round. It’s worth the investment. Will continue to buy.
  • Easy to apply and works
  • Is a little spendy
By Judson
Cats are pest free...
December 25, 2022
Very effective flea control for my cats, & easy to apply. Works for one month or little longer.
  • Effective & easy to apply.
  • None
By Jacqueline
Keeps my Baby Safe!!!
August 7, 2022
Easy to apply, just make sure it is high enough on the neck that they cannot reach it to lick it
  • easy to apply
  • if you do not pply properly, they can each it t
  • make sure you apply high enough that cats cannot lick off
By Katherine
Millville, Nj
Keeps the fleas away
August 8, 2021
My cats don't go outside, but the dogs do. Even though the dogs get top spot, the bugs sometimes hitch a ride. This top spot kills the fleas when they bite. Good product.
  • Works within 20 minutes.
  • Afraid to get the cat wet and even though it is put on the back of the neck one of my cats always reaches it.
By LBumgarner
Hickory, NC
Works, keep fleas and ticks off my pets.
May 23, 2021
Thus far haven't found any fleas or ticks on my pets.
  • Easy to use.
  • Makes the hair fall out on one of my kitties.
By Dave
it works
April 12, 2021
Otis had bumps and scabs from the fleas, this helped stop new problems while the chlorhexidine wipes helped the old problems and now he has great skin

Merchant Response:Otis is glad for the help even if he doesn't like the liquid.
  • easy to apply, long lasting, effective
  • he hates the application of liquid, but I suspect its the easiest way :)
Advantage II Flea Control for Large Cats Over 9 lbs. 4 Month
October 16, 2020
By Joe S.
Rochester, NY
September 25, 2020
Very satisfied.
By Lisa
Mt. Airy, NC
Advantage II Flea Control
September 18, 2020
I order these for my cats and it works great. They do not put up a fight when I put it on them. I even put one on the stray cat that comes around since he is around my cats some. By fighting off fleas, their fur stays soft and silky and they are not scratching. DEFINITELY RECOMMEND!!
By Mike
San Leandro , California
Excellent !
September 14, 2020
Thee best flea control product out there , because it works - tried many others that DO NOT work
By patricia
oshawa, ON
works will
April 28, 2020
keeps them off
By Rita
Birmingham, AL
Good so far!
April 7, 2020
I have seen where my Cats are scratching a lot less since putting these on them. Will buy again.
By mike f.
San Leandro , California
April 2, 2020
The BEST flea control product out there = Always works perfectly / monthly - I have tried other brands to save $$ ,but they Did Not work / stop the fleas - For me its Advantage hands down , the only brand that's worth IT !!

Merchant Response:You got it Mike! Take care in the 'Dro! %uD83D%uDC36
By Tammy w.
Gaston, sc
Great product
July 21, 2019
Advantage ll is a great product for fleas on my cats.
By Harvey
September 24, 2018
Will definitely purchase from again works great....
By Connie
Excellent Value
July 5, 2018
I've checked prices and Entirely Pets always beats the others for same products. Fast, fast delivery. I've been ordering for years and have always been happy. Highly recommended.
  • No need to walk the pet always insi
  • Litter box, of course!
By BigFATcat
San Francisco
Effective for cats and other animals
May 24, 2018
I started using Advantage for my cats and rabbit (vet recommended). The vet will need to tell you the correct dosage for rabbits. It kills the fleas without making the host sick.
  • Safe for cats and small pets
  • May not last for a month
By Tiger
Completely satisfied
September 2, 2017
Works great, even on the barn cats! I will get it again.
By Dale P.
Works Great!
August 15, 2017
I have 5 indoor cats and I put this on all of them. Normally I wouldn't use a flea product because they don't go outside, but of course, my dog brought in fleas. After a day I noticed the cats stopped itching. So it worked right away. It's best to put it on before you go to bed at night. (So you don't pet the area and it has ~8 hours to absorb). Try to get it right onto their skin behind the neck/shoulder blades. It remains oily on their skin for a day or so, so really try to rub it in well. I did notice some of them scratching again after literally 4 weeks, so I reapplied.
By Sallie J.
Auburn WA
July 24, 2017
works very good product. I would buy again
By mamabear
advantage flea control
July 22, 2017
I have 3 adult cats, and never have a flea problem with them, they are inside/outside cats.
By Mikie
Southern California
flea control for kitty
July 13, 2017
Sassy is 10 years old and with this product has never had fleas or any parasite.
By Coley
port hope, Ontario, canada
guaranteed prevention
May 23, 2017
This product will keep your fur baby flea free!
By Coley
port hope, Ontario, canada
guaranteed prevention
May 16, 2017
Excellent. Wouldn't buy any other brand. Keeps my household flea free all year long. I have 4 cats. 16 year old female, 9yr old male, 5yr old female, one yr old male. They all go outside and are flea free guaranteed.
By Cat L.
South Carolina
1 of the best products of its kind.
April 30, 2017
We have been using this product for a least ten (10) years and have it currently on auto ship as we have rescue cats (50+) that are contained on premises. We highly recommend this.
By Kitty L.
Works great
April 6, 2017
I've been using this product for years. I love how my kitties don't scratch from fleas bites!
By 7cats&me
Baton Rouge, Louisiana
100% all around purchase
January 18, 2017
I have seven cats that use Advantage, I buy a years worth of flea drops for all seven cats at one time. I find every order made at Entirely Pets to be good due to it being the lowest cost I can find, the products are always fresh so not to expire before the following 12 months that I need them (before usable expiration date), the delivery is fast & well boxed.
January 2, 2017
By micky
rochester, ny
great product
December 31, 2016
I had purchased another flea topical product and used it for 3 months, but did not see any improvement. I then decided to try this Advantage II and was amazed and how quickly it worked. I now believe the first product was somehow defective. I will continue to purchase this product, from Entirely Pets, because of how well it worked and this company's customer service. I consistently receive my orders in less than 4 days. This is critical, especially when dealing with a flea problem. Entirely Pets is Great!!

Questions and Answers

1 Question & 1 Answer
from pittsburgh, PA asked:
April 7, 2015
what is the use by date on the advantage II on sale?
1 Answer
Advantage Flea Control products have no expiration date.
Submitted by: Customer Service on April 8, 2015