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Zymox Topical Cream with 0.5% Hydrocortisone (1 oz)

Item: RZTC0100W
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Zymox Topical Cream for Hot Spots & Skin Infections

The most common skin condition both dogs and cats can be afflicted with are hot spots. They are characterized by itchy, raw, sometimes bloody patches of skin. In addition to managing hot spots the Zymox topical cream and spray is ideal in wound care as well as other common skin infections.

Regardless if bacterial, fungal or yeast and they can be applied 1x/day as needed with no pre-cleaning or scrubbing of the skin because the LP3 Enzyme System reacts with the infectious pus and debris to form its antimicrobial properties. Pre-cleaning and cleaning during use disrupts this biological system and will negatively affect results. Zymox is safe, gentle and non-toxic and worry-free if a pet licks application site. Both contain hydrocortisone for inflammation relief.

The topical cream features a catheter tip which is ideal for hard to reach applications such as skin folds.

Recommended for use on wounds and the most troublesome skin infections.

Surface Infection:
  • Pyotraumatic dermatitis hot spots, wet eczema, acute moist pyoderma
  • Body fold pyoderma
Superficial Infections:
  • Impetigo
  • Superficial and generalized pyoderma
  • Staphyococcus ssp (including MRSA) Pseudomonas ssp.
Superficial Mycoses:
  • Microsporum, Trichopyton, Epidermophyton (ringworm)
  • Malassezia pachydermatis, Candida albicans


Active Ingredients:
Hydrocortisone 0.5%

Other Ingredients:
Glyceryl Polymethacrylate, Glycerin, Purified Water, Propylene Glycol, Benzyl Alcohol, Isopropyl Myristate, Beta-d-Glucose, Titanium Dioxide, Zinc Gluconate, Potassium Iodide, Lactoperoxidase, Glucose Oxidase, Lysozyme, Lactoferrin, Aloe Vera

Customer Reviews

Review Summary
4 Reviews
75% (3)
25% (1)
0% (0)
0% (0)
0% (0)
100% Recommend this product (4 of 4 responses)
By Susan F.
Palm Beach County, FLorida
Great OTC Treatment for Skin Issues
January 21, 2017
This is the best product for helping with itchy skin issues, whatever the cause. My dog gets staph flare ups on her belly, and at the base of her tail she is prone to yeast infections. When I see trouble starting, I rub this onto her skin at the problem area, and then see how relieved she is of symptoms. Do not wash area before, just as stated on the box and the tube. This really works!!! I have also tried their otic solution for her ears, and that works very well also! Small costs to pay for such incredible relief!
By Mark
Westminster, CO
Zymox Cream Help
December 3, 2015
My dog had small itchy bumps around his neck and head. I used the cream after I clipped his hair. I rubbed it in and then used the Zymox Topical Spray. It has helped considerably. My Vet said I made a good choice.
By Makalea
Awesome product!
May 26, 2015
My Staffy developed a skin irritation/sores between her toes and was constantly licking them. I tried this cream and after the first day, I could see that her sores were getting better. After about a week, they were totally gone! The cream is a little greasy, but IT WORKS! And, it didn't irritate my dog's sensitive skin. Great product to keep on hand.
By Stan
Milwaukee, WI
Excellent product
September 22, 2013
My senior dog had developed three or four scabs on lower stomach near privates. Did some research and it sounded as if she may have a staph infection. This Zymox product said it was effective against staph and MRSA. Applied daily and it's very sticky so they can't lick it off. Within a week they were gone. My dog is 100 pounds so if you have a large dog you'll need to order two. Cheap and effective, this worked for me. Highly recommended.

Questions and Answers

2 Questions & 2 Answers
from Seoul,Korea asked:
June 16, 2019
Hi can i use this to hedgehogs? Just a little since she has corneous on her tail? i think it’s bc of the molds 
1 Answer
Hi Lee, this is only meant to be use with cats and dogs.
Submitted by: Customer Service on July 3, 2019

August 16, 2018
How many times a day should I use for my dog infection? She has extreme fungal infection
1 Answer
Apply once daily or as needed for one to two weeks until application site is healed. May be lightly covered with a sterile bandage.
Submitted by: EntirelyPets on August 23, 2018

Zymox Spray with Hydrocortisone (2 oz)Zymox Spray with Hydrocortisone (2 oz)Reg price: $23.99
Sale price: $17.99
Zymox Spray without Hydrocortisone (2 oz)Zymox Spray without Hydrocortisone (2 oz)Reg price: $20.99
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Zymox Topical Spray with 0.5% Hydrocortisone (2 oz)Zymox Topical Spray with 0.5% Hydrocortisone (2 oz)Reg price: $22.99
Sale price: $16.99
Zymox Cream with Hydrocortisone (1 oz)Zymox Cream with Hydrocortisone (1 oz)Reg price: $23.99
Sale price: $17.99