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  6. 6 MONTH Advantage II Flea Control for Extra Large Dogs (Over 55 lbs)

6 MONTH Advantage II Flea Control for Extra Large Dogs (Over 55 lbs) Video

6 MONTH Advantage II Flea Control for Extra Large Dogs (Over 55 lbs)

Item: 5461782
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Advantage II Flea Treatment for Extra Large Dogs. This highly-effective, veterinarian-recommended treatment is specifically formulated to kill all life stages of fleas on contact with no painful biting required. With three-way protection that kills the eggs, larvae and adults, it breaks the flea life-cycle to help prevent re-infestation of both your house and hound. The waterproof formula for dogs 7 weeks or older and weighing over 55 pounds continues working for up to four weeks, even after bathing or swimming.

  • Veterinarian-recommended treatment kills all life stages of fleas on puppies and dogs 7 weeks or older and weighing over 55 pounds.
  • Begins working within 12 hours to kill fleas on contact.
  • Kills eggs, larvae and adult fleas to break the life cycle and help prevent re-infestation.
  • Waterproof formula continues working for up to four weeks, even after bathing or swimming.
  • Convenient, monthly topical application contains imidacloprid and pyriproxyfen; available in packs of 4 or 6 treatments.


Active Ingredients by Weight
Imidacloprid 9.10%
Pyriproxyfen 0.46%
Other Ingredients 90.44%
Total 100.00%

Useful Information

Advantage II Flea Control for Dogs

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

    How To Open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

    How to Apply

  • Remove one applicator tube from the package. See "HOW TO OPEN" section
  • Hold application tube in an upright position facing away from you and your pet's face and eyes. Pull cap of tube.

  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • The dog should be standing for easy application. Part the hair on the dog's back, between the shoulder blades, until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your pet's eyes or mouth.

  • Discard empty tube as described in Storage and Disposal.
  • Under normal conditions this product is effective for a month. However, in cases of severe flea infestation, re-treatment may be necessary earlier than four (4) weeks. Do not retreat more often than once every seven (7) days. After flea control is obtained, return to a monthly re-treatment schedule.


  • Use only on dogs. Do not use on other animals.
  • Do not apply more than one (1) tube per treatment, even for larger dogs.
  • Do not have contact or allow children to have contact with treated area until completely dry.

CAUTIONS: Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes or clothing. Wash hands thoroughly with soap and warm water handling. Keep out of reach of children. Do not contaminate feed or food.


For external use only. Do not use on puppies under seven weeks of age. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing animals. Individual sensitivities, while rare, may occur after using ANY pesticide products for pets. If signs persist, or become more severe, consult a veterinarian immediately. If your animal is on medication, consult your veterinarian before using this or any other product.

Customer Reviews

48 Reviews
85% (41)
10% (5)
0% (0)
0% (0)
4% (2)
94% Recommend this product (45 of 48 responses)
By Dog l.
January 24, 2019
Review for 6 MONTH Advantage II Flea Control for Extra Large Dogs (Over 55 lbs)
This works so well on my dogs! My dogs cannot use Nexguard due to seizures and this is the next best thing.
ProsWorks well
ConsPut on their backs monthly
By Alaska808
September 24, 2017
Works for me
Use it on a regular basis. No adverse reactions or problems with this product.
By Floydieboy
Abbotsford, BC
October 26, 2015
Great Stuff!
This product is great - I use it on my Cane Corso as a precautionary as he attends doggy daycare and although he has never had fleas, this product will ensure that he never does!
By IsabellaRuby
Los Angeles, CA
May 12, 2015
Great Purchase
On my Golden 9 yrs-no fleas and no fear of them
By Johanna
March 26, 2015
Good product
As I am only using this product I cannot judge whether there is a better one. It is working. My animals do not have fleas.
By Pat
Molokai Hawaii
February 2, 2015
3 Big Dogs say YES
Aloha, It keeps us flea and tick free so Mom doesn't have to worry.
By paisleygirl
Houston, TX
October 7, 2014
Good stuff but needs be new product
I normally use the Advantage II on both my dogs and cats but when I received this it was in the old packaging. My friend had purchased a package the month before in new packaging. This didn't work near as well as it normally does so I was concerned that it had been sitting on the shelf for a long time. I'd rather have newer product so it's fresher and more apt to work better. I'll still use it on my pups but for my cats I use the Advantage multi as it covers for ear mites, heartworms etc.
By sara
June 4, 2014
Not working
This usually works well on my dogs, but not this time. I guess it's time to buy something else!
By Sarge
Buffalo New York
April 14, 2014
The Best Flea Protection
We have used Advantage II Flea Control for all our dogs for over 15 years, and we have yet to see a flea on any of them!

It is easy to apply, and there are no side effects.

Thank you, Entirely Pets, for a product that works perfectly and at a great price!
By Kerty
Orange, MA
April 14, 2014
I have been using this on my dog for years, and highly recomend this, also they make a great one for cat's too. so long nasty fleas!
By PeterA
Staffordville, Ct
November 22, 2013
Only thing that works
Frontline stopped working on our pets. Advantage II is terrific--no fleas, disabled ticks.
By Cindy
Eugene, Oregon
November 21, 2013
Review for 6 MONTH Advantage II Flea Control for Extra Large Dogs (Over 55 lbs)
Works great - I have used Advantage for years and when Advantage II was developed I started using it - it works the best for my animals.
By Tanner
Ontario, Canada
October 31, 2013
Advantage 11
Excellent product for an active dog. Wouldn't try anything else!
By Chuck
Ellettsville, IN
October 25, 2013
Product Really Works!
I was using a generic type of flea and tick medicine that I got at a Farm Store. I noticed a flea infestation and tried numerous sprays and remedies over a 3 week period to rid the dogs of fleas. They would kill the fleas and 2 days later they were back until I used the Advantage II and within 2 days, the fleas were dead and a bath washed many dead fleas down the drain and no more problems with the fleas. I also found 2 ticks dead and still attached which were easily removed. This really works!!
By AngeeeA
Sacramento, CA
July 26, 2013
Away with Fleas
Let start off by making it known, I have many, many pets. Because of this, flea control is a MUST. I don't know how we even made it before Advantage came out. This stuff is amazing! I've been using it for years and highly recommend it. My pets have no fleas at all. We don't even have to use it monthly. Just every few months or so does the trick. Recently we've had a stray show up who was covered in fleas. The first dose was good, but I still noticed some fleas. I did a second dose the following month and I don't see a single flea on him now. Can't say enough great things about this product!
By aureola
south Texas
July 17, 2013
like the product
I have been using Advantage II for a couple of years now...I have no fleas in my house or my yard or my dogs....it just keeps them away
By lee
July 9, 2013
not satisfied
doesn't control fleas for longer than one to two weeks.
By Gov
July 9, 2013
Good solid product from Bayer
We as pet owners must do our best to get and give our pets, or second family members.

This product offers the very best for our loved pets. I use Advantaix ll also, but as we well know is that our pets can come used to a product such as flea med's, so without compromise, I choose Advantage ll for the replacement, also made by Bayer, they just make the best quality products for our loved Pets.....
By Wallymax
Wine Country, California
June 17, 2013
We Love Advantage!
Advantage keeps our two BIG dogs flea free and happy year round. This is a great poduct!
By NAth
June 17, 2013
Chepest cost I ever pay
I ususally buy this product from my vet..even with the Freight from USA to Canada, it is less expensive.
By boxy
June 14, 2013
Dogs are smiling
Truly have nothing but great things to say regarding the product and your company have recommanded your company to all dogs and cat people I meet...
By strawberry
kingston ont Canada
June 2, 2013
Review for 6 MONTH Advantage II Flea Control for Extra Large Dogs (Over 55 lbs)
product worked great . no more fleas :) :)
By Christina
April 1, 2013
great product
It keeps the fleas away on my animal. They die fast if they already have a flea too.
By MIlo
Tacoma, WA
February 7, 2013
Great deal and product
I will be back, great product. My dogs are happy.
By Jumpin 8.
Salem, Oregon
January 29, 2013
6 Month Advantage II flea control xtra lage dg
Advantage II for xtra lge dgs is perfect for my 4 very small dogs. 1 tube is enough for all 4 of my dogs, so save quite a lot of money. It is less expensive at Entirely Pets & the shipping is fast. I have used Entirely Pets many times for years & have always been very satisfied, & If I wasn't, they always make it right.
By kc
January 26, 2013
Great product
We have 4 pets and have tried other products and for the first time in 15 years got fleas. We finally got rid of them and are back to Advantage. Good prices on Entirely Pets is why we bought through them. The shipping was quick and we are happy and will buy again.
By ErinMcD
West Sacramento, CA
January 25, 2013
Look, Ma! No fleas!
Amazingly easy to apply, even on a big, hairy dog like mine. And we have remained completely flea-free since we started using Advantage II several years ago.
By Kay
January 10, 2013
Excellent Product
We have been using this product for some time now and have not seen any evidence of fleas on our dog. He goes in and out all day to play in our extra large yard and since applying this product we haven't had any flea problems.
By roganddon
Federalsburg, Md.
January 10, 2013
came back
I used this product before and liked it very much.Then found less expensive brand that didn,t work any where near as well as Advantage 11. Won,t be changing to any other brand again!
By eaturveggies
December 29, 2012
Review for 6 MONTH Advantage II Flea Control for Extra Large Dogs (Over 55 lbs)
Works great! Lots of deer in our area = lots of ticks. Not on our dogs! Fleas are a non-issue with this product.

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