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  6. 3 PACK Denosyl for Medium Dogs (90 tablets) 225 mg

  • DENO2253PKDENO2253PK
  • DENO2253PKDENO2253PK

3 PACK Denosyl for Medium Dogs (90 tablets) 225 mg

Item: DENO225-3PK
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NOTE: Limited supply item - only three (3) per customer per order.

Description

Denosyl is a daily supplement that helps support proper liver function. Support of a compromised liver, regardless of the cause, is essential if function is to be improved. Denosyl has not only been shown to markedly increase glutathione levels in the livers of dogs and cats, but to go far beyond that. Denosyl has been shown to protect liver cells from cell death and may be useful in cell repair and healing. It's main ingredient is S-Adenosylmethionine (SAMe).

Key Benefits:

  • Denosyl is formulated for liver and brain health
  • Increases levels of glutathione, an important compound for liver health
  • Has also been shown to help protect liver cells from cell death and may help cell reparation and regeneration
  • Increases cerebrospinal fluid in the brain that pets lose as they age
  • Easy to administer tablets for medium dogs

How It Works

Denosyl has been shown to markedly increase liver levels of glutathione,1,2 an important compound for liver health formed when SAMe (S-Adenosylmethionine) is metabolized. Denosyl has also been shown to help protect liver cells from cell death3,4 and may help cell repair and regeneration.5

While best known for supporting the liver in dogs and cats, research has shown that the SAMe in Denosyl may help support cognitive function in dogs.6 Denosyl provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.7-9

References

  1. Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66:330-341.
  2. Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
  3. Webster CRL, Boria P, Usechak P, et al. Vet Therapeutics 2002;3:474-484.
  4. McCool J, Johnston A, Webster CRL. In Proceedings. 21st Annual ACVIM Forum 2003;abstract #134.
  5. Center SA. In Proceedings. 18th Annual ACVIM Forum 2000;550-552.
  6. Rème CA, Dramard V, Kern L, et al. Vet Therap 2008;9(2):69-82.
  7. Tchantchou F, Graves M, Ortiz D, et al. J Nutr Health Aging 2006;10(6):541–544.
  8. Tchantchou F, Graves M, Falcone D, Shea TB. J Alzheimers Dis 2008;14:323–328.
  9. Shea TB, Chan A. J Alzheimers Dis 2008;13:67–70.
  10. Westfall DS, Twedt DC, Steyn PF, et al. J Vet Intern Med 2001;15(5):467-470.
  11. Graham JP, Lipman AH, Newell SM, Roberts GD. Am J Vet Res 2000;61(6):655-657.

Ingredients

S-Adenosylmethionine.

Useful Information

Because the tablet must be kept intact to prevent destruction by moisture, administration range is based on the nearest whole-tablet. The chart below is provided as a guide for administration. Daily administration may also be calculated based on 20 mg/kg of body weight and rounded to the closest tablet size or combination of sizes.

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. Studies have shown that, in many cases, tablets or capsules given as a "dry swallow" do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.10,11 Denosyl 90 mg tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.

Denosyl Canine and Feline Daily* Administration Guide

For Cats (90 mg)
Body Weight Body Weight Number of Tablets Per Day
Up to 12 lbs Up to 5.5 kg 1 tablet
Over 12 lbs Over 5.5 kg 2 tablets
For Small Dogs (90 mg)
Body Weight Body Weight Number of Tablets Per Day
Up to 12 lbs Up to 5.5 kg 1 tablet
For Medium Dogs (225 mg)
Body Weight Body Weight Number of Tablets Per Day
13 - 34 lbs 6 - 15.5 kg 1 tablet
For Large Dogs (425 mg)
Body Weight Body Weight Number of Tablets Per Day
35 - 65 lbs 16 - 29.5 kg 1 tablet
66 - 120 lbs 30 - 54.5 kg 2 tablets
Over 120 lbs Over 54.5 kg 3 tablets

The number of tablets can be gradually reduced or increased at any time depending on the pet's needs.

Many pets are maintained long-term on every-other-day or every-third-day administration.

Storage:

Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat.

FAQ

Denosyl is available enteric-coated tablets for cats and dogs.

The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.

Because it does so much, the liver may be subject to many things: injury, both direct and indirect, infection, and toxicity. Some of the signs and symptoms of compromised liver function in pets may include: weakness, vomiting, poor appetite, and/or seizures. But if there is mild or early stage liver compromise, the pet can appear normal. If you notice any of these symptoms or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.

Your veterinarian will advise you as to the amount to initially administer. Depending on your pet's response and status, your veterinarian may eventually adjust this amount to meet your pet's individual needs. Remember, Denosyl enteric-coated tablets should not be broken. When increasing or decreasing their administration, adjustments should be done in full tablet increments. Some pets are given Denosyl only for a short period of time, although Denosyl may be used longer in other animals.
While response varies, owners may note a change in their pet’s appetite, activity, and attitude.
Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Denosyl and how it may be helping to support your pet’s liver function.
Denosyl has been shown to be well-tolerated by both dogs and cats with a wide margin of safety.
Yes, your veterinarian may recommend combining Denosyl with other products and/or dietary modifications. There are no known adverse interactions of Denosyl with drugs or other supplements. Denosyl may even protect against negative effects on the liver caused by some medications.
While other S-Adenosylmethionine (SAMe) products are available, there can be a significant variance in product quality and activity levels of SAMe. Denosyl is produced using high-quality, researched ingredients and under strict manufacturing standards.
Administration of methionine is not recommended. Providing high levels of methionine to pets with liver compromise may not increase the production of natural S-Adenosylmethionine and has been shown in some cases to increase liver damage.

Like all medicines, Revolt has some side effects. The most common is hair loss at the site of application with or without inflammation (redness, flaking) in cats. Other side effects reported in cats and dogs include vomiting, diarrhea with or without blood, anorexia (decreased appetite), lethargy (sluggishness), salivation, rapid breathing, pruritus (itching), urticaria (welts, hives), erythema (skin redness), ataxia (incoordination), fever and rare instances of death. There have also been rare reports of seizures in dogs.

If you have additional questions about possible side effects, talk to your veterinarian.

In well-controlled clinical studies, selamectin was used safely in dogs and cats receiving other veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.

Tell your veterinarian about all medicines you have given your dog or cat in the past, and any medicines that you are planning to use with Revolt. This should include other medicines that you can get without a prescription. Your veterinarian may want to check that all of your dog's or cat's medicines can be given together.

Revolt is flammable - Keep away from heat, sparks, open flames or other sources of ignition. Store below 30°C (86°F). After application, empty tubes can be placed in your normal household refuse for disposal.

Customer Reviews

Review Summary
4.7
42 Reviews
5
76% (32)
4
21% (9)
3
2% (1)
2
0% (0)
1
0% (0)
98% Recommend this product (41 of 42 responses)
By Huili Q.
New York
good
March 24, 2022
good
By MaggiesMom
FL
Great product
September 16, 2021
Denosyl keeps my dog's compromised liver numbers in an acceptable range to give her a good quality of life. She's 13 and has been taking it for 10 years.
By Pointer M.
NE Ohio
Great value
March 4, 2016
My 13 yr old male GSP is on Denosyl for his liver, and so far he's doing great on it. I like that I can buy a value pack since he takes 2 tablets/day.
By Rivers R.
Excellent product!
November 2, 2015
Libby is an 11 yr old rescue.

Thanks to Denosyl her liver values are up to where they should be and it gives us peace of mind that the supplementation is aiding her liver function!
By Winnie
Liver support
March 24, 2015
This supplement seems to have helped my 15 year old dog. Her numbers were improved at her last check up.
By pj
Baltimore
My vet recommended Denosyl
October 16, 2013
My dog has Cushings disease and this is supposed to help aid her liver function. I can't really tell how well it works. She's been on it for 5 years. I only buy it at Entirely Pets, though I search the web for deal every few months. Entirely Pets always has the best price to be found for Denosyl.
By Hope
Denosyl
September 17, 2013
Great product at an even better price! Thanks
By June
Upstate New York
Worked wonder
August 27, 2013
Denosyl, prescribed by my vet, is an excellent product. I buy fromEntirely Pets because of the low price offered and am very happy with their company.
By TerryL
North East Alabama
Better Buy
July 1, 2013
I was so relieved to find Denosyl at a better price. My Welsh Cardigan Corgi has liver disease and needs this product daily. I ordered the exact same product that I was getting at my vet's but at nearly a 50% savings. Since I recently lost my job, finding Denosyl at EntirelyPets.com was a big relief.
By LikesArt
Atlanta
Seems to be helping
July 1, 2013
My rat terrier has been on this for several years (vet recommended) for liver support and it seems to be keeping her stable.
By TaraTriniti
Lafayette La
Saved my dogs life
June 21, 2013
I could not have asked for a better product!!!!!!
By malbee1023
Batavia, NY
Denosyl for dogs
May 13, 2013
I saved literally $20 per box by ordering here rather than getting it through the vet.
It arrived 2 days after I placed my order, pretty fast.
The blood work on my dog since taking it has improved.
By jamie
New Jersey
Does what's needed
April 30, 2013
I've used this product for several years since my dog was diagnosed with "some liver problems". Apparently, it's working because Jamie no longer is at risk for liver disease. It's a supplement and doesn't seem to have any adverse affect. Worth a try!
By Murph
Review for 3 PACK Denosyl for dogs over 25 lbs (90 tablets) 225 mg
April 5, 2013
The cost is lowest I have seen and I received the medication in a very timely manner.
By IfNotForSitsWhyWarm
Lexington, KY
Best price for these meds
April 1, 2013
This was prescribed by our vet for our older cocker spaniel. She takes it every day, so I have had to find the best price to make the cost hit lower. I assume it works as expected since our vet continues to prescribe it.
By Nan
Seems to help.
March 24, 2013
My Miniature Schnauzer was suffering from multiple seizures a day. Since starting her on Denosyl she has not experienced any seizures.It might be coincidence, but If its not the Densoyl "helping", it's not hurting either.
By Ro
Review for 3 PACK Denosyl for dogs over 25 lbs (90 tablets) 225 mg
March 7, 2013
This product is wonderful...I have used it for my pet Polo for nine years....sadly I just lost him at 14 to his liver issues...but this procuct did help over the years to rebuild his liver function
By Sandi R.
Denosyl
February 19, 2013
My sheltie went from complete liver failure to normal liver function in less than two weeks. She was on hepatic health dog food and took a denosyl every night. The vet said it was a miracle and couldn't believe her health change. She is back to normal food but still takes the denosyl. It's a small price to see her happy face when I get home!
By mrsclean
Great price...
February 9, 2013
I have not found a better price or better service. Very happy I found EntirelyPets.
By JoeB
Vancouver, WA
Excellent product!
February 5, 2013
This is a great product. Adds years to the life of your dog.
By nae
great deal
November 12, 2012
This product has worked great for our dog has proably saved her life.
By Rose
Virginia
Great Purchase
November 5, 2012
I purchased this product at a great price & deliverly was awesome. Will definitely purchase again.
By sandy
Westchester NY
denosyl
October 23, 2012
Product is fantastic. Has maintained my dog's liver in a reasonalbly healthy state. She is on Phenobarbital which can distroy the liver. Have used denosyl for 5 years. My dog is now 15 yrs. old and going strong.
By Fran
Brookfield, MA
Best Purchase Ever
August 21, 2012
This product is great. I find the ordering process the best and most efficient, reliable and dependable. That is what I needed and that is what I received. Customer Service is outstanding.
By Savanna
Waterford, Mi.
Excellent value
July 28, 2012
I love the option of buying a three pack. I have two dogs who take the same dose so one pack only lasts me fifteen days. With the three pack it's convenient and economical. I wish the product would be offered in chewables three pack as the dogs don't like the taste so I put them in Pill Pockets.
By Mel
Singapore
Review for 3 PACK Denosyl for dogs over 25 lbs (90 tablets) 225 mg
June 19, 2012
Product is ok. But we were supposed to purchase the CHEWABLE form.
By KitS
Tucson, AZ
Helps protect liver
June 12, 2012
Our beagle has epilepsy and takes phenobarbital. The denosyl was recommended by our vet to protect his liver several years ago. He is now 17 and doing quite well.
By Soosie
Good price for a 3 pack
June 9, 2012
Good service and prices. My dog takes Denosyl all the time so it was important to find a reasonable source for me to purchase on a regular basis. Thanks for being there.
By frang
Virginia Beach,VA.
denosyl for dogs
June 5, 2012
great price, fast shipping.....best of both worlds.
By Roses1
California
For Health's Sake
May 30, 2012
My senior aged dog has had elevated liver enzymes for the past few years. With Denosyl the health of her liver has stabilized. Great product.

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