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  6. Nutramax Denosyl Liver and Brain Health Supplement for Medium Dogs, With S-Adenosylmethionine (SAMe), 90 Tablets

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Nutramax Denosyl Liver and Brain Health Supplement for Medium Dogs, With S-Adenosylmethionine (SAMe), 90 Tablets

Item: DENO225-3PK
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2. Select count:


NOTE: Limited supply item - only three (3) per customer per order.


Denosyl contains SAMe (s-adenosylmethionine) to help support the liver health of dogs and may support brain health.† It is available in enteric-coated tablets. Denosyl Liver Health Supplements are brought to you by Nutramax Laboratories Veterinary Sciences, the #1 veterinarian recommended supplement company.†*Source: Survey conducted among small animal veterinarians who recommended animal supplements.

Key Benefits:

  • Liver Support: Denosyl features s-adenosylmethionine (SAMe) to support the liver by increasing levels of glutathione, an important antioxidant for liver health and the liver's main detoxifier
  • Bioavailability: The SAMe in Denosyl has been proven to be bioavailable, meaning it enters your pet's bloodstream to help support the liver
  • Cognitive Support: Research has shown that SAMe may also support cognitive function in dogs and act as a neuroprotector
  • From the #1 Veterinarian Recommended Supplement Company*: Nutramax Laboratories Veterinary Sciences has been a leader in pet health for over 30 years, and provides supplements to support joint health, digestive health, and overall wellness
  • Backed by Science: Nutramax Laboratories Veterinary Sciences supplements are veterinarian formulated with high-quality ingredients to ensure your pet is receiving a safe supplement


Active Ingredients:

S-Adenosylmethionine 225 mg.

Useful Information

For dogs 13 - 34 lbs, 1 tablet per day.

Tablets should be given on an empty stomach for optimal absorption. They may be given at least two hours after a meal or one hour before a meal.


Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.


Denosyl is available enteric-coated tablets for cats and dogs.

The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.

Because it does so much, the liver may be subject to many things: injury, both direct and indirect, infection, and toxicity. Some of the signs and symptoms of compromised liver function in pets may include: weakness, vomiting, poor appetite, and/or seizures. But if there is mild or early stage liver compromise, the pet can appear normal. If you notice any of these symptoms or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.

Your veterinarian will advise you as to the amount to initially administer. Depending on your pet's response and status, your veterinarian may eventually adjust this amount to meet your pet's individual needs. Remember, Denosyl enteric-coated tablets should not be broken. When increasing or decreasing their administration, adjustments should be done in full tablet increments. Some pets are given Denosyl only for a short period of time, although Denosyl may be used longer in other animals.
While response varies, owners may note a change in their petís appetite, activity, and attitude.
Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Denosyl and how it may be helping to support your petís liver function.
Denosyl has been shown to be well-tolerated by both dogs and cats with a wide margin of safety.
Yes, your veterinarian may recommend combining Denosyl with other products and/or dietary modifications. There are no known adverse interactions of Denosyl with drugs or other supplements. Denosyl may even protect against negative effects on the liver caused by some medications.
While other S-Adenosylmethionine (SAMe) products are available, there can be a significant variance in product quality and activity levels of SAMe. Denosyl is produced using high-quality, researched ingredients and under strict manufacturing standards.
Administration of methionine is not recommended. Providing high levels of methionine to pets with liver compromise may not increase the production of natural S-Adenosylmethionine and has been shown in some cases to increase liver damage.

Customer Reviews

Review Summary
43 Reviews
77% (33)
21% (9)
2% (1)
0% (0)
0% (0)
100% Recommend this product (43 of 43 responses)
Ft. Worth, Tx
An easy health maintenance
June 6, 2024
My terrier had bloodwork done prior to teeth cleaning, results were alarming high on liver. So it was recommended by our vet to give Denasyl daily. It worked great, so I’ve used it for yrs as a maintenance. Our dog takes it as a treat on an empty stomach. It’s natural ingredients & doesn’t cause any erratic issues.
  • Taste, natural ingredients, it works to reduce liver issues
By Huili Q.
New York
March 24, 2022
By MaggiesMom
Great product
September 16, 2021
Denosyl keeps my dog's compromised liver numbers in an acceptable range to give her a good quality of life. She's 13 and has been taking it for 10 years.
By Pointer M.
NE Ohio
Great value
March 4, 2016
My 13 yr old male GSP is on Denosyl for his liver, and so far he's doing great on it. I like that I can buy a value pack since he takes 2 tablets/day.
By Rivers R.
Excellent product!
November 2, 2015
Libby is an 11 yr old rescue.

Thanks to Denosyl her liver values are up to where they should be and it gives us peace of mind that the supplementation is aiding her liver function!
By Winnie
Liver support
March 24, 2015
This supplement seems to have helped my 15 year old dog. Her numbers were improved at her last check up.
By pj
My vet recommended Denosyl
October 16, 2013
My dog has Cushings disease and this is supposed to help aid her liver function. I can't really tell how well it works. She's been on it for 5 years. I only buy it at Entirely Pets, though I search the web for deal every few months. Entirely Pets always has the best price to be found for Denosyl.
By Hope
September 17, 2013
Great product at an even better price! Thanks
By June
Upstate New York
Worked wonder
August 27, 2013
Denosyl, prescribed by my vet, is an excellent product. I buy fromEntirely Pets because of the low price offered and am very happy with their company.
By TerryL
North East Alabama
Better Buy
July 1, 2013
I was so relieved to find Denosyl at a better price. My Welsh Cardigan Corgi has liver disease and needs this product daily. I ordered the exact same product that I was getting at my vet's but at nearly a 50% savings. Since I recently lost my job, finding Denosyl at was a big relief.
By LikesArt
Seems to be helping
July 1, 2013
My rat terrier has been on this for several years (vet recommended) for liver support and it seems to be keeping her stable.
By TaraTriniti
Lafayette La
Saved my dogs life
June 21, 2013
I could not have asked for a better product!!!!!!
By malbee1023
Batavia, NY
Denosyl for dogs
May 13, 2013
I saved literally $20 per box by ordering here rather than getting it through the vet.
It arrived 2 days after I placed my order, pretty fast.
The blood work on my dog since taking it has improved.
By jamie
New Jersey
Does what's needed
April 30, 2013
I've used this product for several years since my dog was diagnosed with "some liver problems". Apparently, it's working because Jamie no longer is at risk for liver disease. It's a supplement and doesn't seem to have any adverse affect. Worth a try!
By Murph
Review for 3 PACK Denosyl for dogs over 25 lbs (90 tablets) 225 mg
April 5, 2013
The cost is lowest I have seen and I received the medication in a very timely manner.
By IfNotForSitsWhyWarm
Lexington, KY
Best price for these meds
April 1, 2013
This was prescribed by our vet for our older cocker spaniel. She takes it every day, so I have had to find the best price to make the cost hit lower. I assume it works as expected since our vet continues to prescribe it.
By Nan
Seems to help.
March 24, 2013
My Miniature Schnauzer was suffering from multiple seizures a day. Since starting her on Denosyl she has not experienced any seizures.It might be coincidence, but If its not the Densoyl "helping", it's not hurting either.
By Ro
Review for 3 PACK Denosyl for dogs over 25 lbs (90 tablets) 225 mg
March 7, 2013
This product is wonderful...I have used it for my pet Polo for nine years....sadly I just lost him at 14 to his liver issues...but this procuct did help over the years to rebuild his liver function
By Sandi R.
February 19, 2013
My sheltie went from complete liver failure to normal liver function in less than two weeks. She was on hepatic health dog food and took a denosyl every night. The vet said it was a miracle and couldn't believe her health change. She is back to normal food but still takes the denosyl. It's a small price to see her happy face when I get home!
By mrsclean
Great price...
February 9, 2013
I have not found a better price or better service. Very happy I found EntirelyPets.
By JoeB
Vancouver, WA
Excellent product!
February 5, 2013
This is a great product. Adds years to the life of your dog.
By nae
great deal
November 12, 2012
This product has worked great for our dog has proably saved her life.
By Rose
Great Purchase
November 5, 2012
I purchased this product at a great price & deliverly was awesome. Will definitely purchase again.
By sandy
Westchester NY
October 23, 2012
Product is fantastic. Has maintained my dog's liver in a reasonalbly healthy state. She is on Phenobarbital which can distroy the liver. Have used denosyl for 5 years. My dog is now 15 yrs. old and going strong.
By Fran
Brookfield, MA
Best Purchase Ever
August 21, 2012
This product is great. I find the ordering process the best and most efficient, reliable and dependable. That is what I needed and that is what I received. Customer Service is outstanding.
By Savanna
Waterford, Mi.
Excellent value
July 28, 2012
I love the option of buying a three pack. I have two dogs who take the same dose so one pack only lasts me fifteen days. With the three pack it's convenient and economical. I wish the product would be offered in chewables three pack as the dogs don't like the taste so I put them in Pill Pockets.
By Mel
Review for 3 PACK Denosyl for dogs over 25 lbs (90 tablets) 225 mg
June 19, 2012
Product is ok. But we were supposed to purchase the CHEWABLE form.
By KitS
Tucson, AZ
Helps protect liver
June 12, 2012
Our beagle has epilepsy and takes phenobarbital. The denosyl was recommended by our vet to protect his liver several years ago. He is now 17 and doing quite well.
By Soosie
Good price for a 3 pack
June 9, 2012
Good service and prices. My dog takes Denosyl all the time so it was important to find a reasonable source for me to purchase on a regular basis. Thanks for being there.
By frang
Virginia Beach, VA.
denosyl for dogs
June 5, 2012
great price, fast of both worlds.

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