1. Home > 
  2. Dog Supplies > 
  3. Kidney & Liver & Renal Health > 
  4. Liver Support Supplements > 
  5. Denosyl for Dogs & Cats > 
  6. Nutramax Denosyl Liver and Brain Health Supplement for Medium Dogs, With S-Adenosylmethionine (SAMe), 30 Tablets


Nutramax Denosyl Liver and Brain Health Supplement for Medium Dogs, With S-Adenosylmethionine (SAMe), 30 Tablets

Item: DENO225MG
1. Select pet size:
2. Select count:


NOTE: Limited supply item - only three (3) per customer per order.


Denosyl contains SAMe (s-adenosylmethionine) to help support the liver health of dogs and may support brain health.† It is available in enteric-coated tablets. Denosyl Liver Health Supplements are brought to you by Nutramax Laboratories Veterinary Sciences, the #1 veterinarian recommended supplement company.†*Source: Survey conducted among small animal veterinarians who recommended animal supplements.

Key Benefits:

  • Liver Support: Denosyl features s-adenosylmethionine (SAMe) to support the liver by increasing levels of glutathione, an important antioxidant for liver health and the liver's main detoxifier
  • Bioavailability: The SAMe in Denosyl has been proven to be bioavailable, meaning it enters your pet's bloodstream to help support the liver
  • Cognitive Support: Research has shown that SAMe may also support cognitive function in dogs and act as a neuroprotector
  • From the #1 Veterinarian Recommended Supplement Company*: Nutramax Laboratories Veterinary Sciences has been a leader in pet health for over 30 years, and provides supplements to support joint health, digestive health, and overall wellness
  • Backed by Science: Nutramax Laboratories Veterinary Sciences supplements are veterinarian formulated with high-quality ingredients to ensure your pet is receiving a safe supplement


Active Ingredients:

S-Adenosylmethionine 225 mg.

Useful Information

For dogs 13 - 34 lbs, 1 tablet per day.

Tablets should be given on an empty stomach for optimal absorption. They may be given at least two hours after a meal or one hour before a meal.


Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.


Denosyl is available enteric-coated tablets for cats and dogs.

The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.

Because it does so much, the liver may be subject to many things: injury, both direct and indirect, infection, and toxicity. Some of the signs and symptoms of compromised liver function in pets may include: weakness, vomiting, poor appetite, and/or seizures. But if there is mild or early stage liver compromise, the pet can appear normal. If you notice any of these symptoms or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.

Your veterinarian will advise you as to the amount to initially administer. Depending on your pet's response and status, your veterinarian may eventually adjust this amount to meet your pet's individual needs. Remember, Denosyl enteric-coated tablets should not be broken. When increasing or decreasing their administration, adjustments should be done in full tablet increments. Some pets are given Denosyl only for a short period of time, although Denosyl may be used longer in other animals.
While response varies, owners may note a change in their petís appetite, activity, and attitude.
Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Denosyl and how it may be helping to support your petís liver function.
Denosyl has been shown to be well-tolerated by both dogs and cats with a wide margin of safety.
Yes, your veterinarian may recommend combining Denosyl with other products and/or dietary modifications. There are no known adverse interactions of Denosyl with drugs or other supplements. Denosyl may even protect against negative effects on the liver caused by some medications.
While other S-Adenosylmethionine (SAMe) products are available, there can be a significant variance in product quality and activity levels of SAMe. Denosyl is produced using high-quality, researched ingredients and under strict manufacturing standards.
Administration of methionine is not recommended. Providing high levels of methionine to pets with liver compromise may not increase the production of natural S-Adenosylmethionine and has been shown in some cases to increase liver damage.

Customer Reviews

Review Summary
22 Reviews
95% (21)
5% (1)
0% (0)
0% (0)
0% (0)
95% Recommend this product (21 of 22 responses)
By Huili Q.
New York
March 24, 2022
By MaggieMom
This product is keeping my dog's liver numbers in
June 10, 2018
Helps my dog with liver disease. Wouldn't go a day without it.
By Mona
Ellijay, Ga.
Amazing Product
September 24, 2014
Denosyl for dogs saved my little Ginger. Great product. I would recommend it to anyone who has a pet with liver disease.
By Mel
Edmond, OK
Helps my dog's liver problems
September 5, 2014
My dog had an abnormally high liver enzymes reading at her last annual physical. After taking Denosyl for several months, her latest checkup showed her liver enzyme levels were much lower.
By LikesArt
Helps the old girl hold her own
July 28, 2014
My 12-year-old rat terrier has been taking this for years per the vet's orders. It seems to be helping keep her pancreatitis stable.
By tigrattack
Hartwick, NY
Denosyl for dogs over 25 lbs (30 tablets) 225 mg
May 16, 2014
Product exactly as described...inexpensive and shipped fast A+++++

We love our little boy Timmy, he deserves the best and EntirelyPets is the best!
By Moongoon
denosyl for liver
March 3, 2014
My dog was put on this by our vet many years ago when he had to take phenobarb for seisures. It is to protect his liver.
By Tsmom
Great Product
January 30, 2014
My dog has a liver shunt and this product is much cheaper than the price that his vet charges. Thank you for such a great product.
By RTDfour
Denosyl at HALF the price!
August 30, 2013
This product is a liver function pill that our vet requires our terrier to be on. At the vet it costs us over $60 and through EntirelyPets we get it at HALF that price! When you have older dogs that take several medications, it adds up. This site saves us a lot of money! THANK YOU!!
By Suzanne
June 28, 2013
My dog, Molly, was diagnosed with liver disease over three years ago. She was not expected to live two years.

This medication, along with others and a special diet have kept her healthy and alive.

Entirely Pets has the best price.
Denosyl QUICK!
June 21, 2013
I ordered this online because I was in a rush and to get to the vet would, one, take forever, and two, be more expensive. I ordered the Denosyl on here and had it within a few days. It was a little cheaper and saved me time.

Thank you!
By Lainie
Boca Raton, FL
Life Saver
May 23, 2013
When my vet told me my precious pet needed this medication for her liver condition and what the charge was, I was floored.

You have saved my beautiful dog by providing the same medication the vet said was needed and even the same milligram for less than 1/2 the cost I would have paid at the Vets. I am 70 years old and live on social security and in low income housing. You have even saved my life since I was now able to purchase food for myself and for my puppie.
By Rose
December 9, 2012
My Beagle's liver numbers were 4 times out of normal range and became normal after using this product daily for a number of months. Seems like she will have to take it for the rest of her life to keep the numbers in a normal range.
By Vinny
Las Vegas, NV
Great product
October 30, 2012
Is greatly helping to keep my dog's liver functioning well.
By Judy
Oak Lawn, IL
denosyl 225 mg & hexedine soap
October 23, 2012
You have the best price on both the denosyl and hexedine. You have prompt service as far as the shipping. I am more than pleased and will continue to use you
By city-champ
Review for Denosyl for dogs over 25 lbs (30 tablets) 225 mg
July 24, 2012
Used in conjunction with Prednisone and Actigal for feline pancreatitis. So far lower GI symptoms have stopped, however only half-way through entire course of treatment.
By Laurie
Marysville, CA
Great 1st purchase experience
April 25, 2012
Great price compared to other sites and quick delivery. Will definitely make future purchases from Entirely Pets.
By Underthemattress
Northwestern US
Wonderful Lifesaving Product
April 15, 2012
Our 13 yr. old female mini schnauzer has been into emergency vet 4 times now for pancreatitis related issues. Since starting Denosyl and Marin, her liver values have greatly improved and no more tummy issues. Highly recommend and we will in all probability keep her on this for the rest of her life.
By Hootenanny
Rejuvenates you best buddy
January 13, 2012
My pal had three bouts of pancreatitis and elevated liver readings that were off the chart. Even though it's difficult to get my sweetie to have an empty stomach (which is needed to take this medicine), it's been a life saver. Thank you, Denosyl.
By Shelley
Best purchase
October 11, 2011
Excellent customer service and prompt delivery of brand name products. Prices very competitive also. Explanations of product very informative and clear regarding doasge and usage.
By Phyllis
Trussville, Alabama
Denosyl 225mg Tablets
September 13, 2011
I am so thankful for Entirely Pets. My dog had her gallbladder removed and had to start using Denosyl daily. Two different area vets wanted $80-$90 for this same product. When I found out I could order this from Entirely Pets, I have been very satisfied since my first order. They were efficient, cost effective and quick to send it through the mail. I would recommend Entirely Pets to anyone who wants great service and reasonable prices for their products.
By Christine
Save my Dog
January 17, 2008
Denosyl saved my dogs life. My Sheltie is epileptic and the meds for his seizures damaged his liver. He was a very sick dog but my Vet suggested Denosyl and Marin and within a week I noticed major improvement. In a months time his liver fuction is back to normal and he feels great! I highly recommend this product.

Questions and Answers