toTop
  1. Home > 
  2. Dog Supplies > 
  3. Kidney & Liver & Renal Health > 
  4. Liver Support Supplements > 
  5. Denosyl for Dogs & Cats > 
  6. Denosyl for Medium Dogs (30 tablets) 225 mg

  • DENSD4FORDOGDENSD4FORDOG
  • DENSD4FORDOGDENSD4FORDOG

Denosyl for Medium Dogs (30 tablets) 225 mg

Item: DENO225MG
1. Select pet size:
2. Select count:
QTY:-+
This item is currently out of stock!

Notice

NOTE: Limited supply item - only three (3) per customer per order.

Description

Denosyl is a daily supplement that helps support proper liver function. Support of a compromised liver, regardless of the cause, is essential if function is to be improved. Denosyl has not only been shown to markedly increase glutathione levels in the livers of dogs and cats, but to go far beyond that. Denosyl has been shown to protect liver cells from cell death and may be useful in cell repair and healing. It's main ingredient is S-Adenosylmethionine (SAMe).

Key Benefits:

  • Denosyl is formulated for liver and brain health
  • Increases levels of glutathione, an important compound for liver health
  • Has also been shown to help protect liver cells from cell death and may help cell reparation and regeneration
  • Increases cerebrospinal fluid in the brain that pets lose as they age
  • Easy to administer tablets for medium dogs

How It Works

Denosyl has been shown to markedly increase liver levels of glutathione,1,2 an important compound for liver health formed when SAMe (S-Adenosylmethionine) is metabolized. Denosyl has also been shown to help protect liver cells from cell death3,4 and may help cell repair and regeneration.5

While best known for supporting the liver in dogs and cats, research has shown that the SAMe in Denosyl may help support cognitive function in dogs.6 Denosyl provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.7-9

References

  1. Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66:330-341.
  2. Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
  3. Webster CRL, Boria P, Usechak P, et al. Vet Therapeutics 2002;3:474-484.
  4. McCool J, Johnston A, Webster CRL. In Proceedings. 21st Annual ACVIM Forum 2003;abstract #134.
  5. Center SA. In Proceedings. 18th Annual ACVIM Forum 2000;550-552.
  6. Rème CA, Dramard V, Kern L, et al. Vet Therap 2008;9(2):69-82.
  7. Tchantchou F, Graves M, Ortiz D, et al. J Nutr Health Aging 2006;10(6):541–544.
  8. Tchantchou F, Graves M, Falcone D, Shea TB. J Alzheimers Dis 2008;14:323–328.
  9. Shea TB, Chan A. J Alzheimers Dis 2008;13:67–70.
  10. Westfall DS, Twedt DC, Steyn PF, et al. J Vet Intern Med 2001;15(5):467-470.
  11. Graham JP, Lipman AH, Newell SM, Roberts GD. Am J Vet Res 2000;61(6):655-657.

Ingredients

S-Adenosylmethionine.

Useful Information

Because the tablet must be kept intact to prevent destruction by moisture, administration range is based on the nearest whole-tablet. The chart below is provided as a guide for administration. Daily administration may also be calculated based on 20 mg/kg of body weight and rounded to the closest tablet size or combination of sizes.

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. Studies have shown that, in many cases, tablets or capsules given as a "dry swallow" do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.10,11 Denosyl 90 mg tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.

Denosyl Canine and Feline Daily* Administration Guide

For Cats (90 mg)
Body Weight Body Weight Number of Tablets Per Day
Up to 12 lbs Up to 5.5 kg 1 tablet
Over 12 lbs Over 5.5 kg 2 tablets
For Small Dogs (90 mg)
Body Weight Body Weight Number of Tablets Per Day
Up to 12 lbs Up to 5.5 kg 1 tablet
For Medium Dogs (225 mg)
Body Weight Body Weight Number of Tablets Per Day
13 - 34 lbs 6 - 15.5 kg 1 tablet
For Large Dogs (425 mg)
Body Weight Body Weight Number of Tablets Per Day
35 - 65 lbs 16 - 29.5 kg 1 tablet
66 - 120 lbs 30 - 54.5 kg 2 tablets
Over 120 lbs Over 54.5 kg 3 tablets

The number of tablets can be gradually reduced or increased at any time depending on the pet's needs.

Many pets are maintained long-term on every-other-day or every-third-day administration.

Storage:

Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat.

FAQ

Denosyl is available enteric-coated tablets for cats and dogs.

The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.

Because it does so much, the liver may be subject to many things: injury, both direct and indirect, infection, and toxicity. Some of the signs and symptoms of compromised liver function in pets may include: weakness, vomiting, poor appetite, and/or seizures. But if there is mild or early stage liver compromise, the pet can appear normal. If you notice any of these symptoms or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.

Your veterinarian will advise you as to the amount to initially administer. Depending on your pet's response and status, your veterinarian may eventually adjust this amount to meet your pet's individual needs. Remember, Denosyl enteric-coated tablets should not be broken. When increasing or decreasing their administration, adjustments should be done in full tablet increments. Some pets are given Denosyl only for a short period of time, although Denosyl may be used longer in other animals.
While response varies, owners may note a change in their pet’s appetite, activity, and attitude.
Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Denosyl and how it may be helping to support your pet’s liver function.
Denosyl has been shown to be well-tolerated by both dogs and cats with a wide margin of safety.
Yes, your veterinarian may recommend combining Denosyl with other products and/or dietary modifications. There are no known adverse interactions of Denosyl with drugs or other supplements. Denosyl may even protect against negative effects on the liver caused by some medications.
While other S-Adenosylmethionine (SAMe) products are available, there can be a significant variance in product quality and activity levels of SAMe. Denosyl is produced using high-quality, researched ingredients and under strict manufacturing standards.
Administration of methionine is not recommended. Providing high levels of methionine to pets with liver compromise may not increase the production of natural S-Adenosylmethionine and has been shown in some cases to increase liver damage.

Like all medicines, Revolt has some side effects. The most common is hair loss at the site of application with or without inflammation (redness, flaking) in cats. Other side effects reported in cats and dogs include vomiting, diarrhea with or without blood, anorexia (decreased appetite), lethargy (sluggishness), salivation, rapid breathing, pruritus (itching), urticaria (welts, hives), erythema (skin redness), ataxia (incoordination), fever and rare instances of death. There have also been rare reports of seizures in dogs.

If you have additional questions about possible side effects, talk to your veterinarian.

In well-controlled clinical studies, selamectin was used safely in dogs and cats receiving other veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.

Tell your veterinarian about all medicines you have given your dog or cat in the past, and any medicines that you are planning to use with Revolt. This should include other medicines that you can get without a prescription. Your veterinarian may want to check that all of your dog's or cat's medicines can be given together.

Revolt is flammable - Keep away from heat, sparks, open flames or other sources of ignition. Store below 30°C (86°F). After application, empty tubes can be placed in your normal household refuse for disposal.

Customer Reviews

Review Summary
5.0
22 Reviews
5
95% (21)
4
5% (1)
3
0% (0)
2
0% (0)
1
0% (0)
95% Recommend this product (21 of 22 responses)
By Huili Q.
New York
good
March 24, 2022
good
By MaggieMom
FL
This product is keeping my dog's liver numbers in
June 10, 2018
Helps my dog with liver disease. Wouldn't go a day without it.
By Mona
Ellijay, Ga.
Amazing Product
September 24, 2014
Denosyl for dogs saved my little Ginger. Great product. I would recommend it to anyone who has a pet with liver disease.
By Mel
Edmond, OK
Helps my dog's liver problems
September 5, 2014
My dog had an abnormally high liver enzymes reading at her last annual physical. After taking Denosyl for several months, her latest checkup showed her liver enzyme levels were much lower.
By LikesArt
Atlanta
Helps the old girl hold her own
July 28, 2014
My 12-year-old rat terrier has been taking this for years per the vet's orders. It seems to be helping keep her pancreatitis stable.
By tigrattack
Hartwick, NY
Denosyl for dogs over 25 lbs (30 tablets) 225 mg
May 16, 2014
Product exactly as described...inexpensive and shipped fast A+++++

We love our little boy Timmy, he deserves the best and EntirelyPets is the best!
By Moongoon
denosyl for liver
March 3, 2014
My dog was put on this by our vet many years ago when he had to take phenobarb for seisures. It is to protect his liver.
By Tsmom
Great Product
January 30, 2014
My dog has a liver shunt and this product is much cheaper than the price that his vet charges. Thank you for such a great product.
By RTDfour
Denosyl at HALF the price!
August 30, 2013
This product is a liver function pill that our vet requires our terrier to be on. At the vet it costs us over $60 and through EntirelyPets we get it at HALF that price! When you have older dogs that take several medications, it adds up. This site saves us a lot of money! THANK YOU!!
By Suzanne
Denosyl
June 28, 2013
My dog, Molly, was diagnosed with liver disease over three years ago. She was not expected to live two years.

This medication, along with others and a special diet have kept her healthy and alive.

Entirely Pets has the best price.
By RTD4
Denosyl QUICK!
June 21, 2013
I ordered this online because I was in a rush and to get to the vet would, one, take forever, and two, be more expensive. I ordered the Denosyl on here and had it within a few days. It was a little cheaper and saved me time.

Thank you!
By Lainie
Boca Raton, FL
Life Saver
May 23, 2013
When my vet told me my precious pet needed this medication for her liver condition and what the charge was, I was floored.

You have saved my beautiful dog by providing the same medication the vet said was needed and even the same milligram for less than 1/2 the cost I would have paid at the Vets. I am 70 years old and live on social security and in low income housing. You have even saved my life since I was now able to purchase food for myself and for my puppie.
By Rose
Denosyl
December 9, 2012
My Beagle's liver numbers were 4 times out of normal range and became normal after using this product daily for a number of months. Seems like she will have to take it for the rest of her life to keep the numbers in a normal range.
By Vinny
Las Vegas, NV
Great product
October 30, 2012
Is greatly helping to keep my dog's liver functioning well.
By Judy
Oak Lawn, IL
denosyl 225 mg & hexedine soap
October 23, 2012
You have the best price on both the denosyl and hexedine. You have prompt service as far as the shipping. I am more than pleased and will continue to use you
By city-champ
Review for Denosyl for dogs over 25 lbs (30 tablets) 225 mg
July 24, 2012
Used in conjunction with Prednisone and Actigal for feline pancreatitis. So far lower GI symptoms have stopped, however only half-way through entire course of treatment.
By Laurie
Marysville, CA
Great 1st purchase experience
April 25, 2012
Great price compared to other sites and quick delivery. Will definitely make future purchases from Entirely Pets.
By Underthemattress
Northwestern US
Wonderful Lifesaving Product
April 15, 2012
Our 13 yr. old female mini schnauzer has been into emergency vet 4 times now for pancreatitis related issues. Since starting Denosyl and Marin, her liver values have greatly improved and no more tummy issues. Highly recommend and we will in all probability keep her on this for the rest of her life.
By Hootenanny
Rejuvenates you best buddy
January 13, 2012
My pal had three bouts of pancreatitis and elevated liver readings that were off the chart. Even though it's difficult to get my sweetie to have an empty stomach (which is needed to take this medicine), it's been a life saver. Thank you, Denosyl.
By Shelley
Best purchase
October 11, 2011
Excellent customer service and prompt delivery of brand name products. Prices very competitive also. Explanations of product very informative and clear regarding doasge and usage.
By Phyllis
Trussville, Alabama
Denosyl 225mg Tablets
September 13, 2011
I am so thankful for Entirely Pets. My dog had her gallbladder removed and had to start using Denosyl daily. Two different area vets wanted $80-$90 for this same product. When I found out I could order this from Entirely Pets, I have been very satisfied since my first order. They were efficient, cost effective and quick to send it through the mail. I would recommend Entirely Pets to anyone who wants great service and reasonable prices for their products.
By Christine
Save my Dog
January 17, 2008
Denosyl saved my dogs life. My Sheltie is epileptic and the meds for his seizures damaged his liver. He was a very sick dog but my Vet suggested Denosyl and Marin and within a week I noticed major improvement. In a months time his liver fuction is back to normal and he feels great! I highly recommend this product.

Questions and Answers

There are no questions or answers for this item.




RELATED ITEMS
Denosyl for small dogs and cats (30 tablets) 90 mgDenosyl for small dogs and cats (30 tablets) 90 mgReg price: $28.99
Sale price: $21.99
3 Pack Denosyl for small dogs and cats (90 tablets) 90 mg3 Pack Denosyl for small dogs and cats (90 tablets) 90 mgReg price: $85.99
Sale price: $65.97
3 PACK Denosyl for Medium Dogs (90 tablets) 225 mg3 PACK Denosyl for Medium Dogs (90 tablets) 225 mgReg price: $113.99
Sale price: $86.97
Denosyl for Large Dogs (30 tablets) 425 mgDenosyl for Large Dogs (30 tablets) 425 mgReg price: $64.99
Sale price: $49.99