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  6. Denosyl for Large Dogs 425 mg 90 tablets - 3 Pack

  • DENO3PK425DENO3PK425
  • DENO3PK425DENO3PK425
  • DENO3PK425DENO3PK425
  • DENO3PK425DENO3PK425
  • DENO3PK425DENO3PK425

Denosyl for Large Dogs 425 mg 90 tablets - 3 Pack

Item: DENO425MG-3PK
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NOTE: Limited supply item - only three (3) per customer per order.


Denosyl is a daily supplement that helps support proper liver function. Support of a compromised liver, regardless of the cause, is essential if function is to be improved. Denosyl has not only been shown to markedly increase glutathione levels in the livers of dogs and cats, but to go far beyond that. Denosyl has been shown to protect liver cells from cell death and may be useful in cell repair and healing. It's main ingredient is S-Adenosylmethionine (SAMe).

Key Benefits:

  • Denosyl is formulated for liver and brain health
  • Increases levels of glutathione, an important compound for liver health
  • Has also been shown to help protect liver cells from cell death and may help cell reparation and regeneration
  • Increases cerebrospinal fluid in the brain that pets lose as they age
  • Easy to administer tablets for medium dogs

How It Works

Denosyl has been shown to markedly increase liver levels of glutathione,1,2 an important compound for liver health formed when SAMe (S-Adenosylmethionine) is metabolized. Denosyl has also been shown to help protect liver cells from cell death3,4 and may help cell repair and regeneration.5

While best known for supporting the liver in dogs and cats, research has shown that the SAMe in Denosyl may help support cognitive function in dogs.6 Denosyl provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.7-9


  1. Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66:330-341.
  2. Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
  3. Webster CRL, Boria P, Usechak P, et al. Vet Therapeutics 2002;3:474-484.
  4. McCool J, Johnston A, Webster CRL. In Proceedings. 21st Annual ACVIM Forum 2003;abstract #134.
  5. Center SA. In Proceedings. 18th Annual ACVIM Forum 2000;550-552.
  6. Rème CA, Dramard V, Kern L, et al. Vet Therap 2008;9(2):69-82.
  7. Tchantchou F, Graves M, Ortiz D, et al. J Nutr Health Aging 2006;10(6):541–544.
  8. Tchantchou F, Graves M, Falcone D, Shea TB. J Alzheimers Dis 2008;14:323–328.
  9. Shea TB, Chan A. J Alzheimers Dis 2008;13:67–70.
  10. Westfall DS, Twedt DC, Steyn PF, et al. J Vet Intern Med 2001;15(5):467-470.
  11. Graham JP, Lipman AH, Newell SM, Roberts GD. Am J Vet Res 2000;61(6):655-657.



Useful Information

Because the tablet must be kept intact to prevent destruction by moisture, administration range is based on the nearest whole-tablet. The chart below is provided as a guide for administration. Daily administration may also be calculated based on 20 mg/kg of body weight and rounded to the closest tablet size or combination of sizes.

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. Studies have shown that, in many cases, tablets or capsules given as a "dry swallow" do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.10,11 Denosyl 90 mg tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.

Denosyl Canine and Feline Daily* Administration Guide

For Cats (90 mg)
Body Weight Body Weight Number of Tablets Per Day
Up to 12 lbs Up to 5.5 kg 1 tablet
Over 12 lbs Over 5.5 kg 2 tablets
For Small Dogs (90 mg)
Body Weight Body Weight Number of Tablets Per Day
Up to 12 lbs Up to 5.5 kg 1 tablet
For Medium Dogs (225 mg)
Body Weight Body Weight Number of Tablets Per Day
13 - 34 lbs 6 - 15.5 kg 1 tablet
For Large Dogs (425 mg)
Body Weight Body Weight Number of Tablets Per Day
35 - 65 lbs 16 - 29.5 kg 1 tablet
66 - 120 lbs 30 - 54.5 kg 2 tablets
Over 120 lbs Over 54.5 kg 3 tablets

The number of tablets can be gradually reduced or increased at any time depending on the pet's needs.

Many pets are maintained long-term on every-other-day or every-third-day administration.


Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat.


Denosyl is available enteric-coated tablets for cats and dogs.

The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver also helps process some medications into material(s) that can be used by the body; the liver may assist in eliminating medications from the body once they have had their effect. The liver stores vitamins and minerals and works with sugar (carbohydrates, glucose), fats and proteins. It also helps maintain proper blood clotting and removes many body toxins from the blood. Without proper liver function, the pet's health is compromised.

Because it does so much, the liver may be subject to many things: injury, both direct and indirect, infection, and toxicity. Some of the signs and symptoms of compromised liver function in pets may include: weakness, vomiting, poor appetite, and/or seizures. But if there is mild or early stage liver compromise, the pet can appear normal. If you notice any of these symptoms or your pet is just acting differently, you should contact your veterinarian. Many veterinarians run screening tests for middle aged and older patients during the annual examination to ensure that organ function is normal.

Your veterinarian will advise you as to the amount to initially administer. Depending on your pet's response and status, your veterinarian may eventually adjust this amount to meet your pet's individual needs. Remember, Denosyl enteric-coated tablets should not be broken. When increasing or decreasing their administration, adjustments should be done in full tablet increments. Some pets are given Denosyl only for a short period of time, although Denosyl may be used longer in other animals.
While response varies, owners may note a change in their pet’s appetite, activity, and attitude.
Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Denosyl and how it may be helping to support your pet’s liver function.
Denosyl has been shown to be well-tolerated by both dogs and cats with a wide margin of safety.
Yes, your veterinarian may recommend combining Denosyl with other products and/or dietary modifications. There are no known adverse interactions of Denosyl with drugs or other supplements. Denosyl may even protect against negative effects on the liver caused by some medications.
While other S-Adenosylmethionine (SAMe) products are available, there can be a significant variance in product quality and activity levels of SAMe. Denosyl is produced using high-quality, researched ingredients and under strict manufacturing standards.
Administration of methionine is not recommended. Providing high levels of methionine to pets with liver compromise may not increase the production of natural S-Adenosylmethionine and has been shown in some cases to increase liver damage.

Like all medicines, Revolt has some side effects. The most common is hair loss at the site of application with or without inflammation (redness, flaking) in cats. Other side effects reported in cats and dogs include vomiting, diarrhea with or without blood, anorexia (decreased appetite), lethargy (sluggishness), salivation, rapid breathing, pruritus (itching), urticaria (welts, hives), erythema (skin redness), ataxia (incoordination), fever and rare instances of death. There have also been rare reports of seizures in dogs.

If you have additional questions about possible side effects, talk to your veterinarian.

In well-controlled clinical studies, selamectin was used safely in dogs and cats receiving other veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.

Tell your veterinarian about all medicines you have given your dog or cat in the past, and any medicines that you are planning to use with Revolt. This should include other medicines that you can get without a prescription. Your veterinarian may want to check that all of your dog's or cat's medicines can be given together.

Revolt is flammable - Keep away from heat, sparks, open flames or other sources of ignition. Store below 30°C (86°F). After application, empty tubes can be placed in your normal household refuse for disposal.

Customer Reviews

Review Summary
40 Reviews
90% (36)
10% (4)
0% (0)
0% (0)
0% (0)
100% Recommend this product (40 of 40 responses)
By Jean
Great Product and Price
September 16, 2021
Offering the 3 pack was the biggest selling point for me.
  • Great price, fast shipping.
  • None
By David
Chilliwack, BC
March 19, 2021
International order of Denosyl for Large Dogs received very promptly; we have been very satisfied dealing with EntirelyPets for the past several orders, and will do so again
  • very fast, efficient service and delivery, even across the international border, and during the pandemic
  • price for this product has been increasing slightly, but is still a good deal
By Sharon
Prince George, BC
good service
November 2, 2020
Entirely Pets has been very good to deal with, if I have any questions they always get back to me, and are very helpful.
By Catharine
Coquitlam, BC
Great Customer Service
September 14, 2020
When my previous order did not arrive due to issues with shipping during COVID, customer service was very accommodating by offering a credit on my next purchase, and reimbursing me the equivalent amount that I spent with points. My next order arrived promptly, and the credit was issued directly to my bank account! Great customer service!
Merchant Response:Catharine, Thank you for understanding. We will get through this together. We mean only the best for you, your order and your pets.
By Capsparents
Portland, OR
Fair price
October 19, 2018
Our dog Cap has valley fever and our vet remommends Denyosyl to counteract the effects of his prescription medication. We're so glad we found entirely pets! With the semi regular sales they have, it's always have the most competitive price.
By Eyka3006
Chables FR, Schweiz
The best for my dogs
June 27, 2018
I will buy it again and again, thanks for good service
By Heidi
Pennsburg, PA
Great Stuff!!!
April 4, 2017
Our dog Bullet has been using Denosyl to improve the health of his liver. He does very well with these and has been taking them for over 2 years.
By clg144
Richland, WA
Great deal
January 22, 2016
Quality product, great pricing, I really appreciate the good deal..
By Tom
Review for 3 Pack Denosyl for dogs over 35 lbs (90 tablets) 425 mg
November 23, 2015
Product worked as recommended by our vet. lowered certain liver-related enzyme in out dog and she's back to normal
By Patzie
Lexington KY
Supplement that works
November 21, 2015
I hesitate to review supplements that border on being a medication because I am not a medical professional, but I will be happy to share my personal experience. My dog was diagnosed with atypical Addison's disease several years ago. She must take prednisone on a daily basis and long term use has damaged her liver. Her veterinarian recommended Denosyl. She has faithfully taken this supplement 2X a day for years and her liver values have remained "good" for a dog with her problems.
By Dozie's m.
Good value
August 3, 2015
This is a med I used to buy from our vet. It is about 1/2 price from Entirely Pets. So nice to get a bargain on a necessary medication.
By Debsieo
Denosyl seems to help
August 1, 2015
Our furry fellow has had a number of issues over the past year, including now being treated for diabetes with 2 injections of insulin/day. Denosyl treats his sub-par liver function and although I know his vastly improved health is due to a group of treatments (and can't know how much of it is specifically due to the Denosyl) he's in the best health he's been in for a long time and we're happy to continue all therapies, including the Denosyl. We're not going to quibble with success!
By Jen
Middleburg, PA
Helped my dog.
June 3, 2015
My vet recommended this product to help with liver support for my dog's copper storage disease. I'm glad I found this product here at a much more affordable price. It has really helped with his liver values and has extended his life.
By redlady
Gilbertsville, NY
good price for this product
May 19, 2015
I really don't know the effects of my dog taking this medication for his liver. Blood tests have not been redone since the start. I am hoping it is controlling his problem. Good price; good delivery time.
By baltos m.
long island, ny
price can't be beat
May 4, 2015
buying this med for my dog through entirely pets allows me to get one package free!
By linny
Las Vegas Nv.
March 29, 2015
well its almost one month since my Sadie has been taking this and not really sure if it is helping or not. I think it is but will no more when I get her another blood count on her liver. sure hoping that it helped bring the #s down, so we will see.
By Celje
Life saver
September 5, 2014
This product saved my senior dogs life. I would recommend it for liver problems for senior dogs.
By Tom
Denosyl for Cataracts in dogs
May 22, 2014
I use glutathione to control/reverse my cataracts, and I searched for a veterinary product to do the same for my dog Spike. Denosyl is sold for treating the liver, but if you read the "fine print" it greatly increases the dog's own production of glutathione in the liver. If you research glutathione you will learn that it 1.) must be made in the body from other precursors, and 2.) it performs many vital tasks in improving overall health. Denosyl is an excellent source of a precursor for glutathione (but not for human consumption - you can use Sam-E or N-Acetylcystiene to do that). It has significantly improved Spike's health.
By Ellie's M.
Phoenix, Arizona
Used Denosyl for years
April 1, 2014
Great product that has helped my dog who struggles with liver issues. She has been on Denosyl for many years and it has helped to keep her liver values stable.
By Jan
Saves Money
September 3, 2013
This product was prescribed for my dog by her vet. To purchase it from the vet costs twice as much as when you buy it from Entirely Pets. Good service too.
By NancyinTX
Life Saver for my best friend!
May 10, 2013
My then 13 year old Border Collie, Josie, was diagnosed with severe liver disease more than a year ago and declining rapidly. With a little research on of my own I made the decision to put her on a daily regime of a recommended LD product called Marin. When Marin was not readily available I substituted another LD product called Denosyl. To this daily dose I added a supplemental nutrient and antioxidant capsule of Proanthozone along with the vet recommended dose of Prednisone and a strict LD Diet kibble. It's amazing to see the quality of life Josie has enjoyed since I began the routine! She moves a little slower these days when she plays her favorite game of fetch but she is eating well, has a healthy coat and has regained her happy joyful personality! I don't know if it can be attributed to just one thing but, I'm not willing to risk changing any of it. Worth a try for sure. Please, NO MEAT SCRAPES no matter how much you'd like to give your pet a little treat, as just a small piece reverses Josie's condition drastically-learn from my mistake. Best to you and your beloved dog!
By Gene
saved my dogs life
April 15, 2013
This product saved my dogs life , I lost her mother to liver failure . I wished I had found it sooner . When I found Sadie was having the same problem as her mom the Vet said to try this , after 6 mo. her liver numbers were cut in half , I gave her 2 pills per day then after about 9 mo. her numbers were good enough that I now give her just one pill per day and her numbers are in the good range , and have been for about 9 mo. Best stuff ever
By Susan
Excellent Product
February 28, 2013
My dog was having serious liver problems a little more than a year ago and now he is doing great. He has been taking Denosyl for a year now and I wouldn't take him off it!!!
By Lablover
Required med
November 23, 2012
My dog take phenobarbitol and potassium bromide to prevent seizures. He takes Denosyl to keep his liver functioning well. He needs this and I am pleased that Entirely Pets can provide it.
By doris
Quebec, Canada
good product
November 1, 2012
I used to buy Zentonil but Denosyl do the same job. My dog's last blood test was very good.
By Sylvia
Burlington, ON
Denosyl 425mg
September 6, 2012
At the advice of our vet, our dog has just finished a 3-week course of Denosyl 425 and his liver is back to normal. Obviously the product worked and we are truly happy with his quick recovery.
By Red D.
Brought down liver enzymes
July 30, 2012
This product, along with Marin, and over the course of a few months, helped to significantly bring down our senior's high liver enzyme level.
By Clyde R.
North Carolina
Denosyl is a miracle worker!
June 5, 2012
I have a 15 year mixed breed dog who years ago was very ill and near death. The doctor said he had the same thing as Serosis of the liver. He told me to try Denosyl. This made a huge difference. He bounced back and has never been better. It may not work for all dogs but it is worth a try. Entirely Pets also sells it the cheapest.
By Ernie
Carlsbad, NM
March 26, 2012
This product works and the price at Engtirely Pets is better than others.
By fuzz
rhinelander WISCONSIN
great price
January 25, 2012
this product was a third the cost of purchasing through my vet. Thanks

Questions and Answers

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