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  6. 6 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)

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6 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs) Video

6 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)

Item: 5461650
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K9 Advantix II is one of the top choices for eliminating the resident tick or flea population. It is manufactured by Bayer, one of the leading pet care companies in the world. This product promises to kill and repel ticks, fleas, and mosquitoes. Its waterproof formulation remains effective even after the pet gets wet. The K9 Advantix II solution works by attacking all the life stages of the parasites killing adult bugs, larvae, and eggs. The K9 Advantix II Blue is a specialized product for extra large dogs weighing over 55 lbs. This particular pack contains 4 doses, which is good for 4 months of protection against ticks and fleas.

  • For extra large dogs weighing over 55 lbs
  • Manufactured by Bayer
  • Waterproof formulation
  • Repels ticks, fleas and mosquitoes
  • Kill parasites of all life stages
  • For dogs only


Imidacloprid: Imidacloprid is an ectoparasiticide, an antiparasitic agent that targets parasites living primarily on the surface of a host. Chemically classified as a chloronicotinyl nitroguanidine, imidacloprid inhibits neurotransmitter transmission in insects, resulting in paralysis and death.

Benefits: Imidacloprid exhibits both adulticide and larvicidal flea efficacy; it not only kills adult fleas and larvae on your pet, but it also kills larval stages in your pet's immediate surroundings.

Main Purpose: To kill fleas at all stages of their life cycles and stop them from being able to move or feed.

Permethrin: Permethrin is the additional ingredient in Advantix. It belongs to the Type I class of pyrethroid acaricides and insecticides, and it also acts as a repellent. Pyrethroids affect muscle and nerve cells' sodium ion channels by increasing their mean open time, which leads to hyperexcitability and death of the parasite.

Benefits: Thanks to its repelling activity, permethrin reduces parasite bites and thus the risk of diseases and stress for your dog.

Main Purpose: To repel ticks, sand flies, and mosquitoes; to kill ticks and fleas.

Two Proven Ingredients with Enhanced Activity: Imidacloprid and permethrin work together to overwhelm the nervous system of the parasite, providing neurotoxic activity beyond that of each compound alone. This leads to more profound and quicker insect paralysis and death.

Specifically, imidacloprid increases the efficacy of permethrin by activating insect nerve cells and increasing the frequency of neurotransmissions. As a result, more sodium channels are opened and the pyrethroid can interact much better with its target site.

Pyriproxyfen: Pyriproxyfen is a pyridine-based pesticide. A juvenile hormone analog, it interferes with the hormone signaling of growing insects, so that insects in immature stages are unable to mature. Additionally, a female insect that touches the toxin will produce eggs that will not hatch.

Benefits: Pyriproxyfen provides an added layer of protection for pets and their surroundings. It interrupts the flea life cycle at multiple stages, halting the growth and development of insect eggs and larvae and preventing re-infestation.

Main Purpose: To prevent flea eggs from hatching and larvae from growing.

Active Ingredients % by Weight
Imidacloprid 8.80%
Permethrin* 44.00%
Pyriproxyfen 0.44%
Other Ingredients 46.76%
Total 100%

Useful Information

Applying K9 Advantix II to your pet is a fast and easy process. First, remove the K9 Advantix II applicator tube from its packaging and use scissors to peel down the foil. Next, hold the applicator tube in an upright position and pull the cap off the tube. Use the upturned cap to break the protective seal, and you're ready for application.

For easiest application, your dog should be standing upright. Evenly apply the entire contents of the K9 Advantix II tube to two or three spots from the back of the shoulder to the base of the tail. Part the hair at each spot until the skin is visible, then place the tip of the tube on the skin and gently squeeze out a portion of the solution. Be careful not to apply an excessive amount of the solution in any one spot, otherwise some of the solution might run off the side of your dog. Dispose of the container and do not reuse or refill. Do not empty unused product in any indoor or outdoor drain.

For optimal control and prevention of parasites, use K9 Advantix II every month. K9 Advantix II is available in four- and six-month supplies. Do not use K9 Advantix II on cats or any animals other than dogs.

Application Instructions: Evenly apply the entire contents of the tube to four to six spots on the top of the back--from the shoulder to the base of the tail. Apply monthly.

Length of Effectiveness: Under normal conditions, the product is effective for one month. However, in cases of severe flea infestation, re-treatment may be necessary earlier than four weeks. Do not retreat more often than once every seven days. After flea control is attained, return to a monthly re-treatment schedule.

Hazards to Humans: Causes eye irritation. Harmful if swallowed. Do not get in eyes or on clothing. Avoid contact with skin. Wash hands thoroughly with soap and warm water after handling.

Hazards to Domestic Animals:

*For external use on dogs only. *Do NOT use on animals other than dogs. *Do NOT use on puppies under seven weeks of age.

Do not get this product on dog's eyes or mouth. Consult your veterinarian before using this product on debilitated, aged, pregnant, or nursing animals. Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately. If your animal is on medication, consult your veterinarian before using this product.

Do Not Use on Cats: Due to their unique physiology and inability to metabolize certain compounds, cats must not use this product. If applied to a cat, or ingested by a cat that actively grooms a recently treated dog, this product may have serious harmful effects. If this occurs, contact your veterinarian immediately.

Environmental Hazards: This product is extremely toxic to fish. Do not add directly to water. Do not contaminate water when disposing of product or package.

    First Aid: Have the product container or label with you when calling a poison control center or doctor, or when going for treatment.

    If in eyes: Hold eye open and rinse slowly and gently with water for 15 to 20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice.

    If swallowed: Call poison control center or doctor immediately for treatment advice. Have person sip a class of water if able to swallow. Do not induce vomiting unless told to do so by the poison control center or doctor. Do not give anything by mouth to an unconscious person.

    If on skin or clothing: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15 to 20 minutes. Call a poison control center or doctor for treatment advice.

    To physician: Treat patient symptomatically.

Keep out of reach of children.

Customer Reviews

76 Reviews
83% (63)
14% (11)
3% (2)
0% (0)
0% (0)
99% Recommend this product (75 of 76 responses)
By Lablady
Saluda, MC
March 27, 2019
Great product
I have used this product for over 10 years and we had no problems with fleas or ticks...
By Unit D.
Gilmer tx
March 6, 2019
Review for 6 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)
Works best nice price have used for many years never a problem
By gregthebug
Marietta, GA
October 29, 2018
Works well for my Golden Retriever
The fact that K9 Advantix II works not only to kill fleas and ticks, but has a repellant feature as well sole me on the product. As well as the Bayer name. So far, so good, and I've used it with success for over a year.
ProsRepels and kills pests.
ConsA bit greasy for a few days.
By Kimberly
Washington State
May 2, 2018
Works Great!
We have been using Advantix for years now and I have never seen a flea on our dogs =)
ProsEasy to apply
By Leahsmom
Maryville TN
April 10, 2018
Have been using this product for 3 years or more. Never a flea or tick. Very happy with the results.
By Rej
June 19, 2017
K9 Advantix
the product is fine but because the customs paper work was not done I had to pay an additional $22.00 which was really disappointing. I will not order again. Between the shipping cost and the custom cost it makes the product more expensive than buying it at the vet.
By Bev
May 29, 2017
We was looking for something affordable to take care if our dogs.. Thank you for providing an affordable service.
By Marty
October 21, 2016
Great for my dogs
I have used this product for over 10 years with all of my dogs. They have not had fleas or ticks at all. They all do hunt work and are definitely exposed to these pests!
Would not do without it.
By No f.
June 16, 2016
K9 advantix
Have 4 big dogs,k9 advantix does best for them and entirely pets has the best price,thanks for offering and FAST shipping
By Jen
April 13, 2016
Excellent F&T Protection
My golden retriever is a farm dog, and he's out most of the day in the pasture and the woods, so he's in tick territory a lot of the time. I have tried other spot protection, but none worked as well as K9 Advantix. No fleas and almost no ticks. I highly recommend it.
March 23, 2016
Great [product
Works very well on 2 big dogs that have a lot of lawn and woods to roam in
By Pyrparent
December 19, 2015
Really great protection.
I have been using this product for quite a while, and my dogs are flea and tick free. Last spring and summer were bad for ticks, but my dogs never had the first tick on them. They are all long haired dogs, and we live in the country. So I think that says a lot about the protection afforded the dogs by using K9 Advantix II. I would recommend this product.
By Lee
Miami, F
October 31, 2015
Good flea prevention at least cost
K9 Advantix works just as well as Frontline Plus but costs less. With multiple dogs because I rescue effectiveness coupled with cost is a priority. I will NOT use the lower end products they don't work as well. K9 Advantix gets the job done here in Miami, FL for me. *(If ticks are a problem couple K9 Advantix with a Preventic Collar.)
By kate
Cheasapeake, VA
June 13, 2015
Good Purchase
Easy purchase with coupon and free ship.
By Lin
Hollis, Prince of Wales Island, Alaska
March 24, 2015
Great Product for Pest Protection
As always, I received my order in a timely manner for shipping to Alaska, thanks to EntirelyPets! Not every company will ship here, especially flea/tick meds. K9Advantix is a wonderful product, the best I have used for my Newfoundland dogs. Here in my area of Ak. we have no flea issue but the biting flies and mosquitoes are horrible....this completely protects my dog from being bitten. Unlike other flea protection products, this one protects against a large list of pests to keep my dog healthy, pest free and comfortable. As we are in the forest a lot I don't have to worry about him getting ticks and mites from the numerous wild animals around. I love K9 Advantix and I bet my dog Luke would say the same!
By gmn
February 16, 2015
K9 Advantix II
My vet recommended this product. The girls (my 2 female dogs) are very co-operative. Sometimes it runs a bit causing greasy fur but I have had no issues with them licking it off of each other. If they do happen to rub against walls or furniture, it will leave a grease mark, even when it hasn't greased their fur.
It works, I have had no fleas or ticks in their 6 years.
By Kimberly
Washington State
January 21, 2015
We Love This Stuff
Many other people I know struggle with fleas on their pets, but we NEVER have fleas on our dogs.
By burt
January 16, 2015
good change
I've been using Frontline for several years and decided it was time for a change.I am glad i did, as we live in a tick infested area. When my wife brushed my Golden after several days she combed out 3 ticks.
By Pam
Statesville, North Carolina
August 17, 2014
Advantix works great!
Sam stays outside and he is older, so he needs the protection from fleas, ticks, flies, etc that Advantix provides. Entirely Pets has the best price on Advantix and fast service. I won't order from anywhere else.
By kittenonkeys
Central Louisiana
August 6, 2014
K9 Advantix II Flea & Tick Control
I've been using this product for my pets for several years now, and it is very effective. Entirely Pets ships quickly, and this is a convenient way to shop.
By nantucket903
New Jersey
May 30, 2014
Advantix II Blue for Extra Large Dogs
This is a great product keeping the fleas and ticks away from my dogs. No pills to take, just open the foil and put the liquid from the neck to tail, couldn't be simpler.

I recommend my friends to your site because of your variety, prices and fast shipping!

Thank you for offering affordable products for our pets!
By Cassie91
May 16, 2014
Review for 6 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)
K-9 Advantix works great on fleas and ticks, it is also a very reasonable price!
By Just L.
Auburn, Michigan
May 4, 2014
VERY pleased with this product!
We have a German Shepherd who tends to get irritated skin rather easily, so it's really important to me that he is comfortable and itch-free. Between the change in diet and the use of this product, he is a much happier dog! No more scratching and nibbling at himself. K9 Advantix works fast and I love that it kills multiple pests at multiple stages - it pretty much covers all the bases!
By groomer
Woodridge, Il
April 8, 2014
Great product Great Company
I love K9 Advantix, I am a groomer and I have my dog at the shop with me all the time. As you can imagine many dogs come in with fleas and we do flea baths and recommend K9 Advantix but for as long as I have been using the product, even being around all the other dogs with fleas my dog has never gotten fleas.
By gotti
April 2, 2014
the best
have been using this product for years now and it is the best used on my three dogs-no problems
By lilachaze
Upstate NY
February 19, 2014
Good product
But not as easy to use as other flea/tick drops.
By Mary
February 14, 2014
works great
I have used this product for all of my dogs and it works like advertised and I am very satisfied.
By Murdoc
November 14, 2013
Advantix works great
We live in a swampy area with lots of flying insects and have found that Advantix really helps keep mosquitoes and yellow flies away from our dogs.
San Diego, CA
October 11, 2013
Good Purchase
I like this product. It takes care of more little pests that the dogs go through. With the West Nile Virus and others pests, the dogs won't have to suffer with the diseases that these pests cause.
By Deb
Pensacola, FL
September 18, 2013
Flea Free
We have three dogs and a large yard. We are flea free thanks to Advantix II. We use the cat formula for our cat as well.
Easy to administer and Entirely pets makes it very affordable. Makes for happy dogs & cats and happy owners!!

Questions and Answers

1 Question & 1 Answer
from Sackville, Nova Scotia asked:
April 22, 2015
how many ml is in each application of K9advantixII for extra large dog? I have left over advantix for large dog (2.5ml) and want to use it up on a larger (extra large) dog.
1 Answer
Do not use left over doses on other dogs. This product is intended to have a full dose administer to each pet and should not be used in partial doses.
Submitted by: Customer Service on April 22, 2015

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