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  6. K9 Advantix II Small Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 4-10 lbs. | 4-Mo Supply


K9 Advantix II Small Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 4-10 lbs. | 4-Mo Supply

Item: 5458455
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K9 Advantix II helps defend your dog against fleas, ticks, mosquitoes, biting flies, and lice. Simpler than a flea collar and troublesome pills, this vet-recommended topical formula works within 12 hours of initial application, killing adult fleas on contact to stop existing flea infestations and prevent new ones. Once K9 Advantix II is applied, your dog is ready to get right back to the things it loves most. K9 Advantix II pest protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh 4-10 lbs. to use K9 Advantix II Small Dog.

K9 Advantix II Small Dog is a trademark of Elanco or its affiliates.

Key Benefits:

  • K9 Advantix II Small Dog 30-day treatment & prevention protects dogs 4-10 lbs. from fleas, ticks, mosquitoes, biting flies and lice
  • Kills fleas within 12 hours of application
  • Vet-recommended formula kills & repels on contact so fleas don't have to bite your dog to die
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
  • No prescription needed


Imidacloprid: Imidacloprid is an ectoparasiticide, an antiparasitic agent that targets parasites living primarily on the surface of a host. Chemically classified as a chloronicotinyl nitroguanidine, imidacloprid inhibits neurotransmitter transmission in insects, resulting in paralysis and death.

Benefits: Imidacloprid exhibits both adulticide and larvicidal flea efficacy; it not only kills adult fleas and larvae on your pet, but it also kills larval stages in your pet's immediate surroundings.

Main Purpose: To kill fleas at all stages of their life cycles and stop them from being able to move or feed.

Permethrin: Permethrin is the additional ingredient in Advantix. It belongs to the Type I class of pyrethroid acaricides and insecticides, and it also acts as a repellent. Pyrethroids affect muscle and nerve cells' sodium ion channels by increasing their mean open time, which leads to hyperexcitability and death of the parasite.

Benefits: Thanks to its repelling activity, permethrin reduces parasite bites and thus the risk of diseases and stress for your dog.

Main Purpose: To repel ticks, sand flies, and mosquitoes; to kill ticks and fleas.

Two Proven Ingredients with Enhanced Activity: Imidacloprid and permethrin work together to overwhelm the nervous system of the parasite, providing neurotoxic activity beyond that of each compound alone. This leads to more profound and quicker insect paralysis and death.

Specifically, imidacloprid increases the efficacy of permethrin by activating insect nerve cells and increasing the frequency of neurotransmissions. As a result, more sodium channels are opened and the pyrethroid can interact much better with its target site.

Pyriproxyfen: Pyriproxyfen is a pyridine-based pesticide. A juvenile hormone analog, it interferes with the hormone signaling of growing insects, so that insects in immature stages are unable to mature. Additionally, a female insect that touches the toxin will produce eggs that will not hatch.

Benefits: Pyriproxyfen provides an added layer of protection for pets and their surroundings. It interrupts the flea life cycle at multiple stages, halting the growth and development of insect eggs and larvae and preventing re-infestation.

Main Purpose: To prevent flea eggs from hatching and larvae from growing.

Active Ingredients % by Weight
Imidacloprid 8.80%
Permethrin* 44.00%
Pyriproxyfen 0.44%
Other Ingredients 46.76%
Total 100%

Useful Information

Applying K9 Advantix II to your pet is a fast and easy process. First, remove the K9 Advantix II applicator tube from its packaging and use scissors to peel down the foil. Next, hold the applicator tube in an upright position and pull the cap off the tube. Use the upturned cap to break the protective seal, and you're ready for application.

For easiest application, your dog should be standing upright. Evenly apply the entire contents of the K9 Advantix II tube to two or three spots from the back of the shoulder to the base of the tail. Part the hair at each spot until the skin is visible, then place the tip of the tube on the skin and gently squeeze out a portion of the solution. Be careful not to apply an excessive amount of the solution in any one spot, otherwise some of the solution might run off the side of your dog. Dispose of the container and do not reuse or refill. Do not empty unused product in any indoor or outdoor drain.

For optimal control and prevention of parasites, use K9 Advantix II every month. K9 Advantix II is available in four- and six-month supplies. Do not use K9 Advantix II on cats or any animals other than dogs.

Application Instructions: Evenly apply the entire contents of the tube to four to six spots on the top of the back--from the shoulder to the base of the tail. Apply monthly.

Length of Effectiveness: Under normal conditions, the product is effective for one month. However, in cases of severe flea infestation, re-treatment may be necessary earlier than four weeks. Do not retreat more often than once every seven days. After flea control is attained, return to a monthly re-treatment schedule.

Hazards to Humans: Causes eye irritation. Harmful if swallowed. Do not get in eyes or on clothing. Avoid contact with skin. Wash hands thoroughly with soap and warm water after handling.

Hazards to Domestic Animals:

*For external use on dogs only. *Do NOT use on animals other than dogs. *Do NOT use on puppies under seven weeks of age.

Do not get this product on dog's eyes or mouth. Consult your veterinarian before using this product on debilitated, aged, pregnant, or nursing animals. Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately. If your animal is on medication, consult your veterinarian before using this product.

Do Not Use on Cats: Due to their unique physiology and inability to metabolize certain compounds, cats must not use this product. If applied to a cat, or ingested by a cat that actively grooms a recently treated dog, this product may have serious harmful effects. If this occurs, contact your veterinarian immediately.

Environmental Hazards: This product is extremely toxic to fish. Do not add directly to water. Do not contaminate water when disposing of product or package.

    First Aid: Have the product container or label with you when calling a poison control center or doctor, or when going for treatment.

    If in eyes: Hold eye open and rinse slowly and gently with water for 15 to 20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice.

    If swallowed: Call poison control center or doctor immediately for treatment advice. Have person sip a class of water if able to swallow. Do not induce vomiting unless told to do so by the poison control center or doctor. Do not give anything by mouth to an unconscious person.

    If on skin or clothing: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15 to 20 minutes. Call a poison control center or doctor for treatment advice.

    To physician: Treat patient symptomatically.

Keep out of reach of children.

Customer Reviews

Review Summary
26 Reviews
62% (16)
23% (6)
0% (0)
8% (2)
8% (2)
85% Recommend this product (22 of 26 responses)
By who w.
horrible worthless stuff
August 3, 2020
horrible doesnt work on my 7 lb dog Vet says its worthless stay away from it
By Jesse
Best way to keep nasty ticks away!
August 6, 2019
Easy to apply and worth every penny.
  • Fast and easy
  • Not really any
By CajsLilBear
Bye bye fleas
May 7, 2018
My baby is relieved now that the fleas are gone!! It worked almost instantly. The fleas that were left on him just dropped off him dead!!
  • Works great!
Cumberland, Md.
Best product
July 19, 2014
I am very happy with k-9 Advantix ll, because you can get it to fit the size and weight of my pet. The service you get from Entirely Pets has been excellent.
By GolfingGuy
Southern Illinois
May 15, 2014
I have been purchasing the best flee and tick products from EntirelyPets for years. Great company to work with and will continue to do so.
By Sandraelaine
Upstate NY (Adirondacks)
It Works
February 18, 2014
It is getting more and more difficult to find a product that effectively controls fleas and ticks.
This product worked.
By sophie
pleasant valley, ny
k9 advantix II-not happy
October 31, 2013
I am not seeing very good results with this product. Have found two ticks on my dog, both attached, since using this product. I think Frontline Plus is the better option
October 1, 2013
I like this product because it goes by the animals weight. It is a Little expensive, But it works.
By tackettteri
Good stuff
August 15, 2013
There wasn't any fleas what so ever, good stuff, will be buying this for all of my pets
By cathy01
London Ontario
K9 Advantage
June 20, 2013
Product seems to work great.Our dog is outside quite a bit and so far no flees. I would order this product again and it arrived fairly fast.
By kidhauler1948
Southeastern CT
Haven't made up my mind yet !!
May 27, 2013
My Yorkie has used this but has yet to get a full month of protection. We still get 3-4 ticks the last 2 weeks of the month but we do live in the woods in an infested area. No fleas. I am going to use the rest of my purchase before making up my mind.
By Asiedydd
Disappointed - ticks
April 30, 2013
After reading several positive online reviews, I switched to K9 Advantix II. I quickly found it's not at all effective at preventing ticks. I'll be switching back to Frontline.
By Lindy
Boca Raton, Fl.
Thank Goodness!
February 17, 2013
I was desparate.. had mega fleas for the first time ever. Frontline had stopped working and I was terrified to put anything on my Havanese after having read all the reviews.
I actually took 2 days off work so I could be home to monitor in case anything went wrong. Well the fleas started to leave and there were no side affects. I have used it the 2nd time now and still good so I must say that it's working for me.
By Vaslaun
Simple and Easy to use
January 26, 2013
product arrived quickly. read directions inside box and instantly applied on puppy. immediately less itching.
By Lorie
Oxnard, Calif.
K9 Advantix II Small Dog (for dogs up to 10lbs)
December 29, 2012
I never saw fleas on my dogs. Easy to apply. My dogs do play outdoors in the grass and in the dirt area, yet they are protected from fleas. I bathe my own dogs, therefore I am aware of no fleas. I would recommend this product.
By jam
Tired of fleas and ticks
December 16, 2012
I like this product as it does keep the ticks and fleas away. My dog however still gets a few fleas in the summer time and I thought this product was suppose to repel the fleas from even getting on my dog, but a few fleas I can deal with, I can't deal with ticks and this product works for that.
By dutyla
Pittsburgh Pa
December 7, 2012
This product worked fabulously! I was very happy with the results. My dog is 8lbs.and 4 years old.
By Mello
Worked Well
November 22, 2012
We've been battling ticks. Advantix II didn't work 100% as advertised, but it's making it easier to control.
By Ney
Works Great
August 3, 2012
Have used this many times before and it has done a wonderful job.
Best Purchase
July 17, 2012
I am pleased with k9 advantix ll because it works and it is made for smaller dogs. I hope the service I have received from entirely pets continues to be to be the best. Thank you.
By Toot
Wilmington, NC
Very good product, always purchase this product
July 5, 2012
This is an excellent product and the price is reasonable.
By Sherry
Wilmington, NC
Great purchase
March 28, 2012
I have always used this product. It works!
By Nikki
Not a good buy
November 14, 2011
I had been using Frontline but decided to switch and try this because it claimed to repel fleas, bad idea. After 2 weeks my dog still has fleas crawling on her and bitting! I will be switching back to frontline.
By Lyn
Elverta CA
I Love My Pets
October 27, 2011
I have been using Advantix for about six years or longer. I have used other flea prouducts and nothing works like Advantix. I will never put another flea product on my little dogs again. I tell everybody who I know with dogs or cat Advantix is the best. I've even bought their pets Advantix to prove how great it is. I Love My Pets that's why they use Advantix.
By Trace
Timely, but the package was a little smashed
October 9, 2011
I would definitely order from this company again. The order was shipped to me quickly for my little guy. The prices were the lowest I could find. The only issue I had was the packaging was a little smashed. Not sure if it shipped that way of happened in transit. All the contents were unharmed, though.
By Woody
Prunedale, CA
Best Online Pet Supply Store
October 9, 2011
From my first order I was impressed. I ordered flea treatments for my cats and dogs and it arrived the next day! How was that even possible? Not to mention the lowest prices I have found anywhere, Can't recommend Entirely Pets enough. 5 stars.

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