1. Home > 
  2. Dog Supplies > 
  3. Flea & Tick Supplies > 
  4. Topicals > 
  5. K9 Advantix II for Dogs: Flea & Tick Control > 
  6. 4 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)

4 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs) Video

4 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)

Item: 5461626
Compare to: $64.99
and Ships Free!*
You Save: $15.00!(23%)


K9 Advantix II is one of the top choices for eliminating the resident tick or flea population. It is manufactured by Bayer, one of the leading pet care companies in the world. This product promises to kill and repel ticks, fleas, and mosquitos. Its waterproof formulation remains effective even after the pet gets wet. The K9 Advantix II solution works by attacking all the life stages of the parasites killing adult bugs, larvae, and eggs. The K9 Advantix II Green is a specialized product for large dogs weighing 21-55 lbs.

  • For large dogs weighing 21-55 lbs
  • Manufactured by Bayer
  • Waterproof formulation
  • Repels ticks, fleas and mosquitoes
  • Kill parasites of all life stages
  • For dogs only
  • Ingredients

    Imidacloprid is an ectoparasiticide, an antiparasitic agent that targets parasites living primarily on the surface of a host. Chemically classified as a chloronicotinyl nitroguanidine, imidacloprid inhibits neurotransmitter transmission in insects, resulting in paralysis and death.

    Imidacloprid exhibits both adulticide and larvicidal flea efficacy; it not only kills adult fleas and larvae on your pet, but it also kills larval stages in your pet's immediate surroundings.

    Main Purpose
    To kill fleas at all stages of their life cycles and stop them from being able to move or feed.

    Permethrin is the additional ingredient in Advantix. It belongs to the Type I class of pyrethroid acaricides and insecticides, and it also acts as a repellent. Pyrethroids affect muscle and nerve cells' sodium ion channels by increasing their mean open time, which leads to hyperexcitability and death of the parasite.

    Thanks to its repelling activity, permethrin reduces parasite bites and thus the risk of diseases and stress for your dog.

    Main Purpose
    To repel ticks, sand flies, and mosquitoes; to kill ticks and fleas.

    Two Proven Ingredients with Enhanced Activity
    Imidacloprid and permethrin work together to overwhelm the nervous system of the parasite, providing neurotoxic activity beyond that of each compound alone. This leads to more profound and quicker insect paralysis and death.

    Specifically, imidacloprid increases the efficacy of permethrin by activating insect nerve cells and increasing the frequency of neurotransmissions. As a result, more sodium channels are opened and the pyrethroid can interact much better with its target site.

    Pyriproxyfen is a pyridine-based pesticide. A juvenile hormone analog, it interferes with the hormone signaling of growing insects, so that insects in immature stages are unable to mature. Additionally, a female insect that touches the toxin will produce eggs that will not hatch.

    Pyriproxyfen provides an added layer of protection for pets and their surroundings. It interrupts the flea life cycle at multiple stages, halting the growth and development of insect eggs and larvae and preventing reinfestation.

    Main Purpose
    To prevent flea eggs from hatching and larvae from growing.

    Active Ingredients % by Weight
    Imidacloprid 8.80%
    Permethrin* 44.00%
    Pyriproxyfen 0.44%
    Other Ingredients 46.76%
    Total 100%

    Useful Information

    How to Apply

    Applying K9 Advantix II to your pet is a fast and easy process. First, remove the K9 Advantix II applicator tube from its packaging and use scissors to peel down the foil. Next, hold the applicator tube in an upright position and pull the cap off the tube. Use the upturned cap to break the protective seal, and you're ready for application.

    For easiest application, your dog should be standing upright. Evenly apply the entire contents of the K9 Advantix II tube to two or three spots from the back of the shoulder to the base of the tail. Part the hair at each spot until the skin is visible, then place the tip of the tube on the skin and gently squeeze out a portion of the solution. Be careful not to apply an excessive amount of the solution in any one spot, otherwise some of the solution might run off the side of your dog. Dispose of the container and do not reuse or refill. Do not empty unused product in any indoor or outdoor drain.

    For optimal control and prevention of parasites, use K9 Advantix II every month. K9 Advantix II is available in four- and six-month supplies. Do not use K9 Advantix II on cats or any animals other than dogs.

    Application Instructions

    Evenly apply the entire contents of the tube to four to six spots on the top of the back--from the shoulder to the base of the tail. Apply monthly.

    Length of Effectiveness

    Under normal conditions, the product is effective for one month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven days. After flea control is attained, return to a monthly retreatment schedule.

    Hazards to Humans

    Causes eye irritation. Harmful if swallowed. Do not get in eyes or on clothing. Avoid contact with skin. Wash hands thoroughly with soap and warm water after handling.

    Hazards to Domestic Animals

    *For external use on dogs only.
    *Do NOT use on animals other than dogs.
    *Do NOT use on puppies under seven weeks of age.

    Do not get this product on dog's eyes or mouth. Consult your veterinarian before using this product on debilitated, aged, pregnant, or nursing animals. Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately. If your animal is on medication, consult your veterinarian before using this product.

    Do Not Use on Cats

    Due to their unique physiology and inability to metabolize certain compounds, cats must not use this product. If applied to a cat, or ingested by a cat that actively grooms a recently treated dog, this product may have serious harmful effects. If this occurs, contact your veterinarian immediately.

    Environmental Hazards

    This product is extremely toxic to fish. Do not add directly to water. Do not contaminate water when disposing of product or package.

    First Aid

    Have the product container or label with you when calling a poison control center or doctor, or when going for treatment.

    If in eyes: Hold eye open and rinse slowly and gently with water for 15 to 20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice.

    If swallowed: Call poison control center or doctor immediately for treatment advice. Have person sip a class of water if able to swallow. Do not induce vomiting unless told to do so by the poison control center or doctor. Do not give anything by mouth to an unconscious person.

    If on skin or clothing: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15 to 20 minutes. Call a poison control center or doctor for treatment advice.

    To physician: Treat patient symptomatically.

    Keep out of reach of children.

    Customer Reviews

    41 Reviews
    80% (33)
    17% (7)
    0% (0)
    2% (1)
    0% (0)
    98% Recommend this product (40 of 41 responses)
    By Binglebug B.
    Tacoma, WA
    February 15, 2019
    Great Service
    I've used this on several of my brittanys and it keeps them flea free.
    By Jax m.
    September 10, 2018
    Did not work enough
    I wanted To try a new preventative since my current one was not working.
    This helped very little for my dog's fleas.
    I had to replace it after a couple of months with another product.
    By Aussie m.
    Pataskala, Ohio
    August 16, 2018
    Great product
    Switched to this flea/tick after another product I was using failed to protect my baby. Have used this for several years now and have not had any problems.
    ProsWorks fast
    By Pammy
    June 11, 2017
    We Love it!
    We love this product. We have used it before, and it really works. I highly recommend this product!
    We have tried different brands of tick treatments in the past, and those products did not work! Our black lab got ticks from those other brands. With this product, he no longer has or had any ticks.
    By Meddylaker
    Baileyville, ME
    July 27, 2016
    The Best!
    Tried Frontline Plus which was like using nothing but costing $100 for cat and dog. Then, we tried K-9 Advantix and Advantix for our kitty. What a difference. It's been a week and - no fleas, no itching or chewing. Happy pets and pet parents.
    By bren
    April 30, 2016
    4 month advantix
    I use this product all the time, but I usually get it from my vet. thanks for a fantastic deal, as it is quite expensive.
    By danfromdewey
    June 18, 2015
    Easy to apply
    This product is easy to apply as directed and really seems to work so far. I was very leery of the tick & flea products that you gave in a pill or tablet form. Each of these had a list of side effects that were downright scary. K9 Advantix caused no side effects at all, and again was very easy to apply.
    By Susan
    April 7, 2015
    Review for 4 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)
    This products works as it should. We walk in the woods all the time and no ticks or evidence of Lyme's disease. Never had fleas either.
    By Chieko
    North Carolina
    August 20, 2014
    Pleasantly surprised
    It really does repel small knats and flies.
    By Jim
    June 12, 2014
    Good Product
    I recommend this product and would purchase again.
    By Corrine
    Cleveland Ohio
    March 20, 2014
    Advantix II
    Best stuff on the market...protects your dogs from everything,,,and my dogs do not have a allergic reaction to this products like other ones...This is a little pricey, but worth it
    By Angie
    November 13, 2013
    It worked
    I had used frontline for years, and then my dogs got fleas. All 4 of them. I tried everything, from knockout spray, flea dips, flea combs, frontline spray, bought a carpet shampooer, diatamacious earth, nothing helped. I vacuumed every day, and washed every sheet blanket, slipcover in the house every 2 days. After I applied the advantic I saw an 80% improvement within a day.
    By Shirl
    SE TX
    October 17, 2013
    K9 Advantix II -- A good product.
    After trying this product for the first time, I am glad I did. Put this product on some young dogs that were loaded with fleas. 24 hours later the fleas were gone! Would definitely recommend this product!
    By carrolljung1
    Bennett Valley, CA
    October 12, 2013
    Better than Frontline
    We have had a terrible flea problem where I live late summer and fall......Frontline was not working for my dog and for my neighbors' dogs as well. I switched to Advantix because we also have lots of ticks in the area (we live in rural Sonoma County CA) The Advantix has worked better....but our dogs still get fleas before a month on the dogs. Any suggestions????
    By BeagleBoy
    October 12, 2013
    K9 Advantix
    I've used this product for the past 4 yrs and my dog has never had fleas or ticks so I'm assuming this product is very effective. Its easy to use and is very affordable.
    By JacKay
    Edenton, NC
    August 22, 2013
    K9 advantix II
    I have recently adopted a chow/golden mix from the animal shelter. The owners turned him in. He was using this flea and tick preventive when he was turned in. I have been pleased with this product although the vet I use stopped selling it because it was not giving adequate protection for sand fleas. We travel to go to this vet so we do not live on the beach. The product has been fine although he does do a little scratching but I am quite sure he is flea and tick free. We live around pine trees so ticks are very prevalent and I have not seen one on him.
    By Ellie M.
    August 21, 2013
    We've been using another popular brand for years because it also treats for ticks. We live near a wooded area where ticks attack. This dog is unable to take internal flea meds due to pancreatitis and suffers terribly from the flea bites. So, just as horse owners rotate those wormers, it seemed that a change in flea meds couldn't hurt. Discovered that this product also treats for ticks and so we gave it a go. Our dog has now had three quiet weeks of seemingly flea free days and nights.
    On the down side, it is oily and our dog has silky hair so the oil spreads out and looks terrible until we can bath him.
    Also, we no longer have a vibrator on our bed...
    By Desiree
    New York
    August 13, 2013
    Great product!!
    I have been purchasing this product for years now and have never been disappointed!!
    By barbie
    Parsippany, NJ
    July 17, 2013
    very good product
    K9 Advantix is the best product to keep mosquitos away from your dog. Mosquitos are more attracted to light or white color dogs. This was my first time using this product and not one bite since, and this year its a bad season.
    By bandana
    Bayboro, NC
    April 19, 2013
    great product
    Never used advantix before it works really
    well. so far no fleas very good value and
    fast shipping.
    By tdh
    charlotte, nc
    March 13, 2013
    Review for 4 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)
    A friend of mine recommended this product after having tried several others. I decided to not waste my money doing the same thing and have been ordering this for 1.5 years. We have 2 dogs and in that time I have only seen 1 flea on one dog. However, I have had a few bite me and my indoor cats keep getting fleas.
    By Diane
    Sidney, Ohio
    February 21, 2013
    love it
    This product is great no more fleas or ticks.
    By Brittany G.
    Puyallup, WA
    January 8, 2013
    Excellent product
    Fleas just aren't a problem after using this product.
    By Nancy R.
    Sacramento, CA
    December 9, 2012
    Only use this product
    I have used this product for a number of years for my dogs. I use the one for 21-55 lbs and the one for over 55 pounds. Since we have huge yard they play outside a big part of each day in all seasons. They have never had a flea or any other kind of bug. Since one of them is a Golden Retriever, fleas could be devastating. I am thankful for this product and for Entirely Pets.
    By wfbanker
    Wake Forest NC
    November 29, 2012
    Amazing Product
    I've tried many flea products and this is the ONLY one that got rid of my dog's fleas! They were gone the next day!
    By ltlewheaty
    November 27, 2012
    Fantastic costumer service! Fast shipping! Solid product - never any problem wiith fleas or ticks and it's not greasy or oily!
    By Amy H.
    November 23, 2012
    Better than Frontline
    This summer I had serious issues with fleas to the extent that we had our yard treated. The Frontline Plus wasn't touching the problem. I switched to k9 advantix II and noticed a difference immediately.
    By barb1934
    Atlanta GFa
    November 7, 2012
    The Best Product I have used
    Excellent results after a few days use. Easy to use.
    By K320
    November 6, 2012
    Wonderful product
    Very effective product. Very happy with the results!!
    By kellmar
    November 3, 2012
    Great product
    I used to use Advantage for my dog, but then a friend recommended K9 Advantix and it really is a better product. It helps with much more than just fleas & ticks and protects my dog from other pests. I only purchase K9 Advantix through Entirely Pets...great customer service and fast delivery!

    Questions and Answers

    There are no questions or answers for this item.

    6 MONTH K9 Advantix II TEAL for Medium Dogs (11-20 lbs)6 MONTH K9 Advantix II TEAL for Medium Dogs (11-20 lbs)Reg price: $88.99
    Sale price: $67.99
    12 MONTH K9 Advantix II TEAL for Medium Dogs (11-20 lbs)12 MONTH K9 Advantix II TEAL for Medium Dogs (11-20 lbs)Reg price: $170.99
    Sale price: $130.99
    6 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)6 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)Reg price: $88.99
    Sale price: $67.99
    12 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)12 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)Reg price: $170.99
    Sale price: $130.99
    CALL IN YOUR ORDER 800.889.8967

    Stay in touch. Friends fur-ever!

    Terms and Conditions

    You have to agree on terms in order to proceed to the subscription.