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  6. 6 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)

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6 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs) Video

6 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)

Item: 5461634
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K9 Advantix II is one of the top choices for eliminating the resident tick or flea population. It is manufactured by Bayer, one of the leading pet care companies in the world. This product promises to kill and repel ticks, fleas, and mosquitoes. Its waterproof formulation remains effective even after the pet gets wet. The K9 Advantix II solution works by attacking all the life stages of the parasites killing adult bugs, larvae, and eggs. The K9 Advantix II Red is a specialized product for large dogs weighing 21-55 lbs. This particular pack contains 4 doses, which is good for 4 months of protection against ticks and fleas.

  • For large dogs weighing 21-55 lbs
  • Manufactured by Bayer
  • Waterproof formulation
  • Repels ticks, fleas and mosquitoes
  • Kill parasites of all life stages
  • For dogs only


Imidacloprid: Imidacloprid is an ectoparasiticide, an antiparasitic agent that targets parasites living primarily on the surface of a host. Chemically classified as a chloronicotinyl nitroguanidine, imidacloprid inhibits neurotransmitter transmission in insects, resulting in paralysis and death.

Benefits: Imidacloprid exhibits both adulticide and larvicidal flea efficacy; it not only kills adult fleas and larvae on your pet, but it also kills larval stages in your pet's immediate surroundings.

Main Purpose: To kill fleas at all stages of their life cycles and stop them from being able to move or feed.

Permethrin: Permethrin is the additional ingredient in Advantix. It belongs to the Type I class of pyrethroid acaricides and insecticides, and it also acts as a repellent. Pyrethroids affect muscle and nerve cells' sodium ion channels by increasing their mean open time, which leads to hyperexcitability and death of the parasite.

Benefits: Thanks to its repelling activity, permethrin reduces parasite bites and thus the risk of diseases and stress for your dog.

Main Purpose: To repel ticks, sand flies, and mosquitoes; to kill ticks and fleas.

Two Proven Ingredients with Enhanced Activity: Imidacloprid and permethrin work together to overwhelm the nervous system of the parasite, providing neurotoxic activity beyond that of each compound alone. This leads to more profound and quicker insect paralysis and death.

Specifically, imidacloprid increases the efficacy of permethrin by activating insect nerve cells and increasing the frequency of neurotransmissions. As a result, more sodium channels are opened and the pyrethroid can interact much better with its target site.

Pyriproxyfen: Pyriproxyfen is a pyridine-based pesticide. A juvenile hormone analog, it interferes with the hormone signaling of growing insects, so that insects in immature stages are unable to mature. Additionally, a female insect that touches the toxin will produce eggs that will not hatch.

Benefits: Pyriproxyfen provides an added layer of protection for pets and their surroundings. It interrupts the flea life cycle at multiple stages, halting the growth and development of insect eggs and larvae and preventing re-infestation.

Main Purpose: To prevent flea eggs from hatching and larvae from growing.

Active Ingredients % by Weight
Imidacloprid 8.80%
Permethrin* 44.00%
Pyriproxyfen 0.44%
Other Ingredients 46.76%
Total 100%

Useful Information

Applying K9 Advantix II to your pet is a fast and easy process. First, remove the K9 Advantix II applicator tube from its packaging and use scissors to peel down the foil. Next, hold the applicator tube in an upright position and pull the cap off the tube. Use the upturned cap to break the protective seal, and you're ready for application.

For easiest application, your dog should be standing upright. Evenly apply the entire contents of the K9 Advantix II tube to two or three spots from the back of the shoulder to the base of the tail. Part the hair at each spot until the skin is visible, then place the tip of the tube on the skin and gently squeeze out a portion of the solution. Be careful not to apply an excessive amount of the solution in any one spot, otherwise some of the solution might run off the side of your dog. Dispose of the container and do not reuse or refill. Do not empty unused product in any indoor or outdoor drain.

For optimal control and prevention of parasites, use K9 Advantix II every month. K9 Advantix II is available in four- and six-month supplies. Do not use K9 Advantix II on cats or any animals other than dogs.

Application Instructions: Evenly apply the entire contents of the tube to four to six spots on the top of the back--from the shoulder to the base of the tail. Apply monthly.

Length of Effectiveness: Under normal conditions, the product is effective for one month. However, in cases of severe flea infestation, re-treatment may be necessary earlier than four weeks. Do not retreat more often than once every seven days. After flea control is attained, return to a monthly re-treatment schedule.

Hazards to Humans: Causes eye irritation. Harmful if swallowed. Do not get in eyes or on clothing. Avoid contact with skin. Wash hands thoroughly with soap and warm water after handling.

Hazards to Domestic Animals:

*For external use on dogs only. *Do NOT use on animals other than dogs. *Do NOT use on puppies under seven weeks of age.

Do not get this product on dog's eyes or mouth. Consult your veterinarian before using this product on debilitated, aged, pregnant, or nursing animals. Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately. If your animal is on medication, consult your veterinarian before using this product.

Do Not Use on Cats: Due to their unique physiology and inability to metabolize certain compounds, cats must not use this product. If applied to a cat, or ingested by a cat that actively grooms a recently treated dog, this product may have serious harmful effects. If this occurs, contact your veterinarian immediately.

Environmental Hazards: This product is extremely toxic to fish. Do not add directly to water. Do not contaminate water when disposing of product or package.

    First Aid: Have the product container or label with you when calling a poison control center or doctor, or when going for treatment.

    If in eyes: Hold eye open and rinse slowly and gently with water for 15 to 20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice.

    If swallowed: Call poison control center or doctor immediately for treatment advice. Have person sip a class of water if able to swallow. Do not induce vomiting unless told to do so by the poison control center or doctor. Do not give anything by mouth to an unconscious person.

    If on skin or clothing: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15 to 20 minutes. Call a poison control center or doctor for treatment advice.

    To physician: Treat patient symptomatically.

Keep out of reach of children.

Customer Reviews

57 Reviews
75% (43)
11% (6)
4% (2)
4% (2)
7% (4)
88% Recommend this product (50 of 57 responses)
By julia
hamilton, NJ
June 16, 2019
Amazing price and no pests
Great price for this product and keeps the fleas and ticks away! Love!
ProsNo fleas or ticks
By Brooklynn62
Vancouver Island BC
May 24, 2018
Great product
I've been using this product for 10 years and we live in an area that has ticks and fleas year round and Miki has never had a problem with either he is now 11
By Challa
Bloomingdale, GA
April 9, 2018
Pet lover
Have tried many different kinds of flea treatments over the last 30 plus years and K9 Advantix II has been the best to insure my home is flea free. With so many dogs I can not afford to have any chance of fleas breading and this is the best which is also recommended by my vet to add to the to the quality of the product.
By KRrn
North carolina
April 9, 2018
Flea medicine
Have used this since my dogs were puppies.
Effective and easy to use.
By sle200
June 19, 2017
Works Great
I've been using this for years. My dog has never had an issue with fleas or ticks.
By Lesa
Aiken, SC
March 17, 2016
Great Product
I have use the Advantix II on my dogs for years with no problems and n freas. It works great.
By Dayz
Baltimore, MD
August 11, 2015
Worked well for my dog
I've always used this on my German Shepherd dog and she has never had fleas. She has had ticks but only a few, and one of them fell right off of her, dead. So I attribute that to this product. We will continue to use it.
By happy t.
Robinson Township, PA
April 21, 2015
easy to apply
Great products because it is easy to apply. Not only does it prevent & kill flees but protects against ticks.
By Sookie
Miami, FL
March 11, 2015
This product works!
In Florida fleas, ticks and mosquitoes are a constant worry. There is no "cold" season to kill off eggs, so having a product that works to keep my dog, Sookie, flea and tick free is a great blessing. Ever since I began using K9 Advantix II, 4 years ago, the only fleas I have seen are the occasional dead ones that drop off when I brush him. There have been no ticks, and no mosquito bites. So grateful for this product.
By mortgage b.
Williamsburg, Ontario Canada
July 9, 2014
WHAT A DEAL! K-9 Advantix Red (6 month supply)
We've been recommended by our Vet to use this product as we are in a high tick area. I bought the product for years through the local vet. Just by accident, I was shopping Entirely Pets for dog treats when I came across the same product (K-9 Advantix) at half the price. Same stuff, same manufacturer, same dosage, same everything except the price. Been buying ever since at Entirely Pets!!!!!!
By Jeannie
Galway, NY
April 16, 2014
Advantix 2
Great product. I have used it on my dog for 15 years.
By Karen
September 29, 2013
Great product
Easy to use and very effective at flea and tick control-I have never seen any on my dogs
By kat
July 27, 2013
Overall, very good!
But the biting flies still get them when they go out. It's Florida, you can't expect miracles.
By missy m.
savannah, ga.
July 19, 2013
good brand
been using this brand for a while now. used to use front line....but , when I moved down south from Michigan to savannah, it wasn't enough coverage!!!! plus, I brought my horse down with me and , I noticed he would get the occasional tick, which he never got up north, even though we have ticks up there....so, I switched to K-9 advantix II, and no ticks on my long-haired dog! and no flea break-through in 2-3 weeks!!! entirely pets is the best source for your pets needs! the best prices and the fastest shipping!! no matter where I go, entirely pets goes with me!!! thanks a million
By Play
July 3, 2013
Great flea protection by far
I've been using K9 Advantix, since my vet put my dogs on it. I've been very satisfied with this and have used it for the last 3 years. My dogs do well with it, and also do not itch like they use to when I used a different product. Entirely Pets has the best price for all my dogs needs.
By Kiahlily
San Diego, CA
June 27, 2013
This works and good value
Never had a problem with fleas or ticks on my dogs while using this product.
By gotti
May 9, 2013
the best
I only use this p[roduct and it works the best
By brgunter
Columbia, SC
April 23, 2013
Excellent Product
We find this product to be easy to apply; no greasy residue after application, no odor and does a great job for our two babies (adult cocker spaniels).
L.H., N.J. mosquito capital
March 30, 2013
the best repellent
this product does all it says. my dog has not had fleas or ticks on her at all. also, and this is great, in the summer the mosquitoes and flies esp. green heads, do not alight on her to bite; that is a real plus.

I highly recommend this product!
By jam
March 7, 2013
Priced right
I ordered this product for my daughter and the price is cheaper by ordering through your company.
By ohlab
February 10, 2013
Not user friendly
not like the one spot products runs and is very messy to use.
By Abby
January 20, 2013
The best
We had used Frontline in the past, but the fleas became immune to them. We switched to Advantage, then Advantix because it is very effective. We had a flea infestation this summer because of a mild winter, so we had to fight them even harder. I think we finally have the fleas under control.
By figaro
old lyme ct
January 1, 2013
excellent tick and flea repellent
I have used K9 Advantix II on my dogs for the last six years or so. We used Frontline Plus before and were quite happy with the results until one year it just did not seem to impact ticks. We live very close to Old Lyme (yes, of Lyme Disease fame) and needed a product that was more reliable in destroying ticks. Advantix II has been excellent. We highly recommend it.
By sugar
December 30, 2012
Not as good as original formula
Applied this product on my dogs every 30 days without fail all year. Over the summer, both of my dogs who used this product suffered from a severe case of fleas for several months.
By Trumprider
December 29, 2012
No worries
A bit pricey but works great. I'm happy, the dogs are happy. The best.
By jjmom
Asheville, NC
December 17, 2012
Arrived promptly
I ordered the product and it arrived in good condition and very promptly. I would recommend Entirely Pets to anyone who wants to order pet products on line.
By Claudia
December 17, 2012
Great product
Works great. Used to use frontline plus, but switched to K-9 advantix II
By Amber's M.
Portland, OR
December 15, 2012
K9 Advantix II (21-55lbs)
We hike in deep woods where there are ticks. My dog got a bad tick infection with flea prevention alone. Since using this flea/tick combo she's never had another tick on her. Works very well without the bad side effects I've read about with other products out there. She's 52lbs and this dose works great.
By kittenonkeys
Central Louisiana
December 5, 2012
Great value
K9 Advantix II is a product I find very useful in eliminating the flea and tick problem with my 3 dogs. Prior to using it and a similar product, I would get fleas in my house. This is no longer an issue. I will occasionally find a tick, but not to the extent prior to the product.
By Pinschermom
Apopka, FL
December 1, 2012
Best Product Ever
This is the best product for my German Pinscher who is terribly allergic to no see um bites.

Questions and Answers

There are no questions or answers for this item.

12 MONTH K9 Advantix II TEAL for Medium Dogs (11-20 lbs)12 MONTH K9 Advantix II TEAL for Medium Dogs (11-20 lbs)Reg price: $170.99
Sale price: $130.99
4 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)4 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)Reg price: $64.99
Sale price: $49.99
12 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)12 MONTH K9 Advantix II RED for Large Dogs (21-55 lbs)Reg price: $170.99
Sale price: $130.99
4 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)4 MONTH K9 Advantix II BLUE for Extra Large Dogs (over 55 lbs)Reg price: $64.99
Sale price: $49.99
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