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  6. Frontline Plus for Dogs 0-22 lbs - ORANGE, 12 MONTH


Frontline Plus for Dogs 0-22 lbs - ORANGE, 12 MONTH

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Temporary Price Reduction! FRONTLINE Plus Orange for Dogs 0-22 lbs

Recommended by veterinarians, FRONTLINE Plus Orange for Dogs 0-22 pounds is a powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. FRONTLINE Plus is specially formulated for dogs and puppies aged eight weeks and older weighing less than 22 pounds. Available without a prescription, FRONTLINE Plus only needs to be applied once a month for thorough pest control.

life cycle of the commom flea
Flea life cycle.
View larger.
life cycle of ticks
Tick life cycle.
View larger.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. FRONTLINE Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. FRONTLINE kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, FRONTLINE Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in FRONTLINE, fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes three 0.67-milliliter tubes of FRONTLINE Plus for Dogs.

for Dogs 0-22 lbs
  • Kills fleas, flea eggs, ticks, and
    chewing lice
  • Fast-acting formula
  • Includes 12 one-month
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older
    weighing less than 22 pounds
  • Per Dose: $11.17
More Info
Got Fleas?

A product guide to flea
and tick products.

Flea Facts You Should Know

Interesting flea facts to help your
pets be pest free.

Fleas: Understanding the Enemy

All about fleas and prevention.


Helpful information on ticks and your

FAQs about Fleas and Ticks
Frontline Plus for Dogs Lifestyle shot
FRONTLINE Plus for Dogs is Available In:
(0 - 22 pounds)
(23 - 44 pounds)
(45 - 88 pounds)
(89 - 132 pounds)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month



Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients % by Weight
Fipronil 9.8%
(S)-Methoprene 8.8%
Inert Ingredients 81.4%
Total 100%

Some animals are sensitive or allergic to the ingredients in FRONTLINE, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Twelve tubes, each 0.023 fluid ounces (0.67 milliliters)

Useful Information

How FRONTLINE Plus Works

Use FRONTLINE Plus for fast-acting, long-lasting flea and tick control. When you apply FRONTLINE, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, FRONTLINE provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying FRONTLINE Plus to your pet is an easy three-step process. First, remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down. Next, hold the applicator upright and away from your face and body and snap off the tip. Finally, place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.

To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Weight Dosage
Up to 22 pounds Apply contents of one applicator (0.67 milliliter) once per month
23 - 44 pounds Apply contents of one applicator (1.34 milliliters) once per month
45 - 88 pounds Apply contents of one applicator (2.68 milliliters) once per month
89 - 132 pounds Apply contents of one applicator (4.02 milliliters) once per month
All weights Apply contents of one applicator (0.5 milliliter) once per month

Customer Reviews

74 Reviews
84% (62)
14% (10)
0% (0)
0% (0)
3% (2)
96% Recommend this product (71 of 74 responses)
By Major
July 15, 2017
Review for Frontline Plus for Dogs 0-22 lbs - ORANGE, 12 MONTH
I have been using this product for years with no issues. I also have ordered from Entirely Pets for quite sometime. The order is always correct and arrives pretty quick.
By Mw62
Oak hills, CA
June 27, 2017
Flea control
This product works exactly as advertised and I use it on my dogs yearly. Other products don't work as well.
By Owned S.
New Mexico
June 7, 2017
Best price I've found
I've used Frontline Plus many years for flea and tick control. We've been very satisfied with the performance of the products and my dogs have not had any negative reactions to the medication. Add to that EntirelyPets pricing and it's a winner in my book.
By Owned s.
New Mexico
June 2, 2017
Good Flea/tick Product
We've used Frontline Plus on our Shelties for many years and have been pleased with the results. I suggest that those of you with herding dogs (shelties, collies,etc.) have your dog tested for the MDR1 gene anomaly but given a clear test, Frontline Plus is an excellent product for controlling the pests.
By paquette52
Ontario, Canada
March 21, 2017
Frontline Plus
Frontline works perfect on my dogs. Ordered this product either from the US or Canada. Entirely Pets always served me well.
Springfield, PA
October 29, 2016
Frontline Plus-Forever
We have been a loyal Frontline customer for over 20 years. I have used Frontline Plus on my dogs and cats and had no problems or critters.
By Nana
August 24, 2016
No longer works
I purchased a Frontline a Plus for many, many years. Recently it just has not worked well to keep fleas away. Both my small dogs got fleas really bad and they were always current on their applications. My Vet suggested I switch them to a pill taken orally and so far do good.
By lengleman
Bentonville, AR
August 7, 2016
Frontline Plus for Dogs
I have used this product for over 10 years now and we live in a very wooded area which tends to lead to a large volume of ticks in the spring and summer time. With this product I don't have to worry about my animals because I know it works.
By Lonna
May 4, 2016
Wouldn't Skip It
I started the dogs on Frontline again in March and have not found any ticks/fleas on them, which says something, as I have already pulled a tick off myself AND one of my kids. In years past, I have found ticks crawling in our house, in our recycling bin, etc. - lots in ticks here - and I feel better knowing that if a tick latches onto the dogs, it will die and not be crawling around the house looking for another meal!
By Mary
January 12, 2016
Product does what it says it does
No fleas, no ticks, no problems! I've used this product regularly.
By lz
August 22, 2015
Best for Fleas and Ticks
I've tried several products and this one seems to work the best. The fact that it also kills ticks is an added bonus.
By Cindy
NE Ohio
January 17, 2015
Frontline Plus for dogs
I have used this product for many years with no problem AND no flea or tick in sight. But about 2 years ago I tried a flea med that claimed to be as good as Frontline Plus and almost immediately we had fleas. I will stick with Frontline Plus even though it is a little more expensive because it works!
By Yorkie m.
July 7, 2014
Been using this product on my dogs for many years. Entirely Pets has the best prices, hands down... Service is great and they arrive in record time!
By Melissa
April 10, 2014
Frontline Plus is Tried and True
I have been using Frontline Plus on my dogs for many years. Safe to say, we have never had a flea outbreak! The medicine is easy to administer, my dogs don't mind it, except I wish it would absorb more quickly. I have to remember not to pet them for a few hours or else I end up with Frontline on my hands! Entirely Pets has had the lowest prices hands down.
By Ducklady
Annapolis, MD
April 1, 2014
Really works!
I've been using Frontline for several years. Since I have birds, I cannot have fleas in the house because we can't spray inside to exterminate. We've been using Frontline on the dogs and cats, and we've been lucky to have a flea-free home. We've tried other products, but some are not safe for cats. Since my pets sleep together, we have found Frontline to be safe for all of them, and works well for fleas and ticks.
By Kitkat05291959
Palatine, IL
March 15, 2014
Great Deal
Frontline is a great product and the purchase price was awesome!
By Marsh301
Milwaukee, WI
December 25, 2013
Great Product, Excellent Price
Forget about PedMeds. They charge more for their products to pay for their commercials. Some people thought these mail order companies for pet products were expired products or soon to expire. NOT SO. The items I ordered, Frontline, expire at the end of 2015!
By kg
November 15, 2013
Great product
I have used frontline plus for years and find it works as advertised .
By sandyowl
Elkton MD
October 3, 2013
Keeps fleas off my dog
Frontline is very effective at keeping my dog flea free.
By Linda
September 5, 2013
No problem with this product
This productive is effective without any known problems using it
By ncn305
Pittsburgh, PA
August 24, 2013
Frontline Plus
Great product, does what it says it will do. My dogs are flea and tick free all season long. Plus it doesn't irritate their skin.
By Weezie
August 16, 2013
Best deal going!
The prices and fast delivery can't be beat! Been using this product on my Yorkies for years. You won't be sorry purchasing this product, or the service provided by Entirely Pets!
By Kenzie1mom
New Jersey
July 25, 2013
FrontLine Plus the best
Entirely Pets ia a wonderful online service.
I order Frontline Plus and the price was the cheapest anywhere. Even my Vet could not match their price.
I have two dogs and I always get a year's worth of Frontline Plus and split it so each dog is good for six months...
The product was shipped fast and the price could not be beat on any other web site....
By judy
July 24, 2013
3 small dogs/good price at EntirelyPets. This product recommended by vet, (who would like to sell it to me).
By Jill
July 2, 2013
Cheaper by the dozen
Great product at a cheaper price than i can purchase from my vet or pet store.
By fireflyy
Okeechobee, Fl
June 29, 2013
Good product
This is not the first time I used frontline on my dogs. I had used a product my vet had suggested until it got too expensive. Frontline seems to be doing ok. The only thing I have noticed id that when we take the dogs outside, they come back in with one or two fleas on them and it takes a while fro the frontline to kill them.
By lu
Milwaukee, WI
June 22, 2013
effective product
Frontline Plus has worked well for the dogs in my family. We've had no fleas and no ticks since using this. I typically apply it just once every couple of months but ticks are bad this year so I've applied it every 6 weeks thus far.
By Happy G.
Aiea, HI
May 10, 2013
Doctor recommended
We live in Hawaii so it's summer all year long and my dog has never had a flea or tick. It's also easy to apply.
By Tina
May 3, 2013
I would recommend this product to anyone who has a pet. I have been using Frontline for the past 10 years and very satisfied with no complaints whatsoever.
By Lauren
May 1, 2013
Review for Frontline Plus for Dogs 0-22 lbs - ORANGE, 12 MONTH
Great product. I've done a ton of research, looking for the best price for Frontline, and Entirely Pets is the best around. Quick delivery, too. Very satisfied. Thanks so much.

Questions and Answers

There are no questions or answers for this item.

Frontline Plus for Dogs 0-22 lbs- ORANGE, 3 MONTHFrontline Plus for Dogs 0-22 lbs- ORANGE, 3 MONTHReg price: $46.99
Sale price: $35.99
Frontline Plus for Dogs 0-22 lbs - ORANGE, 6 MONTHFrontline Plus for Dogs 0-22 lbs - ORANGE, 6 MONTHReg price: $90.99
Sale price: $69.99
Frontline Plus for Dogs 23-44 lbs - BLUE, 3 MONTHFrontline Plus for Dogs 23-44 lbs - BLUE, 3 MONTHReg price: $46.99
Sale price: $35.49
Frontline Plus for Dogs 23-44 lbs - BLUE, 6 MONTHFrontline Plus for Dogs 23-44 lbs - BLUE, 6 MONTHReg price: $89.99
Sale price: $68.99
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