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  6. Frontline Plus for Dogs 5-22 lbs, 12 Month


Frontline Plus for Dogs 5-22 lbs, 12 Month

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Frontline Plus Orange for Dogs 5-22 pounds is a veterinarian-recommended, powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. Frontline Plus is specially formulated for dogs and puppies aged eight weeks and older weighing 5 - 22 pounds. Available without a prescription, Frontline Plus only needs to be applied once a month for thorough pest control.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. Frontline Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. Frontline kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, Frontline Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in Frontline , fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes twelve 0.67 mL tubes of Frontline Plus for Dogs.

Key Benefits

  • Kills fleas, flea eggs, ticks, and chewing lice
  • Fast-acting formula
  • includes twelve one-month applications
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older weighing 5 - 22 pounds

Frontline Plus for Dogs is Available In:
(5 - 22 lbs)
(23 - 44 lbs)
(45 - 88 lbs)
(89 - 132 lbs)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month


Active Ingredients


Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients% by Weight
Inert Ingredients81.4%

Possible Side Effects

Some animals are sensitive or allergic to the ingredients in Frontline, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Three tubes, each 0.023 fluid ounces (0.67 milliliters)

Useful Information

How Frontline Plus Works

Use Frontline Plus for fast-acting, long-lasting flea and tick control. When you apply Frontline, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, Frontline provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying Frontline Plus to your pet is an easy three-step process:

  1. Remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down.
  2. Hold the applicator upright and away from your face and body and snap off the tip.
  3. Place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Dosage Table

WeightMonthly Dosage
5 - 22 poundsOne applicator (Orange)
23 - 44 poundsOne applicator (Blue)
45 - 88 poundsOne applicator (Purple)
89 - 132 poundsOne applicator (Red)

Storage Directions

Store unused product in original container, out of reach of children and animals.

Customer Reviews

Review Summary
74 Reviews
84% (62)
14% (10)
0% (0)
0% (0)
3% (2)
96% Recommend this product (71 of 74 responses)
By Major
Review for Frontline Plus for Dogs 0-22 lbs - ORANGE, 12 MONTH
July 15, 2017
I have been using this product for years with no issues. I also have ordered from Entirely Pets for quite sometime. The order is always correct and arrives pretty quick.
By Mw62
Oak hills, CA
Flea control
June 27, 2017
This product works exactly as advertised and I use it on my dogs yearly. Other products don't work as well.
By Owned S.
New Mexico
Best price I've found
June 7, 2017
I've used Frontline Plus many years for flea and tick control. We've been very satisfied with the performance of the products and my dogs have not had any negative reactions to the medication. Add to that EntirelyPets pricing and it's a winner in my book.
By Owned s.
New Mexico
Good Flea/tick Product
June 2, 2017
We've used Frontline Plus on our Shelties for many years and have been pleased with the results. I suggest that those of you with herding dogs (shelties, collies,etc.) have your dog tested for the MDR1 gene anomaly but given a clear test, Frontline Plus is an excellent product for controlling the pests.
By paquette52
Ontario, Canada
Frontline Plus
March 21, 2017
Frontline works perfect on my dogs. Ordered this product either from the US or Canada. Entirely Pets always served me well.
Springfield, PA
Frontline Plus-Forever
October 29, 2016
We have been a loyal Frontline customer for over 20 years. I have used Frontline Plus on my dogs and cats and had no problems or critters.
By Nana
No longer works
August 24, 2016
I purchased a Frontline a Plus for many, many years. Recently it just has not worked well to keep fleas away. Both my small dogs got fleas really bad and they were always current on their applications. My Vet suggested I switch them to a pill taken orally and so far do good.
By lengleman
Bentonville, AR
Frontline Plus for Dogs
August 7, 2016
I have used this product for over 10 years now and we live in a very wooded area which tends to lead to a large volume of ticks in the spring and summer time. With this product I don't have to worry about my animals because I know it works.
By Lonna
Wouldn't Skip It
May 4, 2016
I started the dogs on Frontline again in March and have not found any ticks/fleas on them, which says something, as I have already pulled a tick off myself AND one of my kids. In years past, I have found ticks crawling in our house, in our recycling bin, etc. - lots in ticks here - and I feel better knowing that if a tick latches onto the dogs, it will die and not be crawling around the house looking for another meal!
By Mary
Product does what it says it does
January 12, 2016
No fleas, no ticks, no problems! I've used this product regularly.
By lz
Best for Fleas and Ticks
August 22, 2015
I've tried several products and this one seems to work the best. The fact that it also kills ticks is an added bonus.
By Cindy
NE Ohio
Frontline Plus for dogs
January 17, 2015
I have used this product for many years with no problem AND no flea or tick in sight. But about 2 years ago I tried a flea med that claimed to be as good as Frontline Plus and almost immediately we had fleas. I will stick with Frontline Plus even though it is a little more expensive because it works!
By Yorkie m.
July 7, 2014
Been using this product on my dogs for many years. Entirely Pets has the best prices, hands down... Service is great and they arrive in record time!
By Melissa
Frontline Plus is Tried and True
April 10, 2014
I have been using Frontline Plus on my dogs for many years. Safe to say, we have never had a flea outbreak! The medicine is easy to administer, my dogs don't mind it, except I wish it would absorb more quickly. I have to remember not to pet them for a few hours or else I end up with Frontline on my hands! Entirely Pets has had the lowest prices hands down.
By Ducklady
Annapolis, MD
Really works!
April 1, 2014
I've been using Frontline for several years. Since I have birds, I cannot have fleas in the house because we can't spray inside to exterminate. We've been using Frontline on the dogs and cats, and we've been lucky to have a flea-free home. We've tried other products, but some are not safe for cats. Since my pets sleep together, we have found Frontline to be safe for all of them, and works well for fleas and ticks.
By Kitkat05291959
Palatine, IL
Great Deal
March 15, 2014
Frontline is a great product and the purchase price was awesome!
By Marsh301
Milwaukee, WI
Great Product, Excellent Price
December 25, 2013
Forget about PedMeds. They charge more for their products to pay for their commercials. Some people thought these mail order companies for pet products were expired products or soon to expire. NOT SO. The items I ordered, Frontline, expire at the end of 2015!
By kg
Great product
November 15, 2013
I have used frontline plus for years and find it works as advertised .
By sandyowl
Elkton MD
Keeps fleas off my dog
October 3, 2013
Frontline is very effective at keeping my dog flea free.
By Linda
No problem with this product
September 5, 2013
This productive is effective without any known problems using it
By ncn305
Pittsburgh, PA
Frontline Plus
August 24, 2013
Great product, does what it says it will do. My dogs are flea and tick free all season long. Plus it doesn't irritate their skin.
By Weezie
Best deal going!
August 16, 2013
The prices and fast delivery can't be beat! Been using this product on my Yorkies for years. You won't be sorry purchasing this product, or the service provided by Entirely Pets!
By Kenzie1mom
New Jersey
FrontLine Plus the best
July 25, 2013
Entirely Pets ia a wonderful online service.
I order Frontline Plus and the price was the cheapest anywhere. Even my Vet could not match their price.
I have two dogs and I always get a year's worth of Frontline Plus and split it so each dog is good for six months...
The product was shipped fast and the price could not be beat on any other web site....
By judy
July 24, 2013
3 small dogs/good price at EntirelyPets. This product recommended by vet, (who would like to sell it to me).
By Jill
Cheaper by the dozen
July 2, 2013
Great product at a cheaper price than i can purchase from my vet or pet store.
By fireflyy
Okeechobee, Fl
Good product
June 29, 2013
This is not the first time I used frontline on my dogs. I had used a product my vet had suggested until it got too expensive. Frontline seems to be doing ok. The only thing I have noticed id that when we take the dogs outside, they come back in with one or two fleas on them and it takes a while fro the frontline to kill them.
By lu
Milwaukee, WI
effective product
June 22, 2013
Frontline Plus has worked well for the dogs in my family. We've had no fleas and no ticks since using this. I typically apply it just once every couple of months but ticks are bad this year so I've applied it every 6 weeks thus far.
By Happy G.
Aiea, HI
Doctor recommended
May 10, 2013
We live in Hawaii so it's summer all year long and my dog has never had a flea or tick. It's also easy to apply.
By Tina
May 3, 2013
I would recommend this product to anyone who has a pet. I have been using Frontline for the past 10 years and very satisfied with no complaints whatsoever.
By Lauren
Review for Frontline Plus for Dogs 0-22 lbs - ORANGE, 12 MONTH
May 1, 2013
Great product. I've done a ton of research, looking for the best price for Frontline, and Entirely Pets is the best around. Quick delivery, too. Very satisfied. Thanks so much.

Questions and Answers

Frontline Plus for Dogs 5-22 lbs, 3 MonthFrontline Plus for Dogs 5-22 lbs, 3 MonthReg price: $55.99
Sale price: $42.89
Frontline Plus for Dogs 5-22 lbs, 6 MonthFrontline Plus for Dogs 5-22 lbs, 6 MonthReg price: $103.99
Sale price: $79.99
Frontline Plus for Dogs 23-44 lbs, 3 MonthFrontline Plus for Dogs 23-44 lbs, 3 MonthReg price: $55.99
Sale price: $42.89
Frontline Plus for Dogs 23-44 lbs, 6 MonthFrontline Plus for Dogs 23-44 lbs, 6 MonthReg price: $103.99
Sale price: $79.99