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Frontline Plus for Dogs 5-22 lbs, 3 Month Video
Frontline Plus for Dogs 5-22 lbs, 3 Month Video

Frontline Plus for Dogs 5-22 lbs, 3 Month

Item: FPLUS3OR22
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3-month sizes are sent as individual topical doses, does not include box. Frontline Plus products do not expire and do not have expiration dates on the packaging.


Frontline Plus Orange for Dogs 5-22 pounds is a veterinarian-recommended, powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. Frontline Plus is specially formulated for dogs and puppies aged eight weeks and older weighing 5 - 22 pounds. Available without a prescription, Frontline Plus only needs to be applied once a month for thorough pest control.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. Frontline Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. Frontline kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, Frontline Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in Frontline , fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes three 0.67 mL tubes of Frontline Plus for Dogs.

Key Benefits

  • Kills fleas, flea eggs, ticks, and chewing lice
  • Fast-acting formula
  • Includes three one-month applications
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older weighing 5 - 22 pounds

Frontline Plus for Dogs is Available In:
(5 - 22 lbs)
(23 - 44 lbs)
(45 - 88 lbs)
(89 - 132 lbs)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month


Active Ingredients


Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients% by Weight
Inert Ingredients81.4%

Possible Side Effects

Some animals are sensitive or allergic to the ingredients in Frontline, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Three tubes, each 0.023 fluid ounces (0.67 milliliters)

Useful Information

How Frontline Plus Works

Use Frontline Plus for fast-acting, long-lasting flea and tick control. When you apply Frontline, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, Frontline provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying Frontline Plus to your pet is an easy three-step process:

  1. Remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down.
  2. Hold the applicator upright and away from your face and body and snap off the tip.
  3. Place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Dosage Table

WeightMonthly Dosage
5 - 22 poundsOne applicator (Orange)
23 - 44 poundsOne applicator (Blue)
45 - 88 poundsOne applicator (Purple)
89 - 132 poundsOne applicator (Red)

Storage Directions

Store unused product in original container, out of reach of children and animals.

Customer Reviews

Review Summary
96 Reviews
79% (76)
8% (8)
3% (3)
4% (4)
5% (5)
85% Recommend this product (82 of 96 responses)
By Christina
Manahawkin, New Jersey
Frontline Plus for Dogs 0-22 lbs- ORANGE, 3 MONTH
August 6, 2019
we have been using frontline plus for years always have a postive experience with the product.
By Jugi
Customer service
January 4, 2019
I enjoy the speed and ease of ordering online and quick shipping. Excellent customer service
By Snickers M.
Fast delivery
October 15, 2018
I ordered Frontline a month or so ago - just couldn't keep the fleas at bay and off my little dog. Poor boy was scratching like crazy. After one application, the fleas ran for the hills and he is pretty much completely flea free!
  • Good flea control
  • Getting my dog to sit still!
Southern California
Does the job
October 21, 2016
Fortunately the fleas in my part of the country (or town?) have not become resistant to Frontline Plus so it still works on my dogs. I recommend this, especially at the prices from Entirely Pets.
By janamal
north bend wa
Works great
October 7, 2015
I have been using this product for years. Its the only flea medicine that doesn't make my dogs act like their skin is burning, and it works.
By Ladybug
Kent, Washington
fast and reliable
August 18, 2015
Easily trackable delivery. I've ordered before from this company and never a problem with the product
or anything else.
By Snugghawaii
Review for Frontline Plus for Dogs 0-22 lbs- ORANGE, 3 MONTH
July 22, 2015
It is less expensive that your local pet stores or vet office
By donnadee
ear, DE
Great purchase
June 2, 2015
Received item and have used his before Got a lower price due to a discount
By Charlotte
This last purchase didn't work at all.
April 30, 2015
I've used Frontline for years but this latest purchase hasn't worked at all. Both cat, dog and I have been bitten beyond words. I've had to call my pest control specialist to rid the fleas from my house. I've been told and I've seen online that the product isn't the same. Absolutely worthless.
By Barbara
Review for Frontline Plus for Dogs 0-22 lbs- ORANGE, 3 MONTH
April 22, 2015
Am very pleased with the Frontline Plus for Dogs 0-22 lbs. It is a great product and the price from EntirelyPets is a great deal. Would recommend to a friend for sure.
sunrise, fl
Review for Frontline Plus for Dogs 0-22 lbs- ORANGE, 3 MONTH
March 15, 2015
a nice product been using for a year plus
By Wendora
March 13, 2015
I have been using this product for about 2-3 years. It works great and my pets have never experienced any adverse side affects.
By marianne
Texas, near Houston
product ok
March 4, 2015
The product is ok. However it took at least ten days to arrive to Texas from California. When I finally got the box and found the pkg of Frontline inside, it had been opened. I didn't complain but should have probably, but I didn't want to wait for flea protection another 10 days. I had a new rescue dog and needed the product pronto. I think this is the last time I'll order from Entirely Pets.
By camrose
February 25, 2015
The price was right and the delivery timely.
By tmp
Wayne, PA
January 21, 2015
Use if faithfully; consistency is the key.
By Lula B.
Boynton Beach, FL
Awesome product
January 17, 2015
This works great for my dog, Lula Belle. She has never had a problem with fleas, ticks or anything else since starting this. I am very happy that it works so good.
By Marilyn
San Juan, P.R.
Excellent item
September 26, 2014
Frontline is just excellent. I have a dog that most of the time is outside, in the patio. I have never had any trouble with ticks or anything.
By JimmyDee
San Diego, CA
It Keeps On Working
August 1, 2014
With California suffering it's worse drought ever, the flea population is also at it's worst. Frontline has protected my dog from infestation.
By Tuffy's m.
Bristol, CT
This works!
July 4, 2014
My dog Tuffy has long white hair and gets a summer haircut. Frontline plus works all year long and keeps him flea and tick free.This product works for us. I suggest you never miss a 30 day application. I have tried other brands of preventive applications, those were too strong and caused him to vomit and made him lethargic.He got a tick and had Lyme disease while on the "other" product. . Follow the instructions and drop only in one spot on the skin between the shoulder blades don't rub in and don't spread around! Happy summer to all the pups.
By Vicky
The Only Brand I Use
April 23, 2014
My dog's been on Frontline for nearly 14 years now, and even when the vet ask if I'd like to try the new oral meds, I stuck with Frontline (why mess with something that works?). The applicator is very easy to use & she's free of fleas & ticks. Also, EntirelyPets has a great price on these, and their shipping rate isn't too bad, that I've switched and started buying here.
By Linny
Bakersfield, CA
Good Product without Harmful Effects
April 23, 2014
I have a small dog and I heard complaints about serious issues with other products like Vectra and Advantage because that product goes into the dogs nervous system unlike Frontline which does not. I am into the 2nd month of usage and have to admit that I was still finding fleas during the first month. I believe most coming from my yard and I did treat my house with non-chemical products and treated my yard also. Much improved now. Fighting fleas is an ongoing issue and cannot always be resolved within days. I believe Frontline product is safer than other alternatives. I've used many times in the past and will continue to use. I also treated my three cats.
By dishes
proven effective
April 18, 2014
never any trouble with Frontline with my cat or dog. Other products affected the cat and dog (burned or itched) and they absolutely didn't like the others I tried. No problems with Frontline Plus, put it on and the pet acts as if nothing is there, no fleas or ticks seen since I started using.
By Tilly's G.
miami, fl.
Frontline Plus, Plus ,Plus
September 22, 2013
She loves it, it's just what the Doctor ordered
By Little A.
Long Island New York
Only product for my dog
September 12, 2013
Frontline Plus is the best flee & tick med on the market. Have been using it for ever and would never switch
By Stinkey
I'm Pleased--- No Ticks or Flees....
September 11, 2013
Sounds like a title of a song:)

I am very satisfied with Frontlione orange for my Miniature Poodle-- Remy. The products I used in the past--from the vet, seemed to irritate him so much that I just could'nt use them. I'd rather chance Fleas and Ticks than to see him so uncomfortable. Since erractic behavior after application, ie running around in circles, rubbing his nose on the carpet or bed... I am thrilled. So is he. Thanks Frontline
By Shadow
Miami, FL
The best
August 6, 2013
Frontline has proven to be the only flea/tick control that keeps the dog park insects at bay. My friends (other dog owners) have used other brands and their dogs got ticks and even fleas. I've had my dog on this for 4 years now and we go to the dog park everyday where he rolls around in the grass and never have i had a problem.
By Roger
Review for Frontline Plus for Dogs 0-22 lbs- ORANGE, 3 MONTH
August 2, 2013
Product does its job but is almost impossible to open
By Sammy
Portland, OR
Good product, does not expire
July 3, 2013
I like this better than the Advantage because it's waterproof and does not expire. I wash my dog every week, so the waterproofing is a big deal. Works great, my dog hasn't had a flea on his body since I applied it! Thanks for the excellent service from Mark at Entirely Pets!
By Rick
Metro Detroit
As long as we've used Frontline, no fleas!
June 25, 2013
We have used Frontline for several years with two dogs and have never had any fles or other insect probblems. Good product, simple to use.
By hclevin101
Frontline Plus for Dogs 0-22 lbs- ORANGE, 3 MONTH
June 4, 2013
It's been effective. Entirely Pets got it to me quickly.

Questions and Answers

1 Question & 1 Answer
from Southern Minnesota asked:
October 22, 2019

Is this dosage safe for my 3lb Morkie?

The package specifically say "Do not apply to dogs weighing less than 5 lbs"

1 Answer
Please don't this product on your 3 lb dog
Submitted by: Customer Service on October 25, 2019

Frontline Plus for Dogs 89-132 lbs, 6 MonthFrontline Plus for Dogs 89-132 lbs, 6 MonthReg price: $102.99
Sale price: $78.99
Frontline Plus for Dogs 89-132 lbs, 12 MonthFrontline Plus for Dogs 89-132 lbs, 12 MonthReg price: $206.99
Sale price: $158.99
Frontline Plus for Dogs 5-22 lbs, 6 MonthFrontline Plus for Dogs 5-22 lbs, 6 MonthReg price: $103.99
Sale price: $79.99
Frontline Plus for Dogs 5-22 lbs, 12 MonthFrontline Plus for Dogs 5-22 lbs, 12 MonthReg price: $206.99
Sale price: $158.99