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Frontline Plus for Dogs 23-44 lbs, 12 Month Video
Frontline Plus for Dogs 23-44 lbs, 12 Month Video

Frontline Plus for Dogs 23-44 lbs, 12 Month

Item: FPLUS3BL44-12M
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Frontline Plus Orange for Dogs 0-22 pounds is a veterinarian-recommended, powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. Frontline Plus is specially formulated for dogs and puppies aged eight weeks and older weighing less than 22 pounds. Available without a prescription, Frontline Plus only needs to be applied once a month for thorough pest control.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. Frontline Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. Frontline kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, Frontline Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in Frontline , fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes twelve 1.34 mL tubes of Frontline Plus for Dogs.

Key Benefits

  • Kills fleas, flea eggs, ticks, and chewing lice
  • Fast-acting formula
  • includes twelve one-month applications
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older weighing less than 22 pounds

Frontline Plus for Dogs is Available In:
(0 - 22 lbs)
(23 - 44 lbs)
(45 - 88 lbs)
(89 - 132 lbs)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month


Active Ingredients


Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients% by Weight
Inert Ingredients81.4%

Possible Side Effects

Some animals are sensitive or allergic to the ingredients in Frontline, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Three tubes, each 0.023 fluid ounces (0.67 milliliters)

Useful Information

How Frontline Plus Works

Use Frontline Plus for fast-acting, long-lasting flea and tick control. When you apply Frontline, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, Frontline provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying Frontline Plus to your pet is an easy three-step process:

  1. Remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down.
  2. Hold the applicator upright and away from your face and body and snap off the tip.
  3. Place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Dosage Table

WeightMonthly Dosage
Up to 22 poundsOne applicator (Orange)
23 - 44 poundsOne applicator (Blue)
45 - 88 poundsOne applicator (Purple)
89 - 132 poundsOne applicator (Red)

Storage Directions

Store unused product in original container, out of reach of children and animals.

Customer Reviews

Review Summary
38 Reviews
84% (32)
11% (4)
3% (1)
0% (0)
3% (1)
95% Recommend this product (36 of 38 responses)
By Owl01
Excellent company to work with
July 15, 2018
Quick, efficient, able to contact vet for approval
  • Na
  • Ba
By jan
Review for Frontline Plus for Dogs 23-44 lbs - BLUE, 12 MONTH
April 6, 2016
it's the best more people would buy but;canadian dollar is so low it makes it very costly
By Tina M.
Best Purchase Indeed
May 8, 2015
For cocker spaniels it is a MUST. They are nosy and need to have protection from those nasty pests out there.
By siouxc
Slinger, WI
Frontline Plus is a Must Have for Fleas and Ticks
April 16, 2015
I have been using Frontline Plus on our dogs for years. We have never had a Flea or Tick problem with our dogs. We start using it on
April 1 thru Nov. 1. Based on our positive results with this product I would not hesitate to recommend it.
We always purchase Frontline Plus from Entirely Pets. Their prices are by far the lowest. Their service is the best!!
Thank you Entirely Pets!!
By Liz
Garfield, Arkansas
This product works very well
March 20, 2015
I have been using Frontline Plus for about 10 years on my two terriers. We live in a rural area with a lot of deer and ticks. I also experienced a flea infestation when I first moved into our house. I got rid of the fleas with diligent effort, started using Frontline Plus on a regular 4 week schedule and have not seen one flea on our dogs, and maybe 2 ticks each in these 10 years.
By Owned S.
Good price performer
August 20, 2014
We've used Frontline Plus for many years and been happy with the results. Entirely Pets has the best price I've found.
By dls
Review for Frontline Plus for Dogs 23-44 lbs - BLUE, 12 MONTH
July 18, 2014
the product is fine, I have used this since we have our dog.
By gary
shenandoah, virgnia
flea meds.
March 10, 2014
the same thing is was getting at the vets for a cheaper price .
By caroline h.
flea and tick control
February 28, 2014
I've been using frontline plus as per my special vet Dr. Judy Morgan Clayton Veterinary Asso. We have five adopted animals and have used this product for 30 or more years with great success. We would not use anything else for our dear furry friends. Its the best!
By 18thstlocal
Excellent flea protection
February 17, 2014
We've been using frontline for years with our dog and never had a problem with fleas.
By jeani
The Best
January 7, 2014
I have had dogs for about 40 years. Not sure how long I have used frontline but I have no desire to change to another being frontline does its job. Living in the country we have tons of ticks with all the wildlife passing through the surrounding area. Great product
By Lindsey
Bel Air, MD
Excellent Protection
January 7, 2014
I have been using this product for years. It works great. Kills fleas and ticks!
By hallesmom
Greenville, SC
Don't let your best friend go without it
November 13, 2013
I use Frontline for all my dogs...I have NEVER found a flea or tick on either of them..Best product on the market!
By Jack&Jesse
Syracuse, ny
Ready for good weather
April 16, 2013
good timing for a sale. now all set for spring & summer with flea and tick protection.
By DogMom55
Best Price Online
April 11, 2013
It was as described, and a great price. With the free-shipping, I was saved a lot of money by buying Frontline on Entirely Pets.
By 4bostons
Chesapeake, VA
Kills ticks
January 24, 2013
This works very good for fleas, but we use it because of ticks. It provides good protection from ticks for 3-4 weeks.
By Shelby
Great purchase
January 8, 2013
The vet recommended this product. It has worked great for my two dogs!
By Jersey J.
Great Service!
January 1, 2013
Found Entirely Pets to have the best price for Frontline Plus products and received fast and free delivery!
By dihof3
Completely Satisfied
December 30, 2012
I have purchased Frontline Plus Blue several times from Entirely Pets. I always receive the product in a timely manner and feel that the price is the lowest that I can find.
By Floyd
Entirley Satisfied
December 29, 2012
We started using Frontline on our Bichon "Buddy" with great results when he was just a puppy. His vet talked me into trying an oral tablet but it made him sick and we went back to Frontline. He tolerates it well and has had no fleas or ticks in the almost five years we have had him. The most economical way to buy it is purchasing a years supply from Entirley Pets online.
By pin
Frontline Plus Blue for Dogs
November 15, 2012
great and I like being able to get in 6 months supply
By ju
houston, tx
using frontline plus for my cats and dog
November 6, 2012
use this product over 10 years for all of my pets. Do not have any problem.
By 2Aussies
Youngsville NC
October 25, 2012
I have used Frontline for years and my pets have been free of problems.
I started using Entirely Pets about 5 years ago and their service and prices are great. I always check them first when I need something for my Aussies.
August 7, 2012
I've used it for years and never had flea problems.
By Debster
Lakeland, Fla
Frontline Plus Blue.23 to 44 pounds
May 30, 2012
I have always used Frontline Plus, on rare occasions, I have used Comfortis during a particularly bad flea time, but Frontline Plus is my go to flea medicine of choice.
By dihof3
Frontline Plus BLUE for Dogs 23-44 lbs, 12 MONTH
May 30, 2012
I was very pleased with my order. I have already recommended Entirely Pets to my friends and told them about the quality product at a good price.
By Tux
Chesapeake, va
Frontline plus vs pet armour
May 30, 2012
Frontline wins. We use frontline for protection against ticks. We have shorthaired dogs and found frontline stays on longer. Don't know why, maybe doesn't wash off as easily?
By happy c.
Bridgeport, WV
great price - great product
May 3, 2012
You don't have to worry about fleas if you use this product monthly.
By dogfriend
very disappointed
April 25, 2012
I have several dogs and each one without exception continues to have fleas after application. This product does not last 30 days as a matter of fact it is not even effective for one day. It is way over priced for what it claims to do. I called the help line and they were of no help either.
By Dusty's m.
Pensacola, FL
This Product Works!
April 17, 2012
I couldn't be happier with this product. Easy to use and it works wonderfully!

Questions and Answers

Frontline Plus for Dogs 23-44 lbs, 3 MonthFrontline Plus for Dogs 23-44 lbs, 3 MonthReg price: $54.99
Sale price: $42.89
Frontline Plus for Dogs 23-44 lbs, 6 MonthFrontline Plus for Dogs 23-44 lbs, 6 MonthReg price: $102.99
Sale price: $79.99
Frontline Plus for Dogs 45-88 lbs, 3 MonthFrontline Plus for Dogs 45-88 lbs, 3 MonthReg price: $54.99
Sale price: $42.89
Frontline Plus for Dogs 45-88 lbs, 6 MonthFrontline Plus for Dogs 45-88 lbs, 6 MonthReg price: $102.99
Sale price: $79.99