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Frontline Plus for Dogs 45-88 lbs, 3 Month Video
Frontline Plus for Dogs 45-88 lbs, 3 Month Video

Frontline Plus for Dogs 45-88 lbs, 3 Month

Item: FPLUS3PU88
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3-month sizes are sent as individual topical doses, does not include box. Frontline Plus products do not expire and do not have expiration dates on the packaging.


Frontline Plus Orange for Dogs 0-22 pounds is a veterinarian-recommended, powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. Frontline Plus is specially formulated for dogs and puppies aged eight weeks and older weighing less than 22 pounds. Available without a prescription, Frontline Plus only needs to be applied once a month for thorough pest control.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. Frontline Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. Frontline kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, Frontline Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in Frontline , fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes three 2.68 mL tubes of Frontline Plus for Dogs.

Key Benefits

  • Kills fleas, flea eggs, ticks, and chewing lice
  • Fast-acting formula
  • Includes three one-month applications
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older weighing less than 22 pounds

Frontline Plus for Dogs is Available In:
(0 - 22 lbs)
(23 - 44 lbs)
(45 - 88 lbs)
(89 - 132 lbs)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month


Active Ingredients


Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients% by Weight
Inert Ingredients81.4%

Possible Side Effects

Some animals are sensitive or allergic to the ingredients in Frontline, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Three tubes, each 0.023 fluid ounces (0.67 milliliters)

Useful Information

How Frontline Plus Works

Use Frontline Plus for fast-acting, long-lasting flea and tick control. When you apply Frontline, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, Frontline provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying Frontline Plus to your pet is an easy three-step process:

  1. Remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down.
  2. Hold the applicator upright and away from your face and body and snap off the tip.
  3. Place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Dosage Table

WeightMonthly Dosage
Up to 22 poundsOne applicator (Orange)
23 - 44 poundsOne applicator (Blue)
45 - 88 poundsOne applicator (Purple)
89 - 132 poundsOne applicator (Red)

Storage Directions

Store unused product in original container, out of reach of children and animals.

Customer Reviews

Review Summary
102 Reviews
82% (84)
9% (9)
1% (1)
2% (2)
6% (6)
87% Recommend this product (89 of 102 responses)
By Kimkats
Lincoln, ne
Have used it for years and will continue to do so
March 29, 2019
I don't even know how long we've used this stuff. We live on 60 acres with a lot of natural prairie so that means ticks up the wazoo. The few that we find on the dog are dead or on their way out when we find them in top of her fur. Never found an embedded once since we've used this. Great stuff at the best price around!
By howlinghound
No ticks!
June 6, 2016
We use this product on our labs. It does leave a greasy spot between the dog's shoulders for 2 or 3 days, but once absorbed into the coat it is not a problem. We chose this product over other products because our dog frequently go swimming in the summer and the Frontline does not become less effective. We have never had a tick using this product.
By top o.
works as advertised
May 7, 2016
Have used it for years on our 10 year old, using this on our puppy.
By tim
not so sure
May 4, 2016
Ive applied the first vile 2 weeks ago and my dog still has flees...maybe it takes longer or product dosent work ....tim
By smoochie
Not for Frontline, but the service
September 4, 2015
Frontline Plus is a good product; lots of customers would agree to that. The 5 star rating is for expediting; order was placed late Saturday morning. Monday early afternoon it was in my mailbox. Now, we're both located on the west coast in two different states; I'm still curious how this happened with standard shipping and of course over the weekend. Big thanks Entirelypets you are now my go to for pet products.
By Cindy
NE Ohio
Never fail protection
July 23, 2015
I have used Frontline Plus on my 3 dogs for years and it has never failed to give them the flea and tick protection it promises. ONCE I tried another product that claimed to be just like Frontline only cheaper. Never again,,,we had fleas within days of it's use. I will stay with Frontline for the lives of my dogs.
By johnc66
Raleigh, NC
Excellent Product
June 30, 2015
I have been using Frontline Plus for 10 yrs now and have NEVER had an issue with Fleas or Ticks.
By Jack's D.
Good stuff.
May 7, 2015
This stuff works with no noticeable side effects. we use it every flea season.
By Maddie
Great job for doing away with fleas
April 15, 2015
My vet recommended Frontline years ago and now save some cash by using Entirely Pets. Works very, very well.
By Amyaja
Dallas, TX
I rely on this product!
April 7, 2015
Have used on my 10 year old German Shepherd since he was a puppy.
Have never had any problem with fleas or ticks.
By Carol
Seattle, WA
Very convenient
March 3, 2015
It seems I am using the last dose and I don't get to the vet to get more. This is great that I can order when I have used the last one and it is delivered to the house. It is the same product.
By Pat
Good tick control
September 27, 2014
This is the best product we have tried for tick control. It also works well on fleas.
By Marilyn
San Juan, P.R.
Dog in patio
August 19, 2014
I have a dog which most of the time is in our patio, She has been with us for 8 years and we
have never had any problems with ticks or anything.
By Debra K.
Lewiston, Maine
Works great on keeping my dog free flea
July 31, 2014
My dog has an allergy to fleas and I use the Frontline Plus and she hasn't had any fleas at all this year
By Lori
Review for Frontline Plus for Dogs 45-88 lbs - PURPLE, 3 MONTH
June 28, 2014
Have used this product for years. Our dogs have never had fleas & amazing how they keep ticks off them.
By LuLu
Does the Job
June 21, 2014
I don't like putting chemicals on my dog but, have tried "natural" remedies without success. This product does the job and, I've been using it for 3 years. Does not cause seizures like some other products have.
By ChloeK
Great for dogs
May 10, 2014
I have used Frontline Plus in the past and have had no problems with my dog. It seems to work really well.
By Kathryn
Bedford, VA
Great product at a great price.
March 26, 2014
I ordered this with another product to get free shipping. I was going to have to buy it anyway and it was the same price as Walmart and way cheaper than the vet or pet store. This is the only flea and tick that works on my dog. I have tried some of the cheaper ones but they did not work.
I really like Entirely Pets. They have good products at a great price and good service.
By Lucy S.
Oakland, CA
Great Flea Product
March 17, 2014
Frontline is great for my two Chesapeake Bay Retrievers. Entirely Pets has the best prices for this product. It's very easy to apply to both of my dogs.
By Shelsbells
Chatsworth, CA
Excellent Protection
February 8, 2014
This has been our go to flea and tick protection for years on both of our dogs. It is easy to apply, very effective, relatively inexpensive and has no side effects.
By bobcat
Tucson Az
great product
January 1, 2014
i have a service dog who goes everywhere with me. I need a product to keep fleas away from him. This product was highly recommend by my vet and Entirely pets was the cheapest. I would recommend this product for all dogs and cats.
By Jerry
Review for Frontline Plus for Dogs 45-88 lbs - PURPLE, 3 MONTH
December 21, 2013
Excellent product for controlling fleas . Arrived quickly in mail.
By Sunny
no longer viable product
December 11, 2013
We returned the frontline plus products because we have been advised by several dog and cat groomers, rescuers, pet store employees plus our vet that Frontline has not been working for some time and we should switch to another brand...which we did. Hopefully the new product Advantage and Advantix will work better. Your return service was wonderful.
By Dog L.
Best product for ticks
December 8, 2013
We live in an area with a high tick population. This product really works! In the past we have used other brands & still found ticks on our dog. Since switching, the ticks never bite him or nest-in. Wish we could use it on ourselves too! :)
By Kat
Works great
November 23, 2013
Easy to apply, works! Use monthly to avoid fleas in your home.
Not this season, maybe never again
November 14, 2013
I've used Frontline Plus for years, and it's been great. But since it's gone generic, the fleas seem to be immune to it. I've had to switch the flea protection my dogs are using. :(
By chevsam33
November 6, 2013
I only use Frontline on my pets - have tried others but Frontline is the best.
By tleet
was a fan
October 11, 2013
I've used this product for years but recently it is no longer effective on fleas.
By Pat
Kansas City area
Super product
October 9, 2013
Frontline Plus has kept my dog flea and tick free for 5+ years. I wouldn't use anything else!
By Snow
Review for Frontline Plus for Dogs 45-88 lbs - PURPLE, 3 MONTH
October 8, 2013
Frontline is very effective in keeping dogs and cats flee and tick free.

Questions and Answers

Frontline Plus for Dogs 23-44 lbs, 6 MonthFrontline Plus for Dogs 23-44 lbs, 6 MonthReg price: $103.99
Sale price: $79.99
Frontline Plus for Dogs 23-44 lbs, 12 MonthFrontline Plus for Dogs 23-44 lbs, 12 MonthReg price: $206.99
Sale price: $158.99
Frontline Plus for Dogs 45-88 lbs, 6 MonthFrontline Plus for Dogs 45-88 lbs, 6 MonthReg price: $103.99
Sale price: $79.99
Frontline Plus for Dogs 45-88 lbs, 12 MonthFrontline Plus for Dogs 45-88 lbs, 12 MonthReg price: $206.99
Sale price: $158.99