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  6. Frontline Plus for Dogs 89-132 lbs, 6 Month

Frontline Plus for Dogs 89-132 lbs, 6 Month Video
Frontline Plus for Dogs 89-132 lbs, 6 Month Video

Frontline Plus for Dogs 89-132 lbs, 6 Month

Item: FPLUS6RD132
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Frontline Plus Orange for Dogs 0-22 pounds is a veterinarian-recommended, powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. Frontline Plus is specially formulated for dogs and puppies aged eight weeks and older weighing less than 22 pounds. Available without a prescription, Frontline Plus only needs to be applied once a month for thorough pest control.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. Frontline Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. Frontline kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, Frontline Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in Frontline , fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes six 4.02 mL tubes of Frontline Plus for Dogs.

Key Benefits

  • Kills fleas, flea eggs, ticks, and chewing lice
  • Fast-acting formula
  • includes six one-month applications
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older weighing less than 22 pounds

Frontline Plus for Dogs is Available In:
(0 - 22 lbs)
(23 - 44 lbs)
(45 - 88 lbs)
(89 - 132 lbs)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month


Active Ingredients


Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients% by Weight
Inert Ingredients81.4%

Possible Side Effects

Some animals are sensitive or allergic to the ingredients in Frontline, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Three tubes, each 0.023 fluid ounces (0.67 milliliters)

Useful Information

How Frontline Plus Works

Use Frontline Plus for fast-acting, long-lasting flea and tick control. When you apply Frontline, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, Frontline provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying Frontline Plus to your pet is an easy three-step process:

  1. Remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down.
  2. Hold the applicator upright and away from your face and body and snap off the tip.
  3. Place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Dosage Table

WeightMonthly Dosage
Up to 22 poundsOne applicator (Orange)
23 - 44 poundsOne applicator (Blue)
45 - 88 poundsOne applicator (Purple)
89 - 132 poundsOne applicator (Red)

Storage Directions

Store unused product in original container, out of reach of children and animals.

Customer Reviews

Review Summary
35 Reviews
83% (29)
6% (2)
3% (1)
0% (0)
9% (3)
86% Recommend this product (30 of 35 responses)
By Pat
Morristown, TN
The best for my dogs
January 10, 2023
This product has always protected my pets for both fleas and ticks! It's the best!

Merchant Response:Hello Pat, It's great to hear this product is still doing amazing things for your pets!
By Linda G.
So easy!
May 28, 2018
Ordering Frontline on line saved me one more trip to the store, and money! And when you have a dog who wakes you up, you want to be sure he's not bringing fleas and ticks with him!
  • They're so entertaining!
  • lots of work
By Susan L.
Lake Forest, CA
Worry No More!
June 21, 2017
My three dogs, Sage, Minnie, and Chance all receive flea & tic protection via this product. We walk in wooded areas regularly. I'm glad they can leave the worrying about deadly diseases to me and Frontline Plus!
By Cindy
Eustis, Florida
Frontline Plus
May 16, 2017
Great product easy application. Works quickly
By kcc
It works!
June 24, 2016
It seems to work. No fleas, ticks, etc.!
By Paula
Southern California
Frontline didn't work
August 22, 2015
I have used Frontline in the past years but this year in SoCal it didn't work at all. I ended up getting Advantix II which worked like a charm.
By Akitagirl3
Gresham, OR
Excellent Product
August 12, 2015
The only product I trust for my Akita dogs!
By Connie
Frontline Plus does not work anymore
September 12, 2014
The fleas laugh at this stuff. Ended up going to the vet and getting comfortis.
By bikerdave
New Castle DE
July 21, 2014
This product is easy to apply and seems to work well on my 106 lb. German Shepherd
By Charley's M.
St Petersburg, Florida
Review for Frontline Plus for Dogs 89-132 lbs - RED, 6 MONTH
March 7, 2014
This is a safe and very effective product. I've been using it for years with much success. Entirely Pets always has the best price on this product.
By Patricia
Review for Frontline Plus for Dogs 89-132 lbs - RED, 6 MONTH
January 11, 2014
Still the best flea medicine I have used on my pets. The cat version was not as effective. Would love a bedding wash version...
By zzed28
not perfect
December 22, 2013
This product works for the most part, but tends to only last two or three weeks before re appearance of visible fleas.
By Lamblady
flea product
August 22, 2013
This product did not take care of the fleas, I want to know why. Alot of money for a product that does not work:(
By Higgins
Super Fast Delivery
July 30, 2013
Quality product at super price and super fast delivery!
By Amfbob
Frontline Plus- Large Dogs
July 29, 2013
Used this for several years with great success.
By ng
White Pine, TN
Dog and Horses
June 12, 2013
I recently ordered this product and I always get such excellent responses to my orders. They are taken care of in a couple of days and I receive them with no problems. I have a dog and I also have horses, with which I order cosequin, a joint product for the horses, this stuff is wonderful, would not be without it. Entirely Pets always emails me with specials on Dog products and horse products. I highly recommend these products and the savings are
By skittles
best on fleas
June 10, 2013
Have been using this on my dog for years now. Easy and not messy to use. Best product for my big dog.
By larry
Great price
April 23, 2013
Just in time. A very good product @ a very good price.
By Lynn O.
The Villages FL
April 23, 2013
Started using this product close to a year ago and have had absolutely no problems with fleas or ticks on my yellow lab. As you can see, Rusty is very active!
Flea free
April 15, 2013
This size of Frontline Plus allows me to treat both our dogs with the one application. I have a 55 lb. and a 16 lb. It is a savings to do it this way. I use it along with a Preventic Tick Collar for the added tick prevention. Entirely Pets is a trusted business that I have ordered from many times.
By Michele
Great Products
January 24, 2013
Pleasure to do business with - fast and easy.....Same products at reduced orices.
By horse1
Purchase all the time
December 8, 2012
I have never had problems with EntirelyPets with any of my orders. I have checked other places and they seem to have the best deals.
By cc
Frontline Plus
November 25, 2012
This works great for my dogs. No fleas if i use it consistently. However, I tend to skip months. When I do notice a flea on anyone of my dogs, I use Frontline Plus immediately and the next day, no more fleas for a couple of months. I use it more often during summer time. This also helps with ticks!
By DonnaD
Pittsburgh, PA
Great transaction, would buy again
November 6, 2012
Got a great deal on Frontline. It's the only flea and tick suggested by vets and even considered by me. Works great. Fast delivery too!
By jpneenr1
Wilkes-Barre, PA
frontline plus for dogs
August 9, 2012
Frontline plus for dogs.....very good product....never have a problem and easy to apply. provides a great service.
By Mt M.
July 26, 2012
Protects all 3 of my pets, 2 Bouvier & a Mini. Schnauzer.
By Rhonda
Visalia, CA
May 30, 2012
Excellent product, great price and customer service.
By Linn
Solves flea problems.
May 30, 2012
Have used Frontline for a long time, no flea problems, some tics make it into house but don't latch on to dogs.
By dave
jerusalem ohio
good value and fast delivery
April 17, 2012
good value and fast delivery best prices i have seen around
By big d.
Washington state
great products, great prices
April 9, 2012
Frontline works really well and very quickly. It is easy to administer and causes no trauma to my dog.

Questions and Answers

Frontline Plus for Dogs 45-88 lbs, 12 MonthFrontline Plus for Dogs 45-88 lbs, 12 MonthReg price: $205.99
Sale price: $157.99
Frontline Plus for Dogs 89-132 lbs, 3 MonthFrontline Plus for Dogs 89-132 lbs, 3 MonthReg price: $54.99
Sale price: $41.89
Frontline Plus for Dogs 89-132 lbs, 12 MonthFrontline Plus for Dogs 89-132 lbs, 12 MonthReg price: $205.99
Sale price: $157.99
Frontline Plus for Dogs 5-22 lbs, 3 MonthFrontline Plus for Dogs 5-22 lbs, 3 MonthReg price: $54.99
Sale price: $41.89