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  6. Frontline Plus for Dogs 23-44 lbs, 6 Month

Frontline Plus for Dogs 23-44 lbs, 6 Month Video
Frontline Plus for Dogs 23-44 lbs, 6 Month Video

Frontline Plus for Dogs 23-44 lbs, 6 Month

Item: FPLUS6BL44
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Frontline Plus Orange for Dogs 0-22 pounds is a veterinarian-recommended, powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. Frontline Plus is specially formulated for dogs and puppies aged eight weeks and older weighing less than 22 pounds. Available without a prescription, Frontline Plus only needs to be applied once a month for thorough pest control.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. Frontline Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. Frontline kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, Frontline Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in Frontline , fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes six 1.34 mL tubes of Frontline Plus for Dogs.

Key Benefits

  • Kills fleas, flea eggs, ticks, and chewing lice
  • Fast-acting formula
  • includes six one-month applications
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older weighing less than 22 pounds

Frontline Plus for Dogs is Available In:
(0 - 22 lbs)
(23 - 44 lbs)
(45 - 88 lbs)
(89 - 132 lbs)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month


Active Ingredients


Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients% by Weight
Inert Ingredients81.4%

Possible Side Effects

Some animals are sensitive or allergic to the ingredients in Frontline, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Three tubes, each 0.023 fluid ounces (0.67 milliliters)

Useful Information

How Frontline Plus Works

Use Frontline Plus for fast-acting, long-lasting flea and tick control. When you apply Frontline, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, Frontline provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying Frontline Plus to your pet is an easy three-step process:

  1. Remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down.
  2. Hold the applicator upright and away from your face and body and snap off the tip.
  3. Place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Dosage Table

WeightMonthly Dosage
Up to 22 poundsOne applicator (Orange)
23 - 44 poundsOne applicator (Blue)
45 - 88 poundsOne applicator (Purple)
89 - 132 poundsOne applicator (Red)

Storage Directions

Store unused product in original container, out of reach of children and animals.

Customer Reviews

Review Summary
80 Reviews
80% (64)
13% (10)
3% (2)
0% (0)
5% (4)
95% Recommend this product (76 of 80 responses)
By red c.
Works well
August 18, 2017
Though I don't like using a pesticide on my animals, this product has continued to be effective through the years.
By NY T.
Western NY
Still working great for us
November 3, 2016
We have been using Frontline Plus for years, and it continues to work well in our area. EntirelyPets is also great to deal with.
By pebbles
Douglas, Ma
not quite enough
May 15, 2015
Yeah, okay so I am a big girl, so what? Why don't these manufacturers realize that there are those of us who need a larger size dose than 132lb? I would appreciate if if my human only had to empty 1 container per month on the back of my neck rather than 2. It also might in some way mitigate the expense allowing for more money to spend on treats, which I love.
By FurIsFlyin'
New York
Frontline is Great. Been using it forever
March 26, 2015
I have been using frontline since 1492! It's fantastic. Unfortunately, right after I purchased it entirelypets had it on sale. Watch for sales!
By In S.
Seattle, WA
Good value
March 9, 2015
This is a good value for the product. Works fine on my dog. He is allergic to other flea product and this on seems to work fine for him.
By spike29
Boston, MA
Best price, best service!
October 2, 2014
I keep returning to Entirely Pets for my pets Frontline Plus purchase. The price is the best, the product is legitimate and I don't worry about foreign copies of the product. I trust this company with all of my purchases. Very reliable.
By kat
Great Product
September 19, 2014
I use this for my two pups and didn't have a single flea or tick problem.
By zsty a.
vet recommended initially
August 18, 2014
Been using Frontline and now Frontline Plus for years with all of my dogs. My vet recommended this product initially and I have continued to use it regularly. Try to keep up to date with applications, as we travel for dog sporting events and come into contact with many other dogs and we're often near grassy or wooded areas where I seem to come home with the ticks and not the dogs! Product is easy to use.
By Lud 1.
New Jersey
Great product
August 8, 2014
Have been using this product for years on both dogs. Easy to use and no pesty pests. Arrived within days of placing order. Great product
By Kat
Saint Louis, MO
Frontline Plus - great product
August 4, 2014
I've used inferior products in the past and Frontline is the best!
By Nancy
North Hills, CA
Frontline Plus works well
July 28, 2014
Frontline Plus works well on my dogs and they haven't had fleas for years using this product monthly. I use it year round.
By Elizabeth
July 24, 2014
I ordered 3 different packages of frontline. One for my cats one for my larger dogs and one for my smaller dogs. After they had been capstarred for 2 days and hold absolutely no fleas I placed the frontline on my animals just as the instructions stated. Within days my dogs were covered in fleas and chewing themselves til they bled. I asked my vet about this and he said that for some reason frontline has not been working lately and he has received many complaints about the product. I have tried with no success to reach someone to help with this problem. I spent over $144 for a product that not only did not work but has caused me incur more medical expenses because of open sores that my dogs have chewed on themselves trying to rid themselves of fleas. I thought I was getting a good and reliable product but instead I got more problems and no one to help rectify the problem. DO NOT BUY FROM THIS COMPANY!
By JimInPA
Camp Hill, PA
Works well so far
June 7, 2014
It's still early in the season but we haven't had to deal with any fleas yet. The crucial time will be mid-summer and I hope I can maintain this rating.
By happy
Review for Frontline Plus for Dogs 23-44 lbs - BLUE, 6 MONTH
May 15, 2014
much better than advantix (which causes growths on both dogs)
By Ducklady
Annapolis, MD
Keeps the Fleas Away!
April 16, 2014
I have several dogs, cats, and birds, so it is important to keep the fleas out of my house so I won't need an exterminator. I used K-9 Advantix, until I saw the warning about the hazard to cats. I switched to Frontline, and have been extremely pleased with the job it does. We dose the cats and the dogs, and thank heavens we have not had a problem with fleas or ticks in the house or on our pets. It gets the job done!
By Thisby
Frontline Plus works
February 26, 2014
Our dogs have never had fleas and have always been on Frontline Plus. The purchase was easy, shipping was fast, and the price was reasonable.
By Pat
best for ticks
February 14, 2014
We live on a ranch in an area with many ticks. Frontline Plus protects our dogs better than any other product we have tried.
By Pete
Newtown Square, PA
A great product that works!
December 30, 2013
great product ... great seller ... do business with these folks! A+++++ !!!!!
By Owned S.
Excellent price performer
November 26, 2013
I have used Frontline Plus for flea and tick control for many years. Entirely Pets provides the best price performance for the product from a site I believe I can trust. Thank you, Entirely Pets.
By mat
Heartgard Plus
October 16, 2013
Good product selection and super fast service.
By Jeanne
Springfield, Ohio
Great Product
August 25, 2013
Has worked well for years now. I've used it for a long time.
By Joanne
Tick control
August 25, 2013
I live in Lyme disease country, and have been using the yearly Lyme shot along with Frontline Plus during tick season. So far, so good ; )
I only wish it wasn't so expensive and that it repelled ticks, not just killed them after they attached and fed.
By Susan
Great Flea Protection
August 11, 2013
I have been using this product for years. It works very well.
By Lynnie
Austin Tx
Great Product
August 9, 2013
My dog has an allergy to flea bites. His dermatologist dx this product. Flea's be gone!
By Kris
works great
July 22, 2013
traveled to Mn where there are loads of ticks this time of year. They literally dropped off dead! Kopi (my dog) is like a magnet to ticks and Frontline keeps them off
By OsMama
Birmingham, AL
Great Product
July 7, 2013
This has worked wonderfully for my two dogs for several years with no side effects.
By mom k.
Alvaton, KY
good product for tick infested areas
July 3, 2013
I have used this product for years and have found that it does a good job but does not seem to be as effective as it was years in the past. I still find ticks attacked to one of my dogs and she was getting them every day in the spring. She is a house dog and would pick them up when the other dogs didn't. I didn't give the ticks a chance to die from the Frontline Plus because she has such short hair, I could find them with a quick search.
By Lloyd
Luttrell tennessee
Review for Frontline Plus for Dogs 23-44 lbs - BLUE, 6 MONTH
July 2, 2013
we ordered from you all for u are the best place to get this product
By scottk
Frontline Plus
June 18, 2013
This is the only product I will use for my dogs. I have had six dogs over the years, and there has never been a flea or tick problem with Frontline Plus.
By LunaTick
A Solid Winner
May 29, 2013
I have been using Frontline Plus for several years. We live in a high tick area, and it is a rarity to find a live tick on either of my two dogs, even during the height of the season! I am grateful not to have to hand-pick ticks anymore, especially as both dogs are double-coated.

Questions and Answers

3 Questions & 3 Answers
from Kennesaw, GA asked:
April 14, 2015
Where is this product manufactured?
1 Answer
Frontline Plus is manufactured by Merial in France.
Submitted by: Customer Service on April 14, 2015

from Kennesaw, GA asked:
April 14, 2015
Is there an expiration date on this package?
1 Answer
No- Frontline Plus does not have an expiry or best by date.
Submitted by: Customer Service on April 14, 2015

from Portland, OR asked:
January 29, 2015
Hello, I'm Nomamommy ^^ I given it but I'm not found EXP date..... Where is marking EXP date?
1 Answer
This is no mistake- for as long as this product is kept at room temperature and sealed in its original packaging, it will not expire! Source:
Submitted by: Customer Service on January 30, 2015

Frontline Plus for Dogs 5-22 lbs, 12 MonthFrontline Plus for Dogs 5-22 lbs, 12 MonthReg price: $205.99
Sale price: $158.99
Frontline Plus for Dogs 23-44 lbs, 3 MonthFrontline Plus for Dogs 23-44 lbs, 3 MonthReg price: $54.99
Sale price: $42.89
Frontline Plus for Dogs 23-44 lbs, 12 MonthFrontline Plus for Dogs 23-44 lbs, 12 MonthReg price: $205.99
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Frontline Plus for Dogs 45-88 lbs, 3 MonthFrontline Plus for Dogs 45-88 lbs, 3 MonthReg price: $54.99
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