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Frontline Plus for Dogs 89-132 lbs, 12 Month Video
Frontline Plus for Dogs 89-132 lbs, 12 Month Video

Frontline Plus for Dogs 89-132 lbs, 12 Month

Item: FPLUS3RD132-12M
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Frontline Plus Orange for Dogs 0-22 pounds is a veterinarian-recommended, powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. Frontline Plus is specially formulated for dogs and puppies aged eight weeks and older weighing less than 22 pounds. Available without a prescription, Frontline Plus only needs to be applied once a month for thorough pest control.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. Frontline Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. Frontline kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, Frontline Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in Frontline , fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes twelve 4.02 mL tubes of Frontline Plus for Dogs.

Key Benefits

  • Kills fleas, flea eggs, ticks, and chewing lice
  • Fast-acting formula
  • includes twelve one-month applications
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older weighing less than 22 pounds

Frontline Plus for Dogs is Available In:
(0 - 22 lbs)
(23 - 44 lbs)
(45 - 88 lbs)
(89 - 132 lbs)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month


Active Ingredients


Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients% by Weight
Inert Ingredients81.4%

Possible Side Effects

Some animals are sensitive or allergic to the ingredients in Frontline, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Three tubes, each 0.023 fluid ounces (0.67 milliliters)

Useful Information

How Frontline Plus Works

Use Frontline Plus for fast-acting, long-lasting flea and tick control. When you apply Frontline, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, Frontline provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying Frontline Plus to your pet is an easy three-step process:

  1. Remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down.
  2. Hold the applicator upright and away from your face and body and snap off the tip.
  3. Place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Dosage Table

WeightMonthly Dosage
Up to 22 poundsOne applicator (Orange)
23 - 44 poundsOne applicator (Blue)
45 - 88 poundsOne applicator (Purple)
89 - 132 poundsOne applicator (Red)

Storage Directions

Store unused product in original container, out of reach of children and animals.

Customer Reviews

Review Summary
33 Reviews
85% (28)
9% (3)
0% (0)
0% (0)
6% (2)
91% Recommend this product (30 of 33 responses)
By top o.
works as expected
May 7, 2016
Have used this product for 10 years on our German Shepard with great success.
By pebbles
Douglas, Ma
Great product
May 15, 2015
I don't like the thought of Lyme disease or of having pests crawl all over me, so I am grateful that my human uses Frontline on me even though I don't like having to have it applied to the back of my neck. I am 8 years old and have never had a flea or a tick and I live surrounded by thousands of acres of forest and the deer walk through my yard everyday.
By Sharon
Weirton, West Virginia
Frontline Plus
April 5, 2015
I have several dogs and regularly treat them for fleas and ticks. I find that Frontline Plus is the best treatment for them. I have had pets all of my life and have NEVER had a flea infestation. Entirely Pets is the best and most inexpensive company to deal with, and I have been ordering from them for a long, long time. My orders have arrived within two days, and I am extremely happy with the service I receive!
By teecamp427
Boston, MA
Best Flea & Tick Product
August 19, 2014
Have been using this product for years. I have two big yellow labs who are always outside. No fleas or ticks
By fwreed3
Keeps Fleas & Ticks Away!
July 12, 2014
I use frontline on all pets and I never have any problems with fleas or ticks!
By mike
May 24, 2014
great seller, products always as advertised, promptly shipped, and arrive on time. We have been using Entirely Pets for our pet supplements for years and they have always exceeded our expectations.
By Pat
Have not found better
May 8, 2014
I've owned dogs for the last 16 years & cats for 14. Prior to that I had a dog for 5 years, about 40 years ago. To keep him flea & tick free, I used a "tick dip" which required dousing him with the toxic chemical mixture & letting him dry. Don't ask!
More recently I tried many products ( the "dip" had been taken off the market.) First collars, then pills, then holistic preparations, then Frontline Plus. Only Frontline Plus did the job. The wait time after a bath is necessary. A small price. Thank you Frontline Plus.
By outdoor g.
New Albany, PA
Best product out there!
May 5, 2014
I tried about 4 flea/tick products on the market for both my dogs and cats and I think Frontline Plus stands out front!
By helpsdogs
frontline plus
July 21, 2013
was very happy with the price! does its job.
By H2ODogs
Lincoln, NE
Great Purchase
July 3, 2013
I always put frontline on my dogs in the summer months but I was impressed with the price on Entirely Pets and even more impressed with the shipping. My order arrived much sooner than expected which is always appreciated.
By Betty
Longview, Washington
Frontline Plus Kills Fleas
April 2, 2013
I have five dogs and a clowder of cats. I used Frontline for some years, then changed to another brand for awhile, but found that it did not last as long, only about three weeks. Then Frontline updated to Frontline Plus and I returned to it. F-P is effective almost immediately, and lasts about four weeks, which I usually stretch out to five weeks to give the critters a break, except during ardent flea season. We don't have much of a tick problem out here in the Pacific Northwest, so can't address that. So...for flea control, I highly recommend Frontline Plus for both cats and dogs.
By nhskimum
Best Prices - Authentic Product
February 20, 2013
We've used Frontline Plus for a long time and been very satisfied. Two big dogs and a field of ticks means we have to use something effective without harm to our loved ones - 2 and 4 footed. I've also looked extensively for a lower price but Entirely Pets can't be beat. And the service and speed of filling an order is very fast...usually in my mailbox in a couple of days. Even when I mistakenly ordered Frontline Top Spot instead of Plus, they quickly helped me out with no charge.
By Ethel
my dogs love it
November 7, 2012
My 2 large dogs have been on revolution since puppyhood. They are now 8 and 7 years old.Never see signs of ticks or fleas, no positive test results for heartworm. Best on market
By meimei
Austin Tx
frontline plus
August 7, 2012
My vet said this is the fleas med for my mommy dog, It safe and works. I used it for all my puppies
and pregnant dog.
By King R.
Frontline Plus
July 6, 2012
Would NOT recommend. It's all about trial and error as every dog reacts differently.


No reflection on Entirely Pets, they are a good place to shop.
By kat39
Works Great
June 24, 2012
I have been using frontline on my dogs for years. It works great...if I find a tick on them, it is always dead. And they have no bad reactions to the product. EntirelyPets has great prices and customer service!
By MoeBaz
Titus, AL
Best Product Ever
May 31, 2012
I had been using Advantage II, but fleas were still a problem. After switching to Frontline Plus, my dog is so much happier. No more fleas. I will not switch again.
By BezNez
Always the Best for my Pets
May 29, 2012
I have used this product for years and it has never failed to take care of any flea and tick problems. I have two inside dogs and they have never had any problems and I live in the country where they are always subject to issues. Thank you Frontline and thank you Entirely Pets for taking care of my furry little kids.
By Lotsapups
Review for Frontline Plus for Dogs 89-132 lbs - RED, 12 MONTH
April 27, 2012
This products works perfectly to rid our babies of the ticks out in the country.
By Cindy
Great product
March 28, 2012
I use Frontline Plus every month year all year long and have never had a problem with fleas or ticks. Wondeful product.
By tahoe 1.
Lynchburg VA
Frontline Red
March 19, 2012
I have been using this product for many years and am very satisified with the results. It does exactly what they say it will, it is one of the bestproducts of this nature that I have ever used.
By Kaya
San Diego, CA
Frontline Plus
March 15, 2012
I have been using frontline plus for years for my dog. It works great. I compared prices and had the best deal. I ordered this item and received it just a few days later! Quick delivery!

Thank You!
By tubby
cujo says thanx:
March 11, 2012
i administered frontline,and i thought i heard little screams saying jump for it,were all dead anyway,might as well try.cujo doesnt look like hes trying to start an old motorcycle anymore.thanx
By jrp
frontline plus
January 27, 2012
I've used this product for years, have tried similar ones but this seems to work best for my dogs. Great service from, recevied order within 6 days and got the best price for the other sites that were checked.
By golden l.
Great for flea and tick control
January 7, 2012
We have not had any fleas or ticks on our dogs since we began using frontline.
By whynotpugs
Carriere, MS
Very effective
December 1, 2011
This product, unlike Advantix, has never given my dogs any problems or side-effects. I have several who are particularly sensitive to the ingredient in Advantix causing them to be lethargic and generally not feel well the first several days after applying. I buy the largest dose, which is very economical, and use the dosage recommended for smaller dogs. It's worked very well for my multiple dog household. has the best price I've found.
By mrjackson
Martinsburg, WV
Fleas Be Gone
November 29, 2011
Have been using Frontline Plus for our two black labs for years. Have never seen a flea on them!! Have been purchasing from Entirely Pets for several years and have been very satisified with their prices and service!!!
By Betty
Longview, WA
Love Frontline Plus
November 11, 2011
I have five good-sized dogs who seem to attract fleas anywhere, anytime. Frontline Plus almost immediately rids them of fleas, and lasts longer than comparable products. I like to stock up on it when EntirelyPets has it on sale; also appreciate their free shipping (I'm always over their minimum dollar amount).
By Helen
Review for Frontline Plus for Dogs 89-132 lbs - RED, 12 MONTH
October 30, 2011
Product has a reasonable price compared to other stores and the delivery time is excellent.
By Zooey's M.
Pacific Northwest
The One I Use
October 22, 2011
Have been using Frontline PLUS on my dogs for 12 or so years now. Have not heard of anything better so far. It has done the job. As it's rainy & misty a lot during the winter, I need something that will not wear off when rubbing the dogs (currently 3) after they're wet. As long as they're dry for a few days around the application, it works like a charm.
It works pretty well on my cat...

Questions and Answers

Frontline Plus for Dogs 89-132 lbs, 3 MonthFrontline Plus for Dogs 89-132 lbs, 3 MonthReg price: $55.99
Sale price: $42.89
Frontline Plus for Dogs 89-132 lbs, 6 MonthFrontline Plus for Dogs 89-132 lbs, 6 MonthReg price: $102.99
Sale price: $78.99
Frontline Plus for Dogs 5-22 lbs, 3 MonthFrontline Plus for Dogs 5-22 lbs, 3 MonthReg price: $55.99
Sale price: $42.89
Frontline Plus for Dogs 5-22 lbs, 6 MonthFrontline Plus for Dogs 5-22 lbs, 6 MonthReg price: $103.99
Sale price: $79.99