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  6. Frontline Plus for Dogs 45-88 lbs, 6 Month

Frontline Plus for Dogs 45-88 lbs, 6 Month Video
Frontline Plus for Dogs 45-88 lbs, 6 Month Video

Frontline Plus for Dogs 45-88 lbs, 6 Month

Item: FPLUS6PU88
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Individual topical doses are not shipped in a box.


Frontline Plus Orange for Dogs 0-22 pounds is a veterinarian-recommended, powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. Frontline Plus is specially formulated for dogs and puppies aged eight weeks and older weighing less than 22 pounds. Available without a prescription, Frontline Plus only needs to be applied once a month for thorough pest control.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. Frontline Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. Frontline kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, Frontline Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in Frontline , fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes six 2.68 mL tubes of Frontline Plus for Dogs.

Key Benefits

  • Kills fleas, flea eggs, ticks, and chewing lice
  • Fast-acting formula
  • includes six one-month applications
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older weighing less than 22 pounds

Frontline Plus for Dogs is Available In:
(0 - 22 lbs)
(23 - 44 lbs)
(45 - 88 lbs)
(89 - 132 lbs)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month


Active Ingredients


Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients% by Weight
Inert Ingredients81.4%

Possible Side Effects

Some animals are sensitive or allergic to the ingredients in Frontline, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Three tubes, each 0.023 fluid ounces (0.67 milliliters)

Useful Information

How Frontline Plus Works

Use Frontline Plus for fast-acting, long-lasting flea and tick control. When you apply Frontline, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, Frontline provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying Frontline Plus to your pet is an easy three-step process:

  1. Remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down.
  2. Hold the applicator upright and away from your face and body and snap off the tip.
  3. Place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Dosage Table

WeightMonthly Dosage
Up to 22 poundsOne applicator (Orange)
23 - 44 poundsOne applicator (Blue)
45 - 88 poundsOne applicator (Purple)
89 - 132 poundsOne applicator (Red)

Storage Directions

Store unused product in original container, out of reach of children and animals.

Customer Reviews

Review Summary
115 Reviews
84% (97)
9% (10)
3% (3)
1% (1)
3% (4)
92% Recommend this product (106 of 115 responses)
Owego NY
Prices can't be beat!
May 12, 2019
I've always used Frontline Plus for my cats and dogs. And always buy from Entirely Pets. Lowest prices anywhere. Fleas and ticks don't mess with Buck.
  • Wonderful
  • None
By crazyjudi
Works Great
August 7, 2018
Really A good Price. Really fast deliver . Bid Assortment of Brands
By DogsandCats
Excellent produce
April 10, 2018
I have used Frontline Plus for over 20 years and has consistently done a great job of protecting my dogs.
By Mw62
Oak hills, CA
Flea control
June 27, 2017
This product works exactly as advertised and I usr it on my dogs every year. Other products have not worked as well.
By Dean
Great service
June 13, 2017
I'm very pleased with entirely pets and their service. The product is always shipped fast and is packed well.
By Lucy S.
Oakland, CA
Great Buy
June 5, 2017
Entirely Pets has the best prices when it comes to Frontline for my Chesapeake Bay Retriever.
By Akitagirl3
Gresham, OR
A Must Have!
June 3, 2017
I always depend on Fronline Plus for treating my Akitas. It is easy to apply and it keep my crew flea & tick free!
By Cindy
Eustis, Florida
Review for Frontline Plus for Dogs 45-88 lbs - PURPLE, 6 MONTH
May 16, 2017
Great product...easy application works quickly and lasts
By NY T.
Western NY
Effective Product
October 22, 2016
I have been using Frontline Plus for years, and find it very effective. I understand that there are areas where it may not be effective geographically speaking, but it still works for me in western NY.
By Becky
Best Product
June 4, 2016
Great product to help eliminate fleas and ticks. Won't use any other.
By rsg444
New York, NY
excellent product
May 18, 2016
I use this on my greyhound. This was the one the greyhound rescue group recommended, because greyhounds are very sensitive to many flea and tick repellents. I have never had any problems and Frontline Plus always works!
By Dtaylor
Syracuse, NY
Good but Not Perfect
September 14, 2015
I didn't find fleas or ticks on my dogs for years while using Frontline Plus. Unfortunately when one of my cats had fleas, the Frontline didn't prevent the dogs from getting fleas. Took a couple months to completely get rid of the problem. Still use it on all of our pets but don't expect it to be 100% reliable.
By Carol
Frontline +
September 11, 2015
I have always used Frontline on all my dogs. It seems to work the best, and it has never had any bad effects on any of my dogs. Once I tried another product, and my dog got very sick. But no problems with Frontline.
By catlover6
Winston-Salem, NC
July 5, 2015
this is the ONLY product I will use - it keeps the "pests" away and under control
By lengleman
Bentonville, AR
Best Topical Tick Supply I have Found
June 21, 2015
I have used Frontline for years on my dogs and cats and have been very pleased with the way it keeps the ticks off my animals. I live in a very wooded area and ticks are a constant problem. With Frontline Plus it is one less thing I have to worry about as far as pest making my dogs and cats sick.
By Pat N.
Las Cruces, NM
Pest free
June 19, 2015
I have used Frontline Plus in various sizes on my fur babies , both cat and dog since 1990. Some of my babies have gone to the Rainbow Bridge due to age or cancer, but during their lifetime they remained flea and tick free. I have used this product both in Virginia and New Mexico will not use anything else. I trust Frontline Plus!
By carrieg321
Frontline Plus
May 3, 2015
Working great so far! I have used for many years and the product still seems to work well.
By Barbara
Excellent Product
April 15, 2015
I was very pleased with the product and the price of the purchase. Frontline Plus is a great product and I'm glad Entirelypets could supply me with this product. I will definitely get this again.
By bsn
Bye fleas & ticks
March 25, 2015
Our dog is 13 and a half. We've used Frontline products for flea and tick control since he was old enough to be able to use this type of product, and getting it from Entirely Pets is both convenient and economical. Once Frontline Top Spot was no longer available we switched to Frontline Plus. Easy to apply. I'd have rated it 5 stars except that the plastic packaging is difficult to open and I end up having to use a scissors to cut through it.
sunrise, fl
Review for Frontline Plus for Dogs 45-88 lbs - PURPLE, 6 MONTH
March 15, 2015
been using this product on my golden retrievers for a long time - it works
By Witzy
Frontline Plus for large Dogs
August 21, 2014
We have been using Frontline Plus for a long time on our dogs and the product works Great! It's priced just right at Entirely Pets and is an effective flea medicine.
By Virginia
Easy to Use
August 21, 2014
Frontline was recommended to me several years, It is easy to use and Best of All my dog is content while I apply it.
By Gordon l.
Gorham, ME
This works!
August 14, 2014
We have been using Frontline Plus on our Gordon Setter for 4 years. It kills the ticks that do get on her. She has luckily never gotten Lyme disease and we keep her vaccinations current. Frontline works very well. Just reapply in 30 days. We live in a wooded area so need to be careful of ticks.
By Nay
great product at a good price
June 24, 2014
I have used Frontline flea and tick for many years on my cats and dogs. It is an excellent product, My pets have never had any physical problems due to the use of Frontline. My pets have never had flea infestation or tick problems since using it! Entirely Pets pricing is very competitive. thank you Entirely
By Sandy
Good Product
June 23, 2014
I've used Frontline for years and all my dogs over the years have benefited from it's protection.
By Cathy
Atlanta, GA
My Favorite Flea and Tick Product!!!
June 22, 2014
I have tried many topical flea and tick products, and this is by far the best. It lasts for longer than the said amount of time and it actually kills ticks too. So many of the other products wouldn't kill ticks completely. We live in amongst a lot of trees and in a very humid summer environment and this product is the best. I highly recommend it! I use it on my cats too.
By Alphamama
Durham, NC
Great price!
May 27, 2014
Much better price than local pet supply stores and vet's office.
By swampman
whitney ontario.
best price and info.
May 7, 2014
the dog seems to like it, he didn't say he didn't?I didn't realise the money exchange but it still was a good by.
By Ozzi0803
Review for Frontline Plus for Dogs 45-88 lbs - PURPLE, 6 MONTH
March 15, 2014
By Losky
Great product..
February 26, 2014
I have a German wire hair pointer and he goes hunting a lot in thick brush and he has gotten ticks before but everyone I have found on him has been a dead one. Very good product. I have never seen a flea on him dead or alive.

Questions and Answers

Frontline Plus for Dogs 23-44 lbs, 12 MonthFrontline Plus for Dogs 23-44 lbs, 12 MonthReg price: $206.99
Sale price: $158.99
Frontline Plus for Dogs 45-88 lbs, 3 MonthFrontline Plus for Dogs 45-88 lbs, 3 MonthReg price: $55.99
Sale price: $42.89
Frontline Plus for Dogs 45-88 lbs, 12 MonthFrontline Plus for Dogs 45-88 lbs, 12 MonthReg price: $206.99
Sale price: $158.99
Frontline Plus for Dogs 89-132 lbs, 3 MonthFrontline Plus for Dogs 89-132 lbs, 3 MonthReg price: $55.99
Sale price: $42.89