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Frontline Plus for Dogs 23-44 lbs, 3 Month Video
Frontline Plus for Dogs 23-44 lbs, 3 Month Video

Frontline Plus for Dogs 23-44 lbs, 3 Month

Item: FPLUS3BL44
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Special Sale, add to cart to see discount!

3-month sizes are sent as individual topical doses, does not include box. Frontline Plus products do not expire and do not have expiration dates on the packaging.


Frontline Plus Orange for Dogs 0-22 pounds is a veterinarian-recommended, powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. Frontline Plus is specially formulated for dogs and puppies aged eight weeks and older weighing less than 22 pounds. Available without a prescription, Frontline Plus only needs to be applied once a month for thorough pest control.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. Frontline Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. Frontline kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, Frontline Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in Frontline , fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes three 1.34 mL tubes of Frontline Plus for Dogs.

Key Benefits

  • Kills fleas, flea eggs, ticks, and chewing lice
  • Fast-acting formula
  • Includes three one-month applications
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older weighing less than 22 pounds

Frontline Plus for Dogs is Available In:
(0 - 22 lbs)
(23 - 44 lbs)
(45 - 88 lbs)
(89 - 132 lbs)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month


Active Ingredients


Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients% by Weight
Inert Ingredients81.4%

Possible Side Effects

Some animals are sensitive or allergic to the ingredients in Frontline, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Three tubes, each 0.023 fluid ounces (0.67 milliliters)

Useful Information

How Frontline Plus Works

Use Frontline Plus for fast-acting, long-lasting flea and tick control. When you apply Frontline, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, Frontline provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying Frontline Plus to your pet is an easy three-step process:

  1. Remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down.
  2. Hold the applicator upright and away from your face and body and snap off the tip.
  3. Place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Dosage Table

WeightMonthly Dosage
Up to 22 poundsOne applicator (Orange)
23 - 44 poundsOne applicator (Blue)
45 - 88 poundsOne applicator (Purple)
89 - 132 poundsOne applicator (Red)

Storage Directions

Store unused product in original container, out of reach of children and animals.

Customer Reviews

Review Summary
69 Reviews
78% (54)
12% (8)
3% (2)
4% (3)
3% (2)
90% Recommend this product (62 of 69 responses)
By BeagleLover
Waynesboro, PA
Frontline Plus for Dogs 23-44 lbs.
March 6, 2019
I received item fairly quickly. However, I hope this Frontline Plus is the real thing because I received 3 individual tubes instead of a box of 3. I purchased it from this site because it stated that the item was legit.
By SueB
Streamwood, IL
Have used Frontline for years
June 17, 2017
Frontline has worked for our dogs over the years have never had a flea or tick problem since we started using it . We are now on our 4th and 5th dog and highly recommend it. Getting it from Entirely pets saves us a little bit of money so we buy it on line. Comes speedily and they are always accurate. Could only buy 3 doses as we have a growing pup who will be into the next size before summer is over. Next time will be ordering enough to get free delivery and will save more. We looked into the pill form of control but to many side affects to take a chance on.
By ct
May 18, 2017
I am trying it on my poodle for the fist time. So far no ticks.
Southern California
Does the job
October 21, 2016
Fortunately the fleas in my part of the country (or town?) have not become resistant to Frontline Plus so it still works on my dogs. I recommend this, especially at the prices from Entirely Pets.
By Pam
Review for Frontline Plus for Dogs 23-44 lbs - BLUE, 3 MONTH
June 30, 2016
Works great and its not irritating to the skin.
By Candy
Plattsburgh, New York
Frontline Plus for Dogs 23-44 lbs-BLUE
September 3, 2015
I have had multiple dogs for years. I now have 3.
My vet recommended Frontline Plus years ago and I find it to be safe and effective. It works and my dogs are pest free.
By Peregrine
My poodle now tests positive for Lyme Disease...
April 6, 2015
I live in northern Vermont, have been using this product for a number of years, and never had a problem with tick-borne disease ... until last spring.

It may be that I was negligent in re-applying the Frontline Plus in a timely manner, but I was very surprised when a routine blood test showed that he was Lyme-positive. He has had few neurological symptoms, and none recently.

I am going to continue to use this product, but try to avoid woodsy environments where ticks thrive.
By Kelly
Graham, WA
Awesome Product
March 28, 2015
This product works like a charm. Love it.
By Rocky
Boynton Beach, FL
Works Great!
January 17, 2015
This works great for my dog, a pug by the name of Rocky. All other products we have tried related to this have given him allergies. This one does not make him sick and kills the fleas.
By Ricky
September 20, 2014
On time and new brand product. Excellent. Good price
By candi
great flea stuff
July 31, 2014
my dog was itching like crazy before I bought this but after I put it on our beagle, with in a day he completely stopped. great product
By Wendora
July 25, 2014
I have tried other brands in the past, but Frontline works the best for us! We have had nothing but good results.
By Kempestuous
Seattle, WA
July 7, 2014
We usually use Advantage, but since it was on sale I got the Frontline Plus. The next day after I put it on his back, the fur was still wet looking and clumped together. It never did go back to looking normal even after I brushed it multiple times over the next couple of weeks. In fact when I bathed him a few weeks later, I had to cut a whole bunch of the fur off of that spot because it was so matted. Our dog has pure white fur and no undercoat, so it's very easy to spot a flea. With Advantage the most I've ever seen on him is one. When I went to bathe our dog and looked through his fur, there were dozens of fleas and flea droppings everywhere on him for the first time in his life. I will never buy Frontline again!!!!!
By Shelsbells
Los Angeles, CA
Great Product
July 1, 2014
I've been using Frontline Plus for over a dozen years and swear by it. It always works. We've never had a flea or tick issue with either of our Chow Chows. This is a great product with no side effects that we've noticed.
By Tator H.
Norton, OH
Very good price!
April 10, 2014
Shopping all sites and pet stores found best prices here!
By shar
Review for Frontline Plus for Dogs 23-44 lbs - BLUE, 3 MONTH
December 12, 2013
have been using this for years, never had any issues
By C J.
Virginia Beach, VA
Works for a few days only.
October 30, 2013
Does not work on my beagle mix, don't know if it's his coat or if the fleas are immune to it but it only lasted a few days. It used to work great a few years ago when we had a shepard but nothing we have tried has worked on the beagle so it might just be him.
By Ramzzy
Rocklin, CA
Frontline sub par results
October 27, 2013
Like the rates shows, I gave it 2 out of 5 stars because the stuff is only fairly effective and doesn't work nearly as well as I thought & believe it should, especially considering the high pricing of the product...
By Debby
Benton Harbor, Michigan
Works Every Time
October 5, 2013
This stuff never fails, and I can let my dog outside knowing he is protected with Frontline..
By islalvr
Chicago, IL
September 11, 2013
Frontline Plus remains the most reliable product in my opinion. I've found dead ticks on my dog's blanket, so it's definately working. Will stick with Frontline Plus.
By Chris W.
Works better than anything else I've used
September 8, 2013
Works better than the less expensive brands. Recommend it.
By Sandy
July 15, 2013
I bought two Frontline packages and received them in a timely manner. This was the first time I used Entirely Pets and was happy with my purchase.
By Nan
Frontline Plus for Dogs
June 17, 2013
Product works very well and makes Missy happy to be flea free.
By Barb
San Diego, CA
A Must
June 12, 2013
Living in CA this is a must all year long.
Review for Frontline Plus for Dogs 23-44 lbs - BLUE, 3 MONTH
June 4, 2013
I just can not get rid of the fleas. I have tried this product before and it worked but the last two years it is not working.
By crib
Orlando, FL
Flea Protection
May 7, 2013
It was a great product and it was my first time using it. My dogs seem to like it and thats what counts, keeping the pets happy!
By Barb
Greensboro NC
Review for Frontline Plus for Dogs 23-44 lbs - BLUE, 3 MONTH
May 4, 2013
I have gotten Frontline Plus from Entirly Pets for several years and always pleased with the ordering as well as shipment.Prices are better than with any other company and I have really shopped around.My sister told me about this company and I have been very pleased.
By BarkingBandits
April 3, 2013
I think Entirely Pets has the best prices around for Frontline. Frontline works great on all three of my dogs. I never have a problem with ticks or fleas and I live in a wooded area.
By johnc66
Raleigh, NC
Works Great!!
February 21, 2013
Have been using Frontline Plus on our Shiba Inu for the last 7 years. He has never had flea or issue.
By Randy
Finally, Flea Free!
February 20, 2013
What a saga! Fraught with fleas forever! But no - Frontline Plus to the rescue. And finally - my poor, long-suffering beardies are free at last.

Questions and Answers

1 Question & 1 Answer
from Creedmoor, NC asked:
July 16, 2019

If I use Frontline on my dog will it hurt the two indoor cats that might be exposed to the medication?

1 Answer
Hello Anna this should not harm the cat as long as the medication is not directly on them.
Submitted by: Customer Service on July 19, 2019

Frontline Plus for Dogs 5-22 lbs, 6 MonthFrontline Plus for Dogs 5-22 lbs, 6 MonthReg price: $102.99
Sale price: $78.99
Frontline Plus for Dogs 5-22 lbs, 12 MonthFrontline Plus for Dogs 5-22 lbs, 12 MonthReg price: $205.99
Sale price: $157.99
Frontline Plus for Dogs 23-44 lbs, 6 MonthFrontline Plus for Dogs 23-44 lbs, 6 MonthReg price: $102.99
Sale price: $78.99
Frontline Plus for Dogs 23-44 lbs, 12 MonthFrontline Plus for Dogs 23-44 lbs, 12 MonthReg price: $205.99
Sale price: $157.99