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Frontline Plus for Dogs 45-88 lbs, 12 Month Video
Frontline Plus for Dogs 45-88 lbs, 12 Month Video

Frontline Plus for Dogs 45-88 lbs, 12 Month

Item: FPLUS3PU88-12M
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Frontline Plus Orange for Dogs 0-22 pounds is a veterinarian-recommended, powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. Frontline Plus is specially formulated for dogs and puppies aged eight weeks and older weighing less than 22 pounds. Available without a prescription, Frontline Plus only needs to be applied once a month for thorough pest control.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. Frontline Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. Frontline kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, Frontline Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in Frontline , fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes twelve 2.68 mL tubes of Frontline Plus for Dogs.

Key Benefits

  • Kills fleas, flea eggs, ticks, and chewing lice
  • Fast-acting formula
  • includes twelve one-month applications
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older weighing less than 22 pounds

Frontline Plus for Dogs is Available In:
(0 - 22 lbs)
(23 - 44 lbs)
(45 - 88 lbs)
(89 - 132 lbs)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month


Active Ingredients


Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients% by Weight
Inert Ingredients81.4%

Possible Side Effects

Some animals are sensitive or allergic to the ingredients in Frontline, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Three tubes, each 0.023 fluid ounces (0.67 milliliters)

Useful Information

How Frontline Plus Works

Use Frontline Plus for fast-acting, long-lasting flea and tick control. When you apply Frontline, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, Frontline provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying Frontline Plus to your pet is an easy three-step process:

  1. Remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down.
  2. Hold the applicator upright and away from your face and body and snap off the tip.
  3. Place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Dosage Table

WeightMonthly Dosage
Up to 22 poundsOne applicator (Orange)
23 - 44 poundsOne applicator (Blue)
45 - 88 poundsOne applicator (Purple)
89 - 132 poundsOne applicator (Red)

Storage Directions

Store unused product in original container, out of reach of children and animals.

Customer Reviews

Review Summary
88 Reviews
88% (77)
8% (7)
3% (3)
0% (0)
1% (1)
95% Recommend this product (84 of 88 responses)
By Kelly
Does what it says it does
February 14, 2017
Frontline has always been a successful product for out dog. We live near a bunch of trees and it has helped. It has not kept him from getting them but it has kept them from latching on.
By collie
chicago, il
frontline plus for dogs 45-88 lbs
January 28, 2017
used this for years on many dogs, never have had any fleas or ticks, and I have had long hair double coats on all
By Joal
Central Iowa
Speedy service as always!
July 9, 2016
Have used Frontline Plus for years and years.
Good choice to order from Entirely Pets, super fast delivery!
By SueB
Streamwood, IL
Used Fronline Plus for years
June 8, 2016
Excellent price .Product works great have never had fleas or ticks since we started using it. Also we never have any reaction on any of our dogs, Entirely pets had the best price and then there was a special so saved even more
By catlover6
Winston-Salem, NC
April 23, 2016
great to not have to worry when my dog goes out with me that no ticks or fleas will come back in with us
By Akitagirl3
Gresham, OR
Excellent Product
August 12, 2015
The only product I trust for my Akita dogs!
By Terry
July 23, 2015
Using Entirely Pets online is the best! Items are so easy to find and prices are well below the vet's prices. Delivery is great also.
By Petlover7
Don't waste your money!
June 6, 2015
I purchased Frontline Plus and applied it on my dog two weeks ago. My dog now has a bad case of fleas and I can't get rid of them. I have never had fleas in my twenty-five years of owning dogs and cats. I have used Frontline in the past and I was always pleased as my dog was always flea free. Needless to say, I know I applied it correctly and cleaned my house like crazy. FrontlinePlus is supposed to kill fleas in all their life stages. As stated earlier, my dog has a lot of live fleas crawling over her! I used to like this product and recommend it, but now all I can say is DO NOT BUY FRONTLINE PLUS AS IT DOES NOT WORK!!!
By donna w.
new jersey
Review for Frontline Plus for Dogs 45-88 lbs - PURPLE, 12 MONTH
April 23, 2015
Frontline Plus is the best for both dogs and cats.
By Betsy
Frontline Plus
March 17, 2015
We've used Frontline Plus for years and I enjoy the convenence of application. Packaging makes it easy, and our dogs have never had any side effects. We'll stay with this product!
By Dry1223
Knoxville, TN
Tried and true
March 8, 2015
Know there are a lot of other flea and tick products out there but I've been using frontline plus for years. Easy to apply but will create an oil spot on furniture if not careful. Never had a flea or tick on my babies!
By Sharon
Review for Frontline Plus for Dogs 45-88 lbs - PURPLE, 12 MONTH
February 16, 2015
I've used this product for years with great results.
Review for Frontline Plus for Dogs 45-88 lbs - PURPLE, 12 MONTH
January 23, 2015
Frontline Plus is easy to apply. Have had no problems with fleas and ticks. Use it on 5 dogs.
By gailym
September 20, 2014
By Jen
Great Product!
July 28, 2014
I have been buying this product for years and it is great. I have a lot of woods in my back yard and my dogs are always well protected with Frontline plus.
By Retriever B.
West Bend, WI
Good Stuff
July 19, 2014
Fleas and Ticks and bugs! Oh, my! Now the dogs are safe with Frontline Plus.
By tadmore254
Blue Ridge Mnts. Virginia
resistant fleas
June 20, 2014
I don't know what is going on but the fleas and ticks are building up immunity or the company has lowered the effectiveness... but the fleas and ticks act like this product is all free all inclusive vaycay! The bugs are bad this year!
By Gary N.
Lenoir, NC
Great product, great price.
June 19, 2014
Frontline Plus is the only topical flea/tick product I use on my two yellow labs. In my region of NC ticks are a big problem. Using Frontline Plus we see those little monsters either dead, dying, or doing their best to abandon ship. I've used K9 Advantix II, which caused a bad reaction in my dogs and PetArmor, which didn't seem to do anything. Frontline Plus is what I always come back to. has timely specials which allow me to stock up while saving some green.
By warnertv2
Good for our greyhounds
April 26, 2014
We have used this product for many years for all our greyhounds, past and present.
By Magoo M.
Cedar Crest, NM
Best deal on the market
April 2, 2014
Outstanding product, have used it for years
By Jeanne
utica, ny
Frontline Plus for Dogs
April 1, 2014
This product works great for my 2 labs and is the cheapest here on
By kg
does what it is advertised to do
March 24, 2014
I have used this product for several years. This is a very good price on this product.
By Thisby
Excellent product
February 26, 2014
Our dogs have been on Frontline Plus for years and have never had fleas. This is an excellent product. Shipping was fast, and the price was very competitive.
Very good product
January 24, 2014
Been using it since 1997 on three dogs. never had a flea or tick issue. Never had negative effects on the dogs. For us, it has done no harm.
By PajamaMama
Washington, DC
Great Price
January 15, 2014
This is the same thing the vet sells for much more. Buy it from Entirely Pets!
By jeani
frontline Plus
January 7, 2014
Used product for years and it does work on my pets. Ticks were awful this past year. Use as directed and one will be happy they used frontline plus
By junior
frontline plus
December 24, 2013
have been using frontline plus forever it seems and before that regular frontline, maybe 25 plus years. I apply it every 5 weeks just to be safe from fleas because I walk 3 of our 4 dogs daily . It complements the heart guard I am now using now. I was on sentinel for a long time but after the production problem with sentinel (shortage) my vet switched me to heart guard and told me to just stay on it because I am using frontline anyway.
By Tess
Review for Frontline Plus for Dogs 45-88 lbs - PURPLE, 12 MONTH
December 13, 2013
I have been using this product for several years and have no fleas or ticks.
By Vickster
West Virginia
Only Flea Med to Use
November 29, 2013
Frontline Plus has always been the flea/tick medicine I use. Have 5 dogs and live in the country so have to have a product that works.
By Shasta
West Bend, WI
Frontline Plus
November 1, 2013
Just put the Frontline Plus on the dogs, as we do the 1st of every month, year round. Now we can go to training, the field, or the pool facility without fear of bringing home unwanted company.

Questions and Answers

Frontline Plus for Dogs 45-88 lbs, 3 MonthFrontline Plus for Dogs 45-88 lbs, 3 MonthReg price: $55.99
Sale price: $42.89
Frontline Plus for Dogs 45-88 lbs, 6 MonthFrontline Plus for Dogs 45-88 lbs, 6 MonthReg price: $103.99
Sale price: $79.99
Frontline Plus for Dogs 89-132 lbs, 3 MonthFrontline Plus for Dogs 89-132 lbs, 3 MonthReg price: $55.99
Sale price: $42.89
Frontline Plus for Dogs 89-132 lbs, 6 MonthFrontline Plus for Dogs 89-132 lbs, 6 MonthReg price: $102.99
Sale price: $78.99