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Frontline Plus for Dogs 5-22 lbs, 6 Month Video
Frontline Plus for Dogs 5-22 lbs, 6 Month Video

Frontline Plus for Dogs 5-22 lbs, 6 Month

Item: FPLUS6OR22
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Frontline Plus Orange for Dogs 5-22 pounds is a veterinarian-recommended, powerful and easy-to-use formula designed to quickly and effectively kill fleas, ticks, and chewing lice. Frontline Plus is specially formulated for dogs and puppies aged eight weeks and older weighing 5 - 22 pounds. Available without a prescription, Frontline Plus only needs to be applied once a month for thorough pest control.

Quickly Kills Fleas, Ticks, and Chewing Lice

This powerful formula kills up to 100 percent of existing fleas in the first 12 hours after application, and it continues to kill new fleas for at least one month afterward. Frontline Plus prevents the development of new fleas by destroying flea eggs and larvae and by destroying adult fleas before they have a chance to lay eggs. Frontline kills chewing lice and all four major ticks, including ticks that may carry Lyme disease, keeping both your pet and your family protected.

Waterproof Formula

Thanks to its waterproof formula, Frontline Plus won't rinse off when you give your dog a bath or when your dog goes for a swim. The active ingredient in Frontline , fipronil, is stored in the natural oils in your dog's coat, so your pet is sure to stay protected no matter how many puddles he or she tramps through.

EPA Registered Logo

This FRONTLINE Plus product is EPA approved and registered, so it's guaranteed to be the exact same product sold by your Veterinarian. Click here for more information on EPA-approved pet products.

Package Contents

Box includes six 0.67 mL tubes of Frontline Plus for Dogs.

Key Benefits

  • Kills fleas, flea eggs, ticks, and chewing lice
  • Fast-acting formula
  • includes six one-month applications
  • Waterproof formula
  • Easy-to-use applicator
  • For dogs eight weeks and older weighing 5 - 22 pounds

Frontline Plus for Dogs is Available In:
(5 - 22 lbs)
(23 - 44 lbs)
(45 - 88 lbs)
(89 - 132 lbs)
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month
3 month
6 month
12 month


Active Ingredients


Fipronil is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into an insect's cells and blocks chlorine molecules from passing through. This stops the nervous system from working and paralyzes the insect.

Fipronil kills adult fleas and ticks on contact or when consumed, and it can be spread from one insect to another.


Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of your dog, it slowly seeps into the hair follicles and oil glands where the fleas and ticks live.

Main Purpose

To kill adult fleas and ticks.


Methoprene is an insect growth regulator, which means it works by affecting the eggs and larvae of fleas. It interrupts normal levels of growth hormone, preventing a juvenile flea from growing and molting, leading to death.


Specifically designed to target developing larvae and eggs, methoprene prevents a flea population from increasing.

Main Purpose

To break the flea life cycle and stop further infestation.

Active Ingredients% by Weight
Inert Ingredients81.4%

Possible Side Effects

Some animals are sensitive or allergic to the ingredients in Frontline, so be sure to watch for any signs of allergic reaction. If your pet shows signs of itching, restlessness, nausea, lethargy, or breathing difficulty, seek veterinary attention immediately.

Net Contents

Three tubes, each 0.023 fluid ounces (0.67 milliliters)

Useful Information

How Frontline Plus Works

Use Frontline Plus for fast-acting, long-lasting flea and tick control. When you apply Frontline, fipronil, the active ingredient, is stored in the oil glands under your pet's skin. It's then distributed continuously to the skin and hair of your pet through the hair follicles. This way, Frontline provides waterproof, month-long protection against future pests while breaking down the flea and tick life cycles.

Simple Three-Step Application

Applying Frontline Plus to your pet is an easy three-step process:

  1. Remove the Frontline Plus applicator from the child-resistant package and cut or lift off the plastic tab to expose the foil and then peel the foil down.
  2. Hold the applicator upright and away from your face and body and snap off the tip.
  3. Place the Frontline Plus applicator tip on the skin between your pet's shoulder blades and squeeze the applicator to apply the entire contents in a single spot onto your pet's skin.


To prevent harm to you and your pet, read the entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Always point the applicator away from your face, especially your eyes, and wash your hands thoroughly after application. USE ON DOGS ONLY. Do not use on rabbits or other animals.

Dosage Table

WeightMonthly Dosage
5 - 22 poundsOne applicator (Orange)
23 - 44 poundsOne applicator (Blue)
45 - 88 poundsOne applicator (Purple)
89 - 132 poundsOne applicator (Red)

Storage Directions

Store unused product in original container, out of reach of children and animals.

Customer Reviews

Review Summary
114 Reviews
77% (88)
15% (17)
2% (2)
2% (2)
4% (5)
92% Recommend this product (105 of 114 responses)
By S K.
Works Great.
February 16, 2020
I have been using this product on my pets for years. Never had any fleas or ticks.
  • works great, easy to use
By Owned S.
New Mexico
Good experience
June 14, 2018
We've used Frontline Plus for many years on a number of dogs. Our experience has been good. We've not experienced a flea/tick problem and we have not had any negative side effects in any of our dogs. That's a good product in my book.
By Teri
Springfield, MO
Awesome Product, great prices
July 29, 2016
I have three dogs. Two small and one medium. I have, for some time now, order from Entirely Pets. Their prices are great and the product is absolutely awesome. I will never again pay full price from a Veterinary Office. Thank you so very much for your wonderful products and customer service. Delivery is always on time and the packages are never damaged. I recommended several family members to try you.
By Plengle
Frontline Plus for Dogs
June 14, 2016
I have used Frontline and now Frontline Plus for years. This is a product that works and works well on Ticks. We are in a very wooded area and our dogs continue to be tick free with this product.

Also, you have to be careful for knock offs but Entirely Pets have always ship the real item and it is a website that I trust.
By Mjf
Not Working
May 20, 2016
This product after two months is not working as I expected. My pets are still scratching at times, especially in hind end area.
By rsg444
New York, NY
best product of this type
May 18, 2016
I have used Frontline Plus on all my dogs over the years and it always works, and is good for any dog who is sensitive to any of these products.
By G
Good value
March 26, 2016
I purchased this for a better price than was offered at either of the local chain pet stores here in my city. I used this product before and it works well.
By darma
Penn, PA
Frontline plus
March 15, 2016
Excellent product. I have used it on all my dogs with no problems what so ever.
By Chuck
Frontline Plus
March 15, 2016
easy to use vials and is easy to keep track of when used last. Great product.
By George
NE Georgia
Frontline Plus for Dogs
March 15, 2016
Have been using this for my two dogs their entire life (they're pushing 14). Never have had any issue or any fleas or ticks.
By Amber
Roseville, California
Only thing that works
September 30, 2015
Frontline Plus is the only thing that works for my Chug (Pug/Chihuahua). I used to purchase it at the Vet's Office, then the vet changed to another product (ParaStar). The product didn't work. My dog has never had fleas in her life, until she wasn't on the Frontline. What a miserable experience that was. I had to flea bathe her, spray down my house with KnockOut, and get her back on the Frontline. Now everything is great again. If it isn't broken, don't fix it! :)
By Cooper
Website very easy to navigate
September 17, 2015
Took only one try to order exactly what I wanted.
Received on time.
By Cathy
must have
August 25, 2015
I love Frontline Plus. It's easy and it works, why wouldn't you use it?
By Jess B.
Glastonbury, CT
Frontline Plus for dogs does it's job
June 10, 2015
I have never had issues with the critters that this protects against. Have been using this product on my dog for 15 years.
By Lvmydogs40
Not happy
June 8, 2015
Not what I expected. It supposed to kills fleas. But found fleas still on my dogs.
By BusyFLmom
NE Florida
Misleading packaging details
April 22, 2015
I ordered this product based on the size 0-22 lbs. When the product arrived is stated 5-22 lbs. Instructions on the package say "Do not use on pets less than 5 pounds". I have 2 dogs that are under 3 pounds. Product returned!
By Amyaja
Dallas, TX
I rely on this product!
April 7, 2015
I have been using this product on multiple dogs (3-4) for 12 years. I have had NO problems with fleas or ticks!
Love it!
By Jafo
Middle East
The Product was up to it's standard
March 11, 2015
Been using Frontline Plus for years. If your pet doesn't have an adverse reaction to it's use it does the job very well of keeping ticks & fleas at bay.

My concern, when ordering the product, is that it's shipped in a timely manner. And it was.

I'd order it again from EntirelyPets.
By lengleman
Bentonville, AR
Best Tick Medicines I have found
January 30, 2015
I have used Frontline for a number of years to help keep the ticks off my animals (both cats and dogs). I live on 10 acres in a wooded area and while we do not have fleas, ticks abound! This product works.
By Sandy
Does the job
January 16, 2015
I've been using Frontline for years, it keeps the fleas away and my dog doesn't mind the application.
By cynthia
florence az
product performed
September 5, 2014
have used many products this one keeps all my dogs safe
By Owned S.
Good price performer
August 20, 2014
Have a new smaller dog and have started him on Frontline Plus. We've used the product for many years on our older Sheltie and have been happy with the results. Entirely Pets offers an excellent price.
By Marilyn
San Juan, P.R.
4 dogs!
August 19, 2014
I have 4 dogs, three small one big. With Frontline I have never had any problems with ticks or anything. Great product
By DoggieSmile
It Always DRIPS
August 16, 2014
Anyone know a way to apply this stuff without it dripping down the fur?? Don't know if prolonged use, will make it not effective on the bugs. Tried the Advantix, and it is always a vomit following use.
It is a poison, but what else can you use when it's tick season, and it's only good for 30 days on ticks.
Only gets 4 stars cause it is something that has to be used, otherwise too many bug bites. Too expensive, but nowhere else is cheaper.
By buffer66
Portland, OR
Not as Good as I Remember
August 4, 2014
This product used to be pretty effective, but now only seems to work for a couple of weeks. Even then, my little dog seems to be scratching and chewing far to much. Might have to look for a different product/brand the next time I am in the market. That's too bad, because I want my pets to find relief when I purchase and use these products on them.
By Maggie
Indianapolis, IN
Review for Frontline Plus for Dogs 0-22 lbs - ORANGE, 6 MONTH
July 27, 2014
I have been using Frontline for my little dog, Shelby, ever since I was fortunate enough to get her, for almost 13 years, now. It keeps the fleas off of her.
By Wendora
July 25, 2014
I have tried other brands in the past, but Frontline works the best for us! We have had nothing but good results.
By Joanne
Better than risking Lyme Disease
July 21, 2014
If you live in a Lyme Disease area, you have to do something to protect your dog. Frontline kills the ticks after they attach... hopefully before they can spread disease. I've been using Frontline Plus for years along with the yearly Lyme shot, and so far, so good.
By kadir
raleigh, nc
excellent purchase
July 18, 2014
I was able to use a coupon for $10.00 so very pleased with my purchase.
By Katy
Knoxville, TN
WORKS! NO Fleas or Ticks
July 15, 2014
I have been using this product Frontline Plus for my dogs for many years--my formerly adopted 2 schnauzers for their 9-10 years before they died and now for my 2 newly adopted schnauzers that have been with me for 7-8 months. My current vet says yes this product does work - contrary to what many other vets say - except for those who do not use it regularly And/OR who expose their animals to a flea or tick infested situation that already existed or for circumstances where people try to rescue other wild animals that are infested with bugs, such as squirrels. (he has seen it all)
I am not saying that it is the only product that works - just that the products the first vet that I saw tried to sell me one that cost double. I do not know that this product does not cause any adverse effects - but I am very hesitant to give a pill taken internally for fleas/ticks as usually there is a higher chance of worse side effects.

Questions and Answers

1 Question & 1 Answer
from Chicago, IL asked:
September 11, 2014
What time of the year is this to be applied to the dogs coat? Is this a year round process?
1 Answer
This preventive can be applied during any time of the year for monthly protection and can be applied every month for year-round protection.
Submitted by: Customer Service on September 12, 2014

Frontline Plus for Dogs 89-132 lbs, 12 MonthFrontline Plus for Dogs 89-132 lbs, 12 MonthReg price: $205.99
Sale price: $158.99
Frontline Plus for Dogs 5-22 lbs, 3 MonthFrontline Plus for Dogs 5-22 lbs, 3 MonthReg price: $54.99
Sale price: $42.89
Frontline Plus for Dogs 5-22 lbs, 12 MonthFrontline Plus for Dogs 5-22 lbs, 12 MonthReg price: $205.99
Sale price: $158.99
Frontline Plus for Dogs 23-44 lbs, 3 MonthFrontline Plus for Dogs 23-44 lbs, 3 MonthReg price: $54.99
Sale price: $42.89